... to EGFR overexpression. However, there is no significant difference between c-Cbl and SMURF2 in p27Kip1 +/+ and p27Kip1 −/− MEFs (results not shown), suggesting that EGFR protein stability could be regulated independently of c-Cbl and SMURF2. Further to demonstrating the link between p27 Kip1 and EGFR...

... of p27Kip1 accumulation during the cell cycle Science 1996 271 1861 1864 30 Nijhara R. Jana S. S. Goswami S. K. Kumar V. Sarkar D. P. An internal segment (residues 58–119) of the hepatitis B virus X protein is sufficient to activate MAP kinase pathways in mouse liver FEBS...

... of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex Nature (London) 1996 382 325 331 9 Hodge A. Mendenhall M. The cyclin-dependent kinase inhibitory domain of the yeast Sic1 protein is contained within the C-terminal 70 amino acids Mol. Gen. Genet. 1999...

... -galactosidase. The induction of the premature senescence programme is mediated by inhib- ition of Cdk2 kinase activity, and p27KIP1 is required to maintain the senescent phenotype. We propose that the ability to activate an endogenous premature senescence programme allows Bcl-2 to suppress tumour growth...