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Keywords: p300
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Biochem J (2014) 458 (3): 469–479.
Published: 28 February 2014
... proteins CBP (CREB-binding protein) and p300; this has been proposed to increase the transcription of CREB-dependent genes. CREB is also phosphorylated on Ser 133 by MSK1/2 (mitogen- and stress-activated kinase 1/2) in cells in response to the activation of MAPK (mitogen-activated protein kinase...
Includes: Supplementary data
Biochem J (2011) 433 (1): 245–252.
Published: 15 December 2010
... unspliced form by IRE1 (inositol-requiring enzyme 1) during the UPR. However, the post-translational modulation of XBP1s remains largely unknown. In the present study, we demonstrate that XBP1s is a target of acetylation and deacetylation mediated by p300 and SIRT1 (sirtuin 1) respectively. p300 increases...
Biochem J (2008) 415 (3): 477–482.
Published: 15 October 2008
... containing MTF-1 and the histone acetyltransferase p300 which plays an essential role in the activation of MT - I transcription. In the present study, co-immunoprecipitation assays demonstrated that Cr(VI) pretreatment blocks the zinc-induced formation of this co-activator complex. Thus Cr(VI) inhibits mouse...
Biochem J (2007) 407 (3): 451–460.
Published: 12 October 2007
... pocket domain of Rb. p300 catalysed the acetylation of Rb, and SIRT1 was a potent deacetylase for Rb. The ability of SIRT1 to catalyse the deacetylation of Rb was dependent on NAD and was inhibited by the SIRT1 inhibitor nicotinamide. Deacetylated lysine residues within Rb formed a domain similar to the...
Biochem J (2007) 404 (2): 289–298.
Published: 14 May 2007
... addition to ligand-mediated activation, Notch signalling can be further modulated by interactions of Notch IC with a number of other proteins. MAML1 has previously been shown to act co-operatively with the histone acetyltransferase p300 in Notch IC-mediated transcription. In the present study we show that...
Biochem J (2007) 403 (3): 397–407.
Published: 12 April 2007
... posttranslational modifications by MS. We have found that Max is acetylated at several lysine residues (Lys-57, Lys-144 and Lys-145) in mammalian cells. Max acetylation is stimulated by inhibitors of histone deacetylases and by overexpression of the p300 co-activator/HAT (histone acetyltransferase). The p300 HAT...
Includes: Supplementary data
Biochem J (2005) 391 (2): 239–247.
Published: 10 October 2005
...Atsushi Kaida; Yasuo Ariumi; Keiko Baba; Masami Matsubae; Toshifumi Takao; Kunitada Shimotohno CBP [CREB (cAMP-response-element-binding protein)-binding protein] and p300 play critical roles in transcriptional co-activation, cell differentiation, proliferation and apoptosis. Multiple transcription...
Biochem J (2004) 381 (3): e3.
Published: 27 July 2004
...-binding protein) and p300. Their studies revealed that EDTA treatment of native C/H1 leads to irreversible denaturation and aggregation. Of particular concern is their finding that unfolded C/H1 participates in non-specific protein–protein interactions. The implications of these results are significant...
Biochem J (2004) 380 (1): 289–295.
Published: 15 May 2004
...-1α protein amount. Establishing that p53-evoked inhibition of HIF-1 reporter activity was relieved upon co-transfection of p300 suggested competition between p53 and HIF-1 for limiting amounts of the shared co-activator p300. This assumption was confirmed by showing competitive binding of in vitro...
Biochem J (2000) 348 (3): 591–596.
Published: 07 June 2000
... inhibit the Smad7 promoter in human embryonic kidney 293 cells. In human hepatoma HepG2 cells, TNF-α was able to inhibit TGF-β- and activin-mediated transcriptional activation. Furthermore, overexpression of the transcription co-activator p300 could abrogate the inhibitory effect of NF-ĸB on the Smad7...