... pain are associated with several undesirable effects. Buddleja thyrsoides Lam., known as ‘Barbasco’ or ‘Cambara’, is mostly used in several disorders and possesses antirheumatic, anti-inflammatory, and analgesic properties. Here, we investigated the antinociceptive and anti-inflammatory effects...

...J. Grayson Evans; Slobodan M. Todorovic Given the clinical significance of pain disorders and the relative ineffectiveness of current therapeutics, it is important to identify alternative means of modulating nociception. The most obvious pharmacological targets are the ion channels that facilitate...

... and of inflammatory and neuropathic pain. We have described recently that docking-groove-dependent interactions are important for p38 MAPK-mediated signal transduction. Thus virtual screening was performed to identify putative docking-groove-targeted p38 MAPK inhibitors. Several compounds of the benzo-oxadiazol...

... 1 2013 30 1 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 β-arrestin-2 desensitization inflammation pain phosphorylation transient receptor potential vanilloid 1 (TRPV1) Post-translational modifications in the TRPV1 (transient receptor...

... and PKA via AKAP150 is necessary for the phosphorylation and sensitization of TRPV1 (transient receptor potential subfamily V type 1 channel) [ 4 – 6 ]. Phosphorylation of TRPV1 results in sensitization of the channel to activation by multiple pain-evoking stimuli, including noxious heat (>42 °C...