... the underlying mechanisms we employed MS in a comprehensive lipidomic screen of MIN6 β-cells treated for 48 h with palmitate. Both the overall mass and the degree of saturation of major neutral lipids and phospholipids were only modestly increased by palmitate. The mass of GlcCer (glucosylceramide) was augmented...

...Maria L. Watson; Matthew Coghlan; Harinder S. Hundal Saturated fatty acids, such as palmitate, promote accumulation of ceramide, which impairs activation and signalling of PKB (protein kinase B; also known as Akt) to important end points such as glucose transport. SPT (serine palmitoyl transferase...

...Maria V. LOSKOVICH; Vera G. GRIVENNIKOVA; Gary CECCHINI; Andrei D. VINOGRADOV Palmitate rapidly and reversibly inhibits the uncoupled NADH oxidase activity catalysed by activated complex I in inside-out bovine heart submitochondrial particles (IC 50 extrapolated to zero enzyme concentration...

... by oxidative and glycolytic ATP production and the contributions to the oxidative component by glucose, lactate, glutamine, palmitate and oleate. The total ATP turnover over approx. 5days was 26.8 μ mol of ATP·10 7 cells −1 ·h −1 . ATP production was 80% oxidative and 20% glycolytic. Contributions...

..., London © 2000 2000 insulin palmitate phospholipid plasmalogen triacylglycerol Biochem. J. (2000) 352, 79 89 (Printed in Great Britain) 79 Diabetes-induced changes in specific lipid molecular species in rat myocardium Xianlin HAN*, Dana R. ABENDSCHEIN‹, John G. KELLEY* and Richard W. GROSS*1...