...’. Thus, two defined phases follow a square wave increase in glucose both in vivo in man [ 68 ] and when measured from the perfused rat pancreas [ 69 ]. The first phase, lasting 3–10 min, is followed by a nadir and a subsequent, gradually-increasing second phase which may last 60 min or more. Many...

...M. Luisa Campos; Víctor J. Sánchez-Arévalo Lobo; Annie Rodolosse; Cara J. Gottardi; Andrea Mafficini; Stefania Beghelli; Maria Scardoni; Claudio Bassi; Aldo Scarpa; Francisco X. Real The PTF1 (pancreas transcription factor 1) complex is a master regulator of differentiation of acinar cells...

...Xinmiao Fu; Pan Wang; Masayuki Fukui; Cheng Long; Linxiang Yin; Hye Joung Choi; Bao Ting Zhu E 2 (17β-oestradiol), a female sex hormone, has important biological functions in a woman's body. The pancreas, often considered a non-classical E 2 -targeting organ, is known to be functionally regulated...

... Biochemical Society 2011 diabetes enhancer pancreas transcription zinc The animal housing and surgical facilities used for the mice in the present studies meet the American Association for the Accreditation of Laboratory Animal Care standards. All animal protocols were approved...

... 2010 4 5 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 ATP release ATP uptake pancreas purinergic receptor vesicular nucleotide transporter (VNUT) zymogen granule ATP was measured in duplicate, and the samples were pooled for each individual...

... medium, provided the original work is properly cited. AMP-activated protein kinase (AMPK) ATP-sensitive potassium channel (K ATP ) β-cell glucokinase pancreas uncoupling protein 2 (UCP2) Antibodies used were mouse anti-insulin (I-2018; Sigma–Aldrich), rabbit anti-glucagon (ab9379...

... that the chaperone activity of the human pancreas-specific PDI homologue (PDIp) is independent of its enzymatic activity on the basis of the following lines of evidence. First, alkylation of PDIp by iodoacetamide fully abolishes its enzymatic activity, whereas it still retains most of its chaperone activity...

...Annie Rodolosse; Maria-Luisa Campos; Ilse Rooman; Mathieu Lichtenstein; Francisco X. Real p48, also called Ptf1a (pancreas-specific transcription factor 1a), is a tissue-restricted bHLH (basic helix loop helix) transcription factor which is critical for pancreatic commitment during development...

... example of a stem cell compartment, and then examine the evidence for the existence of adult stem cells in two endodermally derived organs: pancreas and liver. We will review the characteristics of the putative stem cells in these tissues and the transcription factors controlling their differentiation...

...Bidyut Ghosh; Steven D. Leach In the developing pancreas, the onset of exocrine differentiation is driven by the activity of the PTF1 (pancreas transciption factor 1) transcriptional complex, which is comprised of the class II bHLH (basic helix–loop–helix) protein, Ptf1-p48 [also known as Ptf1a...

... found that the endocrine pancreas co-expresses two isoforms of GA (glutaminase), denoted as kidney-type (KGA) and liver-type (LGA), with a complementary cellular pattern of expression. Whereas KGA was mainly present in α-cells, LGA was very abundant in β-cells. This spatial segregation may have...

... formation could be modulated. amylin diabetes mellitus islet amyloid islet β-cell pancreas protein aggregation Abbreviations used: AM, acetoxymethyl ester; EthD-1, ethidium homodimer-1; hA, human amylin; (Pro 3 25,28,29 )hA: triprolyl hA; rA, rat amylin. Biochem. J. (2003) 374, 779 784...

...Jan AMSTRUP; Ivana NOVAK P2X 7 nucleotide receptors modulate a spectrum of cellular events in various cells including epithelia, such as exocrine pancreas. Although the pharmacology and channel properties of the P2X 7 receptors have been studied intensively, signal transduction pathways...

... to explain how the ubiquitously expressed USF could contribute to islet-specific IGRP gene expression. Key words: diabetes, pancreas, promoter, transcription. INTRODUCTION The transcriptional mechanisms that direct the specific or enriched expression of genes such as insulin and glucagon to the islets...

...- differentiate into functional hepatocytes and that it could be possible to generate a limitless supply of functional hepatocyte- like cells in Šitro. Key words: cytochrome P450, liver, pancreas, stem cell, steroid. corticoid treatment [10]. More recently, they have suggested that B-13 cells expressCYP2B1}2...

... The Biochemical Society, London ©2002 2002 diabetes enteroendocrine intestine islet pancreas Abbreviations used: EMSA, electrophoretic mobility-shift assay; Foxa, Forkhead box a; GLI, glucagon-like immunoreactivity; GLP, glucagon-like peptide; HNF, hepatocyte nuclear factor; RT-PCR, reverse...

... contributes to the loss of response to high glucose in b-cells exposed to fatty acids. Key words: beta cells, etomoxir, fatty acid oxidation, glucose- stimulated insulin secretion, pancreas. Both malonyl-CoA and LC-CoA participate in the signal transduction for insulin secretion: malonyl-CoA as a regulator...

...Haruo TAKESHITA; Toshihiro YASUDA; Reiko IIDA; Tamiko NAKAJIMA; Shinjiro MORI; Kouichi MOGI; Yasushi KANEKO; Koichiro KISHI We purified four amphibian deoxyribonucleases I from the pancreases of one toad, two frog and one newt species, by using three different column chromatography methods...

... The Biochemical Society, London © 2000 2000 endocrine exocrine intracellular targeting pancreas Biochem. J. (2000) 350, 637 643 (Printed in Great Britain) 637 Targeting of the zymogen-granule protein syncollin in AR42J and AtT-20 cells Alois HODEL and J. Michael EDWARDSON1 Department of Pharmacology...

... appears to be essential for the secretion of BSDL. Key words: AR4-2J cell line, pancreas. enzyme activity which can perturb the lipid metabolism of the cell [11]. The question that now rises in mind is how and when is BSDL released from intracellular membranes and addressed towards secretion? We have...