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Keywords: pancreatic β-cells
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Articles

Palmitate-induced impairment of glucose-stimulated insulin secretion precedes mitochondrial dysfunction in mouse pancreatic islets

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Jonathan Barlow, Verena Hirschberg Jensen, Martin Jastroch, Charles Affourtit
Journal: Biochemical Journal
Biochem J (2016) 473 (4): 487–496.
https://doi.org/10.1042/BJ20151080
Published: 09 February 2016
...Jonathan Barlow; Verena Hirschberg Jensen; Martin Jastroch; Charles Affourtit It has been well established that excessive levels of glucose and palmitate lower glucose-stimulated insulin secretion (GSIS) by pancreatic β-cells. This β-cell ‘glucolipotoxicity’ is possibly mediated by mitochondrial...
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Articles

Secrets of insulin and IGF-1 regulation of insulin secretion revealed

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Peter R. SHEPHERD
Journal: Biochemical Journal
Biochem J (2004) 377 (1): e1–e2.
https://doi.org/10.1042/bj20031747
Published: 01 January 2004
... a resolution: both are required. 1 e-mail [email protected] 17 11 2003 18 11 2003 16 12 2003 The Biochemical Society, London ©2004 2004 glucose metabolism insulin insulin-like growth factor-1 (IGF1) pancreatic β-cells Biochem. J. (2004) 377 (e1 e2) (Printed...
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