...Kayla C. LaRue-Nolan; Glancis Luzeena Raja Arul; Ashley N. Sigafoos; Jiaqi Shi; Martin E. Fernandez-Zapico Pancreatic cancer is a malignancy arising from the endocrine or exocrine compartment of this organ. Tumors from exocrine origin comprise over 90% of all pancreatic cancers diagnosed...

... BCL2 cell survival GLI1 pancreatic cancer SUFU To determine the role SUFU plays in the regulation of GLI TFs in PDAC, we knocked down SUFU in PDAC cell lines Panc-1, AsPC-1 and MiaPaca-2 to assess the effect on GLI activity. C3H/10T1/2 (10T1/2) cells were used as a positive control...

... transcriptional axis regulating the expression of SDF1, a major driver of cancer cell migration, involving the transcription factor GLI1 and histone acetyltransferase p300. We demonstrate that conditioned media from CAFs overexpressing GLI1 induce the migration of pancreatic cancer cells, and this effect...

... dioxygenase 1 JAK/STAT signaling pancreatic cancer IDO1, an immunomodulatory tryptophan-catabolizing enzyme [ 1 ], is expressed in several normal tissues like the lymph node, spleen, thymus, lungs, epididymis, colon, and at the maternal-fetal interface wherein it is known to play a vital role...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ascites fluid KPC metastasis pancreatic cancer SLC6A14 survival Pancreatic ductal adenocarcinoma (PDAC) is lethal. There is a dire need for more efficient treatments to improve survival...

... collectively, these studies demonstrate a functional link between PEPT1 and extracellular protein breakdown in the tumor microenvironment as a key determinant of pancreatic cancer growth, thus identifying PEPT1 as a potential therapeutic target for PDAC. Correspondence: Yangzom D. Bhutia...

..., carbidopa but not dopamine exhibited AhR activity in BxPC3 pancreatic cancer cells whereas minimal activity was observed for both compounds in Panc1 pancreatic cancer cells. In contrast with a previous report, the induction responses and cytotoxicity of carbidopa was observed only at high concentrations...

...Aimin Cai; Hailun Zheng; Zhiwei Chen; Xinlu Lin; Chen Li; Qing yao; Yangzom D. Bhutia; Vadivel Ganapathy; Ruijie Chen; Longfa Kou Gemcitabine is the first-line chemotherapy for pancreatic cancer. To overcome the often-acquired gemcitabine resistance, other drugs are used in combination...

..., and this compound inhibits pancreatic cancer cell and tumor growth. These results are consistent with activities of other AhR-active compounds that inhibit carcinogenesis. Like carbidopa, these chemicals are selective AhR modulators with potential clinical applications that are AhR-dependent. © 2017 The Author(s...

...Jiro Ogura; Seiji Miyauchi; Kazumi Shimono; Shengping Yang; Sathisha Gonchigar; Vadivel Ganapathy; Yangzom D. Bhutia Carbidopa is used with l -DOPA ( l -3,4-dihydroxyphenylalanine) to treat Parkinson's disease (PD). PD patients exhibit lower incidence of most cancers including pancreatic cancer...

... examine the way in which signalling events through these pathways mediates invasion, regulates microRNAs and contributes to chemoresistance. In the complex interplay between the extracellular microenvironment and the proliferation and metastatic potential of pancreatic cancer cells, MT1-MMP can...

... unexplored. In the present study, we found that hHS6ST2 , but not other variants, was activated in human PC (pancreatic cancer). shRNA (short hairpin RNA)-mediated silencing of endogenous hHS6ST2 expression in the PC cell line PANC-1 inhibited cell invasion and migration. hHS6ST2 knockdown also resulted...

... ). 25 5 2010 16 12 2010 20 12 2010 20 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 cyclin A Krüppel-like factor 11 (KLF11) Krüppel-like factor (KLF) protein pancreatic cancer tumour suppression V-Ki-ras2 Kirsten rat sarcoma viral oncogene...