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Keywords: paxillin
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Articles
MEKK2 regulates paxillin ubiquitylation and localization in MDA-MB 231 breast cancer cells
Available to PurchaseMagdalene Ameka, Michael P. Kahle, Mathew Perez-Neut, Saverio Gentile, Ahmed A. Mirza, Bruce D. Cuevas
Journal:
Biochemical Journal
Biochem J (2014) 464 (1): 99–108.
Published: 23 October 2014
... physically associates with the LD1 motif of the focal adhesion protein paxillin. We reveal that MEKK2 induces paxillin ubiquitylation, and that this function requires both the paxillin LD1 motif and MEKK2 kinase activity. Finally, we demonstrate that MEKK2 promotes paxillin redistribution from focal...
Includes: Supplementary data
Articles
Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD 4 motif: evidence that nuclear paxillin promotes cell proliferation
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2009) 418 (1): 173–184.
Published: 28 January 2009
...Jing-Ming Dong; Lei-Shong Lau; Yuen-Wai Ng; Louis Lim; Ed Manser Paxillin, a major focal-adhesion complex component belongs to the subfamily of LIM domain proteins and participates in cell adhesion-mediated signal transduction. It is implicated in cell-motility responses upon activation of cell...
Includes: Supplementary data
Articles
Minimal features of paxillin that are required for the tyrosine phosphorylation of focal adhesion kinase
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2006) 393 (2): 565–573.
Published: 23 December 2005
... protein paxillin is required for the overall tyrosine phosphorylation of FAK in embryonic stem cells [Wade, Bohl and Vande Pol (2002) Oncogene 21 , 96–107]. In the present paper, we identify the minimal structural features of paxillin that are required to support overall FAK tyrosine phosphorylation...
Articles
Characterization of an activated mutant of focal adhesion kinase: ‘SuperFAK’
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2002) 365 (3): 591–603.
Published: 01 August 2002
... be addressed (e-mail [email protected] ). 10 1 2002 16 4 2002 3 5 2002 The Biochemical Society, London ©2002 2002 integrin motility phosphotyrosine paxillin Src Abbreviations used: CE, chicken embryo; CHO, Chinese-hamster ovary; ECM, extracellular matrix; EGFR...
Articles
α1 Integrin cytoplasmic domain is involved in focal adhesion formation via association with intracellular proteins
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2001) 356 (1): 233–240.
Published: 08 May 2001
... the cytoplasmic domain of the α1 integrin subunit are unable to form proper focal adhesions and that phosphorylation on tyrosine residues of focal adhesion components is reduced on α1β1-specific substrates. The α1 cytoplasmic sequence is a specific recognition site for focal adhesion components like paxillin...