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Keywords: peptide
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Articles
Biochem J (2015) 472 (3): 287–295.
Published: 27 November 2015
... consists of targeting the receptor cytoplasmic surfaces interacting with the associated G-proteins using peptides mimicking the intracellular loops of the receptor. Thus, to be fully effective, the peptide mimics must be selectively targeted to the tumour while sparing healthy tissues, translocated across...
Includes: Supplementary data
Articles
Biochem J (2015) 465 (1): 115–125.
Published: 12 December 2014
...Rooban B. Nahomi; Michael A. DiMauro; Benlian Wang; Ram H. Nagaraj Previous studies have identified peptides in the ‘crystallin-domain’ of the small heat-shock protein (sHSP) α-crystallin with chaperone and anti-apoptotic activities. We found that peptides in heat-shock protein Hsp20 (G 71...
Articles
Biochem J (2009) 419 (2): 497–506.
Published: 27 March 2009
... demonstrate inhibition of dimerization using P27 (peptide 27), a peptide dimerization inhibitor of PR previously identified on the basis of kinetic analysis. Incubation of PR MDR with P27, or other dimerization inhibitors, led to a dose- and time-dependent formation of PR monomers based on the change in...
Includes: Supplementary data
Articles
Biochem J (2008) 414 (1): 143–150.
Published: 29 July 2008
...Ruud P. M. Dings; Judith R. Haseman; Kevin H. Mayo Cationic peptides, known to disrupt bacterial membranes, are being developed as promising agents for therapeutic intervention against infectious disease. In the present study, we investigate structure–activity relationships in the bacterial...
Articles
Biochem J (2008) 412 (3): 447–457.
Published: 28 May 2008
... phage-displayed peptide library with murine uPA as bait. We thereby isolated several murine uPA-binding peptide sequences, the predominant of which was the disulfide-bridged constrained sequence CPAYSRYLDC, which we will refer to as mupain-1. A chemically synthesized peptide corresponding to this...
Articles
Biochem J (2008) 411 (1): 151–160.
Published: 13 March 2008
... conjugated p53 peptides [wild-type (containing the wild-type binding site) and mutant (with a mutated 7-amino-acid binding site)] to a TAT peptide sequence to penetrate the cells, and demonstrated that the wild-type p53 peptide disrupted binding of FAK and p53 proteins and significantly inhibited cell...
Articles
Biochem J (2006) 395 (1): e1.
Published: 15 March 2006
... design of antitoxin therapeutics. In this issue of Biochemical Journal , Bracci and co-workers describe the discovery by competitive screening of a phage-display library of a peptide inhibitor of anthrax toxin assembly that shows great promise towards the treatment of anthrax. 1 To whom...
Articles
Biochem J (2005) 385 (1): 29–36.
Published: 14 December 2004
... Tar-1 peptide containing these two arginine residues was able to inhibit in vivo the marked dimerization of a mutant Tar-1 construct that contained two glutamate residues at similar positions. This indicates that hetero-assembly of TM domains can be mediated by the interaction of two oppositely...
Articles
Biochem J (2004) 381 (3): 877–885.
Published: 27 July 2004
...–67) using variable truncated N-terminal GRAB fusion proteins. The sequence of the identified domain was used to design overlapping synthetic peptides of different sizes, which were then immobilized on a membrane and assayed for their α 2 M-binding activity. The peptide screening revealed two binding...
Articles
Biochem J (2003) 373 (1): 281–288.
Published: 01 July 2003
...Ruud P. M. DINGS; Monica M. ARROYO; Nathan A. LOCKWOOD; Loes I. van EIJK; Judy R. HASEMAN; Arjan W. GRIFFIOEN; Kevin H. MAYO Anginex is a designed peptide 33mer that functions as a cytokine-like agent to inhibit angiogenesis. Although this short linear peptide has been shown by NMR and CD to form a...
Articles
Biochem J (2001) 357 (3): 739–747.
Published: 25 July 2001
...Andrew COX; Monica M. ARROYO; Kevin H. MAYO For the designed peptide 33mer, βpep-4, formation of β-sheet structure [Ilyina, Roongta and Mayo (1997) Biochemistry 36 , 5245–5250] is thermodynamically linked to self-association. Dimers and tetramers are stabilized by interactions between hydrophobic...
Articles
Biochem J (2001) 357 (1): 73–81.
Published: 25 June 2001
... 2001 The Biochemical Society, London ©2001 2001 GPCR in vitro translation peptide Xenopus Abbreviations used: AVP, [arginine 8 ]vasopressin; GPCR, G-protein-coupled receptor; OTR, oxytocin receptor; PhAc, phenylacetyl; VPR, vasopressin receptor; V 1a R, V 1a vasopressin...
Articles
Biochem J (2001) 355 (3): 741–750.
Published: 24 April 2001
...@biochem.uthscsa.edu ). 18 8 2000 25 1 2001 16 2 2001 The Biochemical Society, London © 2001 2001 caveolae clathrin-coated pit G-protein-coupled receptor internalization peptide Biochem. J. (2001) 355, 741 750 (Printed in Great Britain) 741 Agonist-promoted trafficking of human...
Articles
Biochem J (2001) 354 (2): 465–472.
Published: 22 February 2001
...Stuart R. HAWTIN; Helen C. HOWARD; Mark WHEATLEY The effects of the peptide hormone oxytocin are mediated by oxytocin receptors (OTRs) expressed by the target tissue. The OTR is a member of the large family of G-protein-coupled receptors. Defining differences between the interaction of agonists and...
Articles
Biochem J (1999) 339 (2): 473–479.
Published: 08 April 1999
...-binding protein), a specific serpin for this protease, as well as somatostatin 1–14. Internally quenched fluorogenic peptides were synthesized with the general structure Abz-peptidyl-EDDnp [Abz, o -aminobenzoic acid; EDDnp, N -(2,4-dinitrophenyl)ethylenediamine], based on the natural reactive-centre loop...