.... However, it was unclear whether and how phosphorylation could stabilize a helix in a broader context. In the current manuscript, we address this challenge using poly-Ala-based model peptides and a suite of circular dichroism and nuclear magnetic resonance spectroscopies. We show that phosphorylation...

... for the everlasting demand of new antibiotic compounds constitute antimicrobial peptides (AMPs). These peptides act against different types of microbes by permeabilizing pathogen cell membranes, whereas being harmless to mammalian cells. Contrarily, another class of membrane-active peptides, namely cell-penetrating...

... a precedent for the rational design of 14-3-3 based PPI inhibitors by utilizing 14-3-3 recognition motif peptides, as a potential antimalarial strategy. For overexpression of GST- Pf 14-3-3I fusion protein, the recombinant plasmid containing pf14-3-3I gene was transformed into E. coli strain Rosetta...

... with S100P binding to all four half molecules in gel-overlay assays. When screened by NMR and ITC for interacting with S100P, four chemically synthesised peptides show interactions with low micromolar dissociation constants. The two highest affinity peptides significantly inhibit binding of S100P to α,β...

...Rinky Rajput; Balasubramani G L; Ankit Srivastava; Divya Wahi; Nidhi Shrivastava; Bishwajit Kundu; Abhinav Grover Compelling evidence implicates self-assembly of amyloid- β (A β 1–42 ) peptides into soluble oligomers and fibrils as a major underlying event in Alzheimer's disease (AD) pathogenesis...

...Noé Quittot; Phuong Trang Nguyen; Armelle Tchoumi Nerée; Marc P. Lussier; Steve Bourgault Secretin is a peptide hormone that exerts pleiotropic physiological functions by specifically binding to its cognate membrane-bound receptor. The membrane catalysis model of peptide–receptor interactions...

... peptides Lipoproteins perform many functions and synthetic mimetics were designed to recreate many of them, as well as to contrive new functions not performed by the native lipoproteins ( Table 1 ). 1 To whom correspondence should be addressed (email [email protected]...

... will be discussed with particular reference to electrospray. The mass analysis of ions will be described, and the concept of tandem MS introduced. Where appropriate, examples of the application of MS in biochemistry will be provided. Although the present review will concentrate on the MS of peptides/proteins...