... infections during surgeries. Antimicrobial resistance (AMR) is attributed to the mismanagement and overuse of these medications and is complicated by a slower rate of the discovery of novel drugs and targets. Bacterial peptidoglycan (PG), a three-dimensional mesh of glycan units, is the foundation...

... a peptidoglycan-synthesizing enzyme and cpxA , encoding a histidine kinase of a two-component signal transduction system that contributed to salt tolerance and flocculation prevention. Both single mutants formed flocs during high salt shock, these flocs contained cytosolic proteins. Δ cpxA exhibited decreased...

...Sukhithasri Vijayrajratnam; Anju Choorakottayil Pushkaran; Aathira Balakrishnan; Anil Kumar Vasudevan; Raja Biswas; Chethampadi Gopi Mohan Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is an intracellular pattern recognition receptor that recognizes bacterial peptidoglycan...

... © The Authors Journal compilation © 2011 Biochemical Society 2011 cell wall penicillin binding-associated and serine/threonine kinase-associated domain (PASTA domain) peptidoglycan PrkC serine/threonine kinase Staphylococcus aureus Signal transduction through reversible protein...

...Jennifer Robertson; Sue Lang; Peter A. Lambert; Patricia E. Martin Gram-positive bacterial cell wall components including PGN (peptidoglycan) elicit a potent pro-inflammatory response in diverse cell types, including endothelial cells, by activating TLR2 (Toll-like receptor 2) signalling...

... these enzymes and their natural substrates, presumably the peptide moieties of peptidoglycan. In general, remarkably little activity has previously been demonstrated in vitro against potential peptide substrates, although in many cases the peptides employed were non-specific and not homologous with the relevant...