...Christian SCHACHTRUP; Tanja EMMLER; Bertram BLECK; Anton SANDQVIST; Friedrich SPENER Retinoic acids and long-chain fatty acids are lipophilic agonists of nuclear receptors such as RXRs (retinoic X receptors) and PPARs (peroxisome-proliferator-activated receptors) respectively. These agonists...

...Guoqiang JIANG; Qing DALLAS-YANG; Subarna BISWAS; Zhihua LI; Bei B. ZHANG Peroxisome-proliferator-activated receptor γ agonists such as rosiglitazone, a thiazolidinedione, improve insulin sensitivity in vivo , but the underlying mechanism(s) remains unclear. Phosphorylation of IRS1 (insulin...

...Robert BABB; Benjamin R. BOWEN Peroxisome-proliferator-activated receptors (PPARs), members of the nuclear hormone receptor superfamily, play an important role in the regulation of lipid metabolism and energy homoeostasis. In a yeast two-hybrid experiment using the zinc-finger transcription factor...

... correspondence should be addressed (e-mail [email protected] ). 31 5 2000 4 1 2001 19 1 2001 The Biochemical Society, London © 2001 2001 fibrate mitochondria obesity peroxisome-proliferator-activated receptor troglitazone Biochem. J. (2001) 355, 105 111 (Printed...

...- and/or ω-oxidation is apparently a determinant of the peroxisome proliferating and hypolipidaemic capacity of fatty acids and derivatives, the relative importance of activation of the peroxisome-proliferator-activated receptor α (PPARα), fatty acid oxidation and triacylglycerol synthesis were examined. We...

... in diabetes and starvation, during intense lipolysis, and in the foetal–neonatal and suckling–weaning transitions. The DNA-binding properties of the peroxisome-proliferator-activated receptor and other transcription factors on the nuclear-receptor-responsive element of the mitochondrial HMG-CoA synthase...