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1-13 of 13
Keywords: peroxynitrite
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Articles
Benjamin Selles, Martin Hugo, Madia Trujillo, Vaibhav Srivastava, Gunnar Wingsle, Jean-Pierre Jacquot, Rafael Radi, Nicolas Rouhier
Journal:
Biochemical Journal
Biochem J (2012) 442 (2): 369–380.
Published: 13 February 2012
... are regenerated by glutathione or Trxs (thioredoxins) respectively. In the present paper we show new data concerning the substrates of poplar Gpx5 and the residues involved in its catalytic mechanism. The present study establishes the capacity of this Cys-Gpx to reduce peroxynitrite with a catalytic efficiency...
Includes: Supplementary data
Articles
Milos R. Filipovic, Jan Miljkovic, Andrea Allgäuer, Ricardo Chaurio, Tatyana Shubina, Martin Herrmann, Ivana Ivanovic-Burmazovic
Journal:
Biochemical Journal
Biochem J (2012) 441 (2): 609–621.
Published: 21 December 2011
...Milos R. Filipovic; Jan Miljkovic; Andrea Allgäuer; Ricardo Chaurio; Tatyana Shubina; Martin Herrmann; Ivana Ivanovic-Burmazovic The reaction of hydrogen sulfide (H 2 S) with peroxynitrite (a key mediator in numerous pathological states) was studied in vitro and in different cellular models...
Includes: Supplementary data
Articles
Khandaker Ahtesham Ahmed, Tomohiro Sawa, Hideshi Ihara, Shingo Kasamatsu, Jun Yoshitake, Md. Mizanur Rahaman, Tatsuya Okamoto, Shigemoto Fujii, Takaaki Akaike
Journal:
Biochemical Journal
Biochem J (2012) 441 (2): 719–730.
Published: 21 December 2011
... demonstrated that peroxynitrite-dependent oxidation and myeloperoxidase-dependent oxidation of nitrite in the presence of H 2 O 2 were two major pathways for guanine nucleotide nitration. Among the guanine nucleotides examined, GTP was the most sensitive to peroxynitrite-mediated nitration. Immunocytochemical...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 410 (2): 359–368.
Published: 12 February 2008
... or released by activated macrophages. Parasites transformed to overexpress TcAPX ( T. cruzi ascorbate-dependent haemoperoxidase) were also more resistant to H 2 O 2 challenge, but unlike TcMPX and TcCPX overexpressing lines, the TcAPX overexpressing parasites were not resistant to peroxynitrite. Whereas...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2007) 407 (1): 89–99.
Published: 12 September 2007
... with the chemical properties of peroxynitrite, at pathophysiological concentrations of NO 2 − and H 2 O 2 . Without external substrates, the targets of the reactive species generated by the metNGB/NO 2 − /H 2 O 2 system are endogenous tyrosine (resulting in the production of 3-nitrotyrosine) and cysteine (oxidized...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2006) 399 (1): 161–168.
Published: 13 September 2006
... by myeloperoxidase and its yield increased with the flux of oxidant. Of the other oxidants tested, only hypobromous acid and peroxynitrite produced substantial amounts of glutathione sulfonamide, but much less than with HOCl. Chloramines were able to generate detectable levels only when at a stoichiometric excess...
Articles
Andrés Trostchansky, Summer Lind, Roberto Hodara, Tomoyuki Oe, Ian A. Blair, Harry Ischiropoulos, Homero Rubbo, José M. Souza
Journal:
Biochemical Journal
Biochem J (2006) 393 (1): 343–349.
Published: 12 December 2005
... upon exposure to fluxes of peroxynitrite (8–20 μM·min −1 ). To investigate the effect of oxidized lipids on α-syn, the protein was incubated with the bifunctional electrophile 4-HNE [4-hydroxy-2( E )-nonenal]. MS analysis showed the formation of three major products corresponding to the native protein...
Articles
Rika Yasuhara, Yoichi Miyamoto, Takaaki Akaike, Teruo Akuta, Masanori Nakamura, Masamichi Takami, Naoko Morimura, Kayoko Yasu, Ryutaro Kamijo
Journal:
Biochemical Journal
Biochem J (2005) 389 (2): 315–323.
Published: 05 July 2005
... oxidase, gp91 phox , as well as inducible NO synthase in ATDC5 cells. Generation of nitrated guanosine and tyrosine suggested the formation of reactive nitrogen species including ONOO − (peroxynitrite), a reaction product of NO and O 2 − , in ATDC5 cells and rat primary chondrocytes treated with IL-1β...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 389 (1): 233–240.
Published: 21 June 2005
...Mario FONTANA; Donatella AMENDOLA; Emanuela ORSINI; Alberto BOFFI; Laura PECCI Peroxynitrite mediates the oxidation of the sulphinic group of both HTAU (hypotaurine) and CSA (cysteine sulphinic acid), producing the respective sulphonates, TAU (taurine) and CA (cysteic acid). The reaction...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 369 (2): 399–406.
Published: 15 January 2003
..., the consumption could be inhibited by superoxide dismutase. A scheme is proposed whereby a ‘vicious cycle’ of superoxide radical (O 2 •- ) formation occurs as a result of oxidation of Hepes to its radical species, fuelled by the subsequent reaction of O 2 •- with NO to form peroxynitrite (ONOO...
Articles
Sophie LANONE, Philippe MANIVET, Jacques CALLEBERT, Jean-Marie LAUNAY, Didier PAYEN, Michel AUBIER, Jorge BOCZKOWSKI, Alexandre MEBAZAA
Journal:
Biochemical Journal
Biochem J (2002) 366 (2): 399–404.
Published: 01 September 2002
..., for the first time, that tyrosine residues of human inducible nitric oxide synthase (NOS2) can be nitrated by peroxynitrite in vitro , leading to a decreased activity. Moreover, we show that NOS2 expressed in a skeletal muscle from septic patients is nitrated on selective tyrosine residues belonging...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 366 (1): 97–107.
Published: 15 August 2002
... stress), resulting from elevated levels of NO and sister compounds, including peroxynitrite (ONOO − ). We have been examining the interaction of EUK-8 and EUK-134 with NO and ONOO − . We find that in the presence of a per-species (H 2 O 2 , ONOO − , peracetate and persulphate), the Mn-Salen complexes...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 340 (3): 657–669.
Published: 08 June 1999
... with peroxynitrite (ONOO - ) (but not NO/O 2 ) results in the selective nitration only of the SERCA2a, suggesting that ONOO - may be the source of the nitrating agent in vivo . A correlation of the SR Ca 2+ -ATPase activity and covalent protein modifications in vitro and in vivo suggests that tyrosine nitration may...