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Keywords: peroxynitrite
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Biochem J (2007) 407 (1): 89–99.
Published: 12 September 2007
... with the chemical properties of peroxynitrite, at pathophysiological concentrations of NO 2 − and H 2 O 2 . Without external substrates, the targets of the reactive species generated by the metNGB/NO 2 − /H 2 O 2 system are endogenous tyrosine (resulting in the production of 3-nitrotyrosine) and cysteine (oxidized...
Includes: Supplementary data
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Biochem J (2006) 393 (1): 343–349.
Published: 12 December 2005
... upon exposure to fluxes of peroxynitrite (8–20 μM·min −1 ). To investigate the effect of oxidized lipids on α-syn, the protein was incubated with the bifunctional electrophile 4-HNE [4-hydroxy-2( E )-nonenal]. MS analysis showed the formation of three major products corresponding to the native protein...
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Biochem J (2005) 389 (1): 233–240.
Published: 21 June 2005
...Mario FONTANA; Donatella AMENDOLA; Emanuela ORSINI; Alberto BOFFI; Laura PECCI Peroxynitrite mediates the oxidation of the sulphinic group of both HTAU (hypotaurine) and CSA (cysteine sulphinic acid), producing the respective sulphonates, TAU (taurine) and CA (cysteic acid). The reaction...
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Biochem J (2003) 369 (2): 399–406.
Published: 15 January 2003
..., the consumption could be inhibited by superoxide dismutase. A scheme is proposed whereby a ‘vicious cycle’ of superoxide radical (O 2 •- ) formation occurs as a result of oxidation of Hepes to its radical species, fuelled by the subsequent reaction of O 2 •- with NO to form peroxynitrite (ONOO...
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