... concentration caused persistent melanin inhibition activity. fungal melanin human melanin inhibitors phagocytosis Rhizopus delemar tyrosinase Melanin is predominantly dark-colored polymer widely distributed in bacteria, fungi, plants, and animals [ 1 ]. Several biological functions...

... isoforms were required for the accumulation of cell TAG and PL. The phagocytic capacity of Gpat3 −/− and Gpat4 −/− BMDM was impaired. Additionally, inhibiting fatty acid β-oxidation reduced phagocytosis only partially, suggesting that lipid accumulation is not necessary for the energy requirements...

...Tomohiro Segawa; Kaoru Hazeki; Kiyomi Nigorikawa; Shin Morioka; Ying Guo; Shunsuke Takasuga; Ken Asanuma; Osamu Hazeki Phosphoinositide 5′-phosphatases have been implicated in the regulation of phagocytosis. However, their precise roles in the phagocytic process are poorly understood. We prepared...

...Jenson Lim; Neil A. Hotchin; Emmanuelle Caron During αMβ2-mediated phagocytosis, the small GTPase Rap1 activates the β2 integrin by binding to a region between residues 732 and 761. Using COS-7 cells transfected with αMβ2, we show that αMβ2 activation by the phorbol ester PMA involves Ser 756 of β2...

...Sang H. Min; Charles S. Abrams Macromolecules can be transported into the cells by endocytosis, either by phagocytosis or by pinocytosis. Typically, phagocytosis involves the uptake of solid large particles mediated by cell-surface receptors, whereas pinocytosis takes up fluid and solutes...

...Namiko Tamura; Kaoru Hazeki; Natsumi Okazaki; Yukiko Kametani; Hiroki Murakami; Yuki Takaba; Yuki Ishikawa; Kiyomi Nigorikawa; Osamu Hazeki PI3K (phosphoinositide 3-kinase) α has been implicated in phagocytosis and fluid-phase pinocytosis in macrophages. The subtype-specific role of PI3K...

... 2 2006 The Biochemical Society, London 2006 C-type lectin Drosophila galactose-specific lectin immunity phagocytosis Insects have an effective defence system against microbial infection that shares many characteristics with the innate immune system of vertebrates [ 1 , 2...

...Edouard M. BEVERS; Marie P. JANSSEN; Paul COMFURIUS; Krishnakumar BALASUBRAMANIAN; Alan J. SCHROIT; Robert F. A. ZWAAL; George M. WILLEMS The plasma protein β 2 GPI (β 2 -glycoprotein I) has been proposed to mediate phagocytosis of apoptotic cells and to play a role in the antiphospholipid syndrome...

... 2003 The Biochemical Society, London ©2003 2003 actin endocytosis migration phagocytosis pinocytosis Abbreviations used: ACK, activated Cdc42-associated tyrosine kinase; Arp2/3 complex, Arp2–Arp3 complex; EGF, epidermal growth factor; GPI, glycosyl-phosphatidylinositol; Hrs...

... and neutrophils eliminate invading micro-orga- nisms and other foreign particles by first ingesting them into a plasma membrane-derived intracellular vacuole, or phagosome. The ingestion, or phagocytosis, is a receptor-mediated, actin- dependent process. The resulting intracellular vacuoles, termed phagosomes...

... mice, following phagocytosis of 59 Fe-labelled transferrin—anti-transferrin immune complexes, showed reduced iron release compared with cells from wild-type iNOS littermates. Uptake of the complexes by macrophages was similar in iNOS-deficient and wild-type mice. Ferritin was up-regulated by IFNγ/LPS...

... be addressed, at Ionix Pharmaceuticals, 185 Cambridge Science Park, Milton Road, Cambridge CB4 0GA, U.K. (e-mail [email protected] ). 13 9 2001 20 12 2001 29 1 2002 The Biochemical Society, London ©2002 2002 antisense kinase inhibitors phagocytosis protein kinase C...

... was equivalent in wild-type and mutant macrophages and was not influenced by interferon-γ/lipopolysaccharide activation. Following phagocytosis of [ 59 Fe]Tf—anti-Tf immune complexes, iron uptake was equivalent and up-regulated similarly with activation, but intracellular distribution was markedly different...

... to the cell surface. 1 To whom correspondence should be addressed (e-mail [email protected] ). 15 8 2000 19 12 2000 30 1 2001 The Biochemical Society, London © 2001 2001 phagocytosis phagosomes recycling vesicular transport Biochem. J. (2001) 355, 409 415...

...-actin magnesium ion phagocytosis superoxide Biochem. J. (2000) 349, 369 375 (Printed in Great Britain) 369 Deactivation of neutrophil NADPH oxidase by actin-depolymerizing agents in a cell-free system Minoru TAMURA1, Masamichi KANNO and Yaeta ENDO Department of Applied Biochemistry, Faculty...