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Keywords: phorbol ester
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Biochem J (2013) 452 (2): 195–209.
Published: 10 May 2013
...Alyssa X. Wu-zhang; Alexandra C. Newton PKC (protein kinase C) has been in the limelight since the discovery three decades ago that it acts as a major receptor for the tumour-promoting phorbol esters. Phorbol esters, with their potent ability to activate two of the three classes of PKC isoenzymes...
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Biochem J (2013) 451 (1): 33–44.
Published: 14 March 2013
... were measured. These mutants showed reduced binding affinities for phorbol ester [PDBu (phorbol 12,13-dibutyrate)] and diacylglycerol [DOG ( sn -1,2-dioctanoylglycerol), SAG ( sn -1-stearoyl 2-arachidonyl glycerol)]. All five full-length PKCθ mutants exhibited reduced phorbol-ester-induced membrane...
Includes: Supplementary data
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Biochem J (2008) 415 (1): 77–85.
Published: 12 September 2008
... 16 6 2008 16 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 eukaryotic initiation factor 6 (eIF6) hispidin phorbol ester protein kinase C (PKC) receptor for activated C-kinase 1 (RACK1) translation initiation Translation requires at least 11...
Includes: Supplementary data
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Biochem J (2008) 412 (3): 495–506.
Published: 28 May 2008
... by PMA. A previously identified phorbol-ester-resistant mutant (K422E) displaying an acidic substitution in a regulatory site, exhibits constitutive traffic but, in contrast with the wild-type, fails to show glycine uptake inhibition, membrane raft redistribution and trafficking modulation by PMA. We...
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Biochem J (2007) 406 (2): 223–236.
Published: 13 August 2007
... The Authors Journal compilation © 2007 Biochemical Society 2007 C1 domain diacylglycerol (DAG) guanine-nucleotide-exchange factor (GEF) membrane binding phorbol ester DAG (diacylglycerol) is a lipid second messenger that is involved in the transduction of signals from most cell-surface...
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Biochem J (2007) 403 (1): 1–12.
Published: 13 March 2007
...Chengfeng Yang; Marcelo G. Kazanietz Chimaerins are the only known RhoGAPs (Rho GTPase-activating proteins) that bind phorbol ester tumour promoters and the lipid second messenger DAG (diacylglycerol), and show specific GAP activity towards the small GTPase Rac. This review summarizes our knowledge...
Includes: Multimedia, Supplementary data
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Biochem J (2005) 392 (1): 163–172.
Published: 08 November 2005
... Desarrollo (CABD), CSIC-Universidad Pablo de Olavide, Carretera de Utrera km. 1, 41013 Sevilla, Spain. 11 7 2005 9 9 2005 9 9 2005 9 9 2005 The Biochemical Society, London 2005 cAMP cytoskeleton 14-3-3 protein phorbol ester phosphodiesterase 3A (PDE3A) protein kinase...
Includes: Supplementary data
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Biochem J (2004) 384 (3): 543–549.
Published: 07 December 2004
...Kelley K. KININGHAM; Chotiros DAOSUKHO; Daret K. ST. CLAIR Cytokines, phorbol esters, radiation and chemotherapeutic drugs up-regulate the expression of MnSOD (manganese superoxide dismutase). Using the VA-13 cell line, we studied the regulation of SOD2 upon treatment with PMA. Pre-treatment...
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Biochem J (2003) 373 (3): 835–843.
Published: 01 August 2003
... or forskolin. These results provide insights into the factors and mechanisms that regulate expression of the hPDE7A gene. Key words: cAMP, cAMP-response-element-binding protein (CREB), CpG island, phorbol ester, transcription. INTRODUCTION Signalling by cyclic nucleotides is a major signal-transduction pathway...
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Biochem J (2001) 358 (1): 193–200.
Published: 08 August 2001
..., London ©2001 2001 ERK/MAP kinase phorbol ester PKC inhibitors metalloproteinase Abbreviations used: ADAM, a disintegrin and metalloproteinase; ERK, extracellular signal-regulated protein kinase; FCS, fetal calf serum; IL, interleukin; MAPK, mitogen-activated protein kinase; MFR, mean...
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Biochem J (2000) 345 (2): 195–200.
Published: 10 January 2000
.... The effect of activation was sensitive to the antioxidant enzymes superoxide dismutase and catalase. When ascorbate was oxidized in situ by chemical or enzymic oxidation, the rates of uptake were similar to those after activation of the cells by phorbol ester; however, in the latter case the extracellular...
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Biochem J (1999) 337 (3): 363–371.
Published: 25 January 1999
...Iris AUGUSTIN; Andrea BETZ; Claudia HERRMANN; Tobias JO; Nils BROSE Munc13-1, a mammalian homologue of Caenorhabditis elegans unc-13p, is a presynaptic phorbol ester receptor that enhances neurotransmitter release. In the present study we analysed the regional, cellular and subcellular expression...
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