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Keywords: phosphatase
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Articles
Biochem J (2020) 477 (9): 1669–1682.
Published: 11 May 2020
... to hypoxia by inducing dormancy regulon expression. The dominant phosphatase activity of DevS under aerobic conditions enables tight negative control, whereas its kinase function activates DevR under hypoxia to induce the dormancy regulon. A net balance in these opposing kinase and phosphatase activities...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (2): 431–444.
Published: 30 January 2020
...Jinho Heo; James M. Larner; David L. Brautigan Protein Ser/Thr phosphatase-6 (PP6) regulates pathways for activation of NF-kB, YAP1 and Aurora A kinase (AURKA). PP6 is a heterotrimer comprised of a catalytic subunit, one of three different SAPS subunits and one of three different ankyrin-repeat...
Articles
Biochem J (2015) 471 (2): 187–198.
Published: 02 October 2015
...Kelly A. Orlando; Christine L. Iosue; Sarah G. Leone; Danielle L. Davies; Dennis D. Wykoff Inorganic phosphate is required for a range of cellular processes, such as DNA/RNA synthesis and intracellular signalling. The phosphate starvation-inducible phosphatase activity of Candida glabrata...
Articles
Biochem J (2015) 469 (1): 107–120.
Published: 19 June 2015
..., and found LRRK2 is hyper-ubiquitinated. Calyculin A treatment prevents inhibitor and PD mutant induced dephosphorylation and reverts LRRK2 to a lesser ubiquitinated species, thus directly implicating phosphatase activity in LRRK2 ubiquitination. This dynamic dephosphorylation–ubiquitination cycle could...
Articles
Biochem J (2013) 451 (1): 45–53.
Published: 14 March 2013
... enzymatic activities has been described which can dephosphorylate nuclear receptors. In the present study we used immunoprecipitation assays coupled to tandem MS analysis to identify novel PPARγ-regulating proteins. We identified the serine/threonine phosphatase PPM1B [PP (protein phosphatase), Mg 2+ /Mn 2...
Includes: Supplementary data
Articles
Biochem J (2013) 449 (3): 673–681.
Published: 09 January 2013
... interaction and protein–DNA interaction. In the present study, we found that the Pph3–Psy2 phosphatase complex is responsible for Rfa2 dephosphorylation both during normal G 1 -phase and under DNA replication stress in Candida albicans . Phosphorylated Rfa2 extracted from pph3 Δ or psy2 Δ G 1 cells exhibited...
Includes: Supplementary data
Articles
Biochem J (2012) 444 (3): 601–609.
Published: 29 May 2012
... correspondence should be addressed (email c.brearley@uea.ac.uk ). 13 10 2011 29 2 2012 20 3 2012 20 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 auxin jasmonate multiple inositol polyphosphate phosphatase phytase Solanum tuberosum...
Includes: Supplementary data
Articles
Biochem J (2012) 441 (2): 571–578.
Published: 21 December 2011
... but not cytoplasmic phosphatases from binding to and dephosphorylating ERK1/2, disclosing an unprecedented mechanism for the spatial regulation of ERK1/2 activation. We also demonstrate that the kinetics of ERK1/2 extranuclear signals can be significantly altered by artificially tethering Mxi2 to the cytoplasm...
Articles
Biochem J (2011) 435 (1): 17–31.
Published: 15 March 2011
... cell growth and in diseases such as cancers. 1 To whom correspondence should be addressed (email rycpoon@ust.hk ). 23 2 2010 11 1 2011 13 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell cycle kinase mitosis phosphatase...
Articles
Biochem J (2010) 431 (2): 237–244.
Published: 28 September 2010
...′-phosphate, a potential intermediate in RNA degradation. We show that human erythrocytes contain a pseudouridine-5′-phosphatase displaying a K m ≤ 1 μM for its substrate. The activity of the partially purified enzyme was dependent on Mg 2+ , and was inhibited by Ca 2+ and vanadate, suggesting...
Articles
Biochem J (2010) 428 (2): 293–304.
Published: 13 May 2010
.... By using PMA and the phosphatase inhibitors cantharidin and calyculin A, we could selectively activate PKC or p38 MAPK respectively to promote TACE-dependent shedding of L-selectin. Interestingly, the intracellular mechanisms leading to the shedding event differed dramatically. For example, regulatory...
Includes: Supplementary data
Articles
Biochem J (2010) 428 (2): 235–245.
Published: 13 May 2010
... the rates of phosphorylation and dephosphorylation or the dependence of TRHR dephosphorylation on the length of agonist exposure. Thus the interactions of GPCRs with GRKs and phosphatases are determined not simply by the amino acid sequences of the substrates, but by regions outside the cytoplasmic tails...
Articles
Biochem J (2010) 426 (1): 65–72.
Published: 27 January 2010
... of Akt. As expected, the tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) emerged as a leading hit: knockdown elevated Akt activation to 70% of maximal generated by acute EGF (epidermal growth factor) stimulation. Importantly, we identified other phosphatases...
Includes: Supplementary data
Articles
Biochem J (2009) 418 (2): 391–401.
Published: 11 February 2009
...Priya R. Sharda; Christopher A. Bonham; Eliseos J. Mucaki; Zareen Butt; Panayiotis O. Vacratsis hYVH1 [human orthologue of YVH1 (yeast VH1-related phosphatase)] is an atypical dual-specificity phosphatase that is widely conserved throughout evolution. Deletion studies in yeast have suggested a role...
Articles
Biochem J (2009) 418 (2): 337–344.
Published: 11 February 2009
... phosphatase) is still very limited. To date, only one vertebrate PHPT has been discovered, and two crystal structures of hPHPT1 (human PHPT1) have been solved. However, these two structures gave different ligand-binding sites and co-ordination patterns. In the present paper, we have solved the solution...
Includes: Supplementary data
Articles
Biochem J (2008) 415 (2): 247–255.
Published: 25 September 2008
... phytochrome-associated protein, PAPP2C ( p hytochrome- a ssociated p rotein p hosphatase type 2C ), interacts in the nucleus with phyA (phytochrome A) and phyB, both in vitro and in vivo . Moreover, the phosphatase activity of PAPP2C and its association with phytochromes were found to be enhanced by red light...
Includes: Supplementary data
Articles
Biochem J (2008) 412 (2): 287–298.
Published: 14 May 2008
...Maria Ekerot; Marios P. Stavridis; Laurent Delavaine; Michael P. Mitchell; Christopher Staples; David M. Owens; Iain D. Keenan; Robin J. Dickinson; Kate G. Storey; Stephen M. Keyse DUSP6 (dual-specificity phosphatase 6), also known as MKP-3 [MAPK (mitogen-activated protein kinase) phosphatase-3...
Articles
Biochem J (2007) 405 (3): 439–444.
Published: 13 July 2007
...Helene Maccario; Nevin M. Perera; Lindsay Davidson; C. Peter Downes; Nick R. Leslie Although PTEN (phosphatase and tensin homologue deleted on chromosome 10) is one of the most commonly mutated tumour suppressors in human cancers, loss of PTEN expression in the absence of mutation appears to occur...
Includes: Supplementary data
Articles
Biochem J (2006) 399 (1): e1.
Published: 13 September 2006
... are unclear. In this issue of the Biochemical Journal , Gallego and colleagues show for the first time that protein phosphatase 1 plays a major role in the stability of mammalian PER2, a key protein in the core clock works. This contrasts somewhat with circadian rhythm control in the fruitfly Drosophila...
Articles
Biochem J (2004) 382 (1): 1–11.
Published: 10 August 2004
...Nick R. LESLIE; C. Peter DOWNES The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation, survival and growth by inactivating PI 3-kinase-dependent signalling. It also suppresses cellular...
Articles
Biochem J (2004) 379 (2): 301–307.
Published: 15 April 2004
...Steven M. WALKER; Nick R. LESLIE; Nevin M. PERERA; Ian H. BATTY; C. Peter DOWNES The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour-suppressor protein is a phosphoinositide 3-phosphatase which antagonizes phosphoinositide 3-kinase-dependent signalling by dephosphorylating...
Articles
Biochem J (2003) 374 (2): 453–461.
Published: 01 September 2003
... apoptosis cytokine receptor phosphatase protein kinase signal transduction Abbreviations used: [ 14 C]-SAPC, stearoyl-arachidonoyl-[ 14 C]phosphatidylcholine; cPLA 2 , cytosolic phospholipase A 2 ; fura 2/AM, fura 2 acetoxymethyl ester; [ 3 H]arachidonic acid, [5,6,8,9,11,12,14,15- 3 H(N...
Articles
Biochem J (2003) 373 (3): 641–659.
Published: 01 August 2003
... modulation of exocytosis. Emerging evidence points to protein phosphatases as key regulators of exocytosis in many cells and, therefore, as potential targets for the design of novel therapies to treat these diseases. Diverse yet exquisite regulatory mechanisms have evolved to direct the specificity...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2003) 371 (2): 463–471.
Published: 15 April 2003
...Jacquelyn A. WOODINGS; Stewart J. SHARP; Laura M. MACHESKY We have found that MIM-B, a putative metastasis suppressor protein, is implicated in actin cytoskeletal control and interaction with a protein tyrosine phosphatase (PTP). MIM was originally described as a protein whose mRNA was M issing i n...
Articles
Biochem J (2003) 371 (1): 15–27.
Published: 01 April 2003
... removing phosphate from tyrosine-phosphorylated substrates, the protein tyrosine phosphatases (PTPases), have a capacity that is several orders of magnitude higher than that of the PTKs. It follows that a relatively minor change in the PTK/PTPase balance can have a major impact on net tyrosine...
Articles
Biochem J (2003) 369 (2): 227–238.
Published: 15 January 2003
... demonstrate a crucial role for Akt in the insulin-stimulated cell cycle progression of Xenopus oocytes, whereas Akt may have an ancillary function in progesterone signalling. Key words: cell cycle, insulin action, phosphatase, progesterone signalling. injection of mRNAs, or the modulation of endogenous...
Articles
Biochem J (2001) 357 (2): 427–435.
Published: 09 July 2001
...Nick R. LESLIE; Deborah BENNETT; Alex GRAY; Ian PASS; Khe HOANG-XUAN; C. Peter DOWNES The tumour suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a lipid phosphatase which can antagonize the phosphoinositide 3-kinase (PI 3-kinase) signalling pathway, promoting...
Articles
Biochem J (2000) 352 (1): 61–70.
Published: 07 November 2000
...Arun BANDYOPADHYAY; Dong Wook SHIN; Jung On AHN; Do Han KIM The present study was undertaken to examine the physical and physiological interaction of protein phosphatase 2B, calcineurin, with the ryanodine receptor (RyR) in rat cardiac tissue and neonatal cardiomyocytes. The presence of calcineurin...
Articles
Biochem J (2000) 350 (3): 901–907.
Published: 08 September 2000
... to which a protein kinase, a phosphatase and the diffusion of signalling proteins control the protein phosphorylation flux and the phospho-protein gradient. Two different cellular geometries were analysed: (1) the kinase is located on one planar membrane and the phosphatase on a second parallel planar...
Articles
Biochem J (2000) 347 (3): 653–660.
Published: 25 April 2000
... microinjected into Xenopus oocytes. Purified, N-terminally truncated forms of cdc25B did not induce GVBD, even though many had phosphatase activity and activated cdc2 in vitro . N-terminally truncated forms of cdc25B inhibited induction of GVBD by longer forms of the enzyme suggesting a direct interaction...
Articles
Biochem J (2000) 346 (3): 827–833.
Published: 07 March 2000
...Nick R. LESLIE; Alex GRAY; Ian PASS; Elaine A. ORCHISTON; C. Peter DOWNES The tumour suppressor protein, PTEN (phosphatase and tensin homolog deleted on chromosome 10), is a phosphatase that can dephosphorylate tyrosine-containing peptides, Shc, focal adhesion kinase and phosphoinositide substrates...