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1-12 of 12
Keywords: phosphatidic acid
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Articles
Journal:
Biochemical Journal
Biochem J (2013) 454 (2): 267–274.
Published: 09 August 2013
...Kai Cai; Marion B. Sewer DGKs (diacylglycerol kinases) catalyse the conversion of diacylglycerol into PA (phosphatidic acid), a positive modulator of mTOR (mammalian target of rapamycin). We have found that chenodeoxycholic acid and the synthetic FXR (farnesoid X receptor) ligand GW4064 induce...
Articles
Fionn McLoughlin, Steven A. Arisz, Henk L. Dekker, Gertjan Kramer, Chris G. de Koster, Michel A. Haring, Teun Munnik, Christa Testerink
Journal:
Biochemical Journal
Biochem J (2013) 450 (3): 573–581.
Published: 28 February 2013
...Fionn McLoughlin; Steven A. Arisz; Henk L. Dekker; Gertjan Kramer; Chris G. de Koster; Michel A. Haring; Teun Munnik; Christa Testerink PA (phosphatidic acid) is a lipid second messenger involved in an array of processes occurring during a plant's life cycle. These include development, metabolism...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 409 (1): 1–18.
Published: 11 December 2007
...Isabel Mérida; Antonia Ávila-Flores; Ernesto Merino DGKs (diacylglycerol kinases) are members of a unique and conserved family of intracellular lipid kinases that phosphorylate DAG (diacylglycerol), catalysing its conversion into PA (phosphatidic acid). This reaction leads to attenuation of DAG...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2007) 404 (1): 31–43.
Published: 26 April 2007
... features a central IQ motif that mediates binding to CaM and is phosphorylated by PKC (protein kinase C). We have analysed the subcellular distribution of Ng and found that it associates to cellular membranes in rat brain. In vitro binding assays revealed that Ng selectively binds to PA (phosphatidic acid...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 398 (1): 1–13.
Published: 27 July 2006
... phospholipase D, phosphatidic acid, PIPKs and PtdIns(4,5) P 2 , contributing to enhancement of PtdIns(4,5) P 2 -mediated cellular events and receptor signalling. Na + , Kir (inwardly rectifying K + ), Ca 2+ and TRP (transient receptor potential) ion channels are regulated by small G-proteins and membrane pools...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2006) 394 (2): 495–500.
Published: 10 February 2006
... interconversion of phosphatidic acid into DAG by LPP1. This may account for the effects of LPP1 on cell migration, as sustained DAG is known to down-regulate PKC isoforms in cells. Therefore the physiological changes in the expression levels of LPP1 might represent a heterologous desensitization mechanism...
Articles
Jaclyn Long, Peter Darroch, Kah Fei Wan, Kok Choi Kong, Nicholas Ktistakis, Nigel J. Pyne, Susan Pyne
Journal:
Biochemical Journal
Biochem J (2005) 391 (1): 25–32.
Published: 26 September 2005
...-deprived LPP2-overexpressing compared with vector-transfected HEK-293 cells; and (ii) serum-deprived LPP2- and LPP3-overexpressing cells exhibited limited intranucleosomal DNA laddering, which was absent in vector-transfected cells. Moreover, LPP2 reduced basal intracellular phosphatidic acid levels...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2003) 369 (2): 319–329.
Published: 15 January 2003
... 2 10 2002 9 10 2002 9 10 2002 1 To whom correspondence should be addressed (e-mail [email protected] ). antigen exocytosis membrane ruffling phosphatidic acid PMA Abbreviations used: ARF, ADP ribosylation factor; Cho, choline; DMEM, Dulbecco's modified...
Articles
Marc A. de la ROCHE, Janet L. SMITH, Maribel RICO, Silvia CARRASCO, Isabel MERIDA, Lucila LICATE, Graham P. CÔTÉ, Thomas T. EGELHOFF
Journal:
Biochemical Journal
Biochem J (2002) 368 (3): 809–815.
Published: 15 December 2002
...Marc A. de la ROCHE; Janet L. SMITH; Maribel RICO; Silvia CARRASCO; Isabel MERIDA; Lucila LICATE; Graham P. CÔTÉ; Thomas T. EGELHOFF Diacylglycerol kinases (DGKs) phosphorylate the neutral lipid diacylglycerol (DG) to produce phosphatidic acid (PA). In mammalian systems DGKs are a complex family...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 366 (1): 187–193.
Published: 15 August 2002
... by using antisense oligodeoxynucleotide to PKCδ, in combination with the specific inhibitor rottlerin. Cell treatment with antisense oligodeoxynucleotide, but not with sense oligodeoxynucleotide, completely eliminated PKCδ expression and resulted in the strong inhibition of SPP-stimulated phosphatidic acid...
Articles
Mini P. SAJAN, Gautam BANDYOPADHYAY, Yoshinori KANOH, Mary L. STANDAERT, Michael J. QUON, Brent C. REED, Ivan DIKIC, Robert V. FARESE
Journal:
Biochemical Journal
Biochem J (2002) 362 (3): 665–674.
Published: 08 March 2002
... increases in phospholipase D (PLD) activity and generation of phosphatidic acid (PA), which directly activated aPKCs. As with aPKCs and glucose transport, sorbitol-stimulated PLD activity was dependent on the ERK pathway. Moreover, PLD-generated PA was required for sorbitol-induced activation of aPKCs...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 345 (3): 401–415.
Published: 25 January 2000
...Mordechai LISCOVITCH; Malgorzata CZARNY; Giusy FIUCCI; Xiaoqing TANG Interaction of extracellular-signal molecules with cell-surface receptors often activates a phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine and other phospholipids, generating phosphatidic acid. The activation...