...Shiho Tomohiro; Ayako Kawaguti; Yukiyo Kawabe; Sakae Kitada; Osamu Kuge PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE...

... of oxysterols on the CDP-choline pathway for PtdCho (phosphatidylcholine) synthesis using wild-type and sterol-resistant CHO (Chinese-hamster ovary) cells expressing a mutant of SCAP [SREBP (sterol-regulatory-element-binding protein) cleavage-activating protein] (CHO-SCAP D443N). [ 3 H]Choline-labelling...

... infection. Ps. aeruginosa triggered secretion of the pro-inflammatory lipase, sPLA 2 IB (phospholipase A 2 IB), from lung epithelium. Ps. aeruginosa and sPLA 2 IB each stimulated basolateral PtdCho (phosphatidylcholine) efflux in lung epithelial cells. Pre-treatment of cells with glyburide, an inhibitor...

...Thomas A. Lagace; Neale D. Ridgway Farnesol (FOH) inhibits the CDP-choline pathway for PtdCho (phosphatidylcholine) synthesis, an activity that is involved in subsequent induction of apoptosis. Interestingly, the rate-limiting enzyme in this pathway, CCTα (CTP:phosphocholine cytidylyltransferase α...

...Alan J. RYAN; Kurt FISHER; Christie P. THOMAS; Rama K. MALLAMPALLI We examined the effects of the bioactive lipid, sphingosine, on the expression of the rate-limiting enzyme involved in surfactant phosphatidylcholine synthesis, CCTα (CTP:phosphocholine cytidylyltransferase α). Sphingosine decreased...

...Neale D. RIDGWAY; Thomas A. LAGACE The synthesis of phosphatidylcholine (PtdCho) by the CDP-choline pathway is under the control of the rate-limiting enzyme CTP:phosphocholine cytidylyltransferase (CCT). Sterol regulatory element binding proteins (SREBPs) have been proposed to regulate CCT...

... of Pemt -/- mice fed any of the diets, there was hepatic steatosis and significantly higher occurrence of TUNEL positive cells compared with wild-type controls. In male, female and pregnant mice, liver phosphatidylcholine concentrations were significantly decreased in Pemt -/- choline deficient...

...Bruno SÉGUI; Victoria ALLEN-BAUME; Shamshad COCKCROFT Mammalian phosphatidylinositol transfer proteins (PITPs) α and β, which share 77% identity, have been shown to exhibit distinct lipid-transfer activities. In addition to transferring phosphatidylinositol (PI) and phosphatidylcholine (PC), PITPβ...

... that the enzyme could utilize both phosphatidylcholine and, much less efficiently, phosphatidylethanolamine, with slight selectivity towards mono- and di-unsaturated species. Phosphatidylinositol was not a substrate. Thus PLD1b and PLD2a hydrolyse a structurally similar substrate pool to generate an identical...

... correspondence should be addressed at: The Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, U.S.A. (e-mail [email protected] ). 2 1 2001 The Biochemical Society, London © 2001 2001 epimastigotes phospholipids phosphatidylcholine...

... To whom correspondence should be addressed (e-mail [email protected] ). 9 7 1998 2 12 1998 19 1 1999 The Biochemical Society, London © 1999 1999 ADP-ribosylation factor cytoskeleton phosphatidylcholine Rho Biochem. J. (1999) 339, 87 93 (Printed in Great Britain) 87...

...Luciana TESSITORE; Irma DIANZANI; Zheng CUI; Dennis E. VANCE Phosphatidylethanolamine N -methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine into phosphatidylcholine. At least two forms of PEMT are present in hepatocytes. However, PEMT activity is negligible...