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Keywords: phosphodiesterases
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Articles
GPCR signaling via cAMP nanodomains
Open Access
Journal:
Biochemical Journal
Biochem J (2025) 482 (10): 519–533.
Published: 13 May 2025
... by phosphodiesterases (PDEs), play a critical role in enabling signal precision and functional effects that are specific to individual stimuli. GPCRs can initiate distinct cAMP responses based on their localization within the cell, with evidence showing that both receptors resident at the plasma membrane...
Articles
Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2018) 475 (1): 191–205.
Published: 05 January 2018
...Feng Wang; Qing He; Kaixuan Su; Tiandi Wei; Sujuan Xu; Lichuan Gu The Asp-His-His and Asp-His-His-associated (DHH/DHHA1) domain-containing phosphodiesterases (PDEs) that catalyze degradation of cyclic di-adenosine monophosphate (c-di-AMP) could be subdivided into two subfamilies based on the final...
Includes: Supplementary data