Page 1 | Search Results | Biochemical Journal

1-50 of 62

Sort by

Sort Order Select

Articles

Retraction: Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B

Biochem J (2025) 482 (07): 363.

https://doi.org/10.1042/BJ20030577_RET

Published: 01 April 2025

... homologue deleted on chromosome 10 (PTEN) phosphoinositide 3-kinase (PI3K) protein kinase B (PKB) S6 kinase (S6K) The authors would like to retract their article “Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B” (DOI: 10.1042/bj20030577...

View articletitled, Retraction: Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B

Articles

Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K–AGC protein kinase connection

Benoit Bilanges, Bart Vanhaesebroeck

Biochem J (2014) 464 (2): e7–e10.

https://doi.org/10.1042/BJ20141218

Published: 14 November 2014

... compilation © 2014 Biochemical Society 2014 autophagy endosome phosphoinositide 3-kinase (PI3K) Phox homology (PX) domain PtdIns(3) P serum- and glucocorticoid-regulated protein kinase 3 (SGK3) vacuolar protein sorting 34 (Vps34) inhibitor Phosphoinositides comprise only a small fraction...

View articletitled, Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K–AGC protein kinase connection

Articles

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Ruzica Bago, Nazma Malik, Michael J. Munson, Alan R. Prescott, Paul Davies, Eeva Sommer, Natalia Shpiro, Richard Ward, Darren Cross, Ian G. Ganley, Dario R. Alessi

Biochem J (2014) 463 (3): 413–427.

https://doi.org/10.1042/BJ20140889

Published: 10 October 2014

... deployed to monitor class I PI3K pathway. mammalian target of rapamycin (mTOR) N-Myc downstream-regulated gene-1 (NDRG1) phosphoinositide 3-kinase (PI3K) protein kinase inhibitor signal transduction inhibitor U20S cell line was kindly provided by John Rouse (MRC Protein Phosphorylation...

View articletitled, Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Includes: Supplementary data

Articles

Insulin-stimulated leptin secretion requires calcium and PI3K/Akt activation

Yue Wang, Yusuf Ali, Chun-Yan Lim, Wanjin Hong, Zhiping P. Pang, Weiping Han

Biochem J (2014) 458 (3): 491–498.

https://doi.org/10.1042/BJ20131176

Published: 28 February 2014

... Society 2014 Akt Ca 2+ insulin leptin phosphoinositide 3-kinase (PI3K) primary adipocyte secretion WAT (white adipose tissue) has gained significant scientific interest as the increasing prevalence of obesity has become a burgeoning public health problem. What was once considered...

View articletitled, Insulin-stimulated leptin secretion requires calcium and PI3K/Akt activation

Includes: Supplementary data

Articles

Physiological expression of the PI3K-activating mutation Pik3ca H1047R combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice

Lauren M. Hare, Toby J. Phesse, Paul M. Waring, Karen G. Montgomery, Kathryn M. Kinross, Kevin Mills, Vincent Roh, Joan K. Heath, Robert G. Ramsay, Matthias Ernst, Wayne A. Phillips

Biochem J (2014) 458 (2): 251–258.

https://doi.org/10.1042/BJ20131412

Published: 14 February 2014

... that occurs in the stem cell at the base of the crypt is reflected in positive β-galactosidase staining beyond a few days. adenomatous polyposis coli ( Apc ) colorectal cancer mouse model phosphoinositide 3-kinase (PI3K) phosphoinositide 3-kinase catalytic α polypeptide (Pik3ca) CRC...

View articletitled, Physiological expression of the PI3K-activating mutation Pik3ca H1047R combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice

Includes: Supplementary data

Articles

PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5) P 3 for polyphosphoinositide-binding domains

Nikhil A. Gokhale, Angelika Zaremba, Agnes K. Janoshazi, Jeremy D. Weaver, Stephen B. Shears

Biochem J (2013) 453 (3): 413–426.

https://doi.org/10.1042/BJ20121528

Published: 12 July 2013

... by trypsin-treatment and cell numbers were ascertained with a Countess cell counter (Life Technologies). diphosphoinositol polyphosphate inositol pyrophosphate phosphoinositide 3-kinase (PI3K) phosphoinositide The phosphate group is a ubiquitous signalling device that establishes...

View articletitled, PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5) P 3 for polyphosphoinositide-binding domains

Includes: Multimedia, Supplementary data

Articles

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

Eeva M. Sommer, Hannah Dry, Darren Cross, Sylvie Guichard, Barry R. Davies, Dario R. Alessi

Biochem J (2013) 452 (3): 499–508.

https://doi.org/10.1042/BJ20130342

Published: 31 May 2013

...) protein kinase inhibitor phosphoinositide 3-kinase (PI3K) signal transduction inhibitor Over 70% of breast cancers possess mutations that trigger activation of the PI3K (phosphoinositide 3-kinase) signalling pathway [ 1 ]. These include mutations that induce overexpression of receptor tyrosine...

View articletitled, Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

Includes: Supplementary data

Articles

Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth

Vinothini Rajeeve, Wayne Pearce, Marta Cascante, Bart Vanhaesebroeck, Pedro R. Cutillas

Biochem J (2013) 450 (3): 619–628.

https://doi.org/10.1042/BJ20121525

Published: 28 February 2013

... by inputting m / z values in the human metabolome database ( http://www.hmdb.ca/ ) allowing an m / z window of 5 p.p.m. cell signalling metabolite profiling phosphoproteomics polyamine phosphoinositide 3-kinase (PI3K) PI3K (phosphoinositide 3-kinase) signalling is involved in the control...

View articletitled, Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth

Includes: Supplementary data

Articles

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis

Zhaohua Zheng, Syazwani I. Amran, Jiuxiang Zhu, Oleg Schmidt-Kittler, Kenneth W. Kinzler, Bert Vogelstein, Peter R. Shepherd, Philip E. Thompson, Ian G. Jennings

Biochem J (2012) 444 (3): 529–535.

https://doi.org/10.1042/BJ20120499

Published: 29 May 2012

... an attractive target in the development of an inhibitor that would target cancer cells [ 3 ]. enzyme kinetics in vitro mutagenesis mechanism of isoform selectivity phosphoinositide 3-kinase (PI3K) small molecule inhibitor © The Authors Journal compilation © 2012 Biochemical Society 2012...

View articletitled, Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis

Includes: Supplementary data

Articles

Regulation and cellular functions of class II phosphoinositide 3-kinases

Marco Falasca, Tania Maffucci

Biochem J (2012) 443 (3): 587–601.

https://doi.org/10.1042/BJ20120008

Published: 16 April 2012

... by the kinase PIKFyve, therefore its synthesis does not seem to be catalysed directly by any PI3Ks. © The Authors Journal compilation © 2012 Biochemical Society 2012 cell migration glucose transport insulin secretion phosphoinositide phosphoinositide 3-kinase (PI3K) Phosphoinositides...

View articletitled, Regulation and cellular functions of class II phosphoinositide 3-kinases

Articles

γ-Enolase C-terminal peptide promotes cell survival and neurite outgrowth by activation of the PI3K/Akt and MAPK/ERK signalling pathways

Anja Hafner, Nataša Obermajer, Janko Kos

Biochem J (2012) 443 (2): 439–450.

https://doi.org/10.1042/BJ20111351

Published: 27 March 2012

..., but EDAC was omitted. actin remodelling γ-enolase extracellular-signalregulated kinase (ERK) neurotrophic effect phosphoinositide 3-kinase (PI3K) RhoA Neurotrophic factors, the molecules that determine nerve growth and regeneration, cell differentiation and survival [ 1 , 2 ], help...

View articletitled, γ-Enolase C-terminal peptide promotes cell survival and neurite outgrowth by activation of the PI3K/Akt and MAPK/ERK signalling pathways

Includes: Supplementary data

Articles

PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances

Lomon So, David A. Fruman

Biochem J (2012) 442 (3): 465–481.

https://doi.org/10.1042/BJ20112092

Published: 24 February 2012

... lymphoma phosphoinositide 3-kinase (PI3K) How do receptors on lymphocytes engage class I PI3K? Antigen receptors, co-stimulatory molecules, cytokine receptors and chemokine receptors can all trigger an increase in PtdIns(3,4,5) P 3 and phosphorylation of Akt. Cross-linking of the BCR leads...

View articletitled, PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances

Includes: Multimedia, Supplementary data

Articles

IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade

Graeme I. Lancaster, Beata Skiba, Christine Yang, Hayley T. Nicholls, Katherine G. Langley, M. H. Stanley Chan, Clinton R. Bruce, Gordon W. Rewcastle, Peter R. Shepherd, Michael Karin, Mark A. Febbraio

Biochem J (2012) 442 (3): 723–732.

https://doi.org/10.1042/BJ20112037

Published: 24 February 2012

... of nuclear factor κB kinase β (IKKβ) insulin phosphoinositide 3-kinase (PI3K) protein kinase B (PKB) Acute [ 3 H]2-deoxyglucose uptake was determined as described previously [ 16 ]. In brief, serum-starved 3T3-L1 adipocytes and WT and Ikk β −/− MEFs were incubated in glucose-free DMEM for 1 h...

View articletitled, IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade

Includes: Supplementary data

Articles

Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

Inma M. Berenjeno, Julie Guillermet-Guibert, Wayne Pearce, Alexander Gray, Stewart Fleming, Bart Vanhaesebroeck

Biochem J (2012) 442 (1): 151–159.

https://doi.org/10.1042/BJ20111741

Published: 27 January 2012

.../licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cancer kinase isoform lipid signalling phosphoinositide 3-kinase (PI3K) phosphatase and tensin homologue deleted on chromosome 10 (PTEN...

View articletitled, Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

Articles

Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo

Greg C. Smith, Wee Kiat Ong, Gordon W. Rewcastle, Jackie D. Kendall, Weiping Han, Peter R. Shepherd

Biochem J (2012) 442 (1): 161–169.

https://doi.org/10.1042/BJ20111913

Published: 27 January 2012

... is properly cited. glucose metabolism insulin mammalian target of rapamycin (mTOR) phosphoinositide 3-kinase (PI3K) phosphoinositide 3-kinase catalytic α polypeptide (PIK3CA) During the metabolic cage studies, data were also obtained on animal movement. Surprisingly this showed that a number...

View articletitled, Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo

Includes: Supplementary data

Articles

Targeted polyubiquitylation of RASSF1C by the Mule and SCF β-TrCP ligases in response to DNA damage

Xin Zhou, Ting-Ting Li, Xu Feng, Esther Hsiang, Yue Xiong, Kun-Liang Guan, Qun-Ying Lei

Biochem J (2012) 441 (1): 227–236.

https://doi.org/10.1042/BJ20111500

Published: 14 December 2011

... responses. 1 To whom correspondence should be addressed (email [email protected] ). 18 8 2011 10 9 2011 12 9 2011 12 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 DNA damage glycogen synthase kinase 3 (GSK3) phosphoinositide 3-kinase...

View articletitled, Targeted polyubiquitylation of RASSF1C by the Mule and SCF β-TrCP ligases in response to DNA damage

Includes: Supplementary data

Articles

Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa

Adam J. Koppers, Lisa A. Mitchell, Ping Wang, Minjie Lin, R. John Aitken

Biochem J (2011) 436 (3): 687–698.

https://doi.org/10.1042/BJ20110114

Published: 27 May 2011

... phosphoinositide 3-kinase (PI3K) reactive oxygen species (ROS) spermatozoon The formation of 8OHdG was measured using a specific antibody (Biotrin OxyDNA Test Kit, Biotrin International) conjugated to FITC. For the positive control, spermatozoa were incubated for 1 h with H 2 O 2 (2 mM) and FeCl 2 ·4H 2...

View articletitled, Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa

Articles

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

Laura R. Pearce, Eeva M. Sommer, Kei Sakamoto, Stephan Wullschleger, Dario R. Alessi

Biochem J (2011) 436 (1): 169–179.

https://doi.org/10.1042/BJ20102103

Published: 27 April 2011

... gene 1 (NDRG1) phosphoinositide 3-kinase (PI3K) Protor/PRR5 serum- and glucocorticoid-induced protein kinase 1 (SGK1) mTOR (mammalian target of rapamycin) protein kinase plays a key role in controlling cell growth and is likely to be over-activated in the majority of cancers. mTOR exists...

View articletitled, Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

Includes: Supplementary data

Articles

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P 2 in regulating insulin sensitivity defined by knock-in analysis

Stephan Wullschleger, David H. Wasserman, Alex Gray, Kei Sakamoto, Dario R. Alessi

Biochem J (2011) 434 (2): 265–274.

https://doi.org/10.1042/BJ20102012

Published: 11 February 2011

... 22 12 2010 4 1 2011 4 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 insulin signalling phosphoinositide 3-kinase (PI3K) pleckstrin homology domain (PH domain) protein tyrosine phosphatase tandem pleckstrin homology-domain-containing protein (TAPP...

View articletitled, Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P 2 in regulating insulin sensitivity defined by knock-in analysis

Includes: Supplementary data

Articles

For a PDK1 inhibitor, the substrate matters

Zachary A. Knight

Biochem J (2011) 433 (2): e1–e2.

https://doi.org/10.1042/BJ20102038

Published: 22 December 2010

... 2011 kinase inhibitor phosphoinositide 3-kinase (PI3K) ribosomal S6 kinase (RSK) p70 ribosomal S6 kinase (S6K) serum- and glucocorticoid-induced protein kinase (SGK) Given the unique position of PDK1 upstream of many protein kinases, a selective PDK1 inhibitor would be a valuable research...

View articletitled, For a PDK1 inhibitor, the substrate matters

Articles

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

Ayaz Najafov, Eeva M. Sommer, Jeffrey M. Axten, M. Phillip Deyoung, Dario R. Alessi

Biochem J (2011) 433 (2): 357–369.

https://doi.org/10.1042/BJ20101732

Published: 22 December 2010

.../Akt1 cancer kinase inhibitor 3-phosphoinositide-dependent protein kinase (PDK1) phosphoinositide 3-kinase (PI3K) p90 ribosomal S6 kinase (RSK) p70 ribosomal S6 kinase (S6K) serum- and glucocorticoid-induced protein kinase (SGK) PDK1 (3-phosphoinositide-dependent protein kinase 1) plays...

View articletitled, Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

Articles

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

Laura R. Pearce, Gordon R. Alton, Daniel T. Richter, John C. Kath, Laura Lingardo, Justin Chapman, Catherine Hwang, Dario R. Alessi

Biochem J (2010) 431 (2): 245–255.

https://doi.org/10.1042/BJ20101024

Published: 28 September 2010

... (phosphoinositide-dependent kinase 1) via its PIF pocket and subsequently the T-loop (Thr 229 in S6K1) is phosphorylated [ 13 ]. Akt/protein kinase B (PKB) cancer kinase inhibitor phosphoinositide 3-kinase (PI3K) p70 ribosomal S6 kinase (S6K) serum- and glucocorticoid-induced protein kinase (SGK...

View articletitled, Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

Includes: Supplementary data

Articles

Role of phosphoinositide 3-kinase β in platelet aggregation and thromboxane A 2 generation mediated by G i signalling pathways

Analia Garcia, Soochong Kim, Kamala Bhavaraju, Simone M. Schoenwaelder, Satya P. Kunapuli

Biochem J (2010) 429 (2): 369–377.

https://doi.org/10.1042/BJ20100166

Published: 28 June 2010

... for 0.2 mm/s. All samples contained exogenously added human fibrinogen (1 mg/ml) without added calcium. Aggregation tracings are representative of results obtained from three separate experiments for three different donors. ADP Akt extracellular-signal-regulated kinase (ERK) phosphoinositide 3...

View articletitled, Role of phosphoinositide 3-kinase β in platelet aggregation and thromboxane A 2 generation mediated by G i signalling pathways

Articles

Role of cellular bioenergetics in smooth muscle cell proliferation induced by platelet-derived growth factor

Jessica Perez, Bradford G. Hill, Gloria A. Benavides, Brian P. Dranka, Victor M. Darley-Usmar

Biochem J (2010) 428 (2): 255–267.

https://doi.org/10.1042/BJ20100090

Published: 13 May 2010

.... In addition, these studies suggest that the LDH pathway may play an important role in regulating the bioenergetic reserve of VSMCs and therefore may be integral to the hyperplastic VSMC phenotype. metabolic flux mitochondrion phosphoinositide 3-kinase (PI3K) platelet-derived growth factor (PDGF...

View articletitled, Role of cellular bioenergetics in smooth muscle cell proliferation induced by platelet-derived growth factor

Includes: Supplementary data

Articles

Mesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathway

Ming-Cheng Chang, Chi-An Chen, Chang-Yao Hsieh, Chien-Nan Lee, Yi-Ning Su, Yu-Hao Hu, Wen-Fang Cheng

Biochem J (2009) 424 (3): 449–458.

https://doi.org/10.1042/BJ20082196

Published: 10 December 2009

... be addressed (email [email protected] ). 10 11 2008 2 9 2009 11 9 2009 11 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 apoptosis cancer mesothelin ovarian cancer paclitaxel phosphoinositide 3-kinase (PI3K) A total of 30...

View articletitled, Mesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathway

Articles

Thyroid-hormone-dependent activation of the phosphoinositide 3-kinase/Akt cascade requires Src and enhances neuronal survival

Xia Cao, Fukushi Kambe, Masako Yamauchi, Hisao Seo

Biochem J (2009) 424 (2): 201–209.

https://doi.org/10.1042/BJ20090643

Published: 11 November 2009

..., such as the ER (oestrogen receptor), AR (androgen receptor) and PR (progesterone receptor) [ 18 ]. Previously, the activation of Src by TH was reported in rat alveolar epithelial cells, but the involvement of TR was not studied [ 19 ]. apoptosis neuron non-genomic action phosphoinositide 3-kinase (PI3K...

View articletitled, Thyroid-hormone-dependent activation of the phosphoinositide 3-kinase/Akt cascade requires Src and enhances neuronal survival

Articles

Glucocorticoids can activate the α-ENaC gene promoter independently of SGK1

Niall McTavish, Jennet Getty, Ann Burchell, Stuart M. Wilson

Biochem J (2009) 423 (2): 189–197.

https://doi.org/10.1042/BJ20090366

Published: 25 September 2009

... epithelium epithelial Na + channel (ENaC) dexamethasone phosphoinositide 3-kinase (PI3K) reporter gene serum- and glucocorticoid-induced protein kinase 1 (SGK1) Figure 2 Activation of SGK1 ( A ) Control (i.e. cells transfected with empty vector; Cont.) cells and cells transiently expressing...

View articletitled, Glucocorticoids can activate the α-ENaC gene promoter independently of SGK1

Articles

High ambient glucose induces angiotensin-independent AT-1 receptor activation, leading to increases in proliferation and extracellular matrix accumulation in MES-13 mesangial cells

Naohiro Yano, Daisuke Suzuki, Masayuki Endoh, Tram N. Cao, John R. Dahdah, Andy Tseng, Joan P. Stabila, Bethany G. McGonnigal, James F. Padbury, Yi-Tang Tseng

Biochem J (2009) 423 (1): 129–143.

https://doi.org/10.1042/BJ20082277

Published: 14 September 2009

... nephropathy fibronectin G-protein-coupled receptor (GPCR) phosphoinositide 3-kinase (PI3K) type IV collagen The kidney is a major target organ of diabetic complications. Mesangial expansion with matrix accumulation is the pathological hallmark of diabetic nephropathy [ 1 ]. Hyperglycaemia...

View articletitled, High ambient glucose induces angiotensin-independent AT-1 receptor activation, leading to increases in proliferation and extracellular matrix accumulation in MES-13 mesangial cells

Articles

Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2β to the nucleus

Hrvoje Banfic, Dora Visnjic, Nikica Mise, Sanjeevi Balakrishnan, Simona Deplano, Yuri E. Korchev, Jan Domin

Biochem J (2009) 422 (1): 53–60.

https://doi.org/10.1042/BJ20090654

Published: 29 July 2009

... (EGF) nuclear matrix nucleus phosphoinositide phosphoinositide 3-kinase (PI3K) receptor The analysis of signal transduction events in mammalian nuclei has a significant history [ 1 ]. PtdIns, DAG (diacylglycerol) and phosphoinositide kinase activity have all been demonstrated in cell...

View articletitled, Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2β to the nucleus

Articles

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

Juan M. García-Martínez, Jennifer Moran, Rosemary G. Clarke, Alex Gray, Sabina C. Cosulich, Christine M. Chresta, Dario R. Alessi

Biochem J (2009) 421 (1): 29–42.

https://doi.org/10.1042/BJ20090489

Published: 12 June 2009

... phosphoinositide 3-kinase (PI3K) p70 ribosomal S6 kinase (S6K) serum and glucocorticoid protein kinase (SGK) The mTOR (mammalian target of rapamycin) protein kinase lies at the nexus of signalling pathways that regulate cell growth and proliferation. Many cancer-driving mutations in genes...

View articletitled, Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

Articles

Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation

Stephen G. Ward, Federica M. Marelli-Berg

Biochem J (2009) 418 (1): 13–27.

https://doi.org/10.1042/BJ20081969

Published: 28 January 2009

... phosphoinositide 3-kinase (PI3K) T-cell antigen receptor (TCR) The transition from bone-marrow-resident haematopoietic stem cells, through the development of T-cell precursors in the thymus, naïve T-cell migration into secondary lymphoid organs for immune response initiation and maturation...

View articletitled, Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation

Includes: Multimedia, Supplementary data

Articles

New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen

Christian Peifer, Dario R. Alessi

Biochem J (2009) 417 (1): e5–e7.

https://doi.org/10.1042/BJ20082243

Published: 12 December 2008

... with metastatic disease, and many with non-metastatic disease, relapse and ultimately die due to tumours becoming resistant to tamoxifen. Akt growth factor signalling pathway phosphoinositide-dependent kinase 1 (PDK1) phosphoinositide 3-kinase (PI3K) tamoxifen sensitization ...

View articletitled, New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen

Articles

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Juan M. García-Martínez, Dario R. Alessi

Biochem J (2008) 416 (3): 375–385.

https://doi.org/10.1042/BJ20081668

Published: 26 November 2008

... mammalian target of rapamycin (mTOR) pathway phosphoinositide 3-kinase (PI3K) serum- and glucocorticoid-induced protein kinase 1 (SGK1) S6 kinase © The Authors Journal compilation © 2008 Biochemical Society 2008 Insulin and growth factors stimulate activation of SGK1 as well as other AGC...

View articletitled, mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

Articles

Regulation of microtubule nucleation from membranes by complexes of membrane-bound γ-tubulin with Fyn kinase and phosphoinositide 3-kinase

Libor Macurek, Eduarda Dráberová, Věra Richterová, Vadym Sulimenko, Tetyana Sulimenko, Lubica Dráberová, Vladimíra Marková, Pavel Dráber

Biochem J (2008) 416 (3): 421–430.

https://doi.org/10.1042/BJ20080909

Published: 26 November 2008

... West Pico; Pierce). detergent-resistant membrane (DRM) Fyn (protein tyrosine kinase p59 Fyn ) phosphoinositide 3-kinase (PI3K) PI3K regulatory subunit (p85α) Src homology 2 (SH2) domain γ-tubulin In most proliferating and migrating animal cells, the centrosome is the main site...

View articletitled, Regulation of microtubule nucleation from membranes by complexes of membrane-bound γ-tubulin with Fyn kinase and phosphoinositide 3-kinase

Includes: Supplementary data

Articles

Receptor for advanced glycation end-products (RAGE) modulates neutrophil adhesion and migration on glycoxidated extracellular matrix

Fatouma Touré, Jean-Marie Zahm, Roselyne Garnotel, Elise Lambert, Noel Bonnet, Ann Marie Schmidt, Fabien Vitry, Jacques Chanard, Philippe Gillery, Philippe Rieu

Biochem J (2008) 416 (2): 255–261.

https://doi.org/10.1042/BJ20080054

Published: 12 November 2008

... the cell perimeter of the digital image. Determinations were made for 20 cells for each condition. advanced glycosylated end-product (AGE) collagen defence neutrophil phosphoinositide 3-kinase (PI3K) receptor for advanced glycosylated end-products (RAGE) Patients with diabetes...

View articletitled, Receptor for advanced glycation end-products (RAGE) modulates neutrophil adhesion and migration on glycoxidated extracellular matrix

Articles

Role of Fyn and PI3K in H 2 O 2 -induced inhibition of apical Cl − /OH − exchange activity in human intestinal epithelial cells

Seema Saksena, Ravinder K. Gill, Sangeeta Tyagi, Waddah A. Alrefai, Krishnamurthy Ramaswamy, Pradeep K. Dudeja

Biochem J (2008) 416 (1): 99–108.

https://doi.org/10.1042/BJ20070960

Published: 28 October 2008

... chloride absorption down-regulated in adenoma (DRA) human intestine putative anion transporter 1 (PAT1) phosphoinositide 3-kinase (PI3K) protein kinase C (PKC) ROS (reactive oxygen species), including H 2 O 2 , O 2 − (superoxide anion), OH − (hydroxyl anion) and HOCl (hypochlorite...

View articletitled, Role of Fyn and PI3K in H 2 O 2 -induced inhibition of apical Cl − /OH − exchange activity in human intestinal epithelial cells

Articles

The life of a cell: apoptosis regulation by the PI3K/PKB pathway

Vincent Duronio

Biochem J (2008) 415 (3): 333–344.

https://doi.org/10.1042/BJ20081056

Published: 15 October 2008

... (PDK1) phosphoinositide 3-kinase (PI3K) protein kinase B (PKB) It is well known that investigations of the pathways that are regulated following activation of the PI3K (phosphoinositide 3-kinase) family of enzymes has been one of the most intensively studied set of signalling events...

View articletitled, The life of a cell: apoptosis regulation by the PI3K/PKB pathway

Articles

Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket

Mark Frazzetto, Cenk Suphioglu, Jiuxiang Zhu, Oleg Schmidt-Kittler, Ian G. Jennings, Susan L. Cranmer, Shaun P. Jackson, Kenneth W. Kinzler, Bert Vogelstein, Philip E. Thompson

Biochem J (2008) 414 (3): 383–390.

https://doi.org/10.1042/BJ20080512

Published: 27 August 2008

... phosphoinositide 3-kinase (PI3K) site-directed mutagenesis small-molecule inhibitor Enzymes of the PI3K (phosphoinositide 3-kinase) family are fundamental to numerous intracellular signalling cascades, catalysing phosphorylation at the 3-hydroxy function of phosphatidylinositols [ 1 , 2 ]. The 3...

View articletitled, Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket

Includes: Supplementary data

Articles

The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase

Nobuo Tsuboi, Tadahiko Utsunomiya, Richard L. Roberts, Hideyuki Ito, Keiko Takahashi, Masaharu Noda, Takamune Takahashi

Biochem J (2008) 413 (1): 193–200.

https://doi.org/10.1042/BJ20071317

Published: 12 June 2008

... 18 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 CD148 protein tyrosine phosphatase p85 phosphoinositide 3-kinase (PI3K) CD148 (also named DEP-1/PTPη) is a transmembrane PTP (protein tyrosine phosphatase) that is composed of an extracellular segment...

View articletitled, The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase

Includes: Supplementary data

Articles

Quantification of PtdIns(3,4,5) P 3 dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods

Shu-Chin Yip, Robert J. Eddy, Angie M. Branch, Huan Pang, Haiyan Wu, Ying Yan, Beth E. Drees, Paul O. Neilsen, John Condeelis, Jonathan M. Backer

Biochem J (2008) 411 (2): 441–448.

https://doi.org/10.1042/BJ20071179

Published: 27 March 2008

... carcinoma cell epidermal growth factor (EGF) phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5) P 3 ] phosphoinositide phosphoinositide 3-kinase (PI3K) pleckstrin homology domain (PH domain) PI3Ks (phosphoinositide 3-kinases) are key regulators of many cellular responses. The class I...

View articletitled, Quantification of PtdIns(3,4,5) P 3 dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods

Articles

The regulation and function of Class III PI3Ks: novel roles for Vps34

Jonathan M. Backer

Biochem J (2008) 410 (1): 1–17.

https://doi.org/10.1042/BJ20071427

Published: 29 January 2008

... of both autophagy and, through the mTOR pathway, protein synthesis, and thus contribute to the integration of cellular responses to changing nutritional status. hVps34 hVps15 phosphoinositide phosphoinositide 3-kinase (PI3K) target of rapamycin (TOR) vacuolar protein sorting 34 (Vps34...

View articletitled, The regulation and function of Class III PI3Ks: novel roles for Vps34

Articles

Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110α and β by protease-activated receptor 2 and β-arrestins

Ping Wang, Puneet Kumar, Chang Wang, Kathryn A. DeFea

Biochem J (2007) 408 (2): 221–230.

https://doi.org/10.1042/BJ20070483

Published: 14 November 2007

... phosphoinositide 3-kinase (PI3K) PI3K regulatory subunit (p85) PI3K regulatory subunit (p110) protease-activated receptor 2 (PAR-2) We have shown that PAR-2 promotes β-arrestin-dependent inhibition and Gαq/Ca 2+ /SFK-dependent stimulation of p85-associated PI3K activity. This was in contrast to previous...

View articletitled, Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110α and β by protease-activated receptor 2 and β-arrestins

Articles

The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2

Ian H. Batty, Jeroen van der Kaay, Alex Gray, Joan F. Telfer, Miles J. Dixon, C. Peter Downes

Biochem J (2007) 407 (2): 255–266.

https://doi.org/10.1042/BJ20070558

Published: 25 September 2007

... correspondence should be addressed (email [email protected] ). 25 4 2007 1 8 2007 2 8 2007 2 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 lipid phosphatase phosphoinositide 3-kinase (PI3K) protein phosphatase reactive oxygen species...

View articletitled, The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2

Articles

Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells

Mariko Tomita, Gregg L. Semenza, Canine Michiels, Takehiro Matsuda, Jun-Nosuke Uchihara, Taeko Okudaira, Yuetsu Tanaka, Naoya Taira, Kazuiku Ohshiro, Naoki Mori

Biochem J (2007) 406 (2): 317–323.

https://doi.org/10.1042/BJ20070286

Published: 13 August 2007

... 2 2007 14 6 2007 19 6 2007 19 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 adult T-cell leukaemia (ATL) Akt human T-cell leukaemia virus type 1 (HTLV-1) hypoxia-inducible factor 1 (HIF-1) phosphoinositide 3-kinase (PI3K) Tax...

View articletitled, Activation of hypoxia-inducible factor 1 in human T-cell leukaemia virus type 1-infected cell lines and primary adult T-cell leukaemia cells

Articles

Controlling cell growth and survival through regulated nutrient transporter expression

Aimee L. Edinger

Biochem J (2007) 406 (1): 1–12.

https://doi.org/10.1042/BJ20070490

Published: 26 July 2007

... oncogenesis phosphoinositide 3-kinase (PI3K) transferrin receptor Less information is available about the regulation of GLUT1 expression by growth and survival factors in non-haemopoetic tissues or by PI3K-independent signalling. Treatment of L6 myotubes with insulin results in an increase in GLUT1...

View articletitled, Controlling cell growth and survival through regulated nutrient transporter expression

Articles

Novel role for insulin as an autocrine growth factor for malignant brain tumour cells

Alexandre Arcaro, Kathrin T. Doepfner, Danielle Boller, Ana S. Guerreiro, Tarek Shalaby, Shaun P. Jackson, Simone M. Schoenwaelder, Olivier Delattre, Michael A. Grotzer, Barbara Fischer

Biochem J (2007) 406 (1): 57–66.

https://doi.org/10.1042/BJ20070309

Published: 26 July 2007

...) cell proliferation central nervous system insulin-like growth factor (IGF) phosphoinositide 3-kinase (PI3K) Total cellular RNA was extracted using the RNeasy Mini kit (Qiagen) according to the manufacturer's instructions. For each RT–PCR, 2 μg of total RNA was used with the Qiagen One...

View articletitled, Novel role for insulin as an autocrine growth factor for malignant brain tumour cells

Includes: Supplementary data

Articles

p56 lck , LFA-1 and PI3K but not SHP-2 interact with G M1 - or G M3 -enriched microdomains in a CD4–p56 lck association-dependent manner

Christiane Barbat, Maylis Trucy, Maurizio Sorice, Tina Garofalo, Valeria Manganelli, Alain Fischer, Fabienne Mazerolles

Biochem J (2007) 402 (3): 471–481.

https://doi.org/10.1042/BJ20061061

Published: 26 February 2007

... be addressed (email [email protected] ). 13 7 2006 14 11 2006 24 11 2006 24 11 2006 The Biochemical Society, London 2007 adhesion molecule CD4 T-cell ganglioside lymphocyte function-associated antigen-1 (LFA-1) phosphoinositide 3-kinase (PI3K) raft CD4 signalling...

View articletitled, p56 lck , LFA-1 and PI3K but not SHP-2 interact with G M1 - or G M3 -enriched microdomains in a CD4–p56 lck association-dependent manner

Includes: Supplementary data

Articles

The centaurin γ-1 GTPase-like domain functions as an NTPase

Meera Soundararajan, Xiaowen Yang, Jonathan M. Elkins, Frank Sobott, Declan A. Doyle

Biochem J (2007) 401 (3): 679–688.

https://doi.org/10.1042/BJ20060555

Published: 12 January 2007

... in the Protein Data Bank under codes 2BMJ (C2 space group) and 2IWR ( P 2 1 2 1 2 1 ). 12 4 2006 19 9 2006 12 10 2006 12 10 2006 centaurin γ-1 (CENTG1) GTPase-activating domain NTPase phosphoinositide 3-kinase (PI3K) phosphoinositide 3-kinase enhancer (PIKE) Cell...

View articletitled, The centaurin γ-1 GTPase-like domain functions as an NTPase

Articles

Ubiquitin–proteasome degradation of serum- and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperone-dependent E3 ligase CHIP

Larissa Belova, Sanjay Sharma, Deanna R. Brickley, Jeremy R. Nicolarsen, Cam Patterson, Suzanne D. Conzen

Biochem J (2006) 400 (2): 235–244.

https://doi.org/10.1042/BJ20060905

Published: 14 November 2006

... 2006 7 8 2006 8 8 2006 The Biochemical Society, London 2006 cell survival C-terminus of Hsc70 interacting protein (CHIP) E3 ligase serum and glucocorticoid-regulated kinase-1 (SGK-1) stress response phosphoinositide 3-kinase (PI3K) ubiquitination SGK-1 (serum...

View articletitled, Ubiquitin–proteasome degradation of serum- and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperone-dependent E3 ligase CHIP

Articles

EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration

Cong Cao, Yun Sun, Sarah Healey, Zhigang Bi, Gang Hu, Shu Wan, Nicola Kouttab, Wenming Chu, Yinsheng Wan

Biochem J (2006) 400 (2): 225–234.

https://doi.org/10.1042/BJ20060816

Published: 14 November 2006

...) human skin fibroblast phosphoinositide 3-kinase (PI3K) wound healing AQPs (aquaporins) are a family of small (∼30 kDa/monomer), hydrophobic, integral membrane proteins that are expressed widely in animal and plant kingdoms, with 13 members having been identified in mammals so far [ 1 , 2...

View articletitled, EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration

Update search

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only