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1-37 of 37
Keywords: phospholipid
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Articles
Glycerol-3-phosphate acyltransferases 3 and 4 direct glycerolipid synthesis and affect functionality in activated macrophages
Available to PurchaseIvana Y. Quiroga, Magali Pellon-Maison, Amanda L. Suchanek, Rosalind A. Coleman, Maria R. Gonzalez-Baro
Journal:
Biochemical Journal
Biochem J (2019) 476 (1): 85–99.
Published: 11 January 2019
... contain large quantities of triacylglycerol (TAG) and phospholipid (PL). The functional consequences of this increment in lipid mass are poorly understood. Here, we studied the contribution of glycerolipid synthesis to lipid accumulation, focusing specifically on the first and rate-limiting enzyme...
Includes: Supplementary data
Articles
Molecular determinants of KA1 domain-mediated autoinhibition and phospholipid activation of MARK1 kinase
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2017) 474 (3): 385–398.
Published: 20 January 2017
... icrotubule a ffinity- r egulating k inases (MARKs) contain a poorly understood regulatory module, the KA1 ( k inase a ssociated-1) domain, at their C-terminus. KA1 domains from MARK1 and several related kinases from yeast to humans have been shown to bind membranes containing anionic phospholipids...
Includes: Supplementary data
Articles
Transcriptional suppression of CTP:phosphoethanolamine cytidylyltransferase by 25-hydroxycholesterol is mediated by nuclear factor-Y and Yin Yang 1
Available to PurchaseHiromi Ando, Chieko Aoyama, Yasuhiro Horibata, Motoyasu Satou, Satomi Mitsuhashi, Masahiko Itoh, Kohei Hosaka, Hiroyuki Sugimoto
Journal:
Biochemical Journal
Biochem J (2015) 471 (3): 369–379.
Published: 16 October 2015
... nuclear factor-Y and RNA polymerase II. CTP:phosphoethanolamine cytidylyltransferase HMG-CoA reductase 25-hydroxycholesterol nuclear factor-Y phosphatidylethanolamine phospholipid Glycerophospholipids such as PE (phosphatidylethanolamine) and PC (phosphatidylcholine), as well...
Includes: Supplementary data
Articles
The hydrogen-peroxide-induced radical behaviour in human cytochrome c –phospholipid complexes: implications for the enhanced pro-apoptotic activity of the G41S mutant
Available to PurchaseBadri S. Rajagopal, Ann N. Edzuma, Michael A. Hough, Katie L. I. M. Blundell, Valerian E. Kagan, Alexandr A. Kapralov, Lewis A. Fraser, Julea N. Butt, Gary G. Silkstone, Michael T. Wilson, Dimitri A. Svistunenko, Jonathan A. R. Worrall
Journal:
Biochemical Journal
Biochem J (2013) 456 (3): 441–452.
Published: 22 November 2013
... of the G41S mutant of human cytochrome c can be explained by a higher than wild-type peroxidase activity triggered by phospholipid binding. A key complex in mitochondrial apoptosis involves cytochrome c and the phospholipid cardiolipin. In this complex cytochrome c has its native axial Met 80 ligand...
Includes: Supplementary data
Articles
Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ)
Available to PurchaseGhazi M. Rahman, Sreejesh Shanker, Nancy E. Lewin, Noemi Kedei, Colin S. Hill, B. V. Venkataram Prasad, Peter M. Blumberg, Joydip Das
Journal:
Biochemical Journal
Biochem J (2013) 451 (1): 33–44.
Published: 14 March 2013
... phospholipid protein kinase C tryptophan PKC (protein kinase C) θ is a serine/threonine kinase [ 1 ]. In humans it is encoded by the PRKCQ gene and is highly expressed in T-cells and thymocytes [ 2 ]. PKCθ plays a crucial role in T-cell activation and is critically involved in immunity. PKCθ...
Includes: Supplementary data
Articles
Autoinhibition mechanism of the plasma membrane calcium pump isoforms 2 and 4 studied through lipid–protein interaction
Available to PurchaseIrene C. Mangialavori, Gerardo Corradi, Débora E. Rinaldi, María Candelaria de la Fuente, Hugo P. Adamo, Juan Pablo F. C. Rossi
Journal:
Biochemical Journal
Biochem J (2012) 443 (1): 125–131.
Published: 14 March 2012
... changes its conformation to a lesser extent than PMCA4, an isoform more sensitive to modulation by calmodulin and acidic phospholipids. This is the first demonstration of a dynamic behaviour of annular lipids and PMCA. 1 These authors contributed equally to this work. For labelling...
Articles
Vesicle trafficking and membrane remodelling in cytokinesis
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Journal:
Biochemical Journal
Biochem J (2011) 437 (1): 13–24.
Published: 14 June 2011
... cytoskeleton membrane trafficking phospholipid soluble N -ethylmaleimide-sensitive fusion protein-attachment protein receptor (SNARE) Mammalian cells exhibit pronounced shape changes during mitosis: cells become rounded in early mitosis, before compacting in metaphase and furrowing in telophase...
Articles
Biochemical and cellular functions of P 4 ATPases
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Journal:
Biochemical Journal
Biochem J (2010) 431 (1): 1–11.
Published: 14 September 2010
...Lieke M. van der Velden; Stan F. J. van de Graaf; Leo W. J. Klomp P 4 ATPases (subfamily IV P-type ATPases) form a specialized subfamily of P-type ATPases and have been implicated in phospholipid translocation from the exoplasmic to the cytoplasmic leaflet of biological membranes. Pivotal roles...
Articles
Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase
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Journal:
Biochemical Journal
Biochem J (2010) 431 (1): 141–148.
Published: 14 September 2010
...Lloyd T. Morgan; Christopher P. Thomas; Hartmut Kühn; Valerie B. O'Donnell Arachidonate-containing oxidized phospholipids are acutely generated by 12-LOX (12-lipoxygenase) in agonist-activated platelets. In the present study, formation of structurally related lipids by oxidation of DHA...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 421 (2): 145–156.
Published: 26 June 2009
...Hong-Wei Xue; Xu Chen; Yu Mei As an important metabolic pathway, phosphatidylinositol metabolism generates both constitutive and signalling molecules that are crucial for plant growth and development. Recent studies using genetic and molecular approaches reveal the important roles of phospholipid...
Articles
Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs
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Journal:
Biochemical Journal
Biochem J (2009) 421 (2): 311–322.
Published: 26 June 2009
... should be addressed (email [email protected] ). 6 1 2009 28 4 2009 30 4 2009 30 4 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 fatty acid fatty acyl-CoA homotetramer hotdog fold thioesterase phospholipid StarD2 Acyl-CoA...
Articles
Hiroyasu Sato, Yoshitaka Taketomi, Yuki Isogai, Seiko Masuda, Tetsuyuki Kobayashi, Kei Yamamoto, Makoto Murakami
Journal:
Biochemical Journal
Biochem J (2009) 421 (1): 17–27.
Published: 12 June 2009
... of mammalian sPLA 2 . dermatitis phospholipase A 2 phospholipid prostaglandin splenomegaly transgenic mouse The contents of PGE 2 (prostaglandin E 2 ) and LTB 4 (leukotriene B 4 ) in mouse skins were quantified using PGE 2 and LTB 4 enzyme immunoassay kits (Cayman Chemicals...
Articles
Effects of phosphatidylethanolamine glycation on lipid–protein interactions and membrane protein thermal stability
Available to PurchaseValeria Levi, Ana M. Villamil Giraldo, Pablo R. Castello, Juan P. F. C. Rossi, F. Luis González Flecha
Journal:
Biochemical Journal
Biochem J (2008) 416 (1): 145–152.
Published: 28 October 2008
... by a complex organization of lipids and proteins interacting and forming domains of different size and stability. In the present study, we analyse the effects of glycation on the interactions between membrane proteins and lipids. The phospholipid affinity for the transmembrane surface of the PMCA (plasma...
Includes: Supplementary data
Articles
The interaction of liver fatty-acid-binding protein (FABP) with anionic phospholipid vesicles: is there extended phospholipid anchorage under these conditions?
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Journal:
Biochemical Journal
Biochem J (2008) 410 (1): 123–129.
Published: 29 January 2008
...Robert M. Hagan; Jane Worner-Gibbs; David C. Wilton Liver FABP (fatty-acid-binding protein) binds a variety of non-polar anionic ligands including fatty acids, fatty acyl CoAs, lysophospholipids and bile acids. Liver FABP is also able to bind to anionic phospholipid vesicles under conditions of low...
Articles
Transcriptional regulation of phospholipid biosynthesis is linked to fatty acid metabolism by an acyl-CoA-binding-protein-dependent mechanism in Saccharomyces cerevisiae
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Journal:
Biochemical Journal
Biochem J (2007) 407 (2): 219–230.
Published: 25 September 2007
.... Depletion of Acb1p resulted in the differential expression of genes encoding proteins involved in fatty acid and phospholipid synthesis (e.g. FAS1 , FAS2 , ACC1 , OLE1 , INO1 and OPI3 ), glycolysis and glycerol metabolism (e.g. GPD1 and TDH1 ), ion transport and uptake (e.g. ITR1 and HNM1 ) and stress...
Includes: Supplementary data
Articles
The lipidation status of acute-phase protein serum amyloid A determines cholesterol mobilization via scavenger receptor class B, type I
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Journal:
Biochemical Journal
Biochem J (2007) 402 (1): 117–124.
Published: 25 January 2007
...) (devoid of ABCA1) failed to mobilize cholesterol to lipid-free or lipid-poor SAA. Only reconstituted vesicles containing phospholipids and SAA promoted SR-BI-mediated cholesterol efflux. Cholesterol efflux from HEK-293 and HEK-293[SR-BI] cells to lipid-free and lipid-poor SAA was minimal, while efficient...
Articles
Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria
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Journal:
Biochemical Journal
Biochem J (2006) 398 (2): 169–176.
Published: 15 August 2006
... lysophosphatidylglycerol mitochondria phospholipid Cardiolipin, also termed diphosphatidylglycerol, represents a unique dimeric phospholipid which consists of four fatty acyl chains that are 14–18 carbon atoms in length. The pattern of the fatty acyl chains varies among biological species, and is almost exclusively...
Articles
Enhanced levels of Pis1p (phosphatidylinositol synthase) improve the growth of Saccharomyces cerevisiae cells deficient in Rsp5 ubiquitin ligase
Available to PurchasePawel Kaliszewski, Thierry Ferreira, Beata Gajewska, Anna Szkopinska, Thierry Berges, Teresa Żołądek
Journal:
Biochemical Journal
Biochem J (2006) 395 (1): 173–181.
Published: 15 March 2006
... was cloned into pGEM-T (Promega) to obtain pGEM-pis1 and its sequence was confirmed. The SpeI–SphI fragment of YEpHA-PIS1 was replaced by the SpeI–SphI fragment transferred from pGEM-pis1. fatty acid phosphatidylinositol synthase (Pis1p) phospholipid Rsp5 ubiquitin ligase Saccharomyces cerevisiae...
Articles
Interaction of three-finger toxins with phospholipid membranes: comparison of S- and P-type cytotoxins
Available to PurchasePeter V. DUBOVSKII, Dmitry M. LESOVOY, Maxim A. DUBINNYI, Anastasiya G. KONSHINA, Yuri N. UTKIN, Roman G. EFREMOV, Alexander S. ARSENIEV
Journal:
Biochemical Journal
Biochem J (2005) 387 (3): 807–815.
Published: 26 April 2005
...-type respectively based on Ser-28 and Pro-30 residues within a putative phospholipid bilayer binding site. Previously, we investigated the interaction of CTII with multilamellar liposomes of dipalmitoylphosphatidylglycerol by wide-line 31 P-NMR spectroscopy. To compare interactions of these proteins...
Articles
Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer
Available to PurchaseAlexander GOONESINGHE, Elizabeth S. MUNDY, Melanie SMITH, Roya KHOSRAVI-FAR, Jean-Claude MARTINOU, Mauro D. ESPOSTI
Journal:
Biochemical Journal
Biochem J (2005) 387 (1): 109–118.
Published: 22 March 2005
.... Bid. 1 To whom correspondence should be addressed (email [email protected] ). 16 8 2004 19 10 2004 25 10 2004 25 10 2004 The Biochemical Society, London 2005 apoptosis Bcl-2 Bid lysolipid mitochondria phospholipid Proteins of the Bcl-2...
Articles
Mapping of an ankyrin-sensitive, phosphatidylethanolamine/phosphatidylcholine mono- and bi-layer binding site in erythroid β-spectrin
Available to PurchaseAnita HRYNIEWICZ-JANKOWSKA, Ewa BOK, Patrycja DUBIELECKA, Anna CHORZALSKA, Witold DIAKOWSKI, Adam JEZIERSKI, Marek LISOWSKI, Aleksander F. SIKORSKI
Journal:
Biochemical Journal
Biochem J (2004) 382 (2): 677–685.
Published: 24 August 2004
.... On the other hand, truncated mutants that lacked even the eight most N-terminal amino acid residues showed a lower (by at least an order of magnitude) affinity and a much higher maximal binding capacity. ankyrin-binding domain membrane skeleton phospholipid β-spectrin spectrin–phospholipid interaction...
Articles
Functional analysis of Chinese hamster phosphatidylserine synthase 1 through systematic alanine mutagenesis
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 381 (3): 853–859.
Published: 27 July 2004
...) is an essential phospholipid for the growth of mammalian cells [ 1 ], comprising approx. 10% of the total phospholipids of various mammalian tissues and cultured cells. PtdSer is known to interact with various proteins, such as protein kinase C [ 2 ], myristoylated alanine-rich C kinase substrate [ 3...
Articles
Lipid dynamics in yeast under haem-induced unsaturated fatty acid and/or sterol depletion
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 378 (3): 899–908.
Published: 15 March 2004
... esters but rather within specific phospholipid species, with a marked preference for PtdIns. This results in an increase in the cellular PtdIns content. However, neutral lipid homoeostasis is perturbed under haem starvation. The contribution of two lipid particle-associated proteins (namely Tgl1p...
Articles
Comparative analysis of tandem C2 domains from the mammalian synaptotagmin family
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Journal:
Biochemical Journal
Biochem J (2004) 378 (2): 681–686.
Published: 01 March 2004
... in calcium-dependent phospholipid binding. We performed a pair-wise amino acid sequence comparison, together with functional studies of rat Syt C2ABs, to examine common and divergent properties within the mammalian family. Sequence analysis indicates three different C2AB classes, the members of which share...
Articles
Proton conductance and fatty acyl composition of liver mitochondria correlates with body mass in birds
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Journal:
Biochemical Journal
Biochem J (2003) 376 (3): 741–748.
Published: 15 December 2003
... birds had the same or perhaps greater surface area per mg of protein than mitochondria from smaller birds. Hence, the lower proton conductance was caused not by surface area changes but by some change in the properties of the inner membrane. Liver mitochondria from larger birds had phospholipid fatty...
Articles
Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice
Available to PurchaseTineke KOK, Vincent W. BLOKS, Henk WOLTERS, Rick HAVINGA, Peter L.M. JANSEN, Bart STAELS, Folkert KUIPERS
Journal:
Biochemical Journal
Biochem J (2003) 369 (3): 539–547.
Published: 01 February 2003
... fibrates. Fibrates induce the hepatic expression of murine multidrug resistance 2 ( Mdr2 ), encoding the canalicular phospholipid translocator. The physiological role of PPARα in regulation of Mdr2 and other genes involved in bile formation is unknown. We found no differences in hepatic expression...
Articles
Ca2+-dependent and phospholipid-independent binding of annexin 2 and annexin 5
Available to PurchaseNicole D. BROOKS, Jean E. GRUNDY, Nadine LAVIGNE, Mélanie C. DERRY, Christina M. RESTALL, ROGER C. MacKENZIE, David M. WAISMAN, Edward L.G. PRYZDIAL
Journal:
Biochemical Journal
Biochem J (2002) 367 (3): 895–900.
Published: 01 November 2002
...Nicole D. BROOKS; Jean E. GRUNDY; Nadine LAVIGNE; Mélanie C. DERRY; Christina M. RESTALL; ROGER C. MacKENZIE; David M. WAISMAN; Edward L.G. PRYZDIAL Annexins are a family of homologous proteins that associate with anionic phospholipid (aPL) in the presence of Ca 2+ . Evidence that the function...
Articles
Cardiolipin prevents rate-dependent uncoupling and provides osmotic stability in yeast mitochondria
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2002) 364 (1): 317–322.
Published: 08 May 2002
... The Biochemical Society, London ©2002 2002 mitochondrial swelling oxidative phosphorylation phospholipid Abbreviations used: BSA, bovine serum albumin; YMUC, yeast mitochondrial unspecific channel. Biochem. J. (2002) 364, 317 322 (Printed in Great Britain) 317 Cardiolipin prevents rate...
Articles
Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the γ-carboxyglutamic acid-rich domain
Available to PurchaseDelphine BORGEL, Pascale GAUSSEM, Christiane GARBAY, Christilla BACHELOT-LOZA, Tahar KAABACHE, Wang-Qing LIU, Brigitte BROHARD-BOHN, Bernard LE BONNIEC, Martine AIACH, Sophie GANDRILLE
Journal:
Biochemical Journal
Biochem J (2001) 360 (2): 499–506.
Published: 26 November 2001
..., showing that TSR must be embedded in the native protein to promote interaction with activated protein C. The binding of rHPS to activated platelets and to phospholipid vesicles was not modified after factor Xa- or thrombin-mediated TSR cleavage, whereas the binding of rTSR-less was markedly reduced...
Articles
FYVE zinc-finger proteins in the plant model Arabidopsis thaliana: identification of PtdIns3P-binding residues by comparison of classic and variant FYVE domains
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Journal:
Biochemical Journal
Biochem J (2001) 359 (1): 165–173.
Published: 24 September 2001
... residue at positions corresponding to the PtdIns3 P -interacting His 4 and Arg 6 of the basic motif. Dot-blot and liposome-binding assays were used in vitro to examine the phospholipid-binding ability of isolated PRAF domains. Whereas the PH domain preferentially bound PtdIns(4,5) P 2 , the variant FYVE...
Articles
Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2001) 356 (2): 317–325.
Published: 24 May 2001
... control and bile-duct-ligated mice. Two genetically altered mouse models were studied: multidrug resistance-2 P-glycoprotein-deficient [ Mdr2 (−/−) ] mice that produce phospholipid/cholesterol-free bile, and cholesterol 7α-hydroxylase-deficient [ Cyp7a (−/−) ] mice, which exhibit qualitative...
Articles
Molten-globule structure and membrane binding of the N-terminal protease-resistant domain (63–193) of the steroidogenic acute regulatory protein (StAR)
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Journal:
Biochemical Journal
Biochem J (2001) 356 (1): 151–158.
Published: 08 May 2001
... the interaction of the N-terminal domain of StAR with membranes. We suggest that this interaction is the key to understanding the mechanism of StAR s action. Key words: CD, detergent, NMR, phospholipid, proteolysis. even transfers cholesterol from phosphatidylcholine (PC) lipo- somes to isolated mitochondria [11...
Articles
Purification of phosphatidylglycerophosphate synthase from Chinese hamster ovary cells
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Journal:
Biochemical Journal
Biochem J (2001) 354 (1): 9–15.
Published: 08 February 2001
... correspondence should be addressed (e-mail [email protected] ). 4 9 2000 1 11 2000 23 11 2000 The Biochemical Society, London © 2001 2001 cardiolipin mitochondria phosphatidylglycerol phospholipid Biochem. J. (2001) 354, 9 15 (Printed in Great Britain) 9 Purification...
Articles
Identification of synapsin I peptides that insert into lipid membranes
Available to PurchaseJames J. CHEETHAM, Sabine HILFIKER, Fabio BENFENATI, Thomas WEBER, Paul GREENGARD, Andrew J. CZERNIK
Journal:
Biochemical Journal
Biochem J (2001) 354 (1): 57–66.
Published: 08 February 2001
... been shown to bind with high affinity to the acidic phospholipids phosphatidylserine and phosphatidylinositol and to penetrate the hydrophobic core of the lipid bilayer. To precisely identify the domains of synapsin I which mediate the interaction with lipids, synapsin I was bound to liposomes...
Articles
Diacylglycerol kinase θ is translocated and phosphoinositide 3-kinase-dependently activated by noradrenaline but not angiotensin II in intact small arteries
Available to PurchaseAnthony J. WALKER, Annette DRAEGER, Brahim HOUSSA, Wim J. VAN BLITTERSWIJK, Vasken OHANIAN, Jacqueline OHANIAN
Journal:
Biochemical Journal
Biochem J (2001) 353 (1): 129–137.
Published: 18 December 2000
... a physiological role in vascular smooth-muscle responses. 1 To whom correspondence should be addressed (e-mail [email protected] ). 2 6 2000 18 9 2000 23 10 2000 The Biochemical Society, London © 2001 2001 diacylglycerol kinase phospholipid protein kinase B smooth muscle...
Articles
Diabetes-induced changes in specific lipid molecular species in rat myocardium
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Journal:
Biochemical Journal
Biochem J (2000) 352 (1): 79–89.
Published: 07 November 2000
... in myocardial plasmenylethanolamine mass and (iv) a 22% decrease in 1-stearoyl-2-arachidonoyl phosphatidylethanolamine content. Each of the changes in phospholipid classes, subclasses and individual molecular species were prevented by insulin treatment after induction of the diabetic state. In sharp contrast...
Articles
Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine
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Journal:
Biochemical Journal
Biochem J (1999) 339 (2): 291–298.
Published: 08 April 1999
...-ethanolamine as phosphobase donors to a broad range of diacylglycerols, resulting in the synthesis of both PtdCho and PtdEtn. In vivo , S. cerevisiae cells (HJ091, cpt1::LEU2 ept1 - ) expressing hCEPT1 efficiently incorporated both radiolabelled choline and ethanolamine into phospholipids, demonstrating...
