... with the loss of enzyme activity and folate binding and underscore the important role of the Pro285 cis-peptide in SHMT structure and function. In this study, we investigate one of the previously identified variants of Forrest SHMT8: a point mutation of Pro285 to serine (P285S) identified in soybean line F650...

... mutants where the effects were quite subtle. The overall results are summarised in Table 2 and also Figure 1A . AMPK melanoma point mutations skin cancer tumour suppressors The AMP-activated protein kinase (AMPK) pathway acts as a sensor of cellular energy and nutrient status...

.... crystallography DNA damage DNA replication and recombination DNA synthesis and repair point mutations Inosine, a purine nucleoside containing hypoxanthine (HX) nucleobase, was first identified in 1965 as the deamination product of adenosine [ 1 ]. Inosine formation in RNA is a major biological...

... experiments are shown for each experimental condition. 9 5 2023 2 6 2023 12 6 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 intracellular signaling point mutations protein kinase A protein–protein interactions...

... syndrome and cancer. Correspondence: Frank McCormick ( [email protected] ) 27 5 2020 1 7 2020 2 7 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer GTPases point mutations stress response...

... be very challenging to extricate, it should still be possible to relate the sequence patterns to the energetic outcomes and the eventual impact on folding and function. kinetic stability point mutations protein conformation sequence evolution statistical model thermodynamics...