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Keywords: polyamine
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Articles
Biochem J (2016) 473 (15): 2315–2329.
Published: 28 July 2016
...Anthony J. Michael Polyamines are evolutionarily ancient polycations derived from amino acids and are pervasive in all domains of life. They are essential for cell growth and proliferation in eukaryotes and are essential, important or dispensable for growth in bacteria. Polyamines present a useful...
Articles
Biochem J (2015) 468 (3): 435–447.
Published: 15 June 2015
...Swati Mandal; Ajeet Mandal; Myung Hee Park The polyamines putrescine, spermidine and spermine are intimately involved in the regulation of cellular growth and viability. Transduction of human embryonic kidney (HEK) 293T cells with an adenovirus encoding a key polyamine catabolic enzyme, spermidine...
Articles
Biochem J (2014) 461 (3): 453–459.
Published: 10 July 2014
...Manuela Cervelli; Emanuela Angelucci; Pasquale Stano; Loris Leboffe; Rodolfo Federico; Giovanni Antonini; Paolo Mariottini; Fabio Polticelli SMO (spermine oxidase) and APAO (acetylpolyamine oxidase) are flavoenzymes that play a critical role in the catabolism of polyamines. Polyamines are basic...
Articles
Biochem J (2013) 453 (3): 467–474.
Published: 12 July 2013
...Mervi T. Hyvönen; Taina Koponen; Janne Weisell; Marko Pietilä; Alex R. Khomutov; Jouko Vepsäläinen; Leena Alhonen; Tuomo A. Keinänen We have shown previously that the polyamine spermidine is indispensable for differentiation of 3T3-L1 preadipocytes. In the present study, we examined the mechanism...
Includes: Supplementary data
Articles
Biochem J (2013) 452 (3): 423–432.
Published: 31 May 2013
...Radika Soysa; Hanka Venselaar; Jacqueline Poston; Buddy Ullman; Marie-Pierre Hasne The TcPOT1.1 gene from Trypanosoma cruzi encodes a high affinity putrescine-cadaverine transporter belonging to the APC (amino acid/polyamine/organocation) transporter superfamily. No experimental three-dimensional...
Includes: Supplementary data
Articles
Biochem J (2013) 451 (2): 145–154.
Published: 28 March 2013
... in the present review with respect to regulation and communication with the sulfur assimilation pathway, the network of the aspartate-derived amino acids and the demand for production of SAM. SAM enters the ethylene, nicotianamine and polyamine biosynthetic pathways and provides the methyl group for the majority...
Articles
Biochem J (2013) 450 (3): 619–628.
Published: 28 February 2013
... small molecule metabolism. A LC (liquid chromatography)-MS screen in colorectal cancer cell lines isogenic for oncogenic PIK3CA mutations revealed an association between PI3K activation and the levels of polyamine pathway metabolites, including 5-methylthioadenosine, putrescine and spermidine...
Includes: Supplementary data
Articles
Biochem J (2013) 450 (1): 47–53.
Published: 24 January 2013
... , that belong to the P 5 -ATPase group have been identified in humans. Mutations of the human gene ATP13A2 underlie a form of PD (Parkinson's disease). Previous studies have suggested a relation between polyamines and P 5B -ATPases. We have recently shown that the cytotoxicity induced by the polyamine analogue...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (3): 727–734.
Published: 16 April 2012
... biosynthesis exopolysaccharide polyamine spermidine/spermine acetyltransferase Ste27 The polyamines spermidine and spermine, and their precursor putrescine, are ubiquitous organic cations found in most cells. These molecules are essential for normal cell growth and differentiation [ 1...
Articles
Biochem J (2012) 442 (3): 693–701.
Published: 24 February 2012
... with two polyamine oxidases, SMO (spermine oxidase) and APAO (N 1 -acetylpolyamine oxidase). We have demonstrated previously that long-chain polyamine analogues, the oligoamines, are inhibitors of LSD1. In the present paper we report the synergistic effects of specific oligoamines in combination with DFMO...
Includes: Supplementary data
Articles
Biochem J (2011) 438 (2): 229–244.
Published: 12 August 2011
...Lyn-Marie Birkholtz; Marni Williams; Jandeli Niemand; Abraham I. Louw; Lo Persson; Olle Heby New drugs are urgently needed for the treatment of tropical and subtropical parasitic diseases, such as African sleeping sickness, Chagas' disease, leishmaniasis and malaria. Enzymes in polyamine...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2011) 433 (1): 139–144.
Published: 15 December 2010
...Anthony E. Pegg; Xiaojing Wang; Charles E. Schwartz; Diane E. McCloskey dcAdoMet (decarboxylated S -adenosylmethionine) is an essential intermediate in the synthesis of polyamines. Its content is normally very low, amounting to less than 5% of that of S -adenosylmethionine itself. It was found...
Articles
Biochem J (2010) 430 (1): 151–159.
Published: 28 July 2010
... polyamines and especially quadrivalent spermine can be considered as potential regulators of the complex dynamical properties of anionic MTs (microtubules). Indeed, the C-terminal tails of tubulin display many negative residues in a row which should enable the formation of a correlated liquid-like phase...
Includes: Supplementary data
Articles
Biochem J (2010) 429 (2): 261–271.
Published: 28 June 2010
... –Xpr–GFP) into the growing tube wall enhanced tube length and germination, consistent with a role of TGase as a modulator of cell wall building and strengthening. The secreted pollen TGase catalysed the cross-linking of both PAs (polyamines) into proteins (released by the pollen tube) and His 6 -Xpr...
Includes: Supplementary data
Articles
Biochem J (2010) 426 (3): 293–306.
Published: 24 February 2010
.... In the present paper, we report that cellular polyamines regulate MEK-1 expression at the post-transcriptional level through the RNA-binding protein HuR (Hu-antigen R) in IECs (intestinal epithelial cells). Decreasing the levels of cellular polyamines by inhibiting ODC (ornithine decarboxylase) stabilized MEK-1...
Includes: Supplementary data
Articles
Biochem J (2009) 424 (3): 431–438.
Published: 10 December 2009
...Andrew J. Palmer; Radiah A. Ghani; Navneet Kaur; Otto Phanstiel; Heather M. Wallace Increased polyamine concentrations play an important role in the development of cancer at all stages, from initiation through to maintenance of the transformed phenotype. One way cancer cells accumulate increased...
Articles
Biochem J (2009) 421 (3): 323–338.
Published: 15 July 2009
...Robert A. Casero, Jr; Anthony E. Pegg In addition to polyamine homoeostasis, it has become increasingly clear that polyamine catabolism can play a dominant role in drug response, apoptosis and the response to stressful stimuli, and contribute to the aetiology of several pathological states...
Articles
Biochem J (2008) 410 (3): 613–619.
Published: 27 February 2008
...Zohar Snapir; Alona Keren-Paz; Zippi Bercovich; Chaim Kahana ODC (ornithine decarboxylase), the first enzyme in the polyamine biosynthesis pathway in mammalian cells, is a labile protein. ODC degradation is stimulated by Az (antizyme), a polyamine-induced protein, which in turn is regulated...
Articles
Biochem J (2008) 409 (2): 563–569.
Published: 21 December 2007
...Martin C. Taylor; Harparkash Kaur; Bernard Blessington; John M. Kelly; Shane R. Wilkinson The trypanocidal activity of the ODC (ornithine decarboxylase) inhibitor DFMO (difluoromethylornithine) has validated polyamine biosynthesis as a target for chemotherapy. As DFMO is one of only two drugs used...
Articles
Biochem J (2008) 409 (1): 187–192.
Published: 11 December 2007
...Kristiina Kanerva; Laura T. Mäkitie; Anna Pelander; Marja Heiskala; Leif C. Andersson ODC (ornithine decarboxylase), the rate-limiting enzyme in polyamine biosynthesis, is regulated by specific inhibitors, AZs (antizymes), which in turn are inhibited by AZI (AZ inhibitor). We originally identified...
Articles
Biochem J (2007) 407 (2): 243–254.
Published: 25 September 2007
...Sujoy Bhattacharya; Huazhang Guo; Ramesh M. Ray; Leonard R. Johnson Inhibition of ornithine decarboxylase by DFMO (α-difluromethylornithine) and subsequent polyamine depletion increases p21Cip1 protein, induces cell cycle arrest and confers resistance to apoptosis on intestinal epithelial cells...
Articles
Biochem J (2006) 397 (3): 437–447.
Published: 13 July 2006
...Sujoy Bhattacharya; Ramesh M. Ray; Leonard R. Johnson Intestinal epithelial (IEC-6) cells are resistant to apoptosis following the inhibition of ODC (ornithine decarboxylase) and subsequent polyamine depletion. The depletion of polyamines rapidly activates NF-κB (nuclear factor κB) and STAT3...
Articles
Biochem J (2006) 397 (1): 77–87.
Published: 14 June 2006
...), or STS (staurosporine). By contrast, the induction of endogenous NF-κB activity, by the depletion of cellular polyamines, promoted resistance to apoptosis, which was prevented by the ectopic expression of the IκBα super-repressor. Furthermore, inhibition of TRPC1 expression by transfection with siRNA...
Articles
Biochem J (2006) 396 (2): 337–345.
Published: 15 May 2006
... by an energy-dependent mechanism the driving force of which is ΔΨ (electrical membrane potential). Although this process showed strict electrophoretic behaviour, qualitatively similar to that of polyamines, agmatine is most probably transported by a specific uniporter. Shared transport with polyamines by means...
Articles
Biochem J (2006) 394 (1): 317–324.
Published: 27 January 2006
... carcinogenesis, in part, by a mechanism leading to the transcriptional activation of the gene encoding SSAT (spermidine/spermine N 1 -acetyltransferase), a rate-limiting enzyme in polyamine catabolism. In the present study, we show that a variety of NSAIDs, including aspirin, sulindac, ibuprofen and indomethacin...
Articles
Biochem J (2005) 392 (2): 335–344.
Published: 22 November 2005
...Sujoy Bhattacharya; Ramesh M. Ray; Leonard R. Johnson Activation of STAT3 (signal transducer and activator of transcription 3) plays a crucial role in cell survival and proliferation. The aim of the present study was to clarify the role of STAT3 signalling in the protection of polyamine-depleted...
Articles
Biochem J (2005) 388 (2): 427–433.
Published: 24 May 2005
...Yusuke TERUI; Mio OHNUMA; Kaori HIRAGA; Etsuko KAWASHIMA; Tairo OSHIMA Extreme thermophiles produce two types of unusual polyamine: long linear polyamines such as caldopentamine and caldohexamine, and branched polyamines such as quaternary ammonium compounds [e.g. tetrakis(3-aminopropyl)ammonium...
Articles
Biochem J (2005) 386 (3): 543–547.
Published: 08 March 2005
...Yanlin WANG; Amy HACKER; Tracy MURRAY-STEWART; Jennifer G. FLEISCHER; Patrick M. WOSTER; Robert A. CASERO, Jr The oxidation of polyamines induced by antitumour polyamine analogues has been associated with tumour response to specific agents. The human spermine oxidase, SMO(PAOh1), is one enzyme...
Articles
Biochem J (2005) 385 (3): 779–785.
Published: 24 January 2005
...Kazuhiro NISHIMURA; Kaori MUROZUMI; Akira SHIRAHATA; Myung Hee PARK; Keiko KASHIWAGI; Kazuei IGARASHI To examine the roles of active hypusinated eIF5A (eukaryotic translation initiation factor 5A) and polyamines in cell proliferation, mouse mammary carcinoma FM3A cells were treated...
Articles
Biochem J (2005) 385 (1): 21–28.
Published: 14 December 2004
...Ursula MANGOLD; Ekkehard LEBERER ODC (ornithine decarboxylase) is the rate-limiting enzyme in polyamine biosynthesis. Polyamines are essential for cellular growth and differentiation but enhanced ODC activity is associated with cell transformation. Post-translationally, ODC is negatively regulated...
Articles
Biochem J (2004) 384 (1): 139–148.
Published: 09 November 2004
...Catherine S. COLEMAN; Bruce A. STANLEY; A. Daniel JONES; Anthony E. PEGG Spermidine/spermine- N 1 -acetyltransferase (SSAT1) is a short-lived polyamine catabolic enzyme inducible by polyamines and polyamine analogues. Induction of SSAT1 plays an important role in polyamine homoeostasis, since the N...
Articles
Biochem J (2004) 384 (1): 47–58.
Published: 09 November 2004
... polyamine transport, was defective in fluoro-BLM-A5 uptake and exhibited extreme resistance to the drug. A simple interpretation of these results is that BLM-A5 may enter the cell through the polyamine transport system. We showed further that after the uptake, fluoro-BLM-A5 accumulated into the vacuole...
Articles
Biochem J (2004) 381 (3): 701–707.
Published: 27 July 2004
... activity. These results provide strong support for the concept that the levels of the higher polyamines spermidine and spermine are not determined only by the relative activities of the two aminopropyltransferases. Other factors such as availability of the aminopropyl donor substrate decarboxylated S...
Includes: Supplementary data
Articles
Biochem J (2004) 379 (3): 849–855.
Published: 01 May 2004
... in mammals. 1 To whom correspondence should be addressed (e-mail aep1@psu.edu ). 6 1 2004 2 2 2004 6 2 2004 6 2 2004 The Biochemical Society, London ©2004 2004 agmatine arginine arginine decarboxylase ornithine polyamine Abbreviations used: ADC, l...
Articles
Biochem J (2004) 377 (2): 439–448.
Published: 15 January 2004
...Lyn-Marie BIRKHOLTZ; Carsten WRENGER; Fourie JOUBERT; Gordon A. WELLS; Rolf D. WALTER; Abraham I. LOUW Polyamine biosynthesis of the malaria parasite, Plasmodium falciparum , is regulated by a single, hinge-linked bifunctional PfAdoMetDC/ODC [ P. falciparum AdoMetDC (S-adenosylmethionine...
Articles
Biochem J (2004) 377 (1): 257–264.
Published: 01 January 2004
... 2004 ornithine decarboxylase phosphoinositide 3-kinase polyamine Raf/MEK/ERK Ras translational regulation Abbreviations used: CAT, chloramphenicol acetyltransferase; eIF4E, eukaryotic initiation factor 4E; ERK, extracellular-signal-regulated kinase; MAPK, mitogen-activated protein...
Articles
Biochem J (2003) 375 (2): 465–470.
Published: 15 October 2003
...Ning QU; Natalia A. IGNATENKO; Phillip YAMAUCHI; David E. STRINGER; Corey LEVENSON; Patrick SHANNON; Scott PERRIN; Eugene W. GERNER Racemic difluoromethylornithine ( d / l -DFMO) is an inhibitor of ODC (ornithine decarboxylase), the first enzyme in eukaryotic polyamine biosynthesis. d / l -DFMO...
Articles
Biochem J (2003) 374 (2): 481–488.
Published: 01 September 2003
...Alun HUGHES; Nicholas I. SMITH; Heather M. WALLACE Naproxen, sulindac and salicylate, three NSAIDs (non-steroidal anti-inflammatory drugs), were cytotoxic to human colorectal cancer cells in culture. Toxicity was accompanied by significant depletion of intracellular polyamine content. Inhibition...
Articles
Biochem J (2003) 373 (2): 629–634.
Published: 15 July 2003
...Tracy MURRAY-STEWART; Nancy B. APPLEGREN; Wendy DEVEREUX; Amy HACKER; Renee SMITH; Yanlin WANG; Robert A. CASERO, Jr Spermidine/spermine N 1 -acetyltransferase (SSAT) activity is typically highly inducible in non-small-cell lung carcinomas in response to treatment with anti-tumour polyamine...
Articles
Biochem J (2003) 371 (2): 549–556.
Published: 15 April 2003
... with the presence of positively charged groups or apolar chains in the substrates. In particular, it was found that the docking of the physiological polyamines, i.e. spermidine and spermine, appears to be modulated by three amino acid residues of the active site, which we have named L - H + , G - H + and IH...
Articles
Biochem J (2002) 367 (3): 665–675.
Published: 01 November 2002
...Slavoljub VUJCIC; Paula DIEGELMAN; Cyrus J. BACCHI; Debora L. KRAMER; Carl W. PORTER During polyamine catabolism, spermine and spermidine are first acetylated by spermidine/spermine N 1 -acetyltransferase (SSAT) and subsequently oxidized by polyamine oxidase (PAO) to produce spermidine...
Articles
Biochem J (2002) 364 (3): 767–775.
Published: 15 June 2002
... for cationic, neutral or anionic amino acids or for the polyamine putrescine. In addition, human glioblastoma cells stably overexpressing a fusion protein between SLC7A4 and the enhanced green fluorescent protein (EGFP) did not exhibit an increased transport activity for l -arginine. The lack of transport...
Articles
Biochem J (2001) 360 (3): 657–665.
Published: 10 December 2001
...Yong-Sun LEE; Young-Dong CHO The cDNA encoding ornithine decarboxylase (ODC; EC 4.1.1.17), a key enzyme in putrescine and polyamine biosynthesis, has been cloned from Nicotiana glutinosa (GenBank® AF 323910), and was expressed in Escherichia coli . The amino acid sequence of N. glutinosa ODC showed...
Articles
Biochem J (2001) 353 (2): 403–409.
Published: 08 January 2001
...Marina FRANCESCHETTI; Colin HANFREY; Sonia SCARAMAGLI; Patrizia TORRIGIANI; Nello BAGNI; Daniel BURTIN; Anthony J. MICHAEL S -Adenosyl- L -methionine decarboxylase (AdoMetDC; EC 4.1.1.50) is one of the key regulatory enzymes in the biosynthesis of polyamines. Isolation of genomic and cDNA sequences...
Articles
Biochem J (2000) 352 (2): 287–292.
Published: 24 November 2000
...Tanja KRAUSE; Kai LÜERSEN; Carsten WRENGER; Tim-Wolf GILBERGER; Sylke MÜLLER; Rolf D. WALTER The polyamines putrescine, spermidine and spermine play an essential role in cell differentiation and proliferation. Inhibition of the rate-limiting enzymes of polyamine biosynthesis, ornithine...
Articles
Biochem J (2000) 345 (1): 69–75.
Published: 17 December 1999
... development. At weaning time, an increase in the intestinal level of polyamines (and especially that of spermine) was observed, owing partly to the higher level of spermine found in solid food given to rats at this period in comparison with the level found in milk. To study the role of this polyamine...
Articles
Biochem J (1999) 340 (3): 753–758.
Published: 08 June 1999
...Dale P. WOOLRIDGE; Jesse D. MARTINEZ; David E. STRINGER; Eugene W. GERNER Overexpression of the BltD gene in Bacillus subtilis causes acetylation of the polyamines spermidine and spermine. BltD is co-regulated with another gene, Blt , which encodes a multidrug export protein whose overexpression...