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1-11 of 11
Keywords: polymorphism
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Articles
Molecular inscription of environmental information into protein suprastructures: temperature effects on unit assembly of α-synuclein oligomers into polymorphic amyloid fibrils
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2014) 464 (2): 259–269.
Published: 14 November 2014
... between 37°C and 43°C, the oligomeric unit assembly led to fibrillar polymorphism from a straight to a curly appearance, as assessed using TEM and small-angle neutron scattering; the different effects on the secondary structures were evaluated using attenuated total reflectance Fourier-transform infrared...
Articles
The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2
Available to PurchaseTim J. Fitzmaurice, David F. Burke, Lee Hopkins, Sujeong Yang, Shuiliang Yu, Man-Sun Sy, Alana M. Thackray, Raymond Bujdoso
Journal:
Biochemical Journal
Biochem J (2008) 409 (2): 367–375.
Published: 21 December 2007
...Tim J. Fitzmaurice; David F. Burke; Lee Hopkins; Sujeong Yang; Shuiliang Yu; Man-Sun Sy; Alana M. Thackray; Raymond Bujdoso Susceptibility to scrapie disease in sheep, the archetypal prion disease, correlates with polymorphisms within the ovine PrP (prion-related protein) gene. The VRQ (Val 136 Arg...
Articles
Ovine plasma prion protein levels show genotypic variation detected by C-terminal epitopes not exposed in cell-surface PrP C
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Journal:
Biochemical Journal
Biochem J (2006) 400 (2): 349–358.
Published: 14 November 2006
... immunoassay polymorphism cellular prion-related protein (PrP C ) transmissible spongiform encephalopathy (TSE) Prion diseases, such as scrapie in sheep, BSE (bovine spongiform encephalopathy) in cattle and CJD (Creutzfeldt–Jakob disease) in humans, are transmissible chronic neurodegenerative...
Articles
Two new FUT2 (fucosyltransferase 2 gene) missense polymorphisms, 739G→A and 839T→C, are partly responsible for non-secretor status in a Caucasian population from Northern Portugal
Available to PurchaseJacinta SERPA, Nuno MENDES, Celso A. REIS, Luis F. SANTOS SILVA, Raquel ALMEIDA, Jacques LE PENDU, Leonor DAVID
Journal:
Biochemical Journal
Biochem J (2004) 383 (3): 469–474.
Published: 26 October 2004
... of the present study was to examine FUT2 (fucosyltransferase 2 gene) polymorphisms in a Caucasian population of non-secretor individuals ( n =36) from northern Portugal and to evaluate the activity of the mutant FUT2 enzymes. The secretor status was determined by UEAI [ Ulex europaeus (gorse) lectin...
Articles
Conformational variation between allelic variants of cell-surface ovine prion protein
Available to PurchaseAlana M. THACKRAY, Sujeong YANG, Edmond WONG, Tim J. FITZMAURICE, Robert J. MORGAN-WARREN, Raymond BUJDOSO
Journal:
Biochemical Journal
Biochem J (2004) 381 (1): 221–229.
Published: 22 June 2004
... were verified by MS to confirm the correct protein sequence and the presence of a disulphide bond. epitope polymorphism PrP C ruminant secondary structure transmissible spongiform encephalopathy Prion diseases, such as scrapie in sheep, bovine spongiform encephalopathy in cattle...
Articles
Paraoxonase-1 promoter haplotypes and serum paraoxonase: a predominant role for polymorphic position −107, implicating the Sp1 transcription factor
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Journal:
Biochemical Journal
Biochem J (2003) 372 (2): 643–649.
Published: 01 June 2003
... the functions of both. There is a wide spectrum of serum PON1 mass in humans, to which promoter polymorphisms make an important contribution. The present studies attempted to define: (i) the relevance in vivo of promoter polymorphisms by analysing haplotype structure; and (ii) molecular mechanisms implicated...
Articles
Identification and characterization of Gbeta3s2, a novel splice variant of the G-protein beta3 subunit
Available to PurchaseDieter ROSSKOPF, Iris MANTHEY, Christiane HABICH, Marzena KIELBIK, Andreas EISENHARDT, Christiane NIKULA, Melanie URBAN, Stefanie KOHNEN, Eva GRAF, Ursula RAVENS, Winfried SIFFERT
Journal:
Biochemical Journal
Biochem J (2003) 371 (1): 223–232.
Published: 01 April 2003
...Dieter ROSSKOPF; Iris MANTHEY; Christiane HABICH; Marzena KIELBIK; Andreas EISENHARDT; Christiane NIKULA; Melanie URBAN; Stefanie KOHNEN; Eva GRAF; Ursula RAVENS; Winfried SIFFERT The T-allele of a polymorphism (C825T) in the gene for the G-protein β3 subunit ( GNB3 ) is associated...
Articles
Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily
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Journal:
Biochemical Journal
Biochem J (2001) 360 (1): 1–16.
Published: 08 November 2001
... of GSTs are discussed. Key words: detoxification, GST, polymorphism, protein, xeno- biotic. has proved robust enough to be extended to non-mammalian enzymes; conversely, new classes described originally in non- mammalian sources have later been found also in mammals. This review focuses...
Includes: Supplementary data
Articles
Sj-FABPc fatty-acid-binding protein of the human blood fluke Schistosoma japonicum: structural and functional characterization and unusual solvent exposure of a portal-proximal tryptophan residue
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Journal:
Biochemical Journal
Biochem J (2000) 349 (1): 377–384.
Published: 26 June 2000
... variants encoded by a single-copy polymorphic gene. In fluorescence-based assays, recombinant Sj-FABPc was found to bind 11-(dansylamino)undecanoic acid (DAUDA), inducing a shift in peak fluorescence emission from 543 to 493 nm. A similar spectral change was observed in dansyl-amino-octanoic acid (in which...
Articles
Mitochondrial aspartate aminotransferase: direction of a single protein with two distinct functions to two subcellular sites does not require alternative splicing of the mRNA
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Journal:
Biochemical Journal
Biochem J (2000) 345 (3): 423–427.
Published: 25 January 2000
... of such pseudogenes can complicate interpretation of expressed-sequence-tag data and single-nucleotide-polymorphism genotyping studies. Using probes derived from the a allele, RNase protection analyses indicated that only a single message for the enzyme was present in 3T3-L1 fibroblasts and adipocytes, despite...
Articles
Gene structure of mouse BIT/SHPS-1
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Journal:
Biochemical Journal
Biochem J (1999) 344 (3): 667–675.
Published: 08 December 1999
... polymorphism SHP-2 Biochem. J. (1999) 344, 667 675 (Printed in Great Britain) 667 Gene structure of mouse BIT/SHPS-1 Shin-ichiro SANO1, Hiroshi OHNISHI and Misae KUBOTA Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194-8511, Japan BIT}SHPS-1}SIRPa}P84 is a unique molecule...
