... interesting drug targets, which highlights the need of understanding their structural flexibility. Detailed studies of polyprotein processing and complex formation require a method that follows these dynamic processes at a molecular level. Native mass spectrometry (MS) probes and detects protein complexes...

... to the inhibition of polyprotein processing in maturing virus particles comparable to that demonstrated for HIV-1 particles. Thus oxidative inactivation of the HIV protease in vitro and in maturing viral particles is not restricted to the type 1 proteases. These studies indicate that two distinct retroviral...