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Keywords: post-translational modification
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Articles
Journal:
Biochemical Journal
Biochem J (2025) 482 (12): 877–899.
Published: 17 June 2025
...Mohammed M. Alhadidy; Rebecca L. Mueller; Jared Lamp; Nicholas M. Kanaan Tau is subject to a broad range of post-translational modifications (PTMs) that regulate its biological activity in health and disease, including microtubule (MT) dynamics, aggregation, and adoption of pathogenic conformations...
Includes: Supplementary data
Articles
In Collection
Cell signaling in the 21st century
Journal:
Biochemical Journal
Biochem J (2023) 480 (16): 1241–1265.
Published: 23 August 2023
...Naoya Kitamura; James J. Galligan Post-translational modifications (PTMs) provide a rapid response to stimuli, finely tuning metabolism and gene expression and maintain homeostasis. Advances in mass spectrometry over the past two decades have significantly expanded the list of known PTMs in biology...
Articles
Protein targeting by the itaconate family in immunity and inflammation
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Journal:
Biochemical Journal
Biochem J (2022) 479 (24): 2499–2510.
Published: 22 December 2022
... in protein structure and function, and can be modified post-translationally, yet compared with other post-translational modifications (PTMs), such as phosphorylation, they are relatively poorly characterized. Cysteine can exist in distinct oxidation states depending on the pH and redox potential of the cell...
Articles
Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly
Available to PurchaseYashwanth Ashok, Carlos Vela-Rodríguez, Chunsong Yang, Heli I. Alanen, Fan Liu, Bryce M. Paschal, Lari Lehtiö
Journal:
Biochemical Journal
Biochem J (2022) 479 (3): 289–304.
Published: 04 February 2022
...Yashwanth Ashok; Carlos Vela-Rodríguez; Chunsong Yang; Heli I. Alanen; Fan Liu; Bryce M. Paschal; Lari Lehtiö Ubiquitination and ADP-ribosylation are post-translational modifications that play major roles in pathways including the DNA damage response and viral infection. The enzymes responsible...
Includes: Supplementary data
Articles
Combinations of histone post-translational modifications
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Journal:
Biochemical Journal
Biochem J (2021) 478 (3): 511–532.
Published: 10 February 2021
...Bethany C. Taylor; Nicolas L. Young Histones are essential proteins that package the eukaryotic genome into its physiological state of nucleosomes, chromatin, and chromosomes. Post-translational modifications (PTMs) of histones are crucial to both the dynamic and persistent regulation of the genome...
Articles
Herpes simplex virus 1 infection induces ubiquitination of UBE1a
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Journal:
Biochemical Journal
Biochem J (2021) 478 (1): 261–279.
Published: 15 January 2021
... of the Biochemical Society 2021 herpesvirus post-translational modification UBE1 ubiquitin proteasome system ubiquitins virus replication Herpes simplex virus 1 (HSV-1) is a human DNA virus and a member of the neurotrophic Alphaherpesvirinae subfamily. HSV-1 causes a variety of diseases...
Articles
Effect of NH 2 -terminal acetylation on the oxygenation properties of vertebrate haemoglobin
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Journal:
Biochemical Journal
Biochem J (2020) 477 (19): 3839–3850.
Published: 12 October 2020
... consequences of post-translational modifications such as NH 2 -terminal acetylation are less well characterized. Many vertebrate taxa express Hb isoforms with NH 2 -terminal acetylation [ 10–13 ], suggesting that such post-translational modifications could contribute to the wide variation in structural...
Includes: Supplementary data
Articles
An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity
Available to PurchaseLucas A. Luna, Zachary Lesecq, Katharine A. White, An Hoang, David A. Scott, Olga Zagnitko, Andrey A. Bobkov, Diane L. Barber, Jamie M. Schiffer, Daniel G. Isom, Christal D. Sohl
Journal:
Biochemical Journal
Biochem J (2020) 477 (16): 2999–3018.
Published: 21 August 2020
... 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 buried ionizable residues cancer enzyme kinetics pH regulation post-translational modification tumor metabolism Isocitrate dehydrogenase 1 (IDH1) is a highly conserved...
Includes: Supplementary data
Articles
A novel polyubiquitin chain linkage formed by viral Ubiquitin is resistant to host deubiquitinating enzymes
Available to PurchaseHitendra Negi, Pothula Purushotham Reddy, Vineeth Vengayil, Chhaya Patole, Sunil Laxman, Ranabir Das
Journal:
Biochemical Journal
Biochem J (2020) 477 (12): 2193–2219.
Published: 22 June 2020
...–pathogen interactions NMR spectroscopy post-translational modification Ubiquitins Ubiquitin (Ub), a 76 residue protein, regulates multiple cellular pathways and is a major way of controlling protein levels in the cell [ 1–3 ]. Ub or Ub polymers are covalently attached to the target protein...
Includes: Supplementary data
Articles
Mechanism of protein cleavage at asparagine leading to protein–protein cross-links
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Journal:
Biochemical Journal
Biochem J (2019) 476 (24): 3817–3834.
Published: 23 December 2019
... are formed intentionally using specific enzymes to enhance the mechanical properties of the proteins and organs in which they reside. age long-lived proteins post-translational modification protein–protein cross-linking spontaneous decomposition In other tissues the mechanisms of age...
Includes: Supplementary data
Articles
The N-terminal domain of unknown function (DUF959) in collagen XVIII is intrinsically disordered and highly O-glycosylated
Available to PurchaseInderjeet Kaur, Salla Ruskamo, Jarkko Koivunen, Ritva Heljasvaara, Jarkko J. Lackman, Valerio Izzi, Ulla E. Petäjä-Repo, Petri Kursula, Taina Pihlajaniemi
Journal:
Biochemical Journal
Biochem J (2018) 475 (22): 3577–3593.
Published: 20 November 2018
...-like domain in ColXVIII (MUCL-C18). As intrinsically disordered regions and their post-translational modifications are often involved in protein interactions, our findings may point towards a role of the flexible mucin-like domain of ColXVIII as an interaction hub affecting cell signaling. Moreover...
Articles
In Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Yugo Tsuchiya, Alexander Zhyvoloup, Jovana Baković, Naam Thomas, Bess Yi Kun Yu, Sayoni Das, Christine Orengo, Clare Newell, John Ward, Giorgio Saladino, Federico Comitani, Francesco L. Gervasio, Oksana M. Malanchuk, Antonina I. Khoruzhenko, Valeriy Filonenko, Sew Yeu Peak-Chew, Mark Skehel, Ivan Gout
Journal:
Biochemical Journal
Biochem J (2018) 475 (11): 1909–1937.
Published: 06 June 2018
... post-translational modification redox signaling Recombinant SaGAPDH activity was determined by measuring the absorbance change at 340 nm and 25°C resulting from the production of NADH. The reaction was carried out in a 150 µl assay mixture containing 20 mM Tris–HCl (pH 8.7), 0.36 µM SaGAPDH...
Articles
Who does TORC2 talk to?
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Journal:
Biochemical Journal
Biochem J (2018) 475 (10): 1721–1738.
Published: 24 May 2018
... ( [email protected] ) 11 2 2018 19 4 2018 23 4 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 mechanistic target of rapamycin post-translational modification translation Signalling through multiprotein...
Articles
Zhenbo Cao, Lorna Mitchell, Oliver Hsia, Miriam Scarpa, Stuart T. Caldwell, Arina D. Alfred, Alexandra Gennaris, Jean-François Collet, Richard C. Hartley, Neil J. Bulleid
Journal:
Biochemical Journal
Biochem J (2018) 475 (4): 827–838.
Published: 28 February 2018
... post-translational modification oxidation–reduction Both cysteine and methionine residues in proteins are susceptible to oxidation by reactive oxygen species [ 1 ]. This oxidation can lead to an alteration of protein function or to a signalling event resulting in a change in gene expression...
Articles
The chromatin remodeling Isw1a complex is regulated by SUMOylation
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Journal:
Biochemical Journal
Biochem J (2017) 474 (20): 3455–3469.
Published: 05 October 2017
.... Correspondence: Catherine Dargemont ( [email protected] ) 3 3 2017 29 8 2017 8 9 2017 12 9 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 chromatin Isw1 post-translational modification SUMOylation...
Articles
Protein CoAlation: a redox-linked post-translational modification
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Journal:
Biochemical Journal
Biochem J (2017) 474 (16): 2897–2899.
Published: 10 August 2017
.... Furthermore, CoAlation was shown to alter the activity of target proteins. These results suggest that CoAlation is a widespread post-translational modification that may have important roles in the metabolic response to stress. © 2017 The Author(s). Published by Portland Press Limited on behalf...
Articles
Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells
Open AccessIn Collection
Awards
Yugo Tsuchiya, Sew Yeu Peak-Chew, Clare Newell, Sheritta Miller-Aidoo, Sriyash Mangal, Alexander Zhyvoloup, Jovana Bakovic´, Oksana Malanchuk, Gonçalo C. Pereira, Vassilios Kotiadis, Gyorgy Szabadkai, Michael R. Duchen, Mark Campbell, Sergio Rodriguez Cuenca, Antonio Vidal-Puig, Andrew M. James, Michael P. Murphy, Valeriy Filonenko, Mark Skehel, Ivan Gout
Journal:
Biochemical Journal
Biochem J (2017) 474 (14): 2489–2508.
Published: 11 July 2017
... (CoAlation). We show that protein CoAlation is a reversible post-translational modification that is induced in mammalian cells and tissues by oxidising agents and metabolic stress. Many key cellular enzymes were found to be CoAlated in vitro and in vivo in ways that modified their activities. Our study...
Includes: Supplementary data
Articles
Active-site maturation and activity of the copper-radical oxidase GlxA are governed by a tryptophan residue
Available to PurchaseAmanda K. Chaplin, Dimitri A. Svistunenko, Michael A. Hough, Michael T. Wilson, Erik Vijgenboom, Jonathan A.R. Worrall
Journal:
Biochemical Journal
Biochem J (2017) 474 (5): 809–825.
Published: 20 February 2017
... 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 EPR spectroscopy free radicals post-translational modification radical-copper oxidase GlxA from the Gram-positive soil-dwelling bacteria Streptomyces is a structurally distinct member...
Includes: Supplementary data
Articles
The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation
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Journal:
Biochemical Journal
Biochem J (2017) 474 (4): 445–469.
Published: 03 February 2017
... be modified with ubiquitin, and post-translational modifications that affect substrate ubiquitination have been observed. Here, we summarize these data and provide an overview of questions driving this field of research. 31 10 2016 12 12 2016 14 12 2016 © 2017 The Author(s); published...
Articles
Mechanisms of Hsp90 regulation
Open Access
Journal:
Biochemical Journal
Biochem J (2016) 473 (16): 2439–2452.
Published: 11 August 2016
..., like Hsp90, are also subject to regulatory mechanisms such as post translational modification. This review, looks at the many different levels by which Hsp90 activity is ultimately regulated. chaperones co-chaperones heat-shock response HSF1 Hsp90 post-translational modification...
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (10): 1297–1314.
Published: 11 May 2016
... chemical biology chemoenzymatic isopeptide ligation post-translational modification semisynthesis ubiquitin ubiquitination ubiquitylation Modification of substrate proteins with ubiquitin (Ub) and polyubiquitin (polyUb) chains of diverse topology is now firmly established as a crucial...
Articles
TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors
Available to PurchaseChristian Bindesbøll, Susanna Tan, Debbie Bott, Tiffany Cho, Laura Tamblyn, Laura MacPherson, Line Grønning-Wang, Hilde Irene Nebb, Jason Matthews
Journal:
Biochemical Journal
Biochem J (2016) 473 (7): 899–910.
Published: 29 March 2016
... regulation liver X receptor nuclear receptor post-translational modification 2 3 7 8-tetrachlorodibenzo- p -dioxin (TCDD)-inducible poly-ADP-ribose polymerase HepG2 and HuH7 human hepatoma cells as well as COS-1 African green monkey kidney cells were cultured in low glucose (1 g/l) DMEM...
Includes: Supplementary data
Articles
Regulation of the p53 response and its relationship to cancer
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Journal:
Biochemical Journal
Biochem J (2015) 469 (3): 325–346.
Published: 23 July 2015
... function of p53 and is essential for transactivation, the repression of some genes and tumour suppression. The C-terminal region contains sequences required for nuclear localization, non-specific DNA binding and regulation. The regulatory region undergoes a variety of PTMs (post-translational modifications...
Articles
Akt/PKB: one kinase, many modifications
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Journal:
Biochemical Journal
Biochem J (2015) 468 (2): 203–214.
Published: 22 May 2015
... phosphorylation of two residues, Thr 308 and Ser 473 , and modification of these two sites has been established as being equivalent to Akt activation. More recently, Akt has been identified as a substrate for many different post-translational modifications, including not only phosphorylation of other residues...
Articles
DUBs, the regulation of cell identity and disease
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2015) 465 (1): 1–26.
Published: 12 December 2014
...Johanna Heideker; Ingrid E. Wertz The post-translational modification of proteins with ubiquitin represents a complex signalling system that co-ordinates essential cellular functions, including proteolysis, DNA repair, receptor signalling and cell communication. DUBs (deubiquitinases), the enzymes...
Articles
Recombinant form of mammalian gp91 phox is active in the absence of p22 phox
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2014) 462 (2): 337–345.
Published: 07 August 2014
... complex. In contrast with what was known from studies in mammalian phagocytes, in Pichia pastoris we succeeded in producing an active catalytic subunit gp91 phox in absence of its membrane partner. heterologous expression NADPH oxidase Pichia pastoris post-translational modification...
Articles
Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity
Available to PurchaseKristen E. Funk, Stefani N. Thomas, Kelsey N. Schafer, Grace L. Cooper, Zhongping Liao, David J. Clark, Austin J. Yang, Jeff Kuret
Journal:
Biochemical Journal
Biochem J (2014) 462 (1): 77–88.
Published: 24 July 2014
... reductive methylation, its ability to promote tubulin polymerization was retained, whereas its aggregation propensity was greatly attenuated at both nucleation and extension steps. These data establish lysine methylation as part of the normal tau post-translational modification signature in human brain...
Articles
The glycation site specificity of human serum transferrin is a determinant for transferrin's functional impairment under elevated glycaemic conditions
Available to PurchaseAndré M. N. Silva, Paulo R. H. Sousa, João T. S. Coimbra, Natércia F. Brás, Rui Vitorino, Pedro A. Fernandes, Maria J. Ramos, Maria Rangel, Pedro Domingues
Journal:
Biochemical Journal
Biochem J (2014) 461 (1): 33–42.
Published: 13 June 2014
... results for the modified peptides may be found in Supplementary Table S2 (at http://www.biochemj.org/bj/461/bj4610033add.htm ). diabetes glycation mass spectrometry (MS) post-translational modification transferrin Diabetes mellitus is a multifactorial disease characterized...
Articles
S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment
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Journal:
Biochemical Journal
Biochem J (2014) 459 (2): 417–425.
Published: 28 March 2014
... and participates during rescue of a common disease-associated mutation. Therapeutic strategies to overcome clinically important defects in cystic fibrosis should consider the role of palmitoylation as a molecular target. cystic fibrosis palmitoylation post-translational modification protein trafficking...
Includes: Supplementary data
Articles
Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn 23 Iowa mutation
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Journal:
Biochemical Journal
Biochem J (2013) 456 (3): 347–360.
Published: 22 November 2013
... exhibiting partial aspartate isomerization at positions 1, 7 and 23. The present study analysed the contribution of the post-translational modification and the D23N mutation to the aggregation/fibrillization and cell toxicity properties of Aβ providing insight into the elicited cell death mechanisms...
Articles
Chemical tools to probe cellular O -GlcNAc signalling
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Journal:
Biochemical Journal
Biochem J (2013) 456 (1): 1–12.
Published: 24 October 2013
...Adam Ostrowski; Daan M. F. van Aalten Protein O -GlcNAcylation is an abundant, dynamic and reversible type of protein post-translational modification in animals that has been implicated in signalling processes linked to innate immunity, stress response, growth factor response, transcription...
Articles
Embryonic poly(A)-binding protein (ePAB) phosphorylation is required for Xenopus oocyte maturation
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Journal:
Biochemical Journal
Biochem J (2012) 445 (1): 93–100.
Published: 15 June 2012
... maturation. We further demonstrate that these phosphorylations are critical for cytoplasmic polyadenylation, but not for ePAB's inherent ability to promote translation. Our results provide the first insight into the role of post-translational modifications in regulating PABP protein activity in vivo...
Includes: Supplementary data
Articles
The proteomic future: where mass spectrometry should be taking us
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Journal:
Biochemical Journal
Biochem J (2012) 444 (2): 169–181.
Published: 11 May 2012
... to achievements previously only dreamed of, including whole-proteome identification, and quantification and extensive mapping of specific PTMs (post-translational modifications). With such capabilities at present, one might conclude that proteomics has already reached its zenith; however, ‘capability’ indicates...
Articles
Matthew Brook, Lora McCracken, James P. Reddington, Zhi-Liang Lu, Nicholas A. Morrice, Nicola K. Gray
Journal:
Biochemical Journal
Biochem J (2012) 441 (3): 803–816.
Published: 16 January 2012
..., as well as RNA, interactions underlie its multi-functional nature; however, it is unclear how its different activities are co-ordinated, since many partners interact via overlapping binding sites. In the present study, we show that human PABP1 is subject to elaborate post-translational modification...
Includes: Supplementary data
Articles
RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation
Available to PurchaseJung Ha Kim, Kabsun Kim, Bang Ung Youn, Hye Mi Jin, Ji-Young Kim, Jang Bae Moon, Aeran Ko, Sang-Beom Seo, Kwang-Youl Lee, Nacksung Kim
Journal:
Biochemical Journal
Biochem J (2011) 436 (2): 253–262.
Published: 13 May 2011
... increases NFATc1 protein levels by post-translational modification. RANKL stimulates NFATc1 acetylation via HATs (histone acetyltransferases), such as p300 and PCAF [p300/CREB (cAMP-response-element-binding protein)-binding protein-associated factor], thereby stabilizing NFATc1 proteins. PCAF physically...
Includes: Supplementary data
Articles
Cytosolic lysine residues enhance anterograde transport and activation of the erythropoietin receptor
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Journal:
Biochemical Journal
Biochem J (2011) 435 (2): 509–518.
Published: 29 March 2011
...Liron Yosha; Orly Ravid; Nathalie Ben-Califa; Drorit Neumann Lysine residues are key residues in many cellular processes, in part due to their ability to accept a wide variety of post-translational modifications. In the present study, we identify the EPO-R [EPO (erythropoietin) receptor] cytosolic...
Articles
Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1)
Available to PurchaseSeung Bum Lee, Jong Hwan Park, John E. Folk, Jason A. Deck, Anthony E. Pegg, Masaaki Sokabe, Christopher S. Fraser, Myung Hee Park
Journal:
Biochemical Journal
Biochem J (2011) 433 (1): 205–213.
Published: 15 December 2010
... metabolism post-translational modification spermidine/spermine-N 1 -acetyltransferase 1 (SSAT1) SSAT1 (spermidine/spermine-N 1 -acetyltransferase 1) is the key enzyme in the metabolism of polyamines and catalyses acetylation of spermidine or spermine at the N 1 of the aminopropyl moiety (reviewed...
Articles
Three factors that modulate the activity of class D β-lactamases and interfere with the post-translational carboxylation of Lys 70
Available to PurchaseLionel Vercheval, Cédric Bauvois, Alexandre di Paolo, Franck Borel, Jean-Luc Ferrer, Eric Sauvage, André Matagne, Jean-Marie Frère, Paulette Charlier, Moreno Galleni, Frédéric Kerff
Journal:
Biochemical Journal
Biochem J (2010) 432 (3): 495–506.
Published: 25 November 2010
... and affinity studies show that this post-translational modification can be affected by the presence of a poor substrate such as moxalactam but also by the V117T substitution. Val 117 is a strictly conserved hydrophobic residue located in the active site. In addition, inhibition of class D β-lactamases...
Includes: Supplementary data
Articles
The arginylation-dependent association of calreticulin with stress granules is regulated by calcium
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Journal:
Biochemical Journal
Biochem J (2010) 429 (1): 63–72.
Published: 14 June 2010
...Marcos A. Carpio; Cecilia López Sambrooks; Edith S. Durand; Marta E. Hallak Post-translational modifications of proteins are important for the regulation of cell functions; one of these modifications is post-translational arginylation. In the present study, we show that cytoplasmic CRT...
Articles
Regulation of LIM-domain-binding 1 protein expression by ubiquitination of Lys 134
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Journal:
Biochemical Journal
Biochem J (2010) 429 (1): 127–136.
Published: 14 June 2010
... compilation © 2010 Biochemical Society 2010 LIM-domain-binding 1 (LDB1) post-translational modification proteasome protein degradation RING finger protein 12 (RNF12) ubiquitin ligase LDB1 (LIM-domain-binding 1) is a highly conserved transcription cofactor that was initially identified...
Articles
SUMO modification regulates the transcriptional activity of XBP1
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Journal:
Biochemical Journal
Biochem J (2010) 429 (1): 95–102.
Published: 14 June 2010
... compilation © 2010 Biochemical Society 2010 post-translational modification protein inhibitor of activated signal transducer and activator of transcription (PIAS) small ubiquitin-related modifier (SUMO) transcriptional regulation unfolded protein response (UPR) X-box-binding protein 1 (XBP1...
Includes: Supplementary data
Articles
Mechanisms, regulation and consequences of protein SUMOylation
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Journal:
Biochemical Journal
Biochem J (2010) 428 (2): 133–145.
Published: 13 May 2010
...Kevin A. Wilkinson; Jeremy M. Henley The post-translational modification SUMOylation is a major regulator of protein function that plays an important role in a wide range of cellular processes. SUMOylation involves the covalent attachment of a member of the SUMO (small ubiquitin-like modifier...
Articles
Post-translational modifications of connexin26 revealed by mass spectrometry
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Journal:
Biochemical Journal
Biochem J (2009) 424 (3): 385–398.
Published: 10 December 2009
...) was used to identify PTMs (post-translational modifications) of Cx26 and to determine whether they occur at sites of disease-causing mutations. Cx26 was isolated from transfected HeLa cells by sequential immunoaffinity and metal chelate chromatography using a tandem C-terminal haemagglutinin epitope...
Articles
Acetylated tubulin associates with the fifth cytoplasmic domain of Na + /K + -ATPase: possible anchorage site of microtubules to the plasma membrane
Available to PurchaseGuillermo G. Zampar, María E. Chesta, Agustín Carbajal, Natalí L. Chanaday, Nicolás M. Díaz, César H. Casale, Carlos A. Arce
Journal:
Biochemical Journal
Biochem J (2009) 422 (1): 129–137.
Published: 29 July 2009
... tubulin-binding domain acetylation cytoskeleton P-type ATPase (P-ATPase) post-translational modification sodium pump NKA (Na + /K + -ATPase, also known as ‘the sodium pump’) is a transmembrane membrane protein that transports three Na + ions out of the cell in exchange for two K + ions...
Articles
Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins
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Journal:
Biochemical Journal
Biochem J (2009) 422 (1): 1–10.
Published: 29 July 2009
... activation of TLRs [ 9 – 12 ]. innate immune system phosphorylation post-translational modification signalling Toll-like receptor (TLR) ubiquitination The first structure of TLR3 was described independently by two groups [ 18 , 19 ]. Both groups showed that the LRR region of TLR3...
Articles
Nitration of cathepsin D enhances its proteolytic activity during mammary gland remodelling after lactation
Available to PurchaseRosa Zaragozá, Luis Torres, Concha García, Pilar Eroles, Fernando Corrales, Ana Bosch, Ana Lluch, Elena R. García-Trevijano, Juan R. Viña
Journal:
Biochemical Journal
Biochem J (2009) 419 (2): 279–288.
Published: 27 March 2009
... after weaning, and for the first time we describe this post-translational modification on this enzyme. Cathepsin D is a major aspartic proteinase of endosomes and lysosomes and is a member of the pepsin family of proteinases [ 17 ]. It is involved in the turnover of cellular proteins as well...
Articles
Connexin43 phosphorylation: structural changes and biological effects
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Journal:
Biochemical Journal
Biochem J (2009) 419 (2): 261–272.
Published: 27 March 2009
... ]. cell signalling connexin gap junction kinase phosphorylation post-translational modification It is evident that these apparent 2–4 kDa or more shifts in connexin migration in SDS/PAGE are not simply due to the addition of the mass of phosphate (80 Da). Instead, there are specific...
Includes: Multimedia, Supplementary data
Articles
Variant c -type cytochromes as probes of the substrate specificity of the E. coli cytochrome c maturation (Ccm) apparatus
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Journal:
Biochemical Journal
Biochem J (2009) 419 (1): 177–186.
Published: 13 March 2009
... (Cys–Xaa–Xaa–Cys–His) motif. In cells, the haem attachment is an enzyme-catalysed post-translational modification. We have previously shown that co-expression of a variant of Escherichia coli cytochrome b 562 containing a CXXCH haem-binding motif with the E. coli Ccm (cytochrome c maturation) proteins...
Includes: Supplementary data
Articles
Yeast chitin synthase 2 activity is modulated by proteolysis and phosphorylation
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Journal:
Biochemical Journal
Biochem J (2009) 417 (2): 547–554.
Published: 23 December 2008
... chitin synthase overexpression regulation phosphorylation post-translational modification proteolytic activation Chitin, a β-1,4-linked polymer of N -acetylglucosamine, is a polysaccharide that has an important structural role in many organisms, such as arthropods, molluscs, cephalopods...
Articles
Carlos García-Estrada, Ricardo V. Ullán, Tania Velasco-Conde, Ramiro P. Godio, Fernando Teijeira, Inmaculada Vaca, Raúl Feltrer, Katarina Kosalková, Elba Mauriz, Juan F. Martín
Journal:
Biochemical Journal
Biochem J (2008) 415 (2): 317–324.
Published: 25 September 2008
... pigment [ 15 ]. Multidomain enzymes, such as PKSs (polyketide synthases) and NRPSs, are in charge of the biosynthesis of secondary metabolites [ 16 – 19 ]. A common feature of these enzymes is that they require a post-translational modification to become active. The apoprotein form (inactive) becomes...
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