...Susann Hüttl; Felix Helfrich; Torben Mentrup; Sebastian Held; Akio Fukumori; Harald Steiner; Paul Saftig; Regina Fluhrer; Bernd Schröder The presenilin homologue signal peptide peptidase-like 2a (SPPL2a) is an intramembrane protease of lysosomes/late endosomes which cleaves type II transmembrane...

... [email protected] . 10 6 2009 3 9 2009 4 9 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 cell signalling parasite invasion pathogenesis presenilin rhomboid protease signal peptide peptidase site-2 protease The remarkable synthetic ability...

... plasticity. By utilizing a sequence comparison analysis, we recently identified HLA-A2 as a potential substrate for the Alzheimer's disease-associated PS1 (presenilin 1)/γ-secretase. α-Secretase-like membrane metalloproteinases are responsible for an initial shedding event, partially mediated by ADAM...

... of ubiquilin, but not its UBL or the UBA domains. Furthermore, we provide evidence suggesting that monomeric ubiquilin is likely to be the active form that is involved in binding presenilin proteins. Our results provide new insight into the regulatory mechanism underlying the interaction of ubiquilin...

...Leann K. Massey; Alex L. Mah; Mervyn J. Monteiro Mutations in presenilin proteins (PS1 and PS2) lead to early-onset Alzheimer's disease. PS proteins are endoproteolytically cleaved into two main fragments: the NTF (PS N-terminal fragment) and the CTF (PS C-terminal fragment). The two fragments...

... inhibitor. When CD43 was transfected into HEK-293 cells expressing dominant-negative PS1 (presenilin-1), the CD43-CTF was accumulated, but not in cells with wild-type PS1. Owing to its accumulation in the presence of a non-functional PS variant, it may thus be a novel γ-secretase substrate. This CTF...

...Kei SUGA; Takami TOMIYAMA; Hiroshi MORI; Kimio AKAGAWA Mutations in presenilins 1 and 2 (PS1 and PS2) account for the majority of cases of early-onset familial Alzheimer's disease. However, the trafficking and interaction of PSs with other proteins in the early secretory pathways are poorly...