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Keywords: processing enzymes
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Culture in 10% O 2 enhances the production of active hormones in neuro-endocrine cells by up-regulating the expression of processing enzymes

Eri Sato, Yoshinori Maeda, Yui Sato, Airi Hinata, Hiroshi Gomi, Daisuke Koga, Seiji Torii, Tsuyoshi Watanabe, Masahiro Hosaka
Journal: Biochemical Journal
Biochem J (2019) 476 (5): 827–842.
https://doi.org/10.1042/BCJ20180832
Published: 12 March 2019
...-processing enzymes PC1/3 and carboxypeptidase E were up-regulated in cells cultured in 10% O 2 , thus facilitating the conversion of prohormones to their active form. Similarly, culturing the mouse β-cell line MIN6 and islet tissue in 10% O 2 also significantly increased the conversion of proinsulin...
View article titled, Culture in 10% O 2 enhances the production of active hormones in neuro-endocrine cells by up-regulating the expression of <span class="search-highlight">processing</span> <span class="search-highlight">enzymes</span>
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Includes: Supplementary data