... the release of NF-κB-regulated cytokines and prostaglandins. In conclusion, DHA and procyanidins are strong and selective inhibitors of cyclo-oxygenase activity and NF-κB activation through a p105/p50-dependent regulatory mechanism. The effect of the DHA/procyanidin pre-treatments on PGE 2 in LPS...

..., ulcer and sebaceous gland hyperplasia. The dermatitis was accompanied by infiltration of neutrophils and macrophages and by elevated levels of pro-inflammatory cytokines, chemokines and prostaglandin E 2 . In addition, Pla2g3 -Tg mice had increased lymph aggregates and mucus in the airway, lymphocytic...

... inhibition of the apoptotic response to serum deprivation, an effect mimicked by treating empty-vector-transfected control cells (CHL-V cells) with prostaglandin E 2 and prevented in COX-2-expressing cells (CHL-C cells) treated with selective inhibitors of COX-2. Serum-deprived CHL-V cells displayed several...

...Pierre-Olivier Hétu; Denis Riendeau Cyclo-oxygenases (COXs) catalyse the synthesis of PGH 2 (prostaglandin H 2 ), which serves as the common substrate for the production of PGE 2 , PGD 2 , PGF 2α , prostacyclin (or PGI 2 ) and TXs (thromboxanes). While COX-1 is the major isoform responsible...

...Claus SCHNEIDER; William E. BOEGLIN; Alan R. BRASH The two COX (cyclo-oxygenase) isoenzymes COX-1 and -2 catalyse the initial step in the conversion of arachidonic acid into PG (prostaglandin) hormones. The identification of an mRNA transcript encoding a splice variant of human COX-1 was reported...

...Hui DENG; Aimin HUANG; Shui-Ping SO; Yue-Zhen LIN; Ke-He RUAN Results from our molecular-modelling and site-directed-mutagenesis studies of prostaglandin I 2 synthase (PGIS) have suggested that the large PGIS cytoplasmic domain is anchored to the endoplasmic reticulum (ER) membrane by the N...

... PGH 2 synthase prostaglandin valdecoxib Abbreviations used: COX, cyclo-oxygenase; NSAIDs, non-steroidal anti-inflammatory drugs; PGs, prostaglandins. Biochem. J. (2001) 357, 709 718 (Printed in Great Britain) 709 A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase...

... and an antagonist of IL-1β/prostaglandin E 2 , is not well characterized in the alveolar epithelium. In a model of foetal alveolar type II epithelial cells in vitro , we showed that lipopolysaccharide endotoxin (LPS) differentially, but selectively, induced the nuclear subunit composition of nuclear factor κB 1 (NF...

... correlated with those measured via classical methodology. Using PACE we have now characterized for the first time the concentration-dependent effects of various inflammatory prostaglandins on CREB phosphorylation in macrophages. PACE is a straightforward and novel technique enabling the large-scale analysis...

...Junko AOKI; Hironori KATOH; Hidekazu YASUI; Yoshiaki YAMAGUCHI; Kazuhiro NAKAMURA; Hiroshi HASEGAWA; Atsushi ICHIKAWA; Manabu NEGISHI We reported previously that activation of the prostaglandin E receptor EP3 subtype triggered neurite retraction through the small GTPase Rho-, and its target, RhoA...