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Keywords: prostate cancer
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Biochem J (2023) 480 (20): 1599–1614.
Published: 13 October 2023
...Emma C. Parsons; Ralf Hoffmann; George S. Baillie Prostate cancer is one of the most common cancers in men and one of the top causes of death in men worldwide. Development and function of both normal prostate cells and early-stage prostate cancer cells are dependent on the cross-talk between...
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Biochem J (2022) 479 (14): 1519–1531.
Published: 21 July 2022
...Claire Soave; Charles Ducker; Seongho Kim; Thomas Strahl; Rayna Rosati; Yanfang Huang; Peter E. Shaw; Manohar Ratnam Prostate cancer (PCa) growth requires tethering of the androgen receptor (AR) to chromatin by the ETS domain transcription factor ELK1 to coactivate critical cell proliferation genes...
Includes: Supplementary data
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Biochem J (2021) 478 (21): 3905–3921.
Published: 09 November 2021
...Nicole M. Naranjo; Israa Salem; Maisha A. Harris; Lucia R. Languino We have previously shown that the αvβ6 integrin plays a key role in promoting prostate cancer (PrCa) and it can be transferred to recipient cells via small extracellular vesicles (sEVs). Furthermore, we have reported in a proteomic...
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Biochem J (2021) 478 (15): 2999–3014.
Published: 10 August 2021
...–14 ]. By design, the assays were performed in AR-negative HEK293T cells to avoid the confounding effects of AR and PARP7 gene induction in PCa cell lines. ADP-ribosylation androgen receptor mono-ADP-ribosyltransferase PARP7 prostate cancer TIPARP More than 1.2 million men...
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Biochem J (2016) 473 (15): 2331–2343.
Published: 28 July 2016
.../molecules that control WDR77 gene expression are unknown. Promoter mapping, gel shift assay and ChIP revealed that the WDR77 promoter contains bona fide response elements for E2F and GATA transcriptional factors as demonstrated in prostate cancer, lung cancer and erythroid cells, as well as in mouse lung...
Includes: Supplementary data
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Biochem J (2016) 473 (4): 449–461.
Published: 09 February 2016
...), prostate cancer cells (PC-3, DU-145, 22Rv1 and LNCaP) and human normal or tumour tissue was assessed by bisulfite sequencing analysis, and then confirmed by COBRA (combined bisulfite restriction analysis) and qAMP (quantitative analysis of DNA methylation using real-time PCR). These results demonstrated...
Includes: Supplementary data
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Biochem J (2012) 442 (3): 483–494.
Published: 24 February 2012
... is a type II transmembrane serine protease that is expressed in several human tissues. Overexpression of hepsin has been found to correlate with tumour progression and metastasis, which is so far best studied for prostate cancer, where more than 90% of such tumours show this characteristic. To enable...
Includes: Supplementary data
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Biochem J (2010) 425 (3): 575–583.
Published: 15 January 2010
...Marc A. Thomas; Darren M. Preece; Jacqueline M. Bentel The homeodomain transcription factor NKX3.1 is a prostate-specific tumour suppressor, expression of which is reduced or undetectable in the majority of metastatic prostate tumours. In the normal prostate and in prostate cancer cells, NKX3.1...
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