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Keywords: protease
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Biochem J (2021) 478 (12): 2233–2245.
Published: 18 June 2021
... of two proteases (caspases 3 and 7) are highly similar, which complicates the design of compounds that selectively interact with a single enzyme exclusively. The recognition of residues other than Asp in the P1 position of the substrate by caspase-3/-7 has been reported, promoting interest in the effects...
Includes: Supplementary data
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Biochem J (2021) 478 (10): 1847–1852.
Published: 18 May 2021
...Shuguo Hou; Jie Zhang; Ping He Plants encode a large number of proteases in activating intracellular signaling through proteolytic cleavages of various protein substrates. One type of the substrates is proligands, including peptide hormones, which are perceived by cell surface-resident receptors...
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Biochem J (2021) 478 (8): 1585–1603.
Published: 28 April 2021
... proteases that are secreted by pathogens, commensals, and mutualists to facilitate mucosal colonization and penetration. Additionally, immunoglobulin A (IgA) proteases promote bacterial colonization in the presence of neutralizing secretory IgA through selective cleavage of the heavily O-glycosylated hinge...
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Biochem J (2018) 475 (19): 3123–3140.
Published: 12 October 2018
..., as they are sites of high mycobacterial burden. Pulmonary cavitation is associated with antibiotic failure and the emergence of antibiotic resistance. For cavities to form, M. tuberculosis induces the overexpression of host proteases, like matrix metalloproteinases and cathepsin, which are secreted from monocyte...
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Biochem J (2018) 475 (15): 2491–2509.
Published: 16 August 2018
... capacity is largely mediated through plasma membrane and cytosol-localized receptors which trigger complex downstream immune signaling cascades. As immune signaling outputs are often associated with a high fitness cost, precise regulation of this signaling is critical. Protease-mediated proteolysis...
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Biochem J (2014) 460 (2): 187–198.
Published: 13 May 2014
...Todd A. Naumann; Donald T. Wicklow; Neil P. J. Price Cmps (chitinase-modifying proteins) are fungal proteases that truncate plant class IV chitinases by cleaving near their N-termini. We previously described Fv-cmp, a fungalysin protease that cleaves a conserved glycine–cysteine bond within...
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Biochem J (2014) 457 (2): 289–300.
Published: 20 December 2013
... (endoplasmic reticulum)-resident protease RCE1 (Ras-converting enzyme 1) and is necessary for the proper localization and function of many of these ‘CaaX’ proteins. In the present paper, we report that several mammalian species have a novel isoform (isoform 2) of RCE1 resulting from an alternate splice site...
Includes: Supplementary data
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Biochem J (2013) 449 (1): 161–166.
Published: 07 December 2012
...Longguang Jiang; Kenneth A. Botkjaer; Lisbeth M. Andersen; Cai Yuan; Peter A. Andreasen; Mingdong Huang An important regulatory mechanism of serine proteases is the proteolytic conversion of the inactive pro-enzyme, or zymogen, into the active enzyme. This activation process is generally considered...
Includes: Supplementary data
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Biochem J (2012) 446 (3): 509–516.
Published: 28 August 2012
...-apoptotic functions, for a considerably longer time frame than does IFNα2. We show that the diversification of α2/β responses progressively builds up at the receptor level as a result of accumulating USP18 (ubiquitin specific protease 18), itself an ISG, which exerts its negative feedback action by taking...
Includes: Supplementary data
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Biochem J (2012) 444 (2): e3–e5.
Published: 11 May 2012
... correspondence should be addressed (email domagoj@gene.com ). 8 3 2012 22 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 dimerization lymphoma mucosa-associated lymphoid tissue translocation gene 1 (MALT1) nuclear factor κB (NF-κB) protease substrate...
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Biochem J (2012) 443 (1): 287–295.
Published: 14 March 2012
...-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) paracaspase positional-scanning substrate library protease substrate specificity The human protein MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) was discovered over a decade ago as a component...
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Biochem J (2010) 427 (3): 391–400.
Published: 14 April 2010
... correspondence should be addressed (email i.clark@uea.ac.uk ). 23 11 2009 5 2 2010 9 2 2010 9 2 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 acetylation GT-box histone deacetylase (HDAC) matrix metalloproteinase (MMP) protease specificity protein...
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Biochem J (2010) 427 (2): 197–203.
Published: 29 March 2010
...Maximilian J. Hartl; Kristian Schweimer; Martin H. Reger; Stephan Schwarzinger; Jochen Bodem; Paul Rösch; Birgitta M. Wöhrl Retroviral proteases have been shown previously to be only active as homodimers. They are essential to form the separate and active proteins from the viral precursors...
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Biochem J (2007) 407 (1): 41–48.
Published: 12 September 2007
...John C. Timmer; Mari Enoksson; Eric Wildfang; Wenhong Zhu; Yoshinobu Igarashi; Jean-Benard Denault; Yuliang Ma; Benjamin Dummitt; Yie-Hwa Chang; Alan E. Mast; Alexey Eroshkin; Jeffrey W. Smith; W. Andy Tao; Guy S. Salvesen Most known organisms encode proteases that are crucial for constitutive...
Includes: Supplementary data
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Biochem J (2007) 407 (1): e1.
Published: 12 September 2007
...Matthew Bogyo Our quest to understand the complex inner workings of the cell depends on the development of new technologies that allow the study of global regulatory events as they happen within their native cellular environment. Post-translational processing of proteins by proteases is one...
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Biochem J (2007) 405 (3): 429–438.
Published: 13 July 2007
...Katrine S. Larsen; Henrik Østergaard; Jais R. Bjelke; Ole H. Olsen; Hanne B. Rasmussen; Leif Christensen; Birthe B. Kragelund; Henning R. Stennicke The remarkably high specificity of the coagulation proteases towards macromolecular substrates is provided by numerous interactions involving...
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Biochem J (2007) 405 (3): 489–494.
Published: 13 July 2007
...Melinda A. Paterson; Anita J. Horvath; Robert N. Pike; Paul B. Coughlin Centerin [ SERPINA9 / GCET1 (germinal centre B-cell-expressed transcript 1)] is a serpin (serine protease inhibitor) whose expression is restricted to germinal centre B-cells and lymphoid malignancies with germinal centre B...
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Biochem J (2007) 403 (1): 49–57.
Published: 13 March 2007
..., whereas the role of SG PG in mucosal MCs has not been explored. In the present study, we have addressed the latter issue by using mice with an inactivated SG gene. Bone marrow cells were differentiated in vitro into the mucosal MC phenotype, expressing the markers mMCP (mouse MC protease) -1 and -2...
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Biochem J (2006) 396 (2): 219–226.
Published: 15 May 2006
...Enrique Álvarez; Alfredo Castelló; Luis Menéndez-Arias; Luis Carrasco The PABP [poly(A)-binding protein] is able to interact with the 3′ poly(A) tail of eukaryotic mRNA, promoting its translation. Cleavage of PABP by viral proteases encoded by several picornaviruses and caliciviruses plays a role...
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Biochem J (2005) 387 (2): 497–506.
Published: 05 April 2005
... of MT1-MMP inhibited shedding of the 50-kDa species. A recombinant 50-kDa species (Tyr 112 –Val 524 ) expressed in cells exhibited enzymatic activity against pro-MMP-2 and galectin-3, and thus this species is a competent protease. The recombinant 50-kDa soluble form also decreased the level of surface...
Includes: Supplementary data
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Biochem J (2005) 385 (3): 755–761.
Published: 24 January 2005
...@mbox.nc.kyushu-u.ac.jp ). 16 8 2004 28 9 2004 30 9 2004 1 10 2004 The Biochemical Society, London 2005 mitochondria polyprotein processing protease protein transport Most mitochondrial proteins are encoded by the nucleus and synthesized by cytoplasmic ribosomes...
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Biochem J (2004) 384 (2): 201–232.
Published: 23 November 2004
.... Fundamentally new mechanisms in protease regulation have been disclosed. Structural evidence suggests that caspases have an unusual catalytic mechanism, and that they are activated by apparently unrelated events, depending on which position in the apoptotic pathway they occupy. Some naturally occurring caspase...
Includes: Supplementary data
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Biochem J (2004) 382 (2): 651–657.
Published: 24 August 2004
...@burnham.org ). 14 5 2004 14 6 2004 21 6 2004 21 6 2004 The Biochemical Society, London 2004 apoptosis caspase-8 FLIP L (FLICE-like inhibitory protein) protease zymogen Apoptotic cell death is carried out through the concerted action of caspases, a family...
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Biochem J (2004) 380 (3): 775–781.
Published: 15 June 2004
..., London ©2004 2004 bradykinin fluorescent peptide inflammation inhibitor kallikrein protease Abbreviations used: ACN, acetonitrile; Abz, o -aminobenzoyl; Aca, ( cis , trans )-aminocyclohexyl-alanine; EDDnp, ethylenediamine 2,4-dinitrophenyl; hK1, mK1, rK1 and pK1, human, mouse, rat...
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Biochem J (2004) 379 (2): 217–227.
Published: 15 April 2004
... on PGs in intracellular locations. Key words: glycosaminoglycan (GAG), protease, proteoglycan (PG), serglycin. INTRODUCTION The proteoglycan (PG) structures we know today have been elucidated mainly from classical studies with material isolated from tissues like tendon and cartilage, and cell types...
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Biochem J (2004) 378 (2): 657–663.
Published: 01 March 2004
...Robert W. MASON; Carolyn A. BERGMAN; Guizhen LU; Jennifer FRENCK HOLBROOK; Katia SOL-CHURCH The mouse genome contains a family of clan C1A proteases that appear to be restricted to rodents within Eutherian (placental) mammals. mRNA analysis has shown that these genes are expressed exclusively...
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Biochem J (2003) 374 (1): 123–129.
Published: 15 August 2003
..., protease, transforming growth factor INTRODUCTION The fibroblast growth factor (FGF) family of heparin-binding proteins consists of 23 members [1 3]. Acidic FGF (FGF-1) and basic FGF (FGF-2) are the two prototypic members of this family. FGFs initiate cell signalling by binding to at least five different...
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Biochem J (2003) 371 (1): 165–173.
Published: 01 April 2003
... gels and CD studies show that the protein undergoes the stressed—relaxed conformational change typical of inhibitory serpins. However, we have not detected complex-forming activity with a set of proteases. Thermal denaturation studies also show that the protein has decreased structural stability under...
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Biochem J (2002) 368 (2): 495–505.
Published: 01 December 2002
... and significant in- crease in sensitivity towards tryptase. Interestingly, INTRODUCTION Proteinase-activated receptors (PARs) are a novel trans- membrane G-protein-coupled receptor (GPCR) family activated by serine proteases [1 3]. Proteolytic cleavage of the PAR N- terminal exodomain exposes a tethered ligand...