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Keywords: protease inhibitor
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Articles
Biochem J (2020) 477 (9): 1701–1719.
Published: 11 May 2020
Includes: Supplementary data
Articles
Biochem J (2019) 476 (3): 499–512.
Published: 05 February 2019
... Press Limited on behalf of the Biochemical Society 2019 cathepsin K collagen exosite inhibitor high-throughput screening osteoporosis protease inhibitor Cysteine cathepsins are found in all life forms and play an important role in mammalian intra- and extracellular protein turnover...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (2): 375–384.
Published: 31 January 2019
... contains insertions of leucine and asparagine (L38↑N↑L) in the hinge region of protease at position 38. This was isolated from a protease inhibitor naïve infant. Isothermal titration calorimetry showed that 10% less of L38↑N↑L protease was in the active conformation as compared with a reference strain. L38...
Articles
Biochem J (2018) 475 (7): 1335–1352.
Published: 16 April 2018
... Kunitz protease inhibitor domain (APPI) for inhibition of the oncogenic protease mesotrypsin, in the presence of three competing serine proteases, anionic trypsin, cationic trypsin and kallikrein-6. We generated a variant, designated APPI P13W/M17G/I18F/F34V , with up to 30-fold greater specificity...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (19): 3189–3204.
Published: 27 September 2016
... peak, containing Xf  PIP, was pooled and concentrated to 1 mg/ml. aminopeptidase crystallography malaria Plasmodium falciparum protease inhibitor substrate specificity In October 2015, the Nobel Prize for medicine was awarded to Youyou Tu for the development of the antimalarial...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (10): 1329–1341.
Published: 11 May 2016
... proteinaceous inhibitors, mesotrypsin presents a formidable challenge to the development of biological inhibitors. We used a powerful yeast display platform for directed evolution, employing a novel multi-modal library screening strategy, to engineer the human amyloid precursor protein Kunitz protease inhibitor...
Includes: Supplementary data
Articles
Biochem J (2013) 452 (2): 331–343.
Published: 10 May 2013
... and Ser 195 , according to the chymotrypsinogen numbering, which is used in the following paragraphs. influenza virus protease inhibitor synthetic substrate transmembrane serine proteinase 2 (TMPRSS2) type II transmembrane serine protease (TTSP) The gene of TMPRSS2 (transmembrane...
Articles
Biochem J (2011) 440 (1): 95–105.
Published: 27 October 2011
... protease inhibitor domain), and of a poor mesotrypsin inhibitor, BPTI (bovine pancreatic trypsin inhibitor), to dissect mesotrypsin specificity at the key P 2 ′ position. We find that bulky and charged residues strongly disfavour binding, whereas acidic residues facilitate catalysis. Crystal structures of...
Articles
Biochem J (2005) 388 (1): 281–289.
Published: 10 May 2005
...Gert SIMONET; Bert BREUGELMANS; Paul PROOST; Ilse CLAEYS; Jozef VAN DAMME; Arnold DE LOOF; Jozef VANDEN BROECK In the last decade, a new serine protease inhibitor family has been described in arthropods. Eight members of the family were purified from locusts and share a conserved cysteine array...
Articles
Biochem J (2004) 378 (3): 705–716.
Published: 15 March 2004
... 23 12 2003 5 1 2004 5 1 2004 The Biochemical Society, London ©2004 2004 clan compound inhibitor domain repeat MEROPS database peptidase inhibitor protease inhibitor Biochem. J. (2004) 378, 705 716 (Printed in Great Britain) 705 REVIEW ARTICLE Evolutionary families of...
Articles
Biochem J (2004) 378 (2): 383–389.
Published: 01 March 2004
... gelatinases rather than collagenases. Hmeprin is inhibited by hydroxamic acid derivatives such as batimastat, galardin and Pro-Leu-Gly-hydroxamate, by TAPI-0 (tumour necrosis factor α protease inhibitor-0) and TAPI-2, and by thiol-based compounds such as captopril. Therapeutic targets for these inhibitors are...
Articles
Biochem J (2003) 374 (3): 739–745.
Published: 15 September 2003
... rfridman@med.wayne.edu ). 11 4 2003 15 5 2003 20 5 2003 20 5 2003 The Biochemical Society, London ©2003 The Biochemical Society, London © 2003 gelatinase matrix metalloproteinase protease protease inhibitor zymogen Abbreviations used: APMA, p...
Articles
Biochem J (2000) 351 (2): 413–420.
Published: 10 October 2000
.... 2 To whom correspondence should be addressed (e-mail nkosower@ccsg.tau.ac.il ). 12 6 2000 The Biochemical Society, London © 2000 2000 Ca2+-dependent protease cell fusion protease inhibitor Biochem. J. (2000) 351, 413 420 (Printed in Great Britain) 413 Regulation of calpain...
Articles
Biochem J (2000) 346 (3): 817–826.
Published: 07 March 2000
... mast cells and suggest that it is associated with a unique type of intracellular granules distinct from MCCPA- and histamine-containing secretory granules and lysosomes. Key words: heparin, histamine, protease inhibitor, secretion. body and axonal fibres within cerebral cortical and primary sensory...
Articles
Biochem J (1999) 338 (1): 107–113.
Published: 08 February 1999
... To whom correspondence should be addressed (e-mail Basaka@ircm.umontreal.ca ). 24 6 1998 28 10 1998 24 11 1998 The Biochemical Society, London © 1999 1999 antiviral property inhibition constant labdane diterpines protease inhibitor Biochem. J. (1999) 338, 107 113...