1-44 of 44
Keywords: protein degradation
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Biochem J (2020) 477 (5): 905–923.
Published: 04 March 2020
...-ubiquitin ligase HECT type domain protein degradation structure Ubiquitination is a vital post-translational modification that affects several key signaling events, including protein homeostasis, DNA damage, innate immunity, and neurodegenerative diseases [ 1 , 2 ]. Ubiquitination is brought...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (2): 477–489.
Published: 31 January 2020
.... Analysis with mass spectrometry identified that BAG6 is one of the major proteins interacting with PAQR9 and such interaction is confirmed by co-immunoprecipitation and co-localization assays. The protein degradation rate of representative MLPs is accelerated by PAQR9 knockdown. Consistently, the...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (21): 3211–3226.
Published: 11 November 2019
...′-TTCCTGGCCATGGAGCGCGGCCGCCATATGGAGTATGAA-3′ and R 5′-TTCATACTCCATATGGCGGCCGCGCTCCATGGCCAGGAA-3′. Mutated cDNAs were subsequently cloned into pcDNA5/FRT/TO by digestion with KpnI and XhoI. DNA sequencing verified the integrity of all mutated cDNAs. proteasome protein degradation protein turnover sphingosine kinase ubiquitin...
Articles
Biochem J (2017) 474 (22): 3719–3732.
Published: 01 November 2017
..., which was consistent with the results of the in vitro cleavage assay ( Figure 1 ). angiogenesis mass spectrometry metalloproteases protein degradation syndecans Syndecans (SDCs), including SDC1–4, are transmembrane proteoglycans that contain glycosaminoglycan chains. SDCs participate...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (19): 3355–3371.
Published: 25 September 2017
... protein degradation because it occurs downstream from many hormones and neurotransmitters, in conditions that raise cyclic adenosine monophosphate or cyclic guanosine monophosphate levels, after calcium influx following synaptic depolarization, and during phases of the cell cycle. Beyond its physiological...
Articles
Biochem J (2017) 474 (10): 1653–1668.
Published: 04 May 2017
..., USP7, stabilized the HIV-1 Tat protein through its deubiquitination. Treatment with either a general DUB inhibitor (PR-619) or USP7-specific inhibitor (P5091) resulted in Tat protein degradation. The USP7-specific inhibitor reduced virus production in a latently infected T-lymphocytic cell line J1.1...
Includes: Supplementary data
Articles
Biochem J (2015) 470 (3): 303–317.
Published: 04 September 2015
... peptide Alzheimer's disease amyloid precursor protein (APP) FE65 serum- and glucocorticoid-induced kinase 1 (SGK1) protein degradation Alzheimer's disease (AD) is a progressive neurodegenerative disease affecting 36 million people worldwide. Despite its long history of discovery, effective...
Includes: Supplementary data
Articles
Biochem J (2015) 469 (3): 469–480.
Published: 23 July 2015
... migration of gastric cancer cells are altered by DDB2. Therefore DDB2 functions as a post-translational regulator of PAQR3 and modulates tumorigenesis. cell proliferation DDB2 gastric cancer protein degradation tumour suppressor ubiquitination DDB2 (damage-specific DNA-binding protein 2...
Articles
Biochem J (2015) 466 (3): 571–585.
Published: 06 March 2015
... have identified novel interacting connexin proteins of CIP75, indicating a role for CIP75 in regulating the levels of connexins in general, through proteasomal degradation. connexin CIP75 ERAD proteasome protein degradation Connexins are tetra-spanning proteins with two extracellular...
Includes: Supplementary data
Articles
Biochem J (2014) 464 (3): 401–411.
Published: 05 December 2014
... reticulum endoplasmic-reticulum-associated degradation (ERAD) glycobiology glycoprotein glycosylation protein degradation protein misfolding 14 8 2014 24 9 2014 24 9 2014 24 9 2014 © 2014 Authors 2014 This is an Open Access article distributed under the terms of the...
Articles
Biochem J (2014) 458 (1): 57–67.
Published: 20 January 2014
... protein degradation protein translocation Cx43 (connexin43) belongs to the connexin family of four-pass transmembrane proteins involved in intercellular communication. The connexin proteins comprise gap junction channels, where individual connexins oligomerize into multimeric plasma membrane...
Articles
Biochem J (2014) 457 (1): 207–214.
Published: 10 December 2013
... APL (acute PML) patients [ 26 , 27 ]. avidity promyelocytic leukaemia protein degradation RING finger protein 4 (RNF4) small ubiquitin-like modifier (SUMO) SUMO-targeted ubiquitin ligase Protein modifications by ubiquitin and Ubl (ubiquitin-like) proteins are involved in the...
Includes: Supplementary data
Articles
Biochem J (2012) 444 (3): 581–590.
Published: 29 May 2012
... proliferation in breast cancer cells. In this loop ATBF1 inhibits the function of oestrogen–ERα signalling, whereas ATBF1 protein levels are fine-tuned by oestrogen-induced transcriptional up-regulation as well as UPP (ubiquitin–proteasome pathway)-mediated protein degradation. In the present study we show that...
Includes: Supplementary data
Articles
Biochem J (2012) 444 (1): 141–151.
Published: 26 April 2012
... (phosphoinositide 3-kinase) pathway [ 3 ] and is activated in many cancers. AZD8055 eukaryotic initiation factor (eIF) mammalian target of rapamycin (mTOR) mRNA translation protein degradation stable isotope-labelling with amino acids in cell culture (SILAC) HeLa cells growing in serum (and...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (3): 681–689.
Published: 16 April 2012
... death both in vitro and in vivo . These results suggest that FE65 facilitates the accumulation of mutant Htt in cells by preventing its degradation via the UPS, and thereby enhances the toxicity of mutant Htt. FE65 huntingtin (Htt) Huntington's disease (HD) protein degradation toxicity...
Articles
Biochem J (2011) 435 (3): 641–649.
Published: 13 April 2011
... induction of the GAL1 gene and we have found that galactose-induced protein degradation of the repressor Mig2 is defective in this strain. Mig2 degradation was also abolished in cells lacking the protein kinase Snf1 and the F-box protein Das1, suggesting that Snf1 triggers galactose-induced protein...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (1): 1–16.
Published: 15 March 2011
... Journal compilation © 2011 Biochemical Society 2011 procoagulant protease therapy protein degradation protein engineering trypsin fold Alteplase, marketed as Activase® (Genentech), was the first t-PA molecule to reach the clinic. It was first approved by the FDA in 1987 to treat AMI...
Includes: Supplementary data
Articles
Biochem J (2011) 434 (2): 233–242.
Published: 11 February 2011
...-type plasminogen activator receptor (u-PAR) glycolipid anchor protein degradation Cells were seeded in four-well chambers (Lab-Tek®; Nunc) and transfected using Lipofectamine™ 2000 (Invitrogen) on the following day with 0.5 μg of u-PAR–EGFP (wild-type or mutated in the u-PAR sequence) and 0.5 μg...
Includes: Supplementary data
Articles
Biochem J (2010) 432 (3): 585–595.
Published: 25 November 2010
... (email Kelvin@usc.edu ). 16 6 2010 24 9 2010 5 10 2010 5 10 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 aging free radical hormesis protein degradation protein oxidation ubiquitin–proteasome system Oxidatively damaged proteins...
Includes: Supplementary data
Articles
Biochem J (2010) 432 (1): 217–226.
Published: 25 October 2010
... 2010 30 8 2010 3 9 2010 3 9 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 degron human thymidylate synthase (hTS) intrinsically disordered region proteasome protein degradation ubiquitin-independent The proteasome is a large multi-subunit...
Articles
Biochem J (2010) 431 (3): 391–402.
Published: 11 October 2010
... activation. 1 To whom correspondence should be addressed (email micln@nus.edu.sg ). 28 7 2010 23 8 2010 26 8 2010 26 8 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 de-ubiquitination proteasome protein degradation regulation of gene...
Includes: Supplementary data
Articles
Biochem J (2010) 429 (1): 127–136.
Published: 14 June 2010
... compilation © 2010 Biochemical Society 2010 LIM-domain-binding 1 (LDB1) post-translational modification proteasome protein degradation RING finger protein 12 (RNF12) ubiquitin ligase LDB1 (LIM-domain-binding 1) is a highly conserved transcription cofactor that was initially identified by...
Articles
Biochem J (2010) 426 (1): 13–17.
Published: 27 January 2010
... ). 24 8 2009 23 11 2009 3 12 2009 3 12 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 half-life mitochondrion proteasome protein degradation uncoupling protein 1 (UCP1) uncoupling protein 3 (UCP3) The UCPs (uncoupling proteins) are a...
Articles
Biochem J (2010) 425 (1): e1–e3.
Published: 14 December 2009
... autophagy Bag3 co-chaperone HspB6 HspB8 muscular dystrophy protein degradation Heat-shock proteins (Hsps), also called molecular chaperones, perform folding, stabilization, trafficking and degradation functions to maintain cellular homoeostasis. Mutation, overexpression or deletion of chaperones...
Articles
Biochem J (2009) 422 (2): 207–215.
Published: 13 August 2009
... 2009 7 7 2009 7 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 Intrinsically disordered protein NMR spectroscopy prokaryote protein degradation Pup ubiquitin Protein degradation is an important mechanism involved in broad cellular events such...
Includes: Supplementary data
Articles
Biochem J (2008) 414 (2): 221–229.
Published: 12 August 2008
... Biochemical Society 2008 cancer mutation neural-precursor-cell-expressed developmentally down-regulated 4-1 (NEDD4-1) phosphatase and tensin homologue deleted on chromosome 10 (PTEN) protein degradation stability ubiquitination Regulation of PTEN protein stability has been a subject of...
Articles
Biochem J (2008) 412 (3): 579–588.
Published: 28 May 2008
...@psu.edu ). 12 2 2008 12 2 2008 21 2 2008 21 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 apoptosis eukaryotic translational initiation factor 2α (eIF2α) protein degradation protein kinase protein synthesis 26S proteasome The...
Articles
Biochem J (2008) 410 (3): 613–619.
Published: 27 February 2008
... 2007 30 11 2007 30 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 antizyme inhibitor (AzI) ornithine decarboxylase (ODC) ODC paralogue (ODCp) polyamine protein degradation ubiquitin Polyamines are natural polycations that are essential for...
Articles
Biochem J (2008) 409 (3): 751–759.
Published: 15 January 2008
...Steven T. Russell; Helen L. Eley; Stacey M. Wyke; Michael J. Tisdale In the present study the role of Akt/PKB (protein kinase B) in PIF- (proteolysis-inducing factor) induced protein degradation has been investigated in murine myotubes. PIF induced transient phosphorylation of Akt at Ser 473 within...
Articles
Biochem J (2007) 401 (1): 217–226.
Published: 11 December 2006
... ). 26 7 2006 24 8 2006 8 9 2006 8 9 2006 The Biochemical Society, London 2007 complex formation hypoxia prolyl hydroxylase domain containing 3 (PHD3) protein degradation Siah2 ubiquitination Regulation of cellular responses to environmental cues relies on post...
Articles
Biochem J (2004) 382 (2): 695–702.
Published: 24 August 2004
... obtained in L-BEVS, suggesting that more tightly folded LUC was produced in N-BEVS. YLC expression was also analysed by Western blotting, revealing significantly less protein degradation in N-BEVS than in L-BEVS, in which extensive degradation was observed. This FRET-based in vivo folding technology showed...
Articles
Biochem J (2004) 381 (3): 761–767.
Published: 27 July 2004
... 2004 23 4 2004 The Biochemical Society, London 2004 hypoxia-inducible factor oxygen sensing post-translational modification prolyl hydroxylation protein degradation von-Hippel-Lindau protein The ability to adapt to acute and chronic hypoxia is crucial for survival of cells...
Articles
Biochem J (2004) 380 (1): 289–295.
Published: 15 May 2004
... hypoxia-inducible factor-1α (HIF-1α) p53 p300 protein degradation transcriptional regulation Abbreviations used: Epo, erythropoietin; HA, haemagglutinin; HIF-1, hypoxia-inducible factor-1; HRP, horseradish peroxidase; IVTT, in vitro transcription/translation; Mdm2, mouse double minute 2...
Articles
Biochem J (2004) 378 (1): 177–184.
Published: 15 February 2004
... be addressed (e-mail j.rivett@bristol.ac.uk ). 24 7 2003 21 10 2003 29 10 2003 29 10 2003 The Biochemical Society, London ©2004 2004 γ-interferon phosphorylation proteasome protein complexes protein degradation protein—protein interactions...
Articles
Biochem J (2003) 373 (1): 201–210.
Published: 01 July 2003
... 3 2003 27 3 2003 The Biochemical Society, London ©2003 2003 apoptosis breast cancer cell caspase activation protein degradation Abbreviations used: Ad-LacZ, adenovirus expressing lacZ gene; FAK, focal adhesion kinase; FAK-NT, FAK N-terminus; Ad-FAK-NT, adenovirus...
Articles
Biochem J (2003) 371 (3): 937–945.
Published: 01 May 2003
... The Biochemical Society, London ©2003 2003 nuclear speckles protein degradation serine/arginine-rich (SR) protein kinase transcription inhibitor Abbreviations used: DRB, 5,6-dichloro-1β- d -ribofuranosyl-benzimidazole; HA, haemagglutinin; RRM, RNA-recognition motif; RS domain...
Articles
Biochem J (2002) 368 (1): 357–363.
Published: 15 November 2002
... ). 1 7 2002 1 8 2002 6 8 2002 6 8 2002 The Biochemical Society, London ©2002 2002 archaea hyperthermophile protease protein degradation Sulfolobus Abbreviations used: Ac, acetyl; AMC, 7-amido-4-methylcoumarin; CBz, benzyloxycarbonyl; E-64, trans...
Articles
Biochem J (2002) 364 (1): 275–284.
Published: 08 May 2002
... enzymically inactive enzymes strongly suggests that they originate from a leakage of autophagosomes, a constituent of the non- selective autophagic}lysosomal pathway for degradation of whole mitochondria. Key words: autophagy, CoA modification, hepatocytes, protein degradation. ATP-dependent proteases, matrix...
Articles
Biochem J (2001) 354 (1): 31–36.
Published: 08 February 2001
... showed that hypo-osmotic activation of p38MAPK INTRODUCTION Autophagic vacuole formation is the initial step of bulk protein degradation in liver. Hepatic autophagosomes have a half-life of approx. 10 min [1]. The exact biochemical events responsible for the regulation of autophagosome formation are only...
Articles
Biochem J (2000) 346 (2): 509–518.
Published: 22 February 2000
... observations made regarding the degradation of these mutant gene products also provide support for putative checkpoints in the endoplasmic reticulum. methotrexate resistance membrane protein N-glycosylation protein degradation 1 To whom correspondence and requests for offprints should be sent...
Articles
Biochem J (2000) 345 (1): 1–15.
Published: 17 December 1999
..., Switzerland. The Biochemical Society, London © 2000 2000 cellular immunity, 26S proteasome protein degradation ubiquitin-mediated proteolysis Biochem. J. (2000) 345, 1 15 (Printed in Great Britain) 1 REVIEW ARTICLE The proteasome activator 11 S REG (PA28) and Class I antigen presentation...
Articles
Biochem J (2000) 345 (1): 129–138.
Published: 17 December 1999
... addressed (e-mail piechaczyk@igm.cnrs-mop.fr). 19 4 1999 24 9 1999 19 10 1999 The Biochemical Society, London © 2000 2000 oncogene protein degradation proteolysis transcription factor Biochem. J. (2000) 345, 129 138 (Printed in Great Britain) 129 The sensitivity of c-Jun...
Articles
Biochem J (1999) 343 (2): 425–433.
Published: 08 October 1999
... standard protein substrates at many sites, suggesting that this proteinase could have a role in the degradation of proteins in addition to processing propeptides in plants. C-terminal propeptide pro-(barley lectin) protein degradation protein processing protein structure The Biochemical Society...
Articles
Biochem J (1999) 340 (2): 453–458.
Published: 25 May 1999
... destabilization of the enzyme during catalytic cycling rather than to the intrinsic instability of the protein molecule. diphenylene iodonium endoplasmic reticulum membrane proteins protein degradation reactive oxygen species The Biochemical Society, London © 1999 1999 2 2 1999 16 3 1999...