... of the Biochemical Society 2017 glycosylation protein function protein stability protein structure Glycosylation is the covalent addition of sugar moieties to the protein co-translationally or as a post-translational modification enzymatically. It is the most frequent, heterogeneous, stereo...

... understanding of the molecular mechanisms underlying the regulation of this kinase activity becomes of paramount importance [ 5 ]. Akt post-translational modification protein function protein kinase B signal transduction Several Akt residues, such as Ser 122 , Ser 137 , Thr 146 , Thr 195...

... protein crystallization protein function protein stability sequence-alignment statistics therapy Measurements were performed on a capillary VP-DSC (differential scanning calorimetry; MicroCal; GE Healthcare) calorimeter with a cell volume of 0.135 ml at the indicated scan rates. DSC scans...

...-dimensional space can occur to preserve global stability. Whereas point mutations can fine-tune the protein function, residue insertions and deletions (‘decorations’ at the structural level) can sometimes modify functional sites and protein interactions more dramatically. We discuss recent developments...