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Keywords: protein kinase
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Biochem J (2025) 482 (08): 369–381.
Published: 16 April 2025
... in the second degron have yet to be identified, and it is thought that the T58 degron is sufficient for efficient Myc degradation under most conditions [ 19 ]. Several studies have shown that the ubiquitination of both N-Myc and c-Myc can be regulated by the protein kinase Aurora A (AurA). AurA binds to N...
Includes: Supplementary data
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Biochem J (2024) 481 (17): 1125–1142.
Published: 27 August 2024
... access for this article was enabled by the participation of University of Melbourne in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. mechanistic target of rapamycin necroptosis protein kinase...
Includes: Supplementary data
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Biochem J (2022) 479 (10): 1059–1082.
Published: 23 May 2022
... is catalysed by any one of four protein kinases, which are generally activated in response to stresses. They form a key arm of the integrated stress response (ISR). Phosphorylated eIF2 inhibits eIF2B (the protein that promotes exchange of eIF2-bound GDP for GTP) and thus impairs general protein synthesis...
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Biochem J (2017) 474 (19): 3355–3371.
Published: 25 September 2017
... that protein half-lives can also be regulated by post-translational modifications of the 26S proteasome. The present study reviews the ability of several kinases to alter proteasome function through subunit phosphorylation. For example, PKA (protein kinase A) and DYRK2 (dual-specificity tyrosine-regulated...
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Biochem J (2015) 469 (3): 409–420.
Published: 23 July 2015
... activates atypical cyclin-dependent kinase 16 (CDK16)/PCTAIRE-1, which involves 14-3-3 binding to cyclin Y through phosphorylation of two residues, namely Ser 100 and Ser 326 . 14-3-3 cyclin-dependent kinase (CDK) intellectual disability mass spectrometry protein kinase The human cyclin...
Includes: Supplementary data
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Biochem J (2014) 462 (2): 199–213.
Published: 07 August 2014
..., the large number of cellular processes modulated by only three intermediaries, i.e. PKA (protein kinase A), Epacs (exchange proteins directly activated by cAMP) and CNG (cyclic nucleotide-gated) channels, poses the question of how selectivity and fine control is achieved by cAMP. One answer rests...
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Biochem J (2014) 460 (2): 165–175.
Published: 13 May 2014
... with secondary hypocalcaemia), a disorder characterized by defective intestinal Mg 2+ transport and impaired renal Mg 2+ reabsorption. TRPM6, together with its homologue TRPM7, are unique proteins as they combine an ion channel domain with a C-terminally fused protein kinase domain. How TRPM6 channel and kinase...
Includes: Supplementary data
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Biochem J (2014) 458 (3): 559–573.
Published: 28 February 2014
... that the WNK (WNK lysine-deficient protein kinase)-activated SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) known to directly phosphorylate and stimulate the N[K]CCs (Na + –K + ion co-transporters), also promote inhibition of the KCCs (K + –Cl − co-transporters...
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Biochem J (2014) 457 (3): 451–461.
Published: 10 January 2014
...Konstantina Stathopoulou; Friederike Cuello; Alexandra J. Candasamy; Elizabeth M. Kemp; Elisabeth Ehler; Robert S. Haworth; Metin Avkiran PKD (protein kinase D) is a serine/threonine kinase implicated in multiple cardiac roles, including the phosphorylation of the class II HDAC5 (histone...
Includes: Supplementary data
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Biochem J (2013) 452 (3): e11–e13.
Published: 31 May 2013
.... A. Hellner K. Sawyer J. Grace M. Li W. Harlow E. Munger K. Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3 Proc. Natl. Acad. Sci. U.S.A. 2010 107 12463 12468 11 Chandarlapaty S. Sawai...
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Biochem J (2012) 446 (2): e5–e7.
Published: 14 August 2012
...Brian E. Ellis Plants contain hundreds of protein kinases that are believed to provide cellular signal transduction services, but the identities of the proteins they are targeting are largely unknown. Using an Arabidopsis MAPK (mitogen-activated protein kinase) (MPK6) as a model, Sörensson et al...
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Biochem J (2012) 445 (3): 431–439.
Published: 13 July 2012
...Michael A. Rieger; Tyler Duellman; Christopher Hooper; Magdalene Ameka; Joanna C. Bakowska; Bruce D. Cuevas MEKK1 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase kinase 1] is a MAP3K (MAPK kinase kinase) that regulates MAPK activation, and is the only...
Includes: Supplementary data
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Biochem J (2012) 441 (2): 553–569.
Published: 21 December 2011
... [email protected] ). 14 2 2011 11 8 2011 11 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 cell signalling mitogen-activated protein kinase (MAPK) phosphorylation proliferation protein kinase 90 kDa ribosomal S6 kinase (RSK) The Ras...
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Biochem J (2012) 441 (1): 325–337.
Published: 14 December 2011
..., which is activated in response to osmotic stress by phosphorylation of its T-loop residue (Ser 382 ). WNK isoforms phosphorylate and activate the related SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1) protein kinases. In the present study, we first...
Includes: Supplementary data
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Biochem J (2010) 431 (3): 411–421.
Published: 11 October 2010
.... Specific peptide inhibitors for PKA (protein kinase A), but not PKG (protein kinase G), abolished cytosol-induced inhibition of MPT onset. Activity assays showed a cGMP- and cAMP-stimulated protein kinase activity in liver cytosol that was completely inhibited by PKI, a PKA peptide inhibitor. Size...
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Biochem J (2010) 431 (2): 227–235.
Published: 28 September 2010
...Svetlana Gershburg; Leann Murphy; Manfred Marschall; Edward Gershburg A sole EBV (Epstein–Barr virus)-encoded protein kinase (EBV-PK) (the BGLF4 gene product) plays important roles in viral infection. Although a number of targets of this protein have been identified, the kinase itself remains...
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Biochem J (2010) 425 (1): 53–54.
Published: 14 December 2009
...Philip Cohen Cell-permeable chemical inhibitors have become invaluable reagents for the study of cellular regulation. In the present paper, using protein kinase inhibitors as the example, a set of criteria are described that should be met before any investigation using such compounds should...
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Biochem J (2009) 423 (2): 279–290.
Published: 25 September 2009
...Susan Goto; Zhong Yao; Christopher G. Proud The human family of MAPK (mitogen-activated protein kinase) signal-integrating kinases (Mnks) comprises four related proteins derived from two genes by alternative splicing. The MNK1 gene gives rise to two proteins, Mnk1a and Mnk1b, which possess distinct...
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Biochem J (2009) 419 (3): 603–610.
Published: 14 April 2009
... the association of PI3Kγ with protein kinase Cα (PKCα). Specific inhibition of PI3Kγ suppresses fMLP-mediated activation of PKCα activity and ROS production, suggesting that the protein kinase activity of PI3Kγ is involved. Our data suggest that the direct interaction of PI3Kγ with PKCα forms a discrete...
Includes: Supplementary data
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Biochem J (2009) 419 (2): 247–259.
Published: 27 March 2009
...Nigel G. Halford; Sandra J. Hey The phosphorylation and dephosphorylation of proteins, catalysed by protein kinases and phosphatases, is the major mechanism for the transduction of intracellular signals in eukaryotic organisms. Signalling pathways often comprise multiple phosphorylation...
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Biochem J (2009) 419 (1): 141–148.
Published: 13 March 2009
... formation. cytoskeleton protein kinase Rho Rho-associated coiled-coil kinase (ROCK) signal transduction ROCK (Rho-associated coiled-coil kinase) [also called ROK (Rho-associated kinase) and Rho kinase] is a large (160 kDa) serine/threonine kinase ubiquitously expressed in mammalian tissue...
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Biochem J (2009) 418 (1): 191–200.
Published: 28 January 2009
... to develop adaptive responses. In this context, protein phosphorylation plays a fundamental role through the activation of multiple protein kinase families. Although the involvement of protein kinases at the plasma membrane and cytosolic levels are now well-documented, their nuclear counterparts are still...
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Biochem J (2008) 412 (3): 579–588.
Published: 28 May 2008
... lacking one of the four kinases known to phosphorylate eIF2α, increased phosphorylation of eIF2α still occurred after inhibition of the 26S proteasome. These three cell lines included a deletion of the PKR (double-stranded-RNA-dependent protein kinase); a deletion of the PERK (PKR-like endoplasmic...
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Biochem J (2008) 412 (2): e15–e16.
Published: 14 May 2008
... presented their discovery that simulated ischaemia causes rapid activation of AMPK (AMP-activated protein kinase) which phosphorylates and activates p38 MAPK (mitogen-activated protein kinase) leading to Bax activation and translocation to mitochondria in isolated cardiac myocytes. This was the first report...
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Biochem J (2008) 411 (2): 249–260.
Published: 27 March 2008
...Abdallah K. Al-Hakim; Anna Zagorska; Louise Chapman; Maria Deak; Mark Peggie; Dario R. Alessi AMPK (AMP-activated protein kinase)-related kinases regulate cell polarity as well as proliferation and are activated by the LKB1-tumour suppressor kinase. In the present study we demonstrate that the AMPK...
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Biochem J (2008) 411 (1): 27–32.
Published: 13 March 2008
... (email [email protected] ). 10 10 2007 5 12 2007 7 12 2007 7 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 consensus sequence peptide substrate Plk3 protein kinase topoisomerase IIα substrate specificity Plk (polo-like...
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Biochem J (2008) 409 (1): 117–127.
Published: 11 December 2007
... of the present results, we propose that AtPI4Kγ4 and AtPI4Kγ7 should be designated UbDKγ4 and UbDKγ7 ( ub iquitin-like d omain k inases γ4 and γ7). These UBL-domain-containing AtPI4Ks correspond to a new PIKK subfamily of protein kinases. Furthermore, UFD1 and RPN10 phosphorylation represents an additional...
Includes: Supplementary data
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Biochem J (2007) 408 (3): 297–315.
Published: 28 November 2007
...Jenny Bain; Lorna Plater; Matt Elliott; Natalia Shpiro; C. James Hastie; Hilary Mclauchlan; Iva Klevernic; J. Simon C. Arthur; Dario R. Alessi; Philip Cohen The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70–80...
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Biochem J (2007) 405 (3): 513–522.
Published: 13 July 2007
...Laura R. Pearce; Xu Huang; Jérôme Boudeau; Rafał Pawłowski; Stephan Wullschleger; Maria Deak; Adel F. M. Ibrahim; Robert Gourlay; Mark A. Magnuson; Dario R. Alessi The mTOR (mammalian target of rapamycin) protein kinase is an important regulator of cell growth. Two complexes of mTOR have been...
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Biochem J (2007) 405 (2): 307–317.
Published: 27 June 2007
... study we have developed a method to express active recombinant LRRK2 and utilized this in a KESTREL (kinase substrate tracking and elucidation) screen that has recently been developed to identify physiological substrates of protein kinases (reviewed in [ 14 ]). This led to the identification of moesin...
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Biochem J (2007) 405 (1): 21–30.
Published: 13 June 2007
... previously identified Dsk1p ( dis1 -suppressing protein kinase) as the orthologue of human SRPK1 in fission yeast. In addition to its similarity of gene structure to higher eukaryotes, fission yeast Schizosaccharomyces pombe is a unicellular eukaryotic organism in which alternative splicing takes place...
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Biochem J (2006) 397 (1): 223–231.
Published: 14 June 2006
...-1), leading to its activation. Recent studies indicated that SPAK and OSR1 are phosphorylated and activated by the WNK1 [with no K (lysine) protein kinase-1] and WNK4, genes mutated in humans affected by Gordon's hypertension syndrome. In the present study, we have identified three residues in NKCC1...
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Biochem J (2006) 397 (1): 213–222.
Published: 14 June 2006
... of Pak with PIX is required for ligand-induced activation of Pak1 in some contexts [ 25 ]. chemotaxis enzyme inhibitor p21-activated kinase (Pak) protein kinase signal transduction T cell Figure 1 Domain structure of Pak1 and the Pak-inhibitory constructs used in the present study Pak...
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Biochem J (2006) 396 (2): 347–354.
Published: 15 May 2006
... 11 2005 6 3 2006 7 3 2006 7 3 2006 The Biochemical Society, London 2006 cAMP hyaluronan synthase (HAS) protein kinase protein phosphorylation signalling HA (hyaluronan, hyaluronic acid) is a ubiquitous component of vertebrate extracellular and cell-associated...
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Biochem J (2005) 391 (1): 17–24.
Published: 26 September 2005
...Alberto C. Vitari; Maria Deak; Nick A. Morrice; Dario R. Alessi Mutations in the human genes encoding WNK1 [with no K (lysine) protein kinase-1] and the related protein kinase WNK4 are the cause of Gordon's hypertension syndrome. Little is known about the molecular mechanism by which WNK isoforms...
Includes: Supplementary data
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Biochem J (2005) 390 (1): 293–302.
Published: 09 August 2005
...Stefano Ferrari; Oriano Marin; Mario A. Pagano; Flavio Meggio; Daniel Hess; Mahmoud El-Shemerly; Agnieszka Krystyniak; Lorenzo A. Pinna AurA (Aurora-A) is a ubiquitous protein kinase regulating entry into mitosis and shown to promote transformation upon overexpression. In order to gain information...
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Biochem J (2005) 389 (2): 389–395.
Published: 05 July 2005
...(3,4,5,6) P 4 1-kinase in Sf9 insect cells and purified the enzyme using Ni–agarose chromatography. Protein kinase activity was eluted from the Ni–agarose column, but this did not co-elute with the Ins(3,4,5,6) P 4 1-kinase, indicating that the protein kinase and inositol kinase activities belong...
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Biochem J (2005) 388 (2): 705–712.
Published: 24 May 2005
... Xenopus eggs. In the present study, we describe a human cell-free system that reproduces a DNA-dependent checkpoint pathway acting on the Chk1 protein kinase. In this system, double-stranded DNA oligonucleotides induce the phosphorylation of Chk1 at activating sites targeted by ATR [ATM (ataxia...
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Biochem J (2005) 385 (3): 695–702.
Published: 24 January 2005
...-activated protein kinase) signal-integrating kinases 1 and 2 respectively] that phosphorylate mammalian eIF4E. Mnk1 is activated by both mitogen- and stress-activated signalling pathways [ERK (extracellular-signal-regulated kinase) and p38 MAPK], whereas Mnk2 contains a MAPK-binding motif that is selective...
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Biochem J (2004) 379 (3): 697–702.
Published: 01 May 2004
...Jiang-Hong LIU; Zhi-Xin WANG Protein phosphorylation and limited proteolysis are two most common regulatory mechanisms involving the energy-dependent covalent modification of regulatory enzymes. In addition to modifying other proteins, many protein kinases and proteases catalyse automodification...
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