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1-32 of 32
Keywords: protein kinase A
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Articles
GPCR signaling via cAMP nanodomains
Open Access
Journal:
Biochemical Journal
Biochem J (2025) 482 (10): 519–533.
Published: 13 May 2025
... BY) . cAMP signaling compartmentalization GPCR phosphodiesterases protein kinase A Membrane receptors and their downstream signaling pathways are integral to the regulation of nearly all biological functions in multicellular organisms. Among these, G protein-coupled receptors (GPCRs) represent...
Articles
Journal:
Biochemical Journal
Biochem J (2025) 482 (10): 485–498.
Published: 13 May 2025
... scaffolds. A-Kinase anchoring proteins (AKAPs) are archetypal signal organizing proteins that compartmentalize protein kinase A (PKA) inside the cell. An amino-terminal docking and dimerization (d/d) domain on the regulatory subunit of the kinase binds with high affinity to an amphipathic helix on the AKAP...
Articles
Protein kinase A and local signaling in cancer
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2024) 481 (22): 1659–1677.
Published: 14 November 2024
...Kacey J. Rosenthal; John D. Gordan; John D. Scott Protein kinase A (PKA) is a basophilic kinase implicated in the modulation of many cell-signaling and physiological processes. PKA also contributes to cancer-relevant events such as growth factor action, cell cycle control, cell migration and tumor...
Articles
Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI
Available to PurchaseIn Collection
Cell signaling in the 21st century
Mitchell H. Omar, Maryanne Kihiu, Dominic P. Byrne, Kyung-Soon Lee, Tyler M. Lakey, Erik Butcher, Patrick A. Eyers, John D. Scott
Journal:
Biochemical Journal
Biochem J (2023) 480 (12): 875–890.
Published: 22 June 2023
... mutations within the PRKACA gene that drive adrenal Cushing's syndrome. These mutations promote perturbations in the catalytic core of protein kinase A (PKAc) that impair autoinhibition by regulatory subunits and compartmentalization via recruitment into AKAP signaling islands. PKAc L205R is found in ∼45...
Articles
Allosteric pluripotency: challenges and opportunities
Available to PurchaseMadoka Akimoto, Karla Martinez Pomier, Bryan VanSchouwen, Jung Ah Byun, Mariia Khamina, Giuseppe Melacini
Journal:
Biochemical Journal
Biochem J (2022) 479 (7): 825–838.
Published: 11 April 2022
... pluripotency as observed in the prototypical Protein Kinase A (PKA) as well as in other signaling systems, from typical multidomain signaling proteins to bacterial enzymes. We identify key drivers of pluripotent allostery and illustrate how hypothesizing allosteric pluripotency may solve apparent discrepancies...
Articles
Kinase-anchoring proteins in ciliary signal transduction
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2021) 478 (8): 1617–1629.
Published: 28 April 2021
... of the Biochemical Society 2021 AKAP cilia protein kinase A A traditional view of cellular regulation posits that enzymes are entities that act in isolation [ 1 ]. However, informed by recent advances, we now appreciate that macromolecular complexes function as units in a remarkably crowded...
Articles
Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495
Available to PurchaseKatrin Spengler, Darya Zibrova, Angela Woods, Christopher G. Langendorf, John W. Scott, David Carling, Regine Heller
Journal:
Biochemical Journal
Biochem J (2020) 477 (17): 3453–3469.
Published: 17 September 2020
...Katrin Spengler; Darya Zibrova; Angela Woods; Christopher G. Langendorf; John W. Scott; David Carling; Regine Heller Activation of AMP-activated protein kinase (AMPK) in endothelial cells by vascular endothelial growth factor (VEGF) via the Ca 2+ /calmodulin-dependent protein kinase kinase 2...
Includes: Supplementary data
Articles
Adenylate control in cAMP signaling: implications for adaptation in signalosomes
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2020) 477 (16): 2981–2998.
Published: 21 August 2020
...Nikhil K. Tulsian; Abhijeet Ghode; Ganesh S. Anand In cAMP-Protein Kinase A (PKA) signaling, A-kinase anchoring protein scaffolds assemble PKA in close proximity to phosphodiesterases (PDE), kinase-substrates to form signaling islands or ‘signalosomes’. In its basal state, inactive PKA holoenzyme...
Includes: Supplementary data
Articles
Ufd1 phosphorylation at serine 229 negatively regulates endoplasmic reticulum-associated degradation by inhibiting the interaction of Ufd1 with VCP
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2019) 476 (18): 2561–2577.
Published: 20 September 2019
... and in vivo by cyclic adenosine monophosphate-dependent protein kinase A (PKA), with this process being enhanced by either forskolin (an adenylyl cyclase activator) or calyculin A (a protein phosphatase inhibitor). Moreover, a phosphomimetic mutant (S229D) of Ufd1 as well as treatment by forskolin, calyculin...
Articles
PKA-site phosphorylation of importin13 regulates its subcellular localization and nuclear transport function
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2018) 475 (16): 2699–2712.
Published: 31 August 2018
... to undergo phosphorylation, but the impact of this on function has not been investigated. Here, we show for the first time that IPO13 is phosphorylated by cAMP-dependent protein kinase A specifically at serine 193. Results from fluorescence recovery after photobleaching and fluorescence loss...
Articles
Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity
Available to PurchaseRobin Lorenz, Eui-Whan Moon, Jeong Joo Kim, Sven H. Schmidt, Banumathi Sankaran, Ioannis V. Pavlidis, Choel Kim, Friedrich W. Herberg
Journal:
Biochemical Journal
Biochem J (2017) 474 (14): 2389–2403.
Published: 06 July 2017
...′-cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) and the 3′,5′-cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG), are preferentially activated by cAMP and cGMP, respectively. However, the molecular basis of this cyclic nucleotide selectivity is still not fully...
Includes: Supplementary data
Articles
Dominic P. Byrne, Matthias Vonderach, Samantha Ferries, Philip J. Brownridge, Claire E. Eyers, Patrick A. Eyers
Journal:
Biochemical Journal
Biochem J (2016) 473 (19): 3159–3175.
Published: 27 September 2016
...Dominic P. Byrne; Matthias Vonderach; Samantha Ferries; Philip J. Brownridge; Claire E. Eyers; Patrick A. Eyers cAMP-dependent protein kinase (PKA) is an archetypal biological signaling module and a model for understanding the regulation of protein kinases. In the present study, we combine...
Includes: Supplementary data
Articles
AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA
Available to PurchaseFrank Götz, Yvette Roske, Maike Svenja Schulz, Karolin Autenrieth, Daniela Bertinetti, Katja Faelber, Kerstin Zühlke, Annika Kreuchwig, Eileen J. Kennedy, Gerd Krause, Oliver Daumke, Friedrich W. Herberg, Udo Heinemann, Enno Klussmann
Journal:
Biochemical Journal
Biochem J (2016) 473 (13): 1881–1894.
Published: 28 June 2016
... with the dimerization/docking (D/D) domains of regulatory subunits of the ubiquitous protein kinase A (PKA). AKAPs tether PKA to defined cellular compartments establishing distinct pools to increase the specificity of PKA signalling. Here, we elucidated the structure of an extended PKA-binding domain of AKAP18β bound...
Includes: Supplementary data
Articles
Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response
Available to PurchaseTung O. Chan, Jin Zhang, Brian C. Tiegs, Brian Blumhof, Linda Yan, Nikhil Keny, Morgan Penny, Xue Li, John M. Pascal, Roger S. Armen, Ulrich Rodeck, Raymond B. Penn
Journal:
Biochemical Journal
Biochem J (2015) 471 (1): 37–51.
Published: 21 September 2015
...Tung O. Chan; Jin Zhang; Brian C. Tiegs; Brian Blumhof; Linda Yan; Nikhil Keny; Morgan Penny; Xue Li; John M. Pascal; Roger S. Armen; Ulrich Rodeck; Raymond B. Penn The Akt protein kinase, also known as protein kinase B, plays key roles in insulin receptor signalling and regulates cell growth...
Includes: Supplementary data
Articles
Mutational analysis of putative phosphate- and proton-binding sites in the Saccharomyces cerevisiae Pho84 phosphate:H + transceptor and its effect on signalling to the PKA and PHO pathways
Available to PurchaseDieter R. Samyn, Lorena Ruiz-Pávon, Michael R. Andersson, Yulia Popova, Johan M. Thevelein, Bengt L. Persson
Journal:
Biochemical Journal
Biochem J (2012) 445 (3): 413–422.
Published: 13 July 2012
... of the PKA (protein kinase A) pathway. These two features led to recognition of Pho84 as a transceptor. Although the physiological role of Pho84 has been studied in depth, the mechanisms underlying the transport and sensor functions are unclear. To obtain more insight into the structure–function...
Includes: Supplementary data
Articles
Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding
Available to PurchaseIngeborg Winge, Jeffrey A. Mckinney, Ming Ying, Clive S. D'Santos, Rune Kleppe, Per M. Knappskog, Jan Haavik
Journal:
Biochemical Journal
Biochem J (2008) 410 (1): 195–204.
Published: 29 January 2008
..., and TPH2, a neuronal form. In the present study human TPH2 was expressed in Escherichia coli and in HEK (human embryonic kidney)-293 cells and phosphorylated using several different mammalian protein kinases. TPH2 was rapidly phosphorylated to a stoichiometry of 2 mol of phosphate/mol of subunit by PKA...
Articles
Inhibition of Rac activation as a mechanism for negative regulation of actin cytoskeletal reorganization and cell motility by cAMP
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2005) 385 (3): 737–744.
Published: 24 January 2005
..., which induced a comparable extent of cAMP elevation as with 10 −8 M PGE 2 , and were potentiated by isobutylmethylxanthine. The protein kinase A inhibitor Rp isomer of adenosine 3′,5′-cyclic monophosphorothioate reduced PGE 2 inhibition of Rac activation and chemotaxis. These results indicate that EP2...
Articles
Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) γ2 gene expression in brown adipocytes: intracellular signalling and effects on PPARγ2 and PPARγ1 protein levels
Available to PurchaseEva M. LINDGREN, Ronni NIELSEN, Natasa PETROVIC, Anders JACOBSSON, Susanne MANDRUP, Barbara CANNON, Jan NEDERGAARD
Journal:
Biochemical Journal
Biochem J (2004) 382 (2): 597–606.
Published: 24 August 2004
... and differentiating cells, with a lagtime of 1 h and lasting up to 4 h, after which expression gradually recovered. The down-regulation was β-adrenoceptor-induced and intracellularly mediated via cAMP and protein kinase A; the signalling pathway did not involve phosphoinositide 3-kinase, Src, p38 mitogen-activated...
Includes: Supplementary data
Articles
AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 379 (1): 1–9.
Published: 01 April 2004
... protein kinases (including tyrosine kinases), protein phosphatases (e.g. calcineurin) and cytoskeletal elements with at least one member of the superfamily of GPCRs, the prototypical β 2 -adrenergic receptor. In this review, the multivalent interactions of AKAP250 with the cell membrane, receptor...
Articles
Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location
Available to PurchaseKonstantina NIKA, Huong HYUNH, Scott WILLIAMS, Surojit PAUL, Nunzio BOTTINI, Kjetil TASKÉN, Paul J. LOMBROSO, Tomas MUSTELIN
Journal:
Biochemical Journal
Biochem J (2004) 378 (2): 335–342.
Published: 01 March 2004
...Konstantina NIKA; Huong HYUNH; Scott WILLIAMS; Surojit PAUL; Nunzio BOTTINI; Kjetil TASKÉN; Paul J. LOMBROSO; Tomas MUSTELIN The HePTP (haematopoietic protein tyrosine phosphatase) is a negative regulator of the ERK2 (extracellular signal-regulated protein kinase 2) and p38 MAP kinases (mitogen...
Articles
Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 378 (1): 151–159.
Published: 15 February 2004
...L. Daniel HOWELL; Roy BORCHARDT; Jolanta KOLE; Andrew M. KAZ; Christoph RANDAK; Jonathan A. COHN Gating of the CFTR Cl − channel is associated with ATP hydrolysis at the nucleotide-binding domains (NBD1, NBD2) and requires PKA (protein kinase A) phosphorylation of the R domain. The manner in which...
Articles
Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain
Available to PurchaseSheraz YAQUB, Hilde ABRAHAMSEN, Bastian ZIMMERMAN, Natalya KHOLOD, Knut Martin TORGERSEN, Tomas MUSTELIN, Friedrich W. HERBERG, Kjetil TASKÉN, Torkel VANG
Journal:
Biochemical Journal
Biochem J (2003) 372 (1): 271–278.
Published: 15 May 2003
...Sheraz YAQUB; Hilde ABRAHAMSEN; Bastian ZIMMERMAN; Natalya KHOLOD; Knut Martin TORGERSEN; Tomas MUSTELIN; Friedrich W. HERBERG; Kjetil TASKÉN; Torkel VANG In the present study, we investigate the mechanism for the protein kinase A (PKA)-mediated activation of C-terminal Src kinase (Csk). Although...
Articles
Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2002) 364 (2): 343–347.
Published: 01 June 2002
... purified rat brain membrane or cytosolic proteins using recombinant hexahistidine-tagged (His 6 -)CSP. Western blotting of the CSP-binding proteins identified synaptotagmin I to be a putative binding partner. Furthermore, pull-down assays using cAMP-dependent protein kinase (PKA)-phosphorylated CSP...
Articles
Novel alternative splice variants of rat phosphodiesterase 7B showing unique tissue-specific expression and phosphorylation
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2002) 361 (2): 211–220.
Published: 08 January 2002
... spermatogenesis. The K m values of recombinant rat PDE7B1, PDE7B2 and PDE7B3 for cAMP were 0.05, 0.07 and 0.05 μ M respectively. Each rat PDE7B variant was the most sensitive to 3-isobutyl-1-methylxanthine (IC 50 1.5–2.1 μ M). Two phosphorylation sites for cAMP-dependent protein kinase (PKA) were found in rat...
Articles
Tight-junction protein zonula occludens 2 is a target of phosphorylation by protein kinase C
Available to PurchaseAntonia AVILA-FLORES, Erika RENDÓN-HUERTA, Jacqueline MORENO, Socorro ISLAS, Abigail BETANZOS, Martha ROBLES-FLORES, Lorenza GONZÁLEZ-MARISCAL
Journal:
Biochemical Journal
Biochem J (2001) 360 (2): 295–304.
Published: 26 November 2001
.... Here we study the interaction between ZO-2 and protein kinase C (PKC). We have constructed two ZO-2 fusion proteins of the middle (3PSG) and C-terminal (AP) regions of the molecule and demonstrate that they are phosphorylated by PKC isoenzymes β, ∊, λ and ∊. To understand the physiological significance...
Articles
Activation of phosphodiesterase 5 and inhibition of guanylate cyclase by cGMP-dependent protein kinase in smooth muscle
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2001) 360 (1): 199–208.
Published: 08 November 2001
...Karnam S. MURTHY The regulation of cGMP-specific phosphodiesterase (PDE) 5 and soluble guanylate cyclase (GC) by cGMP- and cAMP-dependent protein kinases (PKG and PKA respectively) was examined in gastric smooth muscle. The NO donor, sodium nitroprusside (SNP), stimulated PDE5 phosphorylation...
Articles
5-Aminolaevulinate synthase gene promoter contains two cAMP-response element (CRE)-like sites that confer positive and negative responsiveness to CRE-binding protein (CREB)
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2001) 353 (2): 307–316.
Published: 08 January 2001
... involved in the cAMP regulation of rat housekeeping ALAS gene expression. Thus we have examined the ALAS promoter for putative transcription-factor-binding sites that may regulate transcription in a cAMP-dependent protein kinase (PKA)-induced context. Applying both transient transfection assays...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 347 (2): 571–578.
Published: 10 April 2000
... which was attenuated by both wortmannin and rapamycin. It is proposed that the PDE4A4 isoform is involved in compartmentalized cAMP signalling responses in U937 monocytes. interferon-γ lipopolysaccharide phosphoinositide 3-kinase protein kinase A rapamycin Biochem. J. (2000) 347, 571 578...
Articles
Down-regulation of cyclic-nucleotide phosphodiesterase 3B in 3T3-L1 adipocytes induced by tumour necrosis factor α and cAMP
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2000) 346 (2): 337–343.
Published: 22 February 2000
... days after the initiation of differentiation of 3T3-L1 preadipocytes. Treatment of 3T3-L1 adipocytes with 10 ng/ml TNF-α for 24 h produced a maximal (50%) decrease in PDE3B activity, protein and mRNA, which was well correlated with both activation of protein kinase A (PKA) and stimulation of lipolysis...
Articles
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase promoter contains a CREB binding site that regulates cAMP action in Caco-2 cells
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2000) 345 (2): 201–206.
Published: 10 January 2000
..., containing the CRE element of the mit.HMG-CoA synthase promoter fused to the gene for chloramphenicol acetyltransferase, with protein kinase A and a dominant-negative mutant of cAMP-response-element-binding protein (CREB) show that the response to cAMP is mediated by the transcription factor CREB. The CRE...
Articles
Distinct signalling pathways mediate the cAMP response element (CRE)-dependent activation of the calcitonin gene-related peptide gene promoter by cAMP and nerve growth factor
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2000) 345 (2): 233–238.
Published: 10 January 2000
... in the signalling pathways which are required for each stimulus to activate the CGRP promoter. Thus whilst cAMP-mediated activation requires the protein kinase A pathway, NGF-mediated stimulation requires the Ras/Raf mitogen-activated protein kinase kinase-1 (MEK-1)/p42/p44 mitogen-activated protein kinase (MAPK...
Articles
Regulation of protein-synthesis elongation-factor-2 kinase by cAMP in adipocytes
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1998) 336 (3): 525–529.
Published: 15 December 1998
... 10 1998 The Biochemical Society, London © 1998 1998 insulin protein kinase A protein phosphorylation translation Biochem. J. (1998) 336, 525 529 (Printed in Great Britain) 525 RESEARCH COMMUNICATION Regulation of protein-synthesis elongation-factor-2 kinase by cAMP in adipocytes...
