... with increased β-catenin activity. cancer β-catenin glucagon H89 niclosamide protein kinase A (PKA) Type 2 diabetes 1 To whom correspondence should be addressed (email [email protected] ). 10 11 2015 9 3 2016 10 3 2016 10 3 2016 © 2016 The Author(s). published...

... (CBP) CREB-regulated transcription co-activator 2 (CRTC2) CRTC3 mitogen- and stress-activated kinase 1 (MSK1) p300 protein kinase A (PKA) The induction of IE (immediate early) genes plays an important role in the cellular response to many signals. CREB (cAMP-response-element-binding...

.... Friedl S. Drewianka S. Lorenz D. Goncalves A. Furkert J. Vargas C. Schmieder P. Gotz F. Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes J. Biol. Chem. 2011 286 9079...

...) phosphorylation protein kinase A (PKA) Hsp90 (heat-shock protein 90) is a critical intracellular molecular chaperone and is essential for the viability of eukaryotic cells [ 1 ]. Cytoplasmic Hsp90 belongs to the Hsp family and is one of the most abundantly expressed proteins with diverse functions...

... Biochemical Society 2011 Aurora kinase chimaera JNJ-7706621 protein kinase A (PKA) VX-680 Protein phosphorylation is essential to intracellular signal transduction pathways, and more than 500 human protein kinases that carry out the phosphotransfer reactions are ubiquitous, essential...

...-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. alkaline stress gene expression Msn2 Msn4 protein kinase A (PKA) Saccharomyces cerevisiae transcription factor Yeast cells (the strains are listed in Table 1 ) were grown at 28 °C...

... or [email protected] ). kinase peptide array phosphoproteome protein kinase A (PKA) Protein kinases regulate all aspects of cellular behaviour. These key signal transduction enzymes act by phosphorylating target sequences in substrates. This results in modulation of protein function or stability...

... receptor (PR) Ras protein kinase A (PKA) PLD (phospholipase D) has been proposed to play a role in cell differentiation; for example, regulated transcription of PLD1 and/or PLD2 has been observed in C6 glioma cells [ 1 ], and sustained activation of PLD has been reported during...

... XAP2) cAMP-specific phosphodiesterase-4 (PDE4) disrupted in schizophrenia 1 (DISC1) mitogen-activated protein kinase-activated protein kinase 2 (MK2 also called MAPKAPK2) protein kinase A (PKA) tumour necrosis factor α (TNFα) MAPKs (mitogen-activated protein kinases) provide...

... phosphoprotein 50 (EBP50) immunomodulation peptide disruption protein kinase A (PKA) T-cell receptor (TCR) cAMP is an ubiquitous second messenger that mediates signal cues from a multitude of G-protein-coupled receptors and acts through effector molecules, such as type I and type II PKA (protein...

... blotting and immunoprecipitation experiments. Other materials were obtained as indicated, and were of the highest grade available. adipocyte β 3 -adrenergic receptor caveolin-1 insulin protein kinase A (PKA) phosphodiesterase 3 (PDE3) All animals were handled in strict accordance...

... 2009 A-kinase anchoring protein (AKAP) cAMP C-terminal Src kinase (Csk) interleukin-2 (IL-2) protein kinase A (PKA) T-cell activation PKA (protein kinase A or cAMP-dependent protein kinase) has a broad array of substrates and relies on subcellular localization to maintain fidelity...

... significant. ATPase chloride channel cystic fibrosis (CF) nucleotide-binding domain (NBD) protein kinase A (PKA) vesicle flux assay CF (cystic fibrosis), a disease that affects multiple organs including the respiratory, gastrointestinal, pancreatic and reproductive tract, is caused...

... into the regulation of NF-κB-dependent inflammatory responses by TGF-β signalling. inflammatory response nuclear factor-κB (NF-κB) protein kinase A (PKA) RelA acetylation transforming growth factor-β1 (TGF-β1) tumour necrosis factor-α (TNF-α) HeLa (human cervix epithelial) and A549 (human lung...

... The Authors Journal compilation © 2008 Biochemical Society 2008 adenylate kinase ATPase ATP-binding cassette (ABC) superfamily chloride electrodiffusion nucleotide binding domain (NBD) protein kinase A (PKA) The CFTR [CF (cystic fibrosis) transmembrane conductance regulator] is a member...

... 2007 30 10 2007 30 10 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 cryo-electron microscopy 12.6 kDa FK506-binding protein (FKBP12.6) green fluorescent protein (GFP) protein kinase A (PKA) ryanodine receptor type 2 (RyR2) HF (heart failure...

... for MCOLN1 in different cellular processes, including regulation of lysosomal acidification [ 18 ], autophagy of mitochondria [ 22 ] and lysosomal secretion [ 23 ]. lysosome mucolipin 1 (MCOLN1) mucolipidosis IV (MLIV) protein kinase A (PKA) transient receptor potential (TRP) One way to gain...

... assembly hepatitis B virus (HBV) phosphorylation protein kinase A (PKA) Human HBV (hepatitis B virus) is a member of the Hepadnaviridae family and has infected over two billion people worldwide [ 1 ]. Acute infections can result in serious illness, and chronic HBV infection causes liver diseases...

... 3 2005 13 3 2006 The Biochemical Society, London 2006 calcium heart failure (HF) protein kinase A (PKA) ryanodine receptor phosphorylation (RyR phosphorylation) sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase (SERCA) sarcoplasmic reticulum Xiao et al. [ 1 ] show...

..., London 2006 phosphorylation protein kinase A (PKA) pyruvate kinase 1 (Pyk1) substrate specificity yeast kinetics The intracellular transduction of signals from the plasma membrane to cellular compartments evokes a variety of physiological responses. Protein phosphorylation is one...

... Society, London 2006 heart failure (HF) β-adrenergic stimulation protein kinase A (PKA) ryanodine receptor (RyR) phosphorylation phospho-specific antibodies Mouse cardiac myocytes were isolated and cultured as described previously [ 22 ]. In some experiments, cultured mouse cardiac myocytes...

... of the young 1 (MODY1) pancreatic β-cell phosphorylation protein kinase A (PKA) 1 To whom correspondence should be addressed (email [email protected] ). 23 3 2004 10 6 2004 5 7 2004 5 7 2004 HNF4α (hepatocyte nuclear factor 4α) is a nuclear receptor (NR2A1...

... dynamics may differ from the broad cytosol. Currently evolving methodologies are beginning to reveal cAMP fluctuations in these various compartments. Key words: adenylyl cyclase, calcium, cAMP, G-protein, protein kinase A (PKA), raft. INTRODUCTION The ubiquity of cAMP signalling in nature is associated...

...-interacting protein 2) binding. Key words: Caco-2/TC7, fructose, glucose, intestine, protein kinase A (PKA), SLC2A5. INTRODUCTION Intestinal fructose absorption at the brush-border membrane involves GLUT5 transporter activity. GLUT5 (encoded by the SLC2A5 gene), a member of the facilitative sugar transporter...

... The Biochemical Society, London ©2003 2003 phosphoinositide 3-kinase phosphoinositide-dependent kinase-1 (PDK-1) phosphorylation motif protein kinase A (PKA) protein kinase B (PKB)/Akt protein kinase C (PKC) Abbreviations used: PDK-1, phosphoinositide-dependent kinase-1; PH, pleckstrin...