... MAP kinase protein kinase B This article “Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155” (DOI: 10.1042/BCJ3490547 ) is being retracted from the Biochemical Journal at the request of the authors following receipt of a notification...

... factor kappaB p21-activated kinases protein kinase B The development of targeted therapies has changed the face of cancer therapeutics and allowed for a more personalised approach to treatment based on the molecular basis of an individual's tumour. One of the kinases identified as a ‘druggable...

... play more extended roles in nutrient regulation. The Gap1 amino acid, Mep2 ammonium, Pho84 phosphate and Sul1 sulfate transceptors physically interact in vitro and in vivo with the PKA-related Sch9 protein kinase, the yeast homolog of mammalian S6 protein kinase and protein kinase B. Sch9...

... protein kinase B Ras One of the most rapid and dramatic effects of growth factors on responsive cells is to stimulate their actin cytoskeleton into a brief period of ruffling and macropinocytosis [ 1 ]. This can be mimicked with oncogenic Ras [ 2 ] and blocked by phosphoinositide 3-kinase (PI3K...

... ) * These authors contributed equally to this work. 4 1 2017 16 6 2017 28 6 2017 30 6 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 14-3-3 proteins β-catenin protein kinase B pVHL β-Catenin, a major component...

... regulatory mechanism for this family of mitogen-activated protein kinases. The serine/threonine protein kinase Akt (also known as protein kinase B or PKB) is a member of the AGC family of protein kinases, conserved from primitive metazoans to humans. Akt is involved in the regulation of many different...

... regulation. SERT has been implicated in mood disorders. SERT is a primary target for antidepressants used in the therapeutic intervention of psychiatric disorders. antidepressants monoamine transporters phosphorylation protein kinase B trafficking uptake The serotonin [5-HT (5...

...Pascale G. RIBAUX; Patrick B. IYNEDJIAN Previous work showed that acute stimulation of a conditionally active protein kinase B (PKB or cAKT) was sufficient to elicit insulin-like induction of GCK (glucokinase) and SREBP1 (sterol regulatory element-binding protein 1) in hepatocytes [Iynedjian, Roth...

... blocked by rapamycin. p39 in extracts of unstimulated, nutrient-fed cells, but not nutrient-starved cells, was able to bind to 14-3-3s after phosphorylation by protein kinase B (PKB) in vitro . Nutrient starvation did not affect the growth factor-stimulated activation of PKB in vivo . Either cycloheximide...

.... This effect is accompanied by a decrease in the insulin-induced activation of mammalian target of rapamycin (mTOR)-dependent signalling. However, insulin-induced phosphorylation and regulation of protein kinase B, glycogen synthase kinase-3 and FKHR (forkhead in rhabdomyosarcoma) are not affected by H 2 O 2...

.... Changes in SPT activity paralleled changes in ceramide levels. Pharmacological inhibition of ceramide synthesis de novo also prevented the stimulation of extracellular-signal-regulated kinase and the inhibition of protein kinase B triggered by cannabinoids. These findings show that de novo -synthesized...

...]. The activation of PI 3- kinase leads via 3-phosphoinositide-dependent kinase 1 to the stimulation of protein kinase B (PKB) [6,7]. PKB is partially responsible for the regulation of G6Pase gene transcription by insulin [5]. PKB regulates G6Pase gene transcription by the insulin-response unit (IRU) within...

... apoptosis and inhibiting cell-cycle progression and cell motility. We show that very little cellular PTEN is associated with the plasma membrane, but that artificial membrane-targeting of PTEN enhances its inhibition of signalling to protein kinase B (PKB). Evidence for potential targeting of PTEN...

... by survival factors. These signals trigger the protein kinase B (PKB)-catalysed phosphorylation of FKHR at three residues (Thr 24 , Ser 256 and Ser 319 ) by a phosphoinositide 3-kinase-dependent pathway that results in the nuclear exit and inactivation of this transcription factor. Here, we have identified...

...Graham RENA; Alan R. PRESCOTT; Shaodong GUO; Philip COHEN; Terry G. UNTERMAN The transcription factor, forkhead in rhabdomyosarcoma (FKHR), is phosphorylated at three amino acid residues (Thr-24, Ser-256 and Ser-319) by protein kinase B (PKB)α. In the present study, mutagenesis has been used...

... several PI-3K-dependent events, including insulin-stimulated glucose uptake and growth-factor-stimulated cell survival. Here we show that ceramide analogues specifically prevent the recruitment of the PtdIns(3,4,5) P 3 -binding proteins Akt/protein kinase B (PKB) or the general receptor...

... on transient activation of phosphoinositide 3-kinase (PI 3-K). In addition, DGK activity co-immunoprecipitated with protein kinase B, a downstream effector of PI 3-K, and was increased greatly by NA stimulation. The rapid and agonist-specific activation of DGKθ suggests that this pathway may have...

... findings suggest that Akt activation occurs as an acute response to peroxynitrite treatment and could play an important role in influencing cell survival and}or alter the cellular response to other growth regulatory signals. Key words: oxidative stress, signal transduction, protein kinase B. implying...

.... In this short review, the current state of this rapidly expanding field is discussed. 1 To whom correspondence should be addressed (e-mail [email protected] ). The Biochemical Society, London © 2000 2000 autophagy insulin phosphatidylinositol 3-kinase protein kinase B S6 Biochem. J...

..., 70 kDa ribosomal protein S6 kinase ; PDK1 and PDK2, phosphoinositide-dependent kinases 1 and 2; PKB, protein kinase B; mTOR, mammalian target of rapamycin ; TOP, terminal oligopyrimidine. 1 To whom correspondence should be addressed (e-mail jjefferson!psu.edu). eIF4E-binding protein 1 (4E-BP1), which...

... at this site, leading to its own activation. 1 To whom correspondence should be addressed ( [email protected] ). 12 5 1999 22 6 1999 30 6 1999 The Biochemical Society, London © 1999 1999 insulin mass spectrometry protein kinase B signal transduction Biochem. J...

...Takayasu KOBAYASHI; Philip COHEN The PtdIns(3,4,5) P 3 -dependent activation of protein kinase B (PKB) by 3-phosphoinositide-dependent protein kinases-1 and -2 (PDK1 and PDK2 respectively) is a key event in mediating the effects of signals that activate PtdIns 3-kinase. The catalytic domain...

... contributed equally to this work. 7 9 1998 3 11 1998 16 11 1998 The Biochemical Society, London © 1999 1999 lipid binding protein kinase B signal transduction surface plasmon resonance Biochem. J. (1999) 337, 575 583 (Printed in Great Britain) 575 Role...