... homologue deleted on chromosome 10 (PTEN) phosphoinositide 3-kinase (PI3K) protein kinase B (PKB) S6 kinase (S6K) The authors would like to retract their article “Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B” (DOI: 10.1042/bj20030577...

... ]. Similar to PKB, AMPK phosphorylates AS160 and TBC1D1, thereby promoting GLUT4 translocation [ 3 , 23 – 25 ]. AMP-activated protein kinase (AMPK) contraction glucose uptake insulin protein kinase B (PKB) PtdIns(3,5) P 2 Skeletal muscle is the main tissue responsible for glucose disposal...

... The Authors Journal compilation © 2013 Biochemical Society 2013 AGC kinase Akt cancer protein kinase protein kinase B (PKB) resistance serum- and glucocorticoid-regulated kinase (SGK) signalling therapy Activation of the PI3K (phosphoinositide 3-kinase) pathway is one of the most common...

... of nuclear factor κB kinase β (IKKβ) insulin phosphoinositide 3-kinase (PI3K) protein kinase B (PKB) Acute [ 3 H]2-deoxyglucose uptake was determined as described previously [ 16 ]. In brief, serum-starved 3T3-L1 adipocytes and WT and Ikk β −/− MEFs were incubated in glucose-free DMEM for 1 h...

... Society 2011 cancer mammalian target of rapamycin (mTOR) nucleotide pocket protein kinase B (PKB) protein kinase C (PKC) Sin1 Over recent years, the TOR (target of rapamycin) pathway has emerged as one of the key regulators of cell growth, providing a nexus for the integration of growth...

... in inflammatory signalling. glucose transport insulin insulin resistance fatty acid nuclear factor κB (NF-κB) protein kinase B (PKB) 1 To whom correspondence should be addressed (email [email protected] ). 17 9 2010 25 1 2011 17 2 2011 17 2 2011 © The Authors...

[email protected] ). 19 7 2010 5 8 2010 5 8 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 glycolysis protein kinase B (PKB) 6-phosphofructo-2-kinase (PFK-2) serum- and glucocorticoid-induced protein kinase 3 (SGK3) small interfering RNA (siRNA...

... atmosphere of 95% air/5% CO 2 (v/v) at 37 °C. endothelial nitric oxide synthase (eNOS) endothelium insulin nitric oxide phosphorylation protein kinase B (PKB) signalling Type 2 diabetes is associated with a greatly increased risk of atherosclerosis, yet the molecular mechanisms...

... 2009 extracellular-signal-regulated kinase (ERK) human muscle insulin resistance insulin signalling polycystic ovary syndrome (PCOS) protein kinase B (PKB) 1 Present address: Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, U.K. 2...

... palmitate protein kinase B (PKB) protein kinase C (PKC) A short RNA sequence (5′-GGAGCGTTCTGATCTTACA-3′) complimentary to the LCB1 subunit of SPT, was chosen from sequences obtained from web tools on the Dharmacon ( http://www.dharmacon.com ), Promega ( http://www.dharmacon.com ) and Eurogentic...

... (PDK1) phosphoinositide 3-kinase (PI3K) protein kinase B (PKB) It is well known that investigations of the pathways that are regulated following activation of the PI3K (phosphoinositide 3-kinase) family of enzymes has been one of the most intensively studied set of signalling events...

... compilation © 2008 Biochemical Society 2008 breast cancer genetic alteration phosphoinositide 3-kinase inhibitor (PI3K inhibitor) phosphorylation protein kinase B (PKB) S6 Historically, the availability of p110 inhibitors has been largely limited to a single natural product, wortmannin...

... that TBC1D1 and AS160 may have complementary roles in regulating vesicle trafficking in response to insulin and AMPK-activating stimuli in skeletal muscle. 14-3-3 Akt substrate of 160 kDa (AS160) AMP-activated protein kinase (AMPK) metformin obesity protein kinase B (PKB) TBC1D1 1 To whom...

... Nur77 phosphorylation protein kinase B (PKB) ribosomal S6 kinase (RSK) Nur77, and also Nurr1 and Nor1, are able to bind as monomers to NBREs [NGF (nerve growth factor)-induced B factor response element) (AAAGGTCA) and as homodimers to NurREs (Nur response elements) (TGATATTTX6AAATGCCA) in DNA...

... and elucidation (KESTREL) mitogen-activated-protein-kinase-activated protein kinase-2 (MAPKAP-K2) protein kinase B (PKB) serum- and glucocorticoid-induced protein kinase (SGK) Fifty years after the discovery of the first protein kinase–substrate relationship, namely the activation of glycogen...

... (PI3K) protein kinase B (PKB) PTEN Saccharomyces cerevisiae The Sacch. cerevisiae strains used in the present study are listed in Table 1 . Escherichia coli DH5α F′[K12Δ( lacZYA-argF )U169 deoR supE44 thi-1 recA1 endA1 hsdR17 gyrA96 relA1 (φ 80lacZ Δ M15 )F′] was used for routine...

...-regulated heat-stable protein of 24 kDa (CRHSP24) kinase substrate tracking and elucidation (KESTREL) protein kinase B (PKB) p90 ribosomal S6 kinase (RSK) PKB isoforms are members of the AGC subfamily of protein kinases that also include isoforms of SGK (serum- and glucocorticoid-induced protein...

... reproducible activation properties. 2 7 2004 22 9 2004 29 9 2004 29 9 2004 The Biochemical Society, London 2005 Akt allosteric inhibitor inhibitor kinase pleckstrin homology domain protein kinase B (PKB) Akt/PKB (protein kinase B) is a serine/threonine kinase...

... 10 2004 4 10 2004 The Biochemical Society, London 2004 cytoskeleton filamin kinase substrate tracking and elucidation (KESTREL) phosphorylation protein kinase B (PKB) Signals that activate PI 3-kinase (phosphoinositide 3-kinase) and elevate the intracellular...

... neurodegenerative disorder plant protein kinase B (PKB) Important clues came from the crystal structures (see the green structure in Figure 1 ), which showed that each 14-3-3 polypeptide contains nine helices, arranged to form an almost right-angled corner. Two 14-3-3 subunits associate strongly...

.... Description of the FoxO-shut- tling mechanism contributes to the understanding of FoxO fun- ction in relation to signalling and gene regulation. Key words: forkhead, 14-3-3 protein, insulin, protein kinase B (PKB), shuttling. INTRODUCTION Initial studies on FoxO (forkhead box O) factors were performed...

... correspondence should be addressed (e-mail [email protected] ). 3 3 2003 20 6 2003 7 7 2003 7 7 2003 The Biochemical Society, London ©2003 2003 apoptosis Bim extracellular-signal-related kinase (ERK) protease-activated receptor 1 (PAR1) protein kinase B (PKB) thrombin...

... on chromosome 10 (PTEN) phosphoinositide 3-kinase (PI3K) protein kinase B (PKB) S6 kinase (S6K) Abbreviations used: d, Drosophila ; dsRNAi, double-stranded RNA-mediated interference; MAPK, mitogen-activated protein kinase; mTOR, mammalian target of rapamycin; PDK1, 3-phosphoinositide-dependent...