... muscle, the contraction-induced increase in glucose uptake was reduced [ 20 – 22 ]. Similar to PKB, AMPK phosphorylates AS160 and TBC1D1, thereby promoting GLUT4 translocation [ 3 , 23 – 25 ]. AMP-activated protein kinase (AMPK) contraction glucose uptake insulin protein kinase B (PKB) PtdIns...

...-resistant/SGK1-dependent cell lines are sensitive to mTORC1/2 inhibition. It will be interesting to see whether these observations can be verified in clinical samples and in other cancer types than breast. AGC kinase Akt cancer protein kinase protein kinase B (PKB) resistance serum...

... phosphoinositide 3-kinase (PI3K) protein kinase B (PKB) Insulin resistance, which can be defined as a failure of insulin to regulate the metabolism of its target tissues [ 1 ], is a hallmark of obesity and is implicated in the development of Type 2 diabetes. The insulin signalling cascade consists...

... 4 2011 27 7 2011 1 8 2011 1 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cancer mammalian target of rapamycin (mTOR) nucleotide pocket protein kinase B (PKB) protein kinase C (PKC) Sin1 Sin1 proteins contain a number of distinct...

... in inflammatory signalling. 17 9 2010 25 1 2011 17 2 2011 17 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 glucose transport insulin insulin resistance fatty acid nuclear factor κB (NF-κB) protein kinase B (PKB) 1 To whom correspondence...

... compilation © 2010 Biochemical Society 2010 glycolysis protein kinase B (PKB) 6-phosphofructo-2-kinase (PFK-2) serum- and glucocorticoid-induced protein kinase 3 (SGK3) small interfering RNA (siRNA) PKB exists as three isoenzymes (PKBα, β and γ, also known as Akt1, 2 and 3 respectively...

... phosphorylation protein kinase B (PKB) signalling Type 2 diabetes is associated with a greatly increased risk of atherosclerosis, yet the molecular mechanisms that underlie this association remain poorly characterized. Endothelial dysfunction, characterized by reduced NO (nitric oxide) bioavailability...

... insulin resistance insulin signalling polycystic ovary syndrome (PCOS) protein kinase B (PKB) 1 Present address: Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, U.K. 2 To whom correspondence should be addressed (email c.d.sutherland...

... should be addressed (email [email protected] ). 5 6 2008 30 9 2008 16 10 2008 16 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 ceramide diacylglycerol insulin receptor substrate 1 (IRS1) myriocin palmitate protein kinase B (PKB...

...(3,4) P 2 levels, but more work will certainly be required to define the molecular events involved. apoptosis Bcl-2 nuclear factor κB (NF-κB) phosphoinositide-dependent kinase 1 (PDK1) phosphoinositide 3-kinase (PI3K) protein kinase B (PKB) It is well known that investigations...

... phosphoinositide 3-kinase inhibitor (PI3K inhibitor) phosphorylation protein kinase B (PKB) S6 We have generated and characterized a panel of the most potent reported inhibitors with respect to biochemical activity against 18 PI3Ks and protein kinases, as described previously [ 17 ]. With this set...

... substrate of 160 kDa (AS160) AMP-activated protein kinase (AMPK) metformin obesity protein kinase B (PKB) TBC1D1 Rabs are GTP-activated proteins that regulate the flow of vesicle traffic between organelles by interacting with effectors of vesicle formation, motility, docking and fusion [ 1...

... be addressed (email [email protected] ). 17 6 2005 28 9 2005 13 10 2005 13 10 2005 The Biochemical Society, London 2006 apoptosis nuclear orphan receptor Nur77 phosphorylation protein kinase B (PKB) ribosomal S6 kinase (RSK) Nuclear orphan receptors form...

... and elucidation (KESTREL) mitogen-activated-protein-kinase-activated protein kinase-2 (MAPKAP-K2) protein kinase B (PKB) serum- and glucocorticoid-induced protein kinase (SGK) Fifty years after the discovery of the first protein kinase–substrate relationship, namely the activation of glycogen...

... 2005 The Biochemical Society, London 2005 c-Akt phosphorylation phosphoinositide 3-kinase (PI3K) protein kinase B (PKB) PTEN Saccharomyces cerevisiae Generation of PIP 3 (phosphatidylinositol 3,4,5-trisphosphate) at the plasma membrane is key to the regulation of mammalian...

... substrate tracking and elucidation (KESTREL) protein kinase B (PKB) p90 ribosomal S6 kinase (RSK) Signals that activate PI3K (phosphoinositide 3-kinase) and elevate the intracellular concentration of PtdIns(3,4,5) P 3 trigger the activation of PKBα (protein kinase B), also called Akt, which...

... To whom correspondence should be addressed (email [email protected] ). 2 7 2004 22 9 2004 29 9 2004 29 9 2004 The Biochemical Society, London 2005 Akt allosteric inhibitor inhibitor kinase pleckstrin homology domain protein kinase B (PKB) Akt/PKB...

... a new physiological substrate for PKB. cytoskeleton filamin kinase substrate tracking and elucidation (KESTREL) phosphorylation protein kinase B (PKB) The Biochemical Society, London 2004 26 6 2004 24 9 2004 4 10 2004 4 10 2004 1 To whom correspondence...

... neurodegenerative disorder plant protein kinase B (PKB) Important clues came from the crystal structures (see the green structure in Figure 1 ), which showed that each 14-3-3 polypeptide contains nine helices, arranged to form an almost right-angled corner. Two 14-3-3 subunits associate strongly...

.... Description of the FoxO-shut- tling mechanism contributes to the understanding of FoxO fun- ction in relation to signalling and gene regulation. Key words: forkhead, 14-3-3 protein, insulin, protein kinase B (PKB), shuttling. INTRODUCTION Initial studies on FoxO (forkhead box O) factors were performed...

...) protease-activated receptor 1 (PAR1) protein kinase B (PKB) thrombin Abbreviations used: Ac-DEVD-AMC, N -acetyl-Asp-Glu-Val-Asp-7-amino-4-methylcoumarin; Bim, B cl-2- i nteracting m ediator of cell death; Bim S , Bim L and Bim EL , the short, long and extra-long splice variants off Bim...

... on chromosome 10 (PTEN) phosphoinositide 3-kinase (PI3K) protein kinase B (PKB) S6 kinase (S6K) Abbreviations used: d, Drosophila ; dsRNAi, double-stranded RNA-mediated interference; MAPK, mitogen-activated protein kinase; mTOR, mammalian target of rapamycin; PDK1, 3-phosphoinositide-dependent...