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Keywords: protein kinase C
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Articles
In Collection
Cell signaling in the 21st century
Journal:
Biochemical Journal
Biochem J (2023) 480 (24): 2037–2044.
Published: 15 December 2023
... of The Francis Crick Institute in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. apkc atypical pkc cell polarity phospholipids protein kinase c Atypical PKCs (aPKCs) are serine/threonine protein kinases...
Articles
In Collection
Cell signaling in the 21st century
Alexander C. Jones, Alexandr P. Kornev, Jui-Hung Weng, Gerard Manning, Susan S. Taylor, Alexandra C. Newton
Journal:
Biochemical Journal
Biochem J (2023) 480 (16): 1299–1316.
Published: 25 August 2023
...Alexander C. Jones; Alexandr P. Kornev; Jui-Hung Weng; Gerard Manning; Susan S. Taylor; Alexandra C. Newton Conventional protein kinase C (cPKC) isozymes tune the signaling output of cells, with loss-of-function somatic mutations associated with cancer and gain-of-function germline mutations...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2022) 479 (22): 2351–2364.
Published: 23 November 2022
... mice ( Flna fl /Y, termed control) but these effects were essentially abrogated in FLNA-null platelets (platelet-specific knockout). Protein kinase C (PKC), a known FLNA ligand, was also activated by ABT-737, and PKC's phosphorylation of its downstream substrates was attenuated in FLNA-null platelets...
Includes: Supplementary data
Articles
Asad U. Malik, Athanasios Karapetsas, Raja S. Nirujogi, Deep Chatterjee, Toan K. Phung, Melanie Wightman, Robert Gourlay, Nick Morrice, Sebastian Mathea, Stefan Knapp, Dario R. Alessi
Journal:
Biochemical Journal
Biochem J (2022) 479 (18): 1941–1965.
Published: 23 September 2022
..., is activated via a Protein Kinase C (PKC)-dependent mechanism. Here we demonstrate that phosphorylation and activation of LRRK1 in HEK293 cells is blocked by PKC inhibitors including LXS-196 (Darovasertib), a compound that has entered clinical trials. We show multiple PKC isoforms phosphorylate and activate...
Articles
Lisa Watson, Tanya N. Soliman, Khalil Davis, Joanna Kelly, Nicola Lockwood, Xiaoping Yang, Steven Lynham, John D. Scott, Victoria Crossland, Neil Q. McDonald, David J. Mann, Alan Armstrong, Ulrike Eggert, Peter J. Parker
Journal:
Biochemical Journal
Biochem J (2021) 478 (12): 2247–2263.
Published: 18 June 2021
... secondary antibody (GE Healthcare) and Luminata Classico ECL reagent (Millipore) and imaged using an ImageQuant LAS 4000 (GE) set to detect chemiluminescence. 14-3-3 abscission checkpoint aurora kinases midbody protein kinase C Checkpoints acting through the cell cycle serve as critical...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (2): 341–355.
Published: 27 January 2021
... reversibly releases the pseudosubstrate from the active site to allow substrate binding and downstream signalling. Protein kinase C (PKC) isozymes are members of the AGC family of Ser/Thr protein kinases. They are activated in response to extracellular signals and phosphorylate a wide variety...
Articles
In Collection
Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019
Journal:
Biochemical Journal
Biochem J (2019) 476 (8): 1205–1219.
Published: 18 April 2019
... to conventional and novel protein kinase C (PKC) enzymes, limiting local DAG availability in a tissue- and subcellular-restricted manner. Defects in the expression/activity of certain DGK isoforms contribute substantially to cognitive impairment and mental disorders. Abnormal DGK overexpression in tumors...
Articles
Helen R. Heathcote, Sarah J. Mancini, Anastasiya Strembitska, Kunzah Jamal, James A. Reihill, Timothy M. Palmer, Gwyn W. Gould, Ian P. Salt
Journal:
Biochemical Journal
Biochem J (2016) 473 (24): 4681–4697.
Published: 09 December 2016
... phosphorylation. In contrast, VEGF-stimulated AMPKα1 Ser487 phosphorylation was sensitive to inhibitors of protein kinase C (PKC) and PKC activation using phorbol esters or overexpression of PKC-stimulated AMPKα1 Ser487 phosphorylation. Purified PKC and Akt both phosphorylated AMPKα1 Ser487 in vitro with similar...
Includes: Supplementary data
Articles
Ghazi M. Rahman, Sreejesh Shanker, Nancy E. Lewin, Noemi Kedei, Colin S. Hill, B. V. Venkataram Prasad, Peter M. Blumberg, Joydip Das
Journal:
Biochemical Journal
Biochem J (2013) 451 (1): 33–44.
Published: 14 March 2013
...Ghazi M. Rahman; Sreejesh Shanker; Nancy E. Lewin; Noemi Kedei; Colin S. Hill; B. V. Venkataram Prasad; Peter M. Blumberg; Joydip Das PKC (protein kinase C) θ is predominantly expressed in T-cells and is critically involved in immunity. Design of PKCθ-selective molecules to manage autoimmune...
Includes: Supplementary data
Articles
John M. Redden, Andrew V. Le, Arpita Singh, Kyle Federkiewicz, Samantha Smith, Kimberly L. Dodge-Kafka
Journal:
Biochemical Journal
Biochem J (2012) 446 (2): 301–309.
Published: 14 August 2012
... (protein kinase C) and the scaffolding protein AKAP7 (A-kinase-anchoring protein 7). Using protein biochemistry and surface plasmon resonance approaches, we demonstrate that both AKAP7γ and AKAP7α are capable of high-affinity interactions with multiple isoenzymes of PKC. Furthermore, this interaction...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 424 (3): 419–429.
Published: 10 December 2009
... through the regulation of CaM (calmodulin)-mediated signalling. Ng presents a central IQ motif that mediates its binding to CaM and PA (phosphatidic acid) and that can be phosphorylated by PKC (protein kinase C). In the present manuscript, we report that Ng displays a strong nuclear localization when...
Includes: Supplementary data
Articles
James P. Madigan, Brian O. Bodemann, Donita C. Brady, Brian J. Dewar, Patricia J. Keller, Michael Leitges, Mark R. Philips, Anne J. Ridley, Channing J. Der, Adrienne D. Cox
Journal:
Biochemical Journal
Biochem J (2009) 424 (1): 153–161.
Published: 23 October 2009
... of expression and by post-translational modifications such as prenylation and phosphorylation. We show in the present study that, upon PKC (protein kinase C) agonist stimulation, Rnd3 undergoes an electrophoretic mobility shift and its subcellular localization becomes enriched at internal membranes...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 412 (3): 495–506.
Published: 28 May 2008
... prove that the action of PMA on GLYT2 involves PKC (protein kinase C)-dependent and -independent pathways, although an important fraction of the effects are PKC-mediated. We show the additional participation of signalling pathways triggered by the small GTPase Rac1 on PMA action. GLYT2 inhibition by PMA...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 405 (2): 331–340.
Published: 27 June 2007
...Hideyuki Takahashi; Hideo Namiki ATP-competitive inhibitors of PKC (protein kinase C) such as the bisindolylmaleimide GF 109203X, which interact with the ATP-binding site in the PKC molecule, have also been shown to affect several redistribution events of PKC. However, the reason why...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 404 (2): 299–308.
Published: 14 May 2007
... calcium negatively regulates ADP-induced ERK activation and thus reduces agonist-induced thromboxane generation in platelets. aggregation calcium mitogen-activated protein kinase (MAPK) protein kinase C Src family kinase Platelet activation is important for haemostasis and abnormal...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 390 (3): 729–735.
Published: 05 September 2005
... or the proapoptotic protein FADD (Fas-activated death domain protein) respectively. The mechanism by which binding of PEA-15 to these proteins is controlled has not been elucidated. PEA-15 is a phosphoprotein containing a Ser-104 phosphorylated by protein kinase C and a Ser-116 phosphorylated by CamKII (calcium...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 385 (3): 677–684.
Published: 24 January 2005
... with active phorbol esters. Action of phorbol esters was blocked by inhibitors of PKC (protein kinase C) and by its down-regulation. LPA 1 receptor phosphorylation was observed in response to phorbol esters. The effect was rapid ( t 1/2 ∼1 min), intense (2-fold) and sustained (at least 60 min). PKC inhibitors...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 382 (3): 957–966.
Published: 07 September 2004
... from the cytoplasm in PMA-treated cells. In the present study, we identified Ser-22 and Ser-26 within the PH domain as the PMA- and epidermal-growth-factor-dependent phosphorylation sites of DGKδ1. Experiments in vitro and with intact cells suggested that the cPKC (conventional protein kinase C...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 380 (3): 815–821.
Published: 15 June 2004
...-fold increase in receptor protein during 48 h, which was half-maximal at 1 nM and was slowly reversible after hormone withdrawal. Chlordiazepoxide, an inverse agonist, had no effect. TRH up-regulation was mimicked by phorbol ester and blocked by the protein kinase C inhibitor GF109203X in combination...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 379 (1): 1–9.
Published: 01 April 2004
... 10 2003 8 12 2003 9 1 2004 9 1 2004 The Biochemical Society, London ©2004 2004 A-kinase anchoring protein (AKAP) β-adrenergic receptor gravin multivalent signalling complex protein kinase A protein kinase C scaffold Abbreviations used: AKAP, A - k inase...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 378 (3): 1007–1014.
Published: 15 March 2004
... cytoplasmic domain directly binds to and activates PKC-α (protein kinase C-α) in vitro [Oh, Woods and Couchman (1997) J. Biol. Chem. 272 , 8133–8136]. However, whether syndecan-4 has the same activity in vivo needs to be addressed. Using mammalian two-hybrid assays, we showed that syndecan-4 interacted...
Articles
Marisa J. WAINSZELBAUM, María L. BELAUNZARÁN, Estela M. LAMMEL, Mónica FLORIN-CHRISTENSEN, Jorge FLORIN-CHRISTENSEN, Elvira L. D. ISOLA
Journal:
Biochemical Journal
Biochem J (2003) 375 (3): 705–712.
Published: 01 November 2003
... that reside with the free-fatty-acid fraction, especially oleic acid. These compounds stimulate de novo diacylglycerol formation and protein kinase C activity in the parasite. Moreover, metacyclogenesis is stimulated by phorbol esters and cell-permeant diacylglycerol, while protein kinase C down-regulation...
Articles
Lea-Yea CHUANG, Jinn-Yuh GUH, Shu-Fen LIU, Min-Yuan HUNG, Tung-Nan LIAO, Tai-An CHIANG, Jau-Shyang HUANG, Yu-Lun HUANG, Chi-Fong LIN, Yu-Lin YANG
Journal:
Biochemical Journal
Biochem J (2003) 375 (2): 385–393.
Published: 15 October 2003
...-tubule cells. 1 To whom correspondence should be addressed (e-mail [email protected] ). 7 4 2003 16 6 2003 4 7 2003 4 7 2003 The Biochemical Society, London ©2003 2003 diabetic nephropathy glucose isoforms protein kinase C signal transduction...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 373 (2): 603–611.
Published: 15 July 2003
...Lijun WANG; Mark ROLFE; Christopher G. PROUD The α 1 -adrenergic agonist, phenylephrine (PE), exerts hypertrophic effects in the myocardium and activates protein synthesis. Both Ca 2+ -dependent protein kinase C (PKC, PKCα) and Ca 2+ -independent PKC isoforms (PKCδ and ε) are detectably expressed...
Articles
Angie F. KIRWAN, Ashley C. BIBBY, Thierry MVILONGO, Heimo RIEDEL, Thomas BURKE, Sherri Z. MILLIS, Amadeo M. PARISSENTI
Journal:
Biochemical Journal
Biochem J (2003) 373 (2): 571–581.
Published: 15 July 2003
... ). 2 1 2003 4 4 2003 23 4 2003 23 4 2003 The Biochemical Society, London ©2003 2003 Abbreviations used: DAG, diacylglycerol; GST, glutathione S-transferase; PKC, protein kinase C; GST-Rα, regulatory domain of human PKCα fused to GST; mAb, monoclonal antibody...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 372 (3): 787–797.
Published: 15 June 2003
... (Saale), Germany (e-mail [email protected] ). 3 1 2003 7 2 2003 11 3 2003 11 3 2003 The Biochemical Society, London ©2003 2003 Ets protein protein kinase C parathyroid hormone-related protein phorbol ester mitogen-activated protein kinase...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 372 (1): 163–172.
Published: 15 May 2003
... and Jackson (2002) J. Biol. Chem. 277 , 2965–2972] suggests that outside-in signals from both receptors play important roles in regulating platelet-adhesion dynamics under flow. In the present study, we have examined the mechanisms utilized by protein kinase C (PKC) to promote irreversible platelet adhesion...
Articles
Charles S.T. HII, Maurizio COSTABILE, George C. MAYNE, Channing J. DER, Andrew W. MURRAY, Antonio FERRANTE
Journal:
Biochemical Journal
Biochem J (2003) 370 (2): 497–503.
Published: 01 March 2003
..., at least in part, for the phenotype of cord blood T cells. Biochem. J. (2003) 370, 497 503 (Printed in Great Britain) 497 Selective deficiency in protein kinase C isoenzyme expression and inadequacy in mitogen-activated protein kinase activation in cord blood T cells Charles S. T. HII*1, Maurizio COSTABILE...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 369 (3): 485–496.
Published: 01 February 2003
... correspondence should be addressed (e-mail [email protected] ). gelatinase A hypoxia MT1-MMP protein kinase C ventricular remodelling Biochem. J. (2003) 369, 485 496 (Printed in Great Britain) 485 A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 369 (1): 117–128.
Published: 01 January 2003
.... The increase in CPI17 phosphorylation was significantly diminished by Y27632, a Rho kinase inhibitor, and GF109203x, a protein kinase C inhibitor, suggesting that both the protein kinase C and Rho kinase pathways influence the change in CPI17 phosphorylation. On the other hand, a significant level of MBS...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 368 (2): 581–587.
Published: 01 December 2002
... thereafter, and concentration-dependent (EC 50 0.3pM). The phosphoinositide 3-kinase inhibitors wortmannin and LY294002, and the protein kinase C inhibitors staurosporine, Ro 318220 and bisindolylmaleimide, blocked the effect of this growth factor. α 1B -Adrenergic receptor phosphorylation was associated...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 368 (1): 1–15.
Published: 15 November 2002
... 2002 The Biochemical Society, London ©2002 2002 CASK integrin PDZ domain protein kinase C syntenin Abbreviations used: EGF, epidermal growth factor; GAP, GTPase-activating protein; GDI, guanine nucleotide dissociation inhibitor; GEF, guanine nucleotide exchange factor; FAK...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 368 (1): 223–232.
Published: 15 November 2002
...-25 phosphorylation at Ser 187 in response to secretagogues and stimulation of insulin release; (vi) use of protein kinase C (PKC) inhibitors suggests that glucose stimulates SNAP-25 phosphorylation via conventional and non-conventional PKC isoforms. In summary, although SNAP-25 phosphorylation at Ser...
Articles
G-protein-coupled receptors for neurotransmitter amino acids: C-terminal tails, crowded signalosomes
Journal:
Biochemical Journal
Biochem J (2002) 365 (2): 329–336.
Published: 15 July 2002
...-95/Dlg1/ZO-1 ; PICK1, protein interacting with C kinase 1; PKC, protein kinase C; PLC, phospholipase C; TM, transmembrane domain. 1 To whom correspondence should be addressed (e-mail neurochemie!mpih-frankfurt.mpg.de). tional (Ga and Gbc) signalling to downstream effector proteins. In addition...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 363 (1): 95–103.
Published: 22 March 2002
...Jan K. DAVIDSON-MONCADA; Guillermo LOPEZ-LLUCH; Anthony W. SEGAL; Lodewijk V. DEKKER Protein kinases involved in the activation of the NADPH oxidase by Fcγ receptors in neutrophils were studied. Of three different protein kinase C (PKC) inhibitors, Gö 6976 inhibited the NADPH oxidase completely...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 363 (1): 127–136.
Published: 22 March 2002
... A (PKA) and protein kinase C (PKC) synergistically induced the transactivating ability of hnRNP D, and the exon 2-encoded domain was sufficient for this inducibility. In kinase assays PKA phosphorylated Ser-87 of hnRNP D, whereas glycogen synthase kinase-3β (GSK-3β) phosphorylated Ser-83, but only if Ser...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 361 (3): 653–661.
Published: 25 January 2002
...) cells. C 2 -ceramide blocked the translocation of ADP-ribosylation factor-1 (ARF-1) and protein kinase C-α (PKC-α) to the membranes from CHO cells, but not those of MDCK cells. Consequently, C 2 -ceramide blocked the stimulation of phospholipase D1 (PLD1) by the cytosol and guanosine 5′-[γ-thio...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 359 (3): 465–484.
Published: 25 October 2001
... and psychiatric disorders. 1 To whom correspondence should be addressed (e-mail [email protected] ). 2 e-mail [email protected] The Biochemical Society, London ©2001 2001 Homer proteins protein kinase C receptor desensitization receptor phosphorylation signal transduction...
Articles
Sukumar SARKAR, Noriko MIWA, Hiroaki KOMINAMI, Nobuaki IGARASHI, Shun HAYASHI, Taro OKADA, Saleem JAHANGEER, Shun-ichi NAKAMURA
Journal:
Biochemical Journal
Biochem J (2001) 359 (3): 599–604.
Published: 25 October 2001
... investigated the regulation of PLD2 by G M2 activator and various other regulators including ARF. PLD2 was potently stimulated in vitro by G M2 activator in a time- and dose-dependent manner. Neither ARF nor protein kinase C caused any significant changes in PLD2 activity. Importantly, PLD2 responsiveness...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 359 (1): 89–97.
Published: 24 September 2001
... demonstrate that CTGF is internalized from the cell surface in endosomes and accumulates in a juxtanuclear organelle from which the growth factor is then translocated into the cytosol. In the cytosol CTGF is phosphorylated by protein kinase C and PMA treatment can enhance this phosphorylation. Phosphorylated...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 358 (3): 717–726.
Published: 10 September 2001
...: (i) was mimicked by another membrane-permeant diacylglycerol analogue, 1,2-dioctanoyl- sn -glycerol, but not by the membrane-impermeant analogue 1-stearoyl-2-arachidonyl- sn -glycerol; (ii) was not blocked by staurosporin or chelerythrine, inhibitors of protein kinase C; (iii) was enhanced...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 358 (3): 637–646.
Published: 10 September 2001
...-100, contain caveolin-1 and protein kinase C isoforms. The LPP3 isoform was predominantly localized to rat lung CEDs. These lipid-rich domains, including those from isolated rat type II cells, were enriched both in phosphatidylcholine plus sphingomyelin (PC+SM) and cholesterol. Saponin treatment...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 357 (1): 275–282.
Published: 25 June 2001
...Xiangnan DU; Ying JIANG; Weijun QIAN; Xiaolan LU; James P. WALSH We have previously shown that unsaturated fatty acids amplify platelet-derived-growth-factor (PDGF)-induced protein kinase C (PKC) activation in vascular smooth-muscle cells (VSMCs). Diacylglycerol-induced PKC activation is normally...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 355 (3): 691–697.
Published: 24 April 2001
... tyrosine-phosphorylated, in a manner dependent on integrin αIIbβ3-mediated aggregation. In addition, direct activation of protein kinase C with PMA resulted in tyrosine phosphorylation of Hic-5 only when platelets were fully aggregated with the exogenous addition of fibrinogen. Furthermore, PMA-induced Hic...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 355 (3): 779–785.
Published: 24 April 2001
...Songmin CAI; John H. EXTON Phospholipase D (PLD) is regulated by many factors, including protein kinase C (PKC) and small G-proteins of the Rho and ADP-ribosylation factor families. Previous studies revealed that the interaction site of human PLD 1 for RhoA is located in its C-terminus...
Articles
Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signalling
Anna CHIESA, Elena RAPIZZI, Valeria TOSELLO, Paolo PINTON, Maddalena DE VIRGILIO, Kevin E. FOGARTY, Rosario RIZZUTO
Journal:
Biochemical Journal
Biochem J (2001) 355 (1): 1–12.
Published: 26 February 2001
..., protease activity, etc.) has further expanded its applications and made GFP the favourite probe of cell biologists. We will here present two applications in the field of cell signalling, i.e. the use of GFP chimaeras for studying the recruitment of protein kinase C isoforms and the activity...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2001) 354 (1): 99–106.
Published: 08 February 2001
... activation and HB-EGF mRNA induction were inhibited by genistein, indicating a requirement for an upstream tyrosine kinase activity. In contrast, neither response was affected by inhibition of phosphoinositide 3-kinase activity, down-regulation of protein kinase C, or disruption of the actin cytoskeleton...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 353 (3): 603–610.
Published: 25 January 2001
... and PMA increased it. The effect of noradrenaline was concentration-dependent (EC 50 75nM), rapid (maximum at 1min) and transient. Phorbol ester-induced phosphorylation was concentration-dependent (EC 50 25nM), slightly slower (maximum at 5min) and stable for at least 60min. Inhibitors of protein kinase C...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 352 (1): 19–26.
Published: 07 November 2000
...Karen ENGLAND; Martin G. RUMSBY Protein kinase C (PKC) ε in 3T3 and 3T6 fibroblasts and in C6 glioma cells migrated on SDS/PAGE predominantly as a doublet with molecular masses of 87 and 95kDa (PKC ε 87 and PKC ε 95 respectively). PKC ε 95 predominates when cells reach confluency but PKC ε 87...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 350 (3): 655–661.
Published: 08 September 2000
...-family tyrosine kinase inhibitor PP1, as well as specific inhibition of the epidermal growth factor receptor tyrosine kinase (EGFR TK) by PD153035, also blocks PYY stimulation of MAPK. This pathway further requires protein kinase C with EGFR TK inhibition blocking PYY-induced protein kinase Cε (PKCε...
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