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Keywords: protein kinase C
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Biochem J (2023) 480 (24): 2037–2044.
Published: 15 December 2023
... of The Francis Crick Institute in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. apkc atypical pkc cell polarity phospholipids protein kinase c Atypical PKCs (aPKCs) are serine/threonine protein kinases...
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Biochem J (2013) 451 (1): 33–44.
Published: 14 March 2013
...Ghazi M. Rahman; Sreejesh Shanker; Nancy E. Lewin; Noemi Kedei; Colin S. Hill; B. V.  Venkataram Prasad; Peter M. Blumberg; Joydip Das PKC (protein kinase C) θ is predominantly expressed in T-cells and is critically involved in immunity. Design of PKCθ-selective molecules to manage autoimmune...
Includes: Supplementary data
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Biochem J (2012) 446 (2): 301–309.
Published: 14 August 2012
... (protein kinase C) and the scaffolding protein AKAP7 (A-kinase-anchoring protein 7). Using protein biochemistry and surface plasmon resonance approaches, we demonstrate that both AKAP7γ and AKAP7α are capable of high-affinity interactions with multiple isoenzymes of PKC. Furthermore, this interaction...
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Biochem J (2009) 424 (3): 419–429.
Published: 10 December 2009
... through the regulation of CaM (calmodulin)-mediated signalling. Ng presents a central IQ motif that mediates its binding to CaM and PA (phosphatidic acid) and that can be phosphorylated by PKC (protein kinase C). In the present manuscript, we report that Ng displays a strong nuclear localization when...
Includes: Supplementary data
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Biochem J (2009) 424 (1): 153–161.
Published: 23 October 2009
... of expression and by post-translational modifications such as prenylation and phosphorylation. We show in the present study that, upon PKC (protein kinase C) agonist stimulation, Rnd3 undergoes an electrophoretic mobility shift and its subcellular localization becomes enriched at internal membranes...
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Biochem J (2007) 404 (2): 299–308.
Published: 14 May 2007
... be addressed (email spk@temple.edu ). 19 10 2006 29 1 2007 13 2 2007 13 2 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 aggregation calcium mitogen-activated protein kinase (MAPK) protein kinase C Src family kinase Platelet activation...
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Biochem J (2005) 390 (3): 729–735.
Published: 05 September 2005
... or the proapoptotic protein FADD (Fas-activated death domain protein) respectively. The mechanism by which binding of PEA-15 to these proteins is controlled has not been elucidated. PEA-15 is a phosphoprotein containing a Ser-104 phosphorylated by protein kinase C and a Ser-116 phosphorylated by CamKII (calcium...
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Biochem J (2005) 385 (3): 677–684.
Published: 24 January 2005
... with active phorbol esters. Action of phorbol esters was blocked by inhibitors of PKC (protein kinase C) and by its down-regulation. LPA 1 receptor phosphorylation was observed in response to phorbol esters. The effect was rapid ( t 1/2 ∼1 min), intense (2-fold) and sustained (at least 60 min). PKC inhibitors...
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Biochem J (2004) 380 (3): 815–821.
Published: 15 June 2004
...-fold increase in receptor protein during 48 h, which was half-maximal at 1 nM and was slowly reversible after hormone withdrawal. Chlordiazepoxide, an inverse agonist, had no effect. TRH up-regulation was mimicked by phorbol ester and blocked by the protein kinase C inhibitor GF109203X in combination...
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Biochem J (2004) 379 (1): 1–9.
Published: 01 April 2004
..., protein kinase A, protein kinase C, scaffold. INTRODUCTION The discoveries of PKA (protein kinase A) binding to MAP- 2 (microtubule-associated protein 2) [1,2], to a bovine brain calmodulin-binding protein (p75; [3 and to a family of anchoring proteins that can bind the RII regulatory subunit of PKA...
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Biochem J (2003) 375 (3): 705–712.
Published: 01 November 2003
... that reside with the free-fatty-acid fraction, especially oleic acid. These compounds stimulate de novo diacylglycerol formation and protein kinase C activity in the parasite. Moreover, metacyclogenesis is stimulated by phorbol esters and cell-permeant diacylglycerol, while protein kinase C down-regulation...
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Biochem J (2002) 368 (2): 581–587.
Published: 01 December 2002
... thereafter, and concentration-dependent (EC 50 0.3pM). The phosphoinositide 3-kinase inhibitors wortmannin and LY294002, and the protein kinase C inhibitors staurosporine, Ro 318220 and bisindolylmaleimide, blocked the effect of this growth factor. α 1B -Adrenergic receptor phosphorylation was associated...
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Biochem J (2002) 368 (1): 1–15.
Published: 15 November 2002
... 2002 The Biochemical Society, London ©2002 2002 CASK integrin PDZ domain protein kinase C syntenin Abbreviations used: EGF, epidermal growth factor; GAP, GTPase-activating protein; GDI, guanine nucleotide dissociation inhibitor; GEF, guanine nucleotide exchange factor; FAK...
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Biochem J (2002) 365 (2): 329–336.
Published: 15 July 2002
... receptor; PDZ, P SD-95/ D lg1/ Z O-1; PICK1, p rotein i nteracting with C k inase 1 ; PKC, protein kinase C; PLC, phospholipase C; TM, transmembrane domain. Biochem. J. (2002) 365, 329 336 (Printed in Great Britain) 329 REVIEW ARTICLE G-protein-coupled receptors for neurotransmitter amino acids...
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Biochem J (2002) 363 (1): 95–103.
Published: 22 March 2002
...Jan K. DAVIDSON-MONCADA; Guillermo LOPEZ-LLUCH; Anthony W. SEGAL; Lodewijk V. DEKKER Protein kinases involved in the activation of the NADPH oxidase by Fcγ receptors in neutrophils were studied. Of three different protein kinase C (PKC) inhibitors, Gö 6976 inhibited the NADPH oxidase completely...
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Biochem J (2001) 359 (3): 599–604.
Published: 25 October 2001
... investigated the regulation of PLD2 by G M2 activator and various other regulators including ARF. PLD2 was potently stimulated in vitro by G M2 activator in a time- and dose-dependent manner. Neither ARF nor protein kinase C caused any significant changes in PLD2 activity. Importantly, PLD2 responsiveness...
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Biochem J (2001) 359 (1): 89–97.
Published: 24 September 2001
... demonstrate that CTGF is internalized from the cell surface in endosomes and accumulates in a juxtanuclear organelle from which the growth factor is then translocated into the cytosol. In the cytosol CTGF is phosphorylated by protein kinase C and PMA treatment can enhance this phosphorylation. Phosphorylated...
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Biochem J (2001) 358 (3): 637–646.
Published: 10 September 2001
...-100, contain caveolin-1 and protein kinase C isoforms. The LPP3 isoform was predominantly localized to rat lung CEDs. These lipid-rich domains, including those from isolated rat type II cells, were enriched both in phosphatidylcholine plus sphingomyelin (PC+SM) and cholesterol. Saponin treatment...
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Biochem J (2001) 357 (1): 275–282.
Published: 25 June 2001
...Xiangnan DU; Ying JIANG; Weijun QIAN; Xiaolan LU; James P. WALSH We have previously shown that unsaturated fatty acids amplify platelet-derived-growth-factor (PDGF)-induced protein kinase C (PKC) activation in vascular smooth-muscle cells (VSMCs). Diacylglycerol-induced PKC activation is normally...
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Biochem J (2001) 355 (3): 779–785.
Published: 24 April 2001
...Songmin CAI; John H. EXTON Phospholipase D (PLD) is regulated by many factors, including protein kinase C (PKC) and small G-proteins of the Rho and ADP-ribosylation factor families. Previous studies revealed that the interaction site of human PLD 1 for RhoA is located in its C-terminus...
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Biochem J (2001) 355 (1): 1–12.
Published: 26 February 2001
..., protease activity, etc.) has further expanded its applications and made GFP the favourite probe of cell biologists. We will here present two applications in the field of cell signalling, i.e. the use of GFP chimaeras for studying the recruitment of protein kinase C isoforms and the activity...
Includes: Multimedia, Supplementary data
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Biochem J (2001) 353 (3): 603–610.
Published: 25 January 2001
... and PMA increased it. The effect of noradrenaline was concentration-dependent (EC 50 75nM), rapid (maximum at 1min) and transient. Phorbol ester-induced phosphorylation was concentration-dependent (EC 50 25nM), slightly slower (maximum at 5min) and stable for at least 60min. Inhibitors of protein kinase C...
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