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Keywords: protein kinase C (PKC)
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Articles
Biochem J (2014) 457 (1): 151–162.
Published: 10 December 2013
... stress conditions. apoptosis calcineurin/nuclear factor of activated T-cells (NFAT) endoplasmic reticulum stress hypertrophy miRNA protein kinase C (PKC) After cardiomyocytes were grown in serum-starved conditions on 18-mm cover slips, miRNA mimics were transfected into cells with...
Includes: Supplementary data
Articles
Biochem J (2013) 455 (1): 47–56.
Published: 13 September 2013
...-anchoring protein 79 (AKAP79) muscarinic receptor phosphodiesterase 4 (PDE4) protein kinase A (PKA) protein kinase C (PKC) The muscarinic cholinergic receptor, a typical seven-transmembrane GPCR (G-protein-coupled receptor), binds the neurotransmitter acetylcholine and mediates numerous...
Includes: Supplementary data
Articles
Biochem J (2013) 452 (2): 195–209.
Published: 10 May 2013
... Society 2013 kinase activator kinase inhibitor kinase reporter phorbol ester protein kinase C (PKC) PKC (protein kinase C) isoenzymes transduce a wide range of extracellular signals that result in the generation of the lipid second messenger DAG (diacylglycerol), thereby regulating...
Articles
Biochem J (2012) 448 (1): 165–169.
Published: 18 October 2012
... Biochemical Society 2012 B-cell antigen receptor (BCR) B-cell cell survival glycolysis metabolism protein kinase C (PKC) B-cell homoeostasis is critical for maintaining adaptive immunity and to avoid autoimmune and immunodeficiency diseases. In keeping with this, B-cells are dependent upon...
Includes: Supplementary data
Articles
Biochem J (2012) 447 (3): 393–405.
Published: 05 October 2012
... kinase C (PKC) muscarinic receptor somatostatin receptor cAMP (cyclic AMP) impacts on many aspects of the lives of eukaryotic cells to regulate numerous fundamental physiological functions [ 1 , 2 ]. The precise control of cAMP synthesis and subsequent physiological processes occur in a cell...
Includes: Supplementary data
Articles
Biochem J (2012) 447 (2): 193–204.
Published: 26 September 2012
... © The Authors Journal compilation © 2012 Biochemical Society 2012 apoptosis cytoprotection endothelium inflammation protein kinase C (PKC) The vascular endothelium lies at a critical tissue interface and is capable of mounting specific responses to a variety of soluble and physical...
Includes: Supplementary data
Articles
Biochem J (2011) 439 (2): 287–297.
Published: 28 September 2011
..., these data identify Sin1 as a direct interacting partner of mTORC2 target kinases of the PKC and PKB families. © The Authors Journal compilation © 2011 Biochemical Society 2011 cancer mammalian target of rapamycin (mTOR) nucleotide pocket protein kinase B (PKB) protein kinase C (PKC...
Includes: Supplementary data
Articles
Biochem J (2011) 436 (2): 469–480.
Published: 13 May 2011
...) protein kinase C (PKC) Human platelets express the two PAR (protease-activated receptor) subtypes 1 and 4 [ 1 ]. Thrombin, the main effector protease of the coagulation cascade, activates PARs by cleaving off the N-terminal exodomains, and the unmasked ‘new’ N-terminus serves as a tethered ligand...
Includes: Supplementary data
Articles
Biochem J (2011) 433 (1): 145–153.
Published: 15 December 2010
... 27 9 2010 13 10 2010 13 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 activator protein 1 (AP-1) breast cancer cell migration JunB protein kinase C (PKC) TBX3 transcription factor TBX3, a member of the developmentally important T-box...
Articles
Biochem J (2010) 432 (1): 153–163.
Published: 25 October 2010
... ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cytokine lymphocyte protein kinase C (PKC) protein kinase D (PKD) T-cell antigen receptor (TCR...
Articles
Biochem J (2010) 432 (1): 77–87.
Published: 25 October 2010
...-associated mutation F-box WD40 protein 7 (Fbw7) isoform-specific regulation nuclear localization protein kinase C (PKC) Fbw7 (F-box WD40 protein 7) is a conserved F-box WD40 protein, also known as Fbw6 in mice [ 1 ], archipelago in flies [ 2 ], SEL10 in worms [ 3 ] and Cdc4 in yeast [ 4 ]. Fbw7...
Articles
Biochem J (2010) 432 (1): 207–219.
Published: 25 October 2010
... kinase C (PKC) receptor for activated C-kinase 1 (RACK1) cAMP is a ubiquitous second messenger that controls pleiotropic cellular actions through the direct activation of its effectors, PKA (proteins kinase A) and EPAC (exchange protein activated by cAMP) [ 1 , 2 ]. cAMP PDEs (phosphodiesterases...
Includes: Supplementary data
Articles
Biochem J (2010) 429 (3): 565–572.
Published: 14 July 2010
... medium, provided the original work is properly cited. angiogenesis CRT5 inhibitor endothelium protein kinase C (PKC) protein kinase D (PKD) vascular endothelial growth factor (VEGF) PKDs (Protein kinase Ds) are DAG (diacylglycerol)-stimulated serine/threonine protein kinases...
Articles
Biochem J (2010) 429 (2): 335–345.
Published: 28 June 2010
... synthase hypoxia mitochondrion oxidative phosphorylation protein kinase C (PKC) In the mammalian heart, the F 1 F o -ATP synthase supplies over 90% of the required energy and exists as a 16-subunit enzyme complex in the IMM (inner mitochondrial membrane). It has an F 1 domain (3α, 3β, γ, δ and...
Articles
Biochem J (2010) 427 (1): 125–134.
Published: 15 March 2010
... Ca 2+ homoeostasis junctional membrane complex junctophilin 2 muscle hypertrophy protein kinase C (PKC) transient receptor potential cation canonical-type channel 3 (TRPC3) During EC (excitation–contraction) coupling in striated muscle (cardiac and skeletal muscle), the DHPR...
Articles
Biochem J (2010) 425 (2): 445–543.
Published: 23 December 2009
... mukinase@kobe-u.ac.jp ). 5 3 2009 28 9 2009 26 10 2009 26 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 cell-penetrating peptide (CPP) penetration accelerating sequence octa-arginine (LPasR8) PRL protein kinase C (PKC) PKN inhibitor...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (3): 791–801.
Published: 16 January 2009
...) myriocin palmitate protein kinase B (PKB) protein kinase C (PKC) Hyperlipidaemia is one of a cluster of abnormalities associated with the metabolic syndrome and one that is considered important for both development and progression of insulin resistance in skeletal muscle, a tissue that makes a...
Includes: Supplementary data
Articles
Biochem J (2009) 417 (3): 705–715.
Published: 16 January 2009
...@tulane.edu ). 16 6 2008 12 9 2008 16 9 2008 16 9 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 cross-talk extracellular-signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) phosphorylation potassium channel protein kinase C (PKC...
Articles
Biochem J (2008) 416 (1): 47–54.
Published: 28 October 2008
... truncated at residue 149 (Cp149) Ser 106 hepatitis B virus (HBV) protein kinase C (PKC) phosphorylation The number of human HBV (hepatitis B virus) patients exceeds over 400 million people worldwide, causing acute and chronic B type hepatitis in these patients. It has been reported that chronic...
Includes: Supplementary data
Articles
Biochem J (2008) 416 (1): 99–108.
Published: 28 October 2008
...) phosphoinositide 3-kinase (PI3K) protein kinase C (PKC) BAPTA-AM 1,2-bis-( o -aminophenoxy)ethane- N , N , N ′, N ′-tetra-acetic acid tetrakis(acetoxymethyl ester) COX cyclo-oxygenase DAG diacylglycerol DIDS 4,4′-di-isothiocyanostilbene-2,2′-disulfonate DMEM Dulbecco's modified...
Articles
Biochem J (2008) 415 (1): 77–85.
Published: 12 September 2008
... 16 6 2008 16 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 eukaryotic initiation factor 6 (eIF6) hispidin phorbol ester protein kinase C (PKC) receptor for activated C-kinase 1 (RACK1) translation initiation A polysomal profile was performed...
Includes: Supplementary data
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Biochem J (2008) 411 (3): 543–551.
Published: 14 April 2008
... 1 2 2008 1 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 gastric muscle muscle contraction myosin light chain nuclear factor κB (NF-κB) signalling protein kinase C (PKC) Dominant negative RhoA (N19RhoA) or IKK2 [IKK2(K44A)] was subcloned into...
Articles
Biochem J (2008) 411 (2): e15–e16.
Published: 27 March 2008
... activity in situ . 1 email Christer.Larsson@med.lu.se 15 2 2008 18 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 enzyme regulation 14-3-3 protein phosphorylation protein kinase C (PKC) Protein kinase C (PKC) was first identified some 30...
Articles
Biochem J (2007) 408 (1): 51–59.
Published: 29 October 2007
... © The Authors Journal compilation © 2007 Biochemical Society 2007 cell proliferation membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS) neural retina protein kinase C (PKC) proteomics The mature neural retina is organized into a three-layered structure consisting...
Articles
Biochem J (2007) 406 (3): 501–509.
Published: 29 August 2007
... Authors Journal compilation © 2007 Biochemical Society 2007 phospholipase C (PLC) phosphorylation protease-activated receptor (PAR) protein kinase C (PKC) Src family kinase (SFK) thrombin The PKC (protein kinase C) family is composed of ten isoenzymes, which are grouped into three...
Articles
Biochem J (2007) 405 (3): 533–540.
Published: 13 July 2007
... phosphorylation protein kinase C (PKC) Woronin body Filamentous ascomycete and deuteromycete fungi possess the ‘Woronin body’, a unique organelle that seals the septal pore in the event of hyphal damage [ 1 ]. Septal pore plugging by this dense proteinaceous organelle prevents hyphal bleeding and...
Articles
Biochem J (2007) 404 (1): 31–43.
Published: 26 April 2007
... Biochemical Society 2007 calmodulin neurogranin phosphatidic acid phosphatidylinositol 4,5-bisphosphate phospholipase D (PLD) protein kinase C (PKC) Neurogranin (Ng) (also named RC3, p17 or BICK) is a small protein originally identified in rat brain [ 1 – 3 ] that is abundantly expressed in...
Articles
Biochem J (2007) 403 (1): 1–12.
Published: 13 March 2007
... ester protein kinase C (PKC) Rac GTPase-activating protein (RacGAP) The Ras superfamily of small GTPases or small G-proteins is composed of five major families that share similar sequences and biochemical properties: Ras, Rho, Rab, Ran and Arf [ 1 , 2 ]. More than 150 members in the Ras...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2006) 400 (3): 411–419.
Published: 28 November 2006
.... (email bhantash@stanford.edu ). 18 5 2006 26 7 2006 16 8 2006 16 8 2006 The Biochemical Society, London 2006 arginine-vasopressin (AVP) cardiac L-type calcium channel G-protein L6 cell protein kinase C (PKC) The voltage-dependent Ca 2+ channels of the long...
Articles
Biochem J (2006) 399 (3): 493–501.
Published: 13 October 2006
... extracellular-signal-regulated kinase (ERK) pathway G-protein-coupled receptor (GPCR) protein kinase C (PKC) Raf Ras In cardiac myocytes, as in other cell types, numerous cellular processes are sensitive to changes in pH i (intracellular pH). In particular, almost every step in the excitation...
Articles
Biochem J (2006) 397 (1): 109–120.
Published: 14 June 2006
... resonance energy transfer (FRET) protein complex protein kinase C (PKC) renal cell carcinoma (RCC) von Hippel–Lindau protein (pVHL) The VHL (von Hippel–Lindau) tumour-suppressor gene is responsible for inherited familial VHL cancer syndrome, and mutations of the VHL gene, accompanied by loss of...
Includes: Supplementary data
Articles
Biochem J (2006) 393 (2): 555–564.
Published: 23 December 2005
... bisindolylmaleimide I (BIM I) platelet protein kinase C (PKC) Rho kinase thrombin vasodilator-stimulated phosphoprotein (VASP) The multifunctional organizer of the actin cytoskeleton VASP (vasodilator-stimulated phosphoprotein), together with Drosophila Ena (Enabled), is the original member of the Ena...
Articles
Biochem J (2005) 392 (1): 163–172.
Published: 08 November 2005
... kinase C (PKC) Cyclic nucleotide PDEs (phosphodiesterases) hydrolyse cAMP and cGMP, two important second messengers. There are at least 11 mammalian PDE gene families (PDEs 1–11), with multiple isoforms generated by expression from different genes, different transcription initiation sites and...
Includes: Supplementary data
Articles
Biochem J (2004) 384 (3): 543–549.
Published: 07 December 2004
...) nuclear-factor-κB-binding protein (NF-κB-binding protein) phorbol ester protein kinase C (PKC) MnSOD (manganese superoxide dismutase) is an essential antioxidant enzyme that catalyses the conversion of superoxide radical into hydrogen peroxide and molecular oxygen within the mitochondrial matrix...
Articles
Biochem J (2004) 384 (2): 349–355.
Published: 23 November 2004
..., University of Utrecht, The Netherlands (email R.R.Bosch@vet.uu.nl ). 13 5 2004 14 7 2004 13 8 2004 13 8 2004 The Biochemical Society, London 2004 glucose uptake myristoylated protein kinase Cβ peptide inhibitor phorbol ester protein kinase C (PKC) 3T3-L1 adipocyte...
Articles
Biochem J (2004) 382 (1): 101–110.
Published: 10 August 2004
... Biochemical Society, London 2004 G-protein-coupled receptor (GPCR) metabotropic glutamate receptor phosphorylation protein kinase C (PKC) P2X receptor P2Y receptor Extracellular ATP functions as a signalling molecule through the activation of P2X receptors [ 1 ]. Sources of ATP include co...
Articles
Biochem J (2004) 378 (1): 83–92.
Published: 15 February 2004
...J. Ann LE GOOD; David N. BRINDLEY The regulation of protein kinase C (PKC)ζ in relation to its turnover, cell growth and transformation was investigated in Rat2 fibroblasts by over-expressing wild-type or mutant forms of PKCζ. Deletion of the pseudosubstrate site (PSS) produced the most active...
Articles
Biochem J (2003) 376 (3): 667–676.
Published: 15 December 2003
... 3 R) phospholipase C (PLC) protein kinase C (PKC) Abbreviations used: 2-APB, 2-aminoethoxydiphenyl borate; BCR, B-cell receptor; BLNK, B -cell l i nk er; DAG, diacylglycerol; ER, endoplasmic reticulum; eYFP, enhanced yellow fluorescent protein; FBS, foetal bovine serum; fura-2/AM, fura...
Articles
Biochem J (2003) 376 (3): 545–552.
Published: 15 December 2003
...Seng-Lai TAN; Peter J. PARKER Members of the protein kinase C (PKC) family are expressed in many different cell types, where they are known to regulate a wide variety of cellular processes that impact on cell growth and differentiation, cytoskeletal remodelling and gene expression in the response...
Articles
Biochem J (2003) 375 (2): 313–321.
Published: 15 October 2003
... 2003 β2-chimaerin diacylglycerol (DAG) phorbol ester protein kinase C (PKC) Rac-GTPase-activating protein (Rac-GAP) Rho GTPase Abbreviations used: BCR, breakpoint cluster region; DAG, diacylglycerol; DTT, dithiothreitol; EGF, epidermal growth factor; ERK, extracellular-signal...
Articles
Biochem J (2003) 374 (2): 537–543.
Published: 01 September 2003
... Ser 334 , which is regulated by protein kinase C. 1 To whom correspondence should be addressed (e-mail anewton@ucsd.edu ). 13 3 2003 5 6 2003 16 6 2003 16 6 2003 The Biochemical Society, London ©2003 2003 phosphorylation phototransduction protein kinase C (PKC...
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Biochem J (2003) 371 (3): 733–742.
Published: 01 May 2003
...Carole GALLET; Stéphanie BLAIE; Sylviane LÉVY-TOLEDANO; Aïda HABIB The signalling pathways that link G-protein-coupled receptors to mitogen-activated protein kinases involve receptor and non-receptor tyrosine kinases and protein kinase C (PKC). We explored the pathways that are implicated in the...
Articles
Biochem J (2003) 370 (2): 361–371.
Published: 01 March 2003
... The Biochemical Society, London ©2003 2003 phosphoinositide 3-kinase phosphoinositide-dependent kinase-1 (PDK-1) phosphorylation motif protein kinase A (PKA) protein kinase B (PKB)/Akt protein kinase C (PKC) Abbreviations used: PDK-1, phosphoinositide-dependent kinase-1; PH...
Articles
Biochem J (2002) 368 (3): 809–815.
Published: 15 December 2002
... myosin II heavy chain kinase (MHCK) phosphatidic acid protein kinase C (PKC) Abbreviations used: DG, 1,2-diacylglycerol; DGK, diacylglycerol kinase; MHC, myosin II heavy chain; MHCK, myosin II heavy chain kinase; MHC-PKC, myosin heavy chain-protein kinase C; PA, phosphatidic acid; PH...
Articles
Biochem J (1999) 342 (2): 407–414.
Published: 24 August 1999
...@ucl.ac.uk ). 15 1 1999 24 5 1999 21 6 1999 The Biochemical Society, London © 1999 1999 angiotensin II cyclin platelet-derived growth factor (PDGF) protein kinase C (PKC) Biochem. J. (1999) 342, 407 414 (Printed in Great Britain) 407 Differential regulation of extracellular...