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1-9 of 9
Keywords: protein kinase inhibitor
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Articles
Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity
Available to PurchaseGiorgio Cozza, Sofia Zanin, Stefania Sarno, Elena Costa, Cristina Girardi, Giovanni Ribaudo, Mauro Salvi, Giuseppe Zagotto, Maria Ruzzene, Lorenzo A. Pinna
Journal:
Biochemical Journal
Biochem J (2015) 471 (3): 415–430.
Published: 16 October 2015
...-substrate directed derivative has been designed. It is active on cellular ecto-CK2 and its multifunctional mode of binding has been determined by kinetic and mutational analyses. bisubstrate inhibitor cell migration CK2 ecto-kinase protein kinase inhibitor protein phosphorylation signal...
Articles
Ruzica Bago, Nazma Malik, Michael J. Munson, Alan R. Prescott, Paul Davies, Eeva Sommer, Natalia Shpiro, Richard Ward, Darren Cross, Ian G. Ganley, Dario R. Alessi
Journal:
Biochemical Journal
Biochem J (2014) 463 (3): 413–427.
Published: 10 October 2014
... deployed to monitor class I PI3K pathway. mammalian target of rapamycin (mTOR) N-Myc downstream-regulated gene-1 (NDRG1) phosphoinositide 3-kinase (PI3K) protein kinase inhibitor signal transduction inhibitor U20S cell line was kindly provided by John Rouse (MRC Protein Phosphorylation...
Includes: Supplementary data
Articles
Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance
Available to PurchasePeter J. Stogios, Peter Spanogiannopoulos, Elena Evdokimova, Olga Egorova, Tushar Shakya, Nick Todorovic, Alfredo Capretta, Gerard D. Wright, Alexei Savchenko
Journal:
Biochemical Journal
Biochem J (2013) 454 (2): 191–200.
Published: 09 August 2013
... bacteria, and contributes to the clinical obsolescence of this class of antibiotics. One strategy to rescue compromised antibiotics such as aminoglycosides is targeting the enzymes that confer resistance with small molecules. We demonstrated previously that ePK (eukaryotic protein kinase) inhibitors could...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 452 (3): 499–508.
Published: 31 May 2013
...) protein kinase inhibitor phosphoinositide 3-kinase (PI3K) signal transduction inhibitor Over 70% of breast cancers possess mutations that trigger activation of the PI3K (phosphoinositide 3-kinase) signalling pathway [ 1 ]. These include mutations that induce overexpression of receptor tyrosine...
Includes: Supplementary data
Articles
High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules
Available to PurchasePaul D. Andrews, Melissa Becroft, Anders Aspegren, Jane Gilmour, Martyn J. James, Scott McRae, Robert Kime, Robert W. Allcock, Achamma Abraham, Zhong Jiang, Raimund Strehl, Joanne C. Mountford, Graeme Milligan, Miles D. Houslay, David R. Adams, Julie A. Frearson
Journal:
Biochemical Journal
Biochem J (2010) 432 (1): 21–35.
Published: 25 October 2010
... protein kinase inhibitor Rhoassociated kinase (ROCK) Y-27632 Poor recovery after single-cell enzymatic passage of hES cells (human embryonic stem cells) is a considerable obstacle to accurate cell counting and efficient culture expansion. This is of particular importance when using hES cells...
Includes: Supplementary data
Articles
Mechanism of membrane redistribution of protein kinase C by its ATP-competitive inhibitors
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2007) 405 (2): 331–340.
Published: 27 June 2007
... as described previously [ 27 ]. ATP-binding site diacylglycerol protein kinase C protein kinase inhibitor translocation Figure 2 ATP-competitive inhibitors selectively induce membrane redistribution of DAG-sensitive PKCs ( A ) HeLa cells transiently expressing PKCα–, PKCδ– or PKCζ–GFP were...
Articles
A sharper instrument for dissecting signalling events: a specific AGC kinase inhibitor
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2007) 401 (1): e1.
Published: 11 December 2006
... protein kinase (MAPK) p90 ribosomal S6 kinase (RSK) protein kinase inhibitor small-molecule inhibitor There are four closely related RSK (p90 ribosomal S6 kinase) genes in the human genome (RSK1–4), which belong to the AGC family of protein kinases. RSKs phosphorylate a number of protein...
Articles
Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA)
Available to PurchaseStefania SARNO, Erika De MOLINER, Maria RUZZENE, Mario A. PAGANO, Roberto BATTISTUTTA, Jenny BAIN, Doriano FABBRO, Joseph SCHOEPFER, Matthew ELLIOTT, Pascal FURET, Flavio MEGGIO, Giuseppe ZANOTTI, Lorenzo A. PINNA
Journal:
Biochemical Journal
Biochem J (2003) 374 (3): 639–646.
Published: 15 September 2003
... role of CK2 in living cells and may pave the way for the develop- ment of drugs depending on CK2 activity. Key words: dual-specificity tyrosine-phosphorylated and -regu- lated kinase 1a (DYRK1a), protein kinase inhibitor, protein phosphorylation, 4,5,6,7-tetrabromobenzotriazole (TBB). INTRODUCTION CK2...
Articles
A non-radioactive method for the assay of many serine/threonine-specific protein kinases
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2002) 366 (3): 977–981.
Published: 15 September 2002
...-throughput screening for protein-kinase inhibitors has involved strategies that measure the effect of compounds on the incorporation of radiolabelled phosphate P and $$P) into peptide and protein substrates. However, one of the major drawbacks of such Abbreviations used: AMPK, AMP-activated protein kinase...