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Keywords: protein kinase inhibitor
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Biochem J (2015) 471 (3): 415–430.
Published: 16 October 2015
...-substrate directed derivative has been designed. It is active on cellular ecto-CK2 and its multifunctional mode of binding has been determined by kinetic and mutational analyses. bisubstrate inhibitor cell migration CK2 ecto-kinase protein kinase inhibitor protein phosphorylation signal...
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Biochem J (2013) 454 (2): 191–200.
Published: 09 August 2013
... bacteria, and contributes to the clinical obsolescence of this class of antibiotics. One strategy to rescue compromised antibiotics such as aminoglycosides is targeting the enzymes that confer resistance with small molecules. We demonstrated previously that ePK (eukaryotic protein kinase) inhibitors could...
Includes: Supplementary data
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Biochem J (2013) 452 (3): 499–508.
Published: 31 May 2013
...) protein kinase inhibitor phosphoinositide 3-kinase (PI3K) signal transduction inhibitor Over 70% of breast cancers possess mutations that trigger activation of the PI3K (phosphoinositide 3-kinase) signalling pathway [ 1 ]. These include mutations that induce overexpression of receptor tyrosine...
Includes: Supplementary data
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Biochem J (2007) 405 (2): 331–340.
Published: 27 June 2007
... as described previously [ 27 ]. ATP-binding site diacylglycerol protein kinase C protein kinase inhibitor translocation Figure 2 ATP-competitive inhibitors selectively induce membrane redistribution of DAG-sensitive PKCs ( A ) HeLa cells transiently expressing PKCα–, PKCδ– or PKCζ–GFP were...
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Biochem J (2007) 401 (1): e1.
Published: 11 December 2006
... protein kinase (MAPK) p90 ribosomal S6 kinase (RSK) protein kinase inhibitor small-molecule inhibitor There are four closely related RSK (p90 ribosomal S6 kinase) genes in the human genome (RSK1–4), which belong to the AGC family of protein kinases. RSKs phosphorylate a number of protein...
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Articles
Biochem J (2002) 366 (3): 977–981.
Published: 15 September 2002
...-throughput screening for protein-kinase inhibitors has involved strategies that measure the effect of compounds on the incorporation of radiolabelled phosphate P and $$P) into peptide and protein substrates. However, one of the major drawbacks of such Abbreviations used: AMPK, AMP-activated protein kinase...