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1-27 of 27
Keywords: protein oxidation
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Articles
Journal:
Biochemical Journal
Biochem J (2024) 481 (23): 1855–1866.
Published: 04 December 2024
... the Creative Commons Attribution License 4.0 (CC BY) . glyceraldehyde-3-phosphate dehydrogenase hydrogen peroxide macromolecular crowding peroxymonocarbonate protein oxidation redox regulation Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an asymmetric homotetrameric NAD + -dependent...
Includes: Supplementary data
Articles
Rhodobacter sphaeroides methionine sulfoxide reductase P reduces R - and S -diastereomers of methionine sulfoxide from a broad-spectrum of protein substrates
Available to PurchaseLionel Tarrago, Sandrine Grosse, Marina I. Siponen, David Lemaire, Béatrice Alonso, Guylaine Miotello, Jean Armengaud, Pascal Arnoux, David Pignol, Monique Sabaty
Journal:
Biochemical Journal
Biochem J (2018) 475 (23): 3779–3795.
Published: 06 December 2018
... against deleterious protein oxidation [ 28 , 29 ]. R. sphaeroides MsrP (RsMsrP) shares 50% of identical amino acid residues with EcMsrP and transcriptomic analyses evidenced that RsmsrP is strongly induced under high-light conditions, suggesting a putative role in protecting the periplasm against 1 O...
Includes: Supplementary data
Articles
Protein oxidation and peroxidation
Open Access
Journal:
Biochemical Journal
Biochem J (2016) 473 (7): 805–825.
Published: 29 March 2016
... Lon), can be efficient, protein hydroperoxides inhibit these pathways and this may contribute to the accumulation of modified proteins in cells. Available evidence supports an association between protein oxidation and multiple human pathologies, but whether this link is causal remains...
Articles
Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain
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Journal:
Biochemical Journal
Biochem J (2014) 463 (2): 177–189.
Published: 22 September 2014
... to development of AD. The most relevant proteomics findings highlight that disturbance of protein homoeostasis and energy production are central mechanisms of neurodegeneration and overlap in aging DS and AD. Protein oxidation affects crucial intracellular functions and may be considered a ‘leitmotif...
Articles
Role of Helicobacter pylori methionine sulfoxide reductase in urease maturation
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2013) 450 (1): 141–148.
Published: 24 January 2013
... ). 12 9 2012 24 10 2012 27 11 2012 27 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 accessory protein amino acid modification GTPase nickel (Ni) oxidative stress protein oxidation Helicobacter pylori is a Gram-negative...
Articles
Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)
Available to PurchaseKatrina A. Hadfield, David I. Pattison, Bronwyn E. Brown, Liming Hou, Kerry-Anne Rye, Michael J. Davies, Clare L. Hawkins
Journal:
Biochemical Journal
Biochem J (2013) 449 (2): 531–542.
Published: 14 December 2012
... cholesterol efflux hypothiocyanous acid high-density lipoprotein myeloperoxidase protein oxidation rHDLs containing apoA-I complexed to PLPC (1-palmitoyl-2-linoleoyl- sn -glycero-3-phosphocholine) (Avanti Polar Lipids) (initial PLPC/apoA-I molar ratio, 100:1) were prepared using the cholate dialysis...
Includes: Supplementary data
Articles
Molecular targets of oxidative stress
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Journal:
Biochemical Journal
Biochem J (2011) 434 (2): 201–210.
Published: 11 February 2011
... ROS stress include membrane lipid integrity and activity of ROS-susceptible proteins, including proteins required for faithful translation of mRNA. Protein oxidation also triggers accumulation of toxic protein aggregates or induction of apoptotic cell death. This burgeoning understanding...
Articles
The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes
Available to PurchaseAndrew M. Pickering, Alison L. Koop, Cheryl Y. Teoh, Gennady Ermak, Tilman Grune, Kelvin J. A. Davies
Journal:
Biochemical Journal
Biochem J (2010) 432 (3): 585–595.
Published: 25 November 2010
..., siRNA knockdown of the 20S proteasome, immunoproteasome or PA28αβ regulator blocked 50–100% of these adaptive increases in cell division and DNA replication, and immunoproteasome knockdown largely abolished protection against protein oxidation. All forms of the proteasome (see [ 18 , 19 ] for reviews...
Includes: Supplementary data
Articles
Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3
Available to PurchaseAlexander V. Peskin, Andrew G. Cox, Péter Nagy, Philip E. Morgan, Mark B. Hampton, Michael J. Davies, Christine C. Winterbourn
Journal:
Biochemical Journal
Biochem J (2010) 432 (2): 313–321.
Published: 12 November 2010
... Society 2010 hydroperoxide oxidative stress peroxidase peroxiredoxin (Prx) protein oxidation thiol Reduced monomers and disulfide-bonded dimers were separated by non-reducing SDS/PAGE (10, 12 or 15% gels). Gels were either silver-stained or transferred on to a PVDF membrane and blotted...
Includes: Supplementary data
Articles
Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides
Available to PurchaseMartin D. Rees, Steven E. Bottle, Kathryn E. Fairfull-Smith, Ernst Malle, John M. Whitelock, Michael J. Davies
Journal:
Biochemical Journal
Biochem J (2009) 421 (1): 79–86.
Published: 12 June 2009
... nitroxide protein oxidation superoxide All reactions involving the MPO-H 2 O 2 -Cl − system contained MPO (10–500 nM), Cl − (100 mM), H 2 O 2 (10–50 μM) and Met (methionine) (250 μM). Reactions were performed at pH 7.4 and 25 °C and were initiated by the addition of H 2 O 2 or MPO...
Includes: Supplementary data
Articles
Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation
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Journal:
Biochemical Journal
Biochem J (2008) 416 (3): 441–452.
Published: 26 November 2008
... be useful biomarkers of HOSCN-mediated protein oxidation. 1 To whom correspondence should be addressed (email [email protected] ). 17 7 2007 24 7 2008 24 7 2008 24 7 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 hypochlorous acid (HOCl...
Articles
Oxidation of myosin by haem proteins generates myosin radicals and protein cross-links
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2008) 410 (3): 565–574.
Published: 27 February 2008
.... 1 To whom correspondence should be addressed (email [email protected] ). EPR spectroscopy horseradish peroxidase (HRP) myoglobin myosin protein oxidation radical Oxidation of a protein by radicals in the presence of O 2 can result in major alterations to the physical...
Articles
Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals
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Journal:
Biochemical Journal
Biochem J (2007) 407 (3): 321–329.
Published: 12 October 2007
... Journal compilation © 2007 Biochemical Society 2007 aging antioxidant protein oxidation methionine sulfoxide reductase (Msr) selenoprotein ROS (reactive oxygen species), such as superoxide anion, hydroxyl radical and hydrogen peroxide, may be generated at various sites in cells during...
Articles
Radiation-induced oxidative damage to the DNA-binding domain of the lactose repressor
Available to PurchaseNathalie Gillard, Stephane Goffinont, Corinne Buré, Marie Davidkova, Jean-Claude Maurizot, Martine Cadene, Melanie Spotheim-Maurizot
Journal:
Biochemical Journal
Biochem J (2007) 403 (3): 463–472.
Published: 12 April 2007
... quartz cells. Dosimetry was performed using Fricke's chemical dosimeter. ionizing radiation lactose repressor mass spectrometry Monte Carlo simulation protein oxidation radiolytic attack The headpiece conformation was studied by CD with a JASCO J-810 dichrograph. The spectra...
Articles
Degradation of extracellular matrix and its components by hypobromous acid
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2007) 401 (2): 587–596.
Published: 21 December 2006
... were prepared as described previously [ 18 ]. bromamine eosinophil peroxidase extracellular matrix glycosaminoglycan heparan sulfate myeloperoxidase protein oxidation EPO (eosinophil peroxidase) and MPO (myeloperoxidase) are highly basic haem enzymes that are released...
Articles
Fragmentation of extracellular matrix by hypochlorous acid
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Journal:
Biochemical Journal
Biochem J (2003) 376 (1): 219–227.
Published: 15 November 2003
... should be addressed (e-mail [email protected] ). 15 5 2003 3 7 2003 11 8 2003 11 8 2003 The Biochemical Society, London ©2003 2003 chloramine extracellular matrix glycosaminoglycan hypochlorite myeloperoxidase protein oxidation Abbreviations used: ECM...
Articles
Characterization of non-covalent oligomers of proteins treated with hypochlorous acid
Available to PurchaseAnna L. P. CHAPMAN, Christine C. WINTERBOURN, Stephen O. BRENNAN, T. William JORDAN, Anthony J. KETTLE
Journal:
Biochemical Journal
Biochem J (2003) 375 (1): 33–40.
Published: 01 October 2003
... injury. The Biochemical Society, London ©2003 2003 haemoglobin myeloperoxidase myoglobin neutrophil protein aggregation protein oxidation Abbreviations used: DNP, 2,4-dinitrophenylhydrazine; ESI, electrospray ionization; HDL, high-density lipoprotein; LDL, low-density lipoprotein...
Articles
Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells
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Journal:
Biochemical Journal
Biochem J (2003) 373 (2): 531–537.
Published: 15 July 2003
... with the two-dimensional patterns of oxidized recombinant MsrA, revealed oxidative modifications of cysteine residues. Key words: isoform, methionine sulphoxide reductase, post- translational modification, protein oxidation. INTRODUCTION The mitochondria have been described as the major source of reactive...
Articles
Detection of HOCl-mediated protein oxidation products in the extracellular matrix of human atherosclerotic plaques
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Journal:
Biochemical Journal
Biochem J (2003) 370 (2): 729–735.
Published: 01 March 2003
... to involve the formation and subsequent decomposition of protein chloramines. Biochem. J. (2003) 370, 729 735 (Printed in Great Britain) 729 Detection of HOCl-mediated protein oxidation products in the extracellular matrix of human atherosclerotic plaques Alan A. WOODS, Stuart M. LINTON and Michael J...
Articles
Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3
Available to PurchaseMartin D. BRAND, Reinald PAMPLONA, Manuel PORTERO-OTÍN, Jesús R. REQUENA, Stephen J. ROEBUCK, Julie A. BUCKINGHAM, John C. CLAPHAM, Susana CADENAS
Journal:
Biochemical Journal
Biochem J (2002) 368 (2): 597–603.
Published: 01 December 2002
... and treatments, suggesting that high protein expression, or some secondary result of uncoupling, may cause the observed correlation between basal proton conductance and phospholipid fatty acyl composition. Key words: peroxidation, protein oxidation, proton leak, reactive oxygen species, superoxide. The mechanism...
Articles
Activated neutrophils oxidize extracellular proteins of endothelial cells in culture: effect of nitric oxide donors
Available to PurchaseGrzegorz A. CZAPSKI, Diana AVRAM, Dmitri V. SAKHAROV, Karel W.A. WIRTZ, Joanna B. STROSZNAJDER, Everard H.W. PAP
Journal:
Biochemical Journal
Biochem J (2002) 365 (3): 897–902.
Published: 01 August 2002
...Grzegorz A. CZAPSKI; Diana AVRAM; Dmitri V. SAKHAROV; Karel W.A. WIRTZ; Joanna B. STROSZNAJDER; Everard H.W. PAP Protein oxidation of human umbilical-vein endothelial cells (HUVEC) in culture was examined under various conditions of oxidative stress. Extracellular protein (ECP) oxidation...
Articles
Selectivity of protein oxidative damage during aging in Drosophila melanogaster
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Journal:
Biochemical Journal
Biochem J (2001) 360 (1): 209–216.
Published: 08 November 2001
...Nilanjana DAS; Rodney L. LEVINE; William C. ORR; Rajindar S. SOHAL The purpose of the present study was to determine whether oxidation of various proteins during the aging process occurs selectively or randomly, and whether the same proteins are damaged in different species. Protein oxidative...
Articles
Rat peptide methionine sulphoxide reductase: cloning of the cDNA, and down-regulation of gene expression and enzyme activity during aging
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2001) 355 (3): 819–825.
Published: 24 April 2001
... 29 1 2001 20 2 2001 The Biochemical Society, London © 2001 2001 post-translational modification protein oxidation protein repair Biochem. J. (2001) 355, 819 825 (Printed in Great Britain) 819 Rat peptide methionine sulphoxide reductase : cloning of the cDNA, and down...
Articles
Oxidative modification of H-ras: S-thiolation and S-nitrosylation of reactive cysteines
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Journal:
Biochemical Journal
Biochem J (2001) 355 (1): 145–153.
Published: 26 February 2001
... can be extensive in io, that both S-nitrosylated and S-glutathiolated forms may be important, and that oxidation may occur on reactive cysteines that are normally targeted for lipid-modification reactions. Key words: glutathione, MAP kinase, protein oxidation, S-nitroso cysteine. a thioester linkage...
Articles
Peroxidation of proteins before lipids in U937 cells exposed to peroxyl radicals
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Journal:
Biochemical Journal
Biochem J (2000) 350 (1): 215–218.
Published: 09 August 2000
.... Our results suggest that protein hydroperoxides might have a significant role as intermediates in the development of biological damage initiated by reactive oxygen species. Key words: free radical, lipid oxidation, protein hydroperoxide, protein oxidation. MATERIALS AND METHODS All reagents were of AR...
Articles
Histone H1- and other protein- and amino acid-hydroperoxides can give rise to free radicals which oxidize DNA
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 344 (1): 125–134.
Published: 08 November 1999
... DNA damage DNA-protein cross-links EPR protein hydroperoxides protein oxidation Biochem. J. (1999) 344, 125 134 (Printed in Great Britain) 125 Histone H1- and other protein- and amino acid-hydroperoxides can give rise to free radicals which oxidize DNA Catherine LUXFORD, Benedicte MORIN, Roger...
Articles
Secondary radicals derived from chloramines of apolipoprotein B-100 contribute to HOCl-induced lipid peroxidation of low-density lipoproteins
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Journal:
Biochemical Journal
Biochem J (1999) 339 (3): 489–495.
Published: 26 April 1999
... of HOCl in vivo ), protein oxidation is rapid and followed by an extended period of lipid peroxidation during which further protein oxidation does not occur. The secondary lipid peroxidation process involves EPR-detectable radicals, is attenuated by a radical trap or treatment of HOCl-oxidized LDL...
