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Keywords: protein stability
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Biochem J (2018) 475 (14): 2271–2291.
Published: 25 July 2018
...). Published by Portland Press Limited on behalf of the Biochemical Society 2018 binding IDP molecular interactions nuclear–protein protein conformation protein stability NUPR1 is an 82-residue-long (8 kDa), highly basic, monomeric IDP that is overexpressed during the acute phase...
Includes: Supplementary data
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Biochem J (2018) 475 (12): 2107–2125.
Published: 29 June 2018
... resistance of an enzyme. antimicrobial resistance dihydrofolate reductase molecular evolution protein stability trade-off trimethoprim During the evolution of proteins, structural stability constrains the sequence space that a protein can access and mutations that have large destabilizing...
Includes: Supplementary data
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Biochem J (2017) 474 (14): 2333–2347.
Published: 03 July 2017
... the functional differences in various N-glycosylation sites on the protein. 10 2 2017 14 4 2017 19 4 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 glycosylation protein function protein stability protein structure...
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Biochem J (2017) 474 (3): 427–443.
Published: 20 January 2017
... on behalf of the Biochemical Society 2017 Aap biofilm dimerization intercellular adhesion protein stability Staphylococcus Staphylococcus epidermidis is a commensal gram-positive bacterium of the skin and is the staphylococcal species that most frequently colonizes humans [ 1...
Includes: Supplementary data
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Biochem J (2016) 473 (20): 3611–3620.
Published: 11 October 2016
... equilibrium model to the data truncated ∼2–3°C above the temperatures of the maximum of the DSC transitions. protein engineering protein stability resurrected proteins thioredoxin The engineering of proteins with enhanced stability has drawn considerable attention for many years [ 1 , 2...
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Biochem J (2016) 473 (14): 2087–2096.
Published: 12 July 2016
... cytotoxicity molecular mechanism protein aggregation protein stability Crystallins are the predominant soluble proteins in vertebrate lens. According to their elution positions on size-exclusion chromatography (SEC), crystallins can be categorized into three families (α-, β- and γ-crystallins...
Includes: Supplementary data
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Biochem J (2015) 468 (1): 99–108.
Published: 05 May 2015
... was used to remove remaining free label. aggregation antibody α 1 -antitrypsin polymerization protein stability α 1 -Antitrypsin ( SERPINA1 ) is an acute-phase glycoprotein, secreted by hepatocytes and abundant in the plasma. A member of the serpin superfamily, the primary role of α 1...
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Biochem J (2015) 468 (1): 145–158.
Published: 05 May 2015
..., is monomeric but also forms oligomers, which posits Arc to be a flexible hub protein. Arc biophysical characterization oligomerization presenilin-1 protein purification protein stability synaptic plasticity Storage of information in the brain is thought to require the plasticity of neural...
Includes: Supplementary data
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Biochem J (2013) 451 (3): 453–461.
Published: 12 April 2013
.... In contrast, DBC1 overexpression significantly enhanced Rev-erbα protein stability by preventing its ubiquitination and degradation. The regulation of Rev-erbα protein levels and function by DBC1 depends on both the N-terminal and C-terminal domains of DBC1. More importantly, in cells depleted of DBC1...
Includes: Supplementary data
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Biochem J (2012) 447 (2): 313–320.
Published: 26 September 2012
...-terminus of Hsc70 (heat-shock cognate 70)-interacting protein (CHIP) heat-shock protein 90 (Hsp90) proteasomal degradation protein stability PTK6 protein tyrosine kinase 6 (PTK6) tyrosine kinase The molecular mechanisms of PTK6 in tumour progression and metastasis have been unveiled...
Includes: Supplementary data
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Biochem J (2012) 442 (3): 573–581.
Published: 24 February 2012
...) has been identified as one of the main regulators of drought and heat responses, and it is regulated through protein stability. In the present paper we describe evidence that the interaction with RCD1 (RADICAL-INDUCED CELL DEATH 1) contributes to the control of DREB2A under a range of conditions...
Includes: Supplementary data
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Biochem J (2011) 436 (3): 661–669.
Published: 27 May 2011
... (AP-1) c-Jun c-Jun N-terminal kinase c-Jun dimerization protein 2 (JDP2) phosphorylation protein stability 12 7 2010 21 3 2011 4 4 2011 4 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Total RNA was extracted from MEF cells using...
Includes: Supplementary data
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Biochem J (2010) 429 (2): 243–249.
Published: 28 June 2010
...) mutational effect protein evolution protein stability single-molecule analysis Proteins must undergo adaptive changes during evolution when, for instance, the environment surrounding the organism is altered or when they are recruited for new roles [ 1 , 2 ]. Although these changes must involve...
Includes: Supplementary data
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Biochem J (2009) 421 (1): 87–96.
Published: 12 June 2009
... of this glycosylation on the overall Gibbs free energy ( ) of the protein has not been evaluated. It has been reported recently that the increased protein stabilization by glycosylation originated from destabilization of the unfolded state rather than stabilization of the folded state and this effect...
Includes: Supplementary data
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Biochem J (2008) 415 (1): 155–163.
Published: 12 September 2008
... Biochemical Society 2008 epithelial sodium channel (ENaC) HECT (homologous with E6-associated protein C-terminus) domain protein stability self-ubiquitination ubiquitin ligase WW domain Ubiquitination plays a critical role in many cellular processes, primarily regulating protein stability...
Includes: Supplementary data
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Biochem J (2008) 410 (2): 237–244.
Published: 12 February 2008
... function of this elusive protein. © The Authors Journal compilation © 2008 Biochemical Society 2008 binding affinity co-ordination copper octapeptide prion protein (PrP) protein stability Figure 6 Three-dimensional model of component 1 of the co-ordination mode of copper at the fifth...
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Biochem J (2007) 407 (2): 277–284.
Published: 25 September 2007
... system. NGN activity has been shown extensively to be controlled at the transcriptional level. However, in addition, recent findings have indicated that the levels of NGN protein may also be regulated. In the present study, we have demonstrated that NGN protein stability was regulated in both Xenopus...
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Biochem J (2007) 405 (3): 439–444.
Published: 13 July 2007
... or 48 h with CT99021 had no effect on the expression of PTEN in these cells, despite reducing phosphorylation of Thr 366 ( Figure 2 , and results not shown). This suggests that additional circumstances must be met before the effects of Thr 366 phosphorylation on protein stability can be revealed...
Includes: Supplementary data
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Biochem J (2007) 404 (3): 487–497.
Published: 29 May 2007
... cycle 42) homologous protein (Chp) GTPase-binding domain p21-activated kinase (Pak) proteasome protein stability Rho-GTPase Group I Paks are composed of a C-terminal catalytic domain and an N-terminal regulatory domain, through which Pak interacts with numerous proteins. A number of proline...
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Biochem J (2006) 397 (1): 179–186.
Published: 14 June 2006
... active with similar HIF prolyl hydroxylase activity but that they differ in their responses to oestrogen, cell confluence and proteasomal inhibition. We show that the two PHD1 species are subject to proteolytic regulation but differ markedly in their protein stability. Though each isoform has...
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Biochem J (2005) 389 (3): 685–694.
Published: 26 July 2005
... chaperone/usher pathway protein stability protein folding Most Gram-negative pathogens express adhesive surface organelles that allow them to specifically target and bind to host tissues and cause infection. A periplasmic chaperone/usher machinery is used for the controlled assembly of many...
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Biochem J (2005) 388 (1): 39–45.
Published: 10 May 2005
...-affinity drug-binding sites. anaesthesia anaesthetic halothane human serum albumin isothermal titration calorimetry protein stability The Biochemical Society, London 2005 20 7 2004 19 11 2004 6 1 2005 6 1 2005 1 To whom correspondence should be addressed...
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Biochem J (2001) 357 (1): 269–274.
Published: 25 June 2001
... in affinity for binding of warfarin to H242Q and K199A and a smaller decrease in affinity for W214A and R218H. The findings show that Trp-214 is not as essential for the high-affinity binding ofwarfarin as has previously been thought. Key words: conformational changes, high-affinity binding, protein stability...
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Biochem J (2001) 357 (1): 297–303.
Published: 25 June 2001
...-mail behrmann@rwth-aachen.de ). 22 2 2001 26 3 2001 20 4 2001 The Biochemical Society, London ©2001 2001 PD098059 proliferation protein stability Abbreviations used: Cdk, cyclin-dependent kinase; ERK, extracellular signal-regulated protein kinase; GAPDH, glyceraldehyde-3...
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Biochem J (2000) 347 (3): 807–814.
Published: 25 April 2000
... The Biochemical Society, London © 2000 2000 alanine scan four-way junction proteinDNA interaction protein stability structure-specific recognition Biochem. J. (2000) 347, 807 814 (Printed in Great Britain) 807 Alanine mutagenesis of high-mobility-group-protein-1 box B (HMG1-B) Susann TAUDTE, Hong XIN...
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Biochem J (2000) 347 (1): 193–197.
Published: 27 March 2000
... protein stability protein unfolding Biochem. J. (2000) 347, 193 197 (Printed in Great Britain) 193 Electrostatic interactions affecting the active site of class Sigma glutathione S-transferase Julie M. STEVENS*, Richard N. ARMSTRONG‹ and Heini W. DIRR*1 *Protein Structure Function Research Programme...
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Biochem J (2000) 345 (3): 711–717.
Published: 25 January 2000
..., University of Delhi, New Delhi - 110 002, India. 3 To whom correspondence should be addressed (e-mail faizana@del3.vsnl.net.in). 28 7 1999 27 9 1999 12 11 1999 The Biochemical Society, London © 2000 2000 cytochrome c lysozyme myoglobin protein stability ribonuclease...
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