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Articles

The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α 1 -adrenergic receptors

Daniel N. Meijles, Stephen J. Fuller, Joshua J. Cull, Hajed O. Alharbi, Susanna T.E. Cooper, Peter H. Sugden, Angela Clerk

Biochem J (2021) 478 (11): 2059–2079.

https://doi.org/10.1042/BCJ20210144

Published: 08 June 2021

...Daniel N. Meijles; Stephen J. Fuller; Joshua J. Cull; Hajed O. Alharbi; Susanna T.E. Cooper; Peter H. Sugden; Angela Clerk Insulin and insulin-like growth factor stimulate protein synthesis and cardioprotection in the heart, acting through their receptors (INSRs, IGF1Rs) and signalling via protein...

View articletitled, The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α 1 -adrenergic receptors

Includes: Supplementary data

Articles

Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells

Roman V. Lenchine, Sushma R. Rao, Xuemin Wang, Danielle Meiwen Fang, Christopher G. Proud

Biochem J (2021) 478 (8): 1547–1569.

https://doi.org/10.1042/BCJ20210126

Published: 21 April 2021

... have explored the roles of two potential survival mechanisms, autophagy and elongation factor 2 kinase (eEF2K), which, when activated, inhibits the resource-intensive elongation stage of protein synthesis. Both processes are regulated through the nutrient-sensitive AMP-activated protein kinase...

View articletitled, Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells

Includes: Supplementary data

Articles

Full-length NF-κB repressing factor contains an XRN2 binding domain

Jana Alexandrova, David Piñeiro, Rebekah Jukes-Jones, Ryan Mordue, Mark Stoneley, Anne E. Willis

Biochem J (2020) 477 (4): 773–786.

https://doi.org/10.1042/BCJ20190733

Published: 27 February 2020

... Commons Attribution License 4.0 (CC BY) . protein synthesis ribosome biogenesis RNA-binding proteins XRN2 XTBD The published sequence of the previously described short version of human NKRF contained only 11 amino acids of the XTBD, and based on previous elegant structural studies...

View articletitled, Full-length NF-κB repressing factor contains an XRN2 binding domain

Includes: Supplementary data

Articles

Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits

Noel C. Wortham, Joanna D. Stewart, Sean Harris, Mark J. Coldwell, Christopher G. Proud

Biochem J (2016) 473 (5): 571–580.

https://doi.org/10.1042/BJ20150828

Published: 24 February 2016

...Noel C. Wortham; Joanna D. Stewart; Sean Harris; Mark J. Coldwell; Christopher G. Proud The eukaryotic translation initiation factor eIF2B is a multi-subunit complex with a crucial role in the regulation of global protein synthesis in the cell. The complex comprises five subunits, termed α through...

View articletitled, Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits

Includes: Supplementary data

Articles

p58 IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity

Anne Roobol, Jo Roobol, Amandine Bastide, John R. P. Knight, Anne E. Willis, C. Mark Smales

Biochem J (2015) 465 (2): 213–225.

https://doi.org/10.1042/BJ20140852

Published: 06 January 2015

...Anne Roobol; Jo Roobol; Amandine Bastide; John R. P. Knight; Anne E. Willis; C. Mark Smales One of the key cellular responses to stress is the attenuation of mRNA translation and protein synthesis via the phosphorylation of eIF2α (eukaryotic translation initiation factor 2α). This is mediated...

View articletitled, p58 IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity

Includes: Supplementary data

Articles

Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation

John R. P. Knight, Amandine Bastide, Anne Roobol, Jo Roobol, Thomas J. Jackson, Wahyu Utami, David A. Barrett, C. Mark Smales, Anne E. Willis

Biochem J (2015) 465 (2): 227–238.

https://doi.org/10.1042/BJ20141014

Published: 06 January 2015

... of protein synthesis. Global control of translation is mediated by modification of translation factors to allow reprogramming of the translatome and synthesis of specific proteins that are required for stress protection or initiation of apoptosis. In the present study, we have investigated how global protein...

View articletitled, Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation

Includes: Supplementary data

Articles

A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators

Yu-Chiang Lai, Samanta Kviklyte, Didier Vertommen, Louise Lantier, Marc Foretz, Benoît Viollet, Stefan Hallén, Mark H. Rider

Biochem J (2014) 460 (3): 363–375.

https://doi.org/10.1042/BJ20131673

Published: 29 May 2014

... of a small-molecule AMPK activator that efficiently activates AMPK and stimulates glucose uptake and fatty acid oxidation in skeletal muscle. AMP-activated protein kinase activator (AMPK activator) acetyl-CoA carboxylase (ACC) fatty acid oxidation glycogen protein synthesis Rat...

View articletitled, A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators

Includes: Supplementary data

Articles

The non-steroidal anti-inflammatory drug indomethacin activates the eIF2α kinase PKR, causing a translational block in human colorectal cancer cells

Claudia Brunelli, Carla Amici, Mara Angelini, Chiara Fracassi, Giuseppe Belardo, M. Gabriella Santoro

Biochem J (2012) 443 (2): 379–386.

https://doi.org/10.1042/BJ20111236

Published: 27 March 2012

..., causing rapid phosphorylation of eIF2α (the α-subunit of eukaryotic translation initiation factor 2) and inhibiting protein synthesis in colorectal carcinoma and other types of cancer cells. The PKR-mediated translational block was followed by inhibition of CRC cell proliferation and apoptosis induction...

View articletitled, The non-steroidal anti-inflammatory drug indomethacin activates the eIF2α kinase PKR, causing a translational block in human colorectal cancer cells

Includes: Supplementary data

Articles

Phosphorylation of eIF2α in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase

Azmi Yerlikaya, Scot R. Kimball, Bruce A. Stanley

Biochem J (2008) 412 (3): 579–588.

https://doi.org/10.1042/BJ20080324

Published: 28 May 2008

...Azmi Yerlikaya; Scot R. Kimball; Bruce A. Stanley The present study demonstrates that even brief inhibition of degradation by the 26S proteasome inhibits global protein synthesis, mediated through increased phosphorylation of eIF2α (eukaryotic translational initiation factor 2α) by the HRI (haem...

View articletitled, Phosphorylation of eIF2α in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase

Articles

15-Deoxyspergualin inhibits eukaryotic protein synthesis through eIF2α phosphorylation

T. N. C. Ramya, Namita Surolia, Avadhesha Surolia

Biochem J (2007) 401 (2): 411–420.

https://doi.org/10.1042/BJ20060879

Published: 21 December 2006

...T. N. C. Ramya; Namita Surolia; Avadhesha Surolia DSG (15-deoxyspergualin), an immunosuppressant with tumoricidal properties, binds potently to the regulatory C-terminal ‘EEVD’ motif of Hsps (heat-shock proteins). In the present study we demonstrate that DSG inhibits eukaryotic protein synthesis...

View articletitled, 15-Deoxyspergualin inhibits eukaryotic protein synthesis through eIF2α phosphorylation

Articles

The case for regulating indispensable amino acid metabolism: the branched-chain α-keto acid dehydrogenase kinase-knockout mouse

Susan M. Hutson

Biochem J (2006) 400 (1): e1.

https://doi.org/10.1042/BJ20061506

Published: 27 October 2006

...Susan M. Hutson BCAAs (branched-chain amino acids) are indispensable (essential) amino acids that are required for body protein synthesis. Indispensable amino acids cannot be synthesized by the body and must be acquired from the diet. The BCAA leucine provides hormone-like signals to tissues...

View articletitled, The case for regulating indispensable amino acid metabolism: the branched-chain α-keto acid dehydrogenase kinase-knockout mouse

Articles

Misincorporation of free m -tyrosine into cellular proteins: a potential cytotoxic mechanism for oxidized amino acids

Hande Gurer-Orhan, Nuran Ercal, Suneetha Mare, Subramaniam Pennathur, Hilmi Orhan, Jay W. Heinecke

Biochem J (2006) 395 (2): 277–284.

https://doi.org/10.1042/BJ20051964

Published: 28 March 2006

... incorporated into proteins. Incorporation of m -tyrosine into cellular proteins was sensitive to inhibition by cycloheximide, suggesting that protein synthesis was involved. Protein synthesis using a cell-free transcription/translation system showed that m -tyrosine was incorporated into proteins in vitro...

View articletitled, Misincorporation of free m -tyrosine into cellular proteins: a potential cytotoxic mechanism for oxidized amino acids

Articles

The selective recruitment of mRNA to the ER and an increase in initiation are important for glucose-stimulated proinsulin synthesis in pancreatic β-cells

Isabel C. Greenman, Edith Gomez, Claire E. J. Moore, Terence P. Herbert

Biochem J (2005) 391 (2): 291–300.

https://doi.org/10.1042/BJ20050468

Published: 10 October 2005

... of proinsulin mRNA to the ER compared with other mRNAs encoding secretory proteins. This, as far as we are aware, is the first example whereby mRNAs encoding secretory proteins are selectively recruited to the ER and provides a novel regulatory mechanism for secretory protein synthesis. Contrary to previous...

View articletitled, The selective recruitment of mRNA to the ER and an increase in initiation are important for glucose-stimulated proinsulin synthesis in pancreatic β-cells

Articles

Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)

Mark ROLFE, Laura E. McLEOD, Phillip F. PRATT, Christopher G. PROUD

Biochem J (2005) 388 (3): 973–984.

https://doi.org/10.1042/BJ20041888

Published: 07 June 2005

...Mark ROLFE; Laura E. McLEOD; Phillip F. PRATT; Christopher G. PROUD The hypertrophic G q -protein-coupled receptor agonist PE (phenylephrine) activates protein synthesis. We showed previously that activation of protein synthesis by PE requires MEK [MAPK (mitogen-activated protein kinase)/ERK...

View articletitled, Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)

Articles

Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism

Troy A. HORNBERGER, Rudy STUPPARD, Kevin E. CONLEY, Mark J. FEDELE, Marta L. FIOROTTO, Eva R. CHIN, Karyn A. ESSER

Biochem J (2004) 380 (3): 795–804.

https://doi.org/10.1042/bj20040274

Published: 15 June 2004

... in the translational efficiency. 1 To whom correspondence should be addressed (e-mail [email protected] ). 18 2 2004 13 3 2004 19 3 2004 19 3 2004 The Biochemical Society, London ©2004 2004 hypertrophy mammalian target of rapamycin (mTOR) mechanotransduction protein synthesis...

View articletitled, Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism

Articles

Regulation of protein synthesis by eIF4E phosphorylation in adult cardiocytes: the consequence of secondary structure in the 5′-untranslated region of mRNA

William J. TUXWORTH, Jr, Atif N. SAGHIR, Laura S. SPRUILL, Donald R. MENICK, Paul J. McDERMOTT

Biochem J (2004) 378 (1): 73–82.

https://doi.org/10.1042/bj20031027

Published: 15 February 2004

...William J. TUXWORTH, Jr; Atif N. SAGHIR; Laura S. SPRUILL; Donald R. MENICK; Paul J. McDERMOTT In adult cardiocytes, eIF4E (eukaryotic initiation factor 4E) activity and protein synthesis are increased concomitantly in response to stimuli that induce hypertrophic growth. We tested the hypothesis...

View articletitled, Regulation of protein synthesis by eIF4E phosphorylation in adult cardiocytes: the consequence of secondary structure in the 5′-untranslated region of mRNA

Articles

Ca2+-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes

Lijun WANG, Mark ROLFE, Christopher G. PROUD

Biochem J (2003) 373 (2): 603–611.

https://doi.org/10.1042/bj20030454

Published: 15 July 2003

...Lijun WANG; Mark ROLFE; Christopher G. PROUD The α 1 -adrenergic agonist, phenylephrine (PE), exerts hypertrophic effects in the myocardium and activates protein synthesis. Both Ca 2+ -dependent protein kinase C (PKC, PKCα) and Ca 2+ -independent PKC isoforms (PKCδ and ε) are detectably expressed...

View articletitled, Ca2+-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes

Articles

Osmotic regulation of insulin-induced mitogen-activated protein kinase phosphatase (MKP-1) expression in H4IIE rat hepatoma cells

Mohammad Reza LORNEJAD-SCHÄFER, Christine SCHÄFER, Dirk GRAF, Dieter HÄUSSINGER, Freimut SCHLIESS

Biochem J (2003) 371 (2): 609–619.

https://doi.org/10.1042/bj20021357

Published: 15 April 2003

...-duesseldorf.de ). 29 8 2002 10 1 2003 15 1 2003 15 1 2003 The Biochemical Society, London ©2003 2003 cell volume insulin resistance liver protein synthesis rapamycin Abbreviations used: CHX, cycloheximide; DTT, dithiothreitol; eIF-4E, eukaryotic initiation factor 4E...

View articletitled, Osmotic regulation of insulin-induced mitogen-activated protein kinase phosphatase (MKP-1) expression in H4IIE rat hepatoma cells

Articles

Oxidative stress increases eukaryotic initiation factor 4E phosphorylation in vascular cells

Roger F. DUNCAN, Hazel PETERSON, Curt H. HAGEDORN, Alex SEVANIAN

Biochem J (2003) 369 (2): 213–225.

https://doi.org/10.1042/bj20020435

Published: 15 January 2003

...Roger F. DUNCAN; Hazel PETERSON; Curt H. HAGEDORN; Alex SEVANIAN Dysregulated cell growth can be caused by increased activity of protein synthesis eukaryotic initiation factor (eIF) 4E. Dysregulated cell growth is also characteristic of atherosclerosis. It is postulated that exposure of vascular...

View articletitled, Oxidative stress increases eukaryotic initiation factor 4E phosphorylation in vascular cells

Articles

The type 2 vascular endothelial growth factor receptor recruits insulin receptor substrate-1 in its signalling pathway

Duraisamy SENTHIL, Goutam GHOSH CHOUDHURY, Basant K. BHANDARI, Balakuntalam S. KASINATH

Biochem J (2002) 368 (1): 49–56.

https://doi.org/10.1042/bj20020137

Published: 15 November 2002

...-induced PI 3-kinase activity in IRS-1 immunoprecipitates. Additionally, VEGF-induced protein synthesis was also impaired by antisense but not sense IRS-1 oligonucleotide. These data provide the first evidence that binding of VEGF to its type 2 receptor promotes association of IRS-1 with the receptor...

View articletitled, The type 2 vascular endothelial growth factor receptor recruits insulin receptor substrate-1 in its signalling pathway

Articles

Glucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1

Jigna PATEL, Xuemin WANG, Christopher G. PROUD

Biochem J (2001) 358 (2): 497–503.

https://doi.org/10.1042/bj3580497

Published: 24 August 2001

...-mail [email protected] ). 15 12 2000 13 6 2001 22 6 2001 The Biochemical Society, London ©2001 2001 mRNA translation mTOR protein synthesis translation factor Abbreviations used: eIF, eukaryotic initiation factor; 4E-BP1, eIF4E binding protein 1; CHO, Chinese-hamster...

View articletitled, Glucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1

Articles

Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain

Cristina MARTÍN de la VEGA, Jozef BURDA, Miroslava NEMETHOVA, Celia QUEVEDO, Alberto ALCÁZAR, M. Elena MARTÍN, Viera DANIELISOVA, Juan L. FANDO, Matilde SALINAS

Biochem J (2001) 357 (3): 819–826.

https://doi.org/10.1042/bj3570819

Published: 25 July 2001

... phosphorylation protein synthesis Abbreviations used: DTT, dithiothreitol; eIF, eukaryotic initiation factor; eIF2α, α subunit of eIF2; eIF2α(P), phosphorylated α subunit of eIF2; 4E-BP1, eIF4E-binding protein; eIF4E(P), phosphorylated eIF4E; IEF, isoelectric focusing; m 7 GTP, 7-methylguanosine...

View articletitled, Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain

Articles

Hierarchies of ATP-consuming processes: direct compared with indirect measurements, and comparative aspects

Wolfgang WIESER, Gerhard KRUMSCHNABEL

Biochem J (2001) 355 (2): 389–395.

https://doi.org/10.1042/bj3550389

Published: 06 April 2001

... and phylogenetic status of the species from which the cells were derived. We confined our study to the two most prominent ATP consumers of cells: protein synthesis and the Na + /K + -ATPase, measuring their activity directly by [ 3 H]leucine incorporation and Rb + -flux respectively. We found large differences...

View articletitled, Hierarchies of ATP-consuming processes: direct compared with indirect measurements, and comparative aspects

Articles

Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity

Tricia A. DIGGLE, Tatiana SUBKHANKULOVA, Kathryn S. LILLEY, Nita SHIKOTRA, Anne E. WILLIS, Nicholas T. REDPATH

Biochem J (2001) 353 (3): 621–626.

https://doi.org/10.1042/bj3530621

Published: 25 January 2001

...+ /CaM-independent eEF-2K activity to a similar extent, providing a mechanistic link between elevated cAMP and the inhibition of protein synthesis [Diggle, Redpath, Heesom and Denton (1998) Biochem. J. 336 , 525–529]. Here we describe the expression of glutathione S-transferase (GST)-eEF-2K fusion...

View articletitled, Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity

Articles

Apoptosis of haematopoietic cells upon thymidylate synthase inhibition is independent of p53 accumulation and CD95–CD95 ligand interaction

Cristina MUÑOZ-PINEDO, F. Javier OLIVER, Abelardo LÓPEZ-RIVAS

Biochem J (2001) 353 (1): 101–108.

https://doi.org/10.1042/bj3530101

Published: 18 December 2000

...Cristina MUÑOZ-PINEDO; F. Javier OLIVER; Abelardo LÓPEZ-RIVAS Treatment of haematopoietic BA/F3 cells with the thymidylate synthase inhibitor 5-fluoro-2′-deoxyuridine (FUdR) activated apoptosis through a mechanism that required continuous protein synthesis and was inhibited by Bcl-2 over-expression...

View articletitled, Apoptosis of haematopoietic cells upon thymidylate synthase inhibition is independent of p53 accumulation and CD95–CD95 ligand interaction

Articles

l-Leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the l-leucine-induced up-regulation of System A amino acid transport

Karine PEYROLLIER, Eric HAJDUCH, Anne S. BLAIR, Russell HYDE, Harinder S. HUNDAL

Biochem J (2000) 350 (2): 361–368.

https://doi.org/10.1042/bj3500361

Published: 23 August 2000

... of glycogen synthase kinase-3 (GSK-3). Leucine enhanced System A transport by ≈ 50%. We have shown previously that this stimulation is protein-synthesis-dependent and in the current study we show that it was blocked by both wortmannin and rapamycin. Our findings indicate that PI3K and the mammalian target...

View articletitled, l-Leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the l-leucine-induced up-regulation of System A amino acid transport

Articles

Glucose and amino acids modulate translation factor activation by growth factors in PC12 cells

Miranda KLEIJN, Christopher G. PROUD

Biochem J (2000) 347 (2): 399–406.

https://doi.org/10.1042/bj3470399

Published: 10 April 2000

...Miranda KLEIJN; Christopher G. PROUD In PC12 phaeochromocytoma cells, protein synthesis is activated by epidermal and nerve growth factors (EGF and NGF). EGF and NGF also regulate a number of components of the translational machinery in these cells. Here we show that the ability of EGF and NGF...

View articletitled, Glucose and amino acids modulate translation factor activation by growth factors in PC12 cells

Articles

Pancreatic eukaryotic initiation factor-2α kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

Ruchira SOOD, Amy C. PORTER, Kun MA, Lawrence A. QUILLIAM, Ronald C. WEK

Biochem J (2000) 346 (2): 281–293.

https://doi.org/10.1042/bj3460281

Published: 22 February 2000

... kinase protein synthesis translation Biochem. J. (2000) 346, 281 293 (Printed in Great Britain) 281 Pancreatic eukaryotic initiation factor-2a kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum...

View articletitled, Pancreatic eukaryotic initiation factor-2α kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

Articles

Histone synthesis in Leishmania infantum is tightly linked to DNA replication by a translational control

Manuel SOTO, Luis QUIJADA, Carlos ALONSO, Jose M. REQUENA

Biochem J (2000) 346 (1): 99–105.

https://doi.org/10.1042/bj3460099

Published: 08 February 2000

...). 12 7 1999 25 10 1999 25 11 1999 The Biochemical Society, London © 2000 2000 DNA synthesis hydroxyurea post-transcriptional regulation protein synthesis Biochem. J. (2000) 346, 99 105 (Printed in Great Britain) 99 Histone synthesis in Leishmania infantum is tightly linked...

View articletitled, Histone synthesis in Leishmania infantum is tightly linked to DNA replication by a translational control

Articles

Immunosuppressants FK506 and rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation

Suzanne MIYAMOTO, Brian SAFER

Biochem J (1999) 344 (3): 803–812.

https://doi.org/10.1042/bj3440803

Published: 08 December 1999

... either directly or indirectly reduce protein synthesis. Therefore a kinetic study was conducted in human primary T lymphocytes examining increased synthesis of proteins stimulated by either ionomycin+phorbol myristate acetate (PMA) or PMA alone. Three patterns of protein expression were observed...

View articletitled, Immunosuppressants FK506 and rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation

Articles

Cellular stress in Xenopus kidney cells enhances the phosphorylation of eukaryotic translation initiation factor (eIF)4E and the association of eIF4F with poly(A)-binding protein

Christopher S. FRASER, Virginia M. PAIN, Simon J. MORLEY

Biochem J (1999) 342 (3): 519–526.

https://doi.org/10.1042/bj3420519

Published: 05 September 1999

... resulted in the activation of protein synthesis, enhanced phosphorylation of eIF4E and increased binding of the adapter protein, eIF4G, and poly(A)-binding protein (PABP) to eIF4E to form the functional initiation factor complex, eIF4F/PABP. We now show that cellular stresses such as arsenite, anisomycin...

View articletitled, Cellular stress in Xenopus kidney cells enhances the phosphorylation of eukaryotic translation initiation factor (eIF)4E and the association of eIF4F with poly(A)-binding protein

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