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Keywords: protein synthesis
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Biochem J (2021) 478 (11): 2059–2079.
Published: 08 June 2021
...Daniel N. Meijles; Stephen J. Fuller; Joshua J. Cull; Hajed O. Alharbi; Susanna T.E. Cooper; Peter H. Sugden; Angela Clerk Insulin and insulin-like growth factor stimulate protein synthesis and cardioprotection in the heart, acting through their receptors (INSRs, IGF1Rs) and signalling via protein...
Includes: Supplementary data
Biochem J (2021) 478 (8): 1547–1569.
Published: 21 April 2021
... have explored the roles of two potential survival mechanisms, autophagy and elongation factor 2 kinase (eEF2K), which, when activated, inhibits the resource-intensive elongation stage of protein synthesis. Both processes are regulated through the nutrient-sensitive AMP-activated protein kinase and...
Includes: Supplementary data
Biochem J (2020) 477 (4): 773–786.
Published: 27 February 2020
... Creative Commons Attribution License 4.0 (CC BY) . protein synthesis ribosome biogenesis RNA-binding proteins XRN2 XTBD Ribosomes are complex macromolecular machines that translate the genetic code into functional polypeptides. They are comprised of four ribosomal RNAs (rRNA) and ∼80...
Includes: Supplementary data
Biochem J (2016) 473 (5): 571–580.
Published: 24 February 2016
...Noel C. Wortham; Joanna D. Stewart; Sean Harris; Mark J. Coldwell; Christopher G. Proud The eukaryotic translation initiation factor eIF2B is a multi-subunit complex with a crucial role in the regulation of global protein synthesis in the cell. The complex comprises five subunits, termed α through...
Includes: Supplementary data
Biochem J (2015) 465 (2): 213–225.
Published: 06 January 2015
...Anne Roobol; Jo Roobol; Amandine Bastide; John R. P. Knight; Anne E. Willis; C. Mark Smales One of the key cellular responses to stress is the attenuation of mRNA translation and protein synthesis via the phosphorylation of eIF2α (eukaryotic translation initiation factor 2α). This is mediated by...
Includes: Supplementary data
Biochem J (2015) 465 (2): 227–238.
Published: 06 January 2015
... of protein synthesis. Global control of translation is mediated by modification of translation factors to allow reprogramming of the translatome and synthesis of specific proteins that are required for stress protection or initiation of apoptosis. In the present study, we have investigated how global...
Includes: Supplementary data
Biochem J (2014) 460 (3): 363–375.
Published: 29 May 2014
... (AMPK activator) acetyl-CoA carboxylase (ACC) fatty acid oxidation glycogen protein synthesis 1 Correspondence may be addressed to either of these authors, who made an equal contribution to this work (email mark.rider@uclouvain.be or stefan.hallen@astrazeneca.com ). AMPK (AMP...
Includes: Supplementary data
Biochem J (2012) 443 (2): 379–386.
Published: 27 March 2012
..., causing rapid phosphorylation of eIF2α (the α-subunit of eukaryotic translation initiation factor 2) and inhibiting protein synthesis in colorectal carcinoma and other types of cancer cells. The PKR-mediated translational block was followed by inhibition of CRC cell proliferation and apoptosis induction...
Includes: Supplementary data
Biochem J (2008) 412 (3): 579–588.
Published: 28 May 2008
...Azmi Yerlikaya; Scot R. Kimball; Bruce A. Stanley The present study demonstrates that even brief inhibition of degradation by the 26S proteasome inhibits global protein synthesis, mediated through increased phosphorylation of eIF2α (eukaryotic translational initiation factor 2α) by the HRI (haem...
Biochem J (2007) 401 (2): 411–420.
Published: 21 December 2006
...T. N. C. Ramya; Namita Surolia; Avadhesha Surolia DSG (15-deoxyspergualin), an immunosuppressant with tumoricidal properties, binds potently to the regulatory C-terminal ‘EEVD’ motif of Hsps (heat-shock proteins). In the present study we demonstrate that DSG inhibits eukaryotic protein synthesis by...
Biochem J (2006) 400 (1): e1.
Published: 27 October 2006
...Susan M. Hutson BCAAs (branched-chain amino acids) are indispensable (essential) amino acids that are required for body protein synthesis. Indispensable amino acids cannot be synthesized by the body and must be acquired from the diet. The BCAA leucine provides hormone-like signals to tissues such...
Biochem J (2006) 395 (2): 277–284.
Published: 28 March 2006
... incorporated into proteins. Incorporation of m -tyrosine into cellular proteins was sensitive to inhibition by cycloheximide, suggesting that protein synthesis was involved. Protein synthesis using a cell-free transcription/translation system showed that m -tyrosine was incorporated into proteins in vitro by a...
Biochem J (2005) 391 (2): 291–300.
Published: 10 October 2005
... proinsulin mRNA to the ER compared with other mRNAs encoding secretory proteins. This, as far as we are aware, is the first example whereby mRNAs encoding secretory proteins are selectively recruited to the ER and provides a novel regulatory mechanism for secretory protein synthesis. Contrary to previous...
Biochem J (2005) 388 (3): 973–984.
Published: 07 June 2005
...Mark ROLFE; Laura E. McLEOD; Phillip F. PRATT; Christopher G. PROUD The hypertrophic G q -protein-coupled receptor agonist PE (phenylephrine) activates protein synthesis. We showed previously that activation of protein synthesis by PE requires MEK [MAPK (mitogen-activated protein kinase)/ERK...
Biochem J (2004) 380 (3): 795–804.
Published: 15 June 2004
... protein synthesis rapamycin ribosomal S6 kinase (p70 S6k ) Abbreviations used: CNT, control; EDL muscle, extensor digitorum longus muscle; eEF2, eukaryotic elongation factor 2; eIF, eukaryotic initiation factor; GSK-3β, glycogen synthase kinase-3β; IGF, insulin-like growth factor; mTOR...
Biochem J (2004) 378 (1): 73–82.
Published: 15 February 2004
...William J. TUXWORTH, Jr; Atif N. SAGHIR; Laura S. SPRUILL; Donald R. MENICK; Paul J. McDERMOTT In adult cardiocytes, eIF4E (eukaryotic initiation factor 4E) activity and protein synthesis are increased concomitantly in response to stimuli that induce hypertrophic growth. We tested the hypothesis...
Biochem J (2003) 373 (2): 603–611.
Published: 15 July 2003
...Lijun WANG; Mark ROLFE; Christopher G. PROUD The α 1 -adrenergic agonist, phenylephrine (PE), exerts hypertrophic effects in the myocardium and activates protein synthesis. Both Ca 2+ -dependent protein kinase C (PKC, PKCα) and Ca 2+ -independent PKC isoforms (PKCδ and ε) are detectably expressed...
Biochem J (2003) 371 (2): 609–619.
Published: 15 April 2003
...-duesseldorf.de ). 29 8 2002 10 1 2003 15 1 2003 15 1 2003 The Biochemical Society, London ©2003 2003 cell volume insulin resistance liver protein synthesis rapamycin Abbreviations used: CHX, cycloheximide; DTT, dithiothreitol; eIF-4E, eukaryotic initiation factor 4E...
Biochem J (2003) 369 (2): 213–225.
Published: 15 January 2003
...Roger F. DUNCAN; Hazel PETERSON; Curt H. HAGEDORN; Alex SEVANIAN Dysregulated cell growth can be caused by increased activity of protein synthesis eukaryotic initiation factor (eIF) 4E. Dysregulated cell growth is also characteristic of atherosclerosis. It is postulated that exposure of vascular...
Biochem J (2002) 368 (1): 49–56.
Published: 15 November 2002
...-induced PI 3-kinase activity in IRS-1 immunoprecipitates. Additionally, VEGF-induced protein synthesis was also impaired by antisense but not sense IRS-1 oligonucleotide. These data provide the first evidence that binding of VEGF to its type 2 receptor promotes association of IRS-1 with the receptor...
Biochem J (2001) 358 (2): 497–503.
Published: 24 August 2001
... addressed (e-mail c.g.proud@dundee.ac.uk ). 15 12 2000 13 6 2001 22 6 2001 The Biochemical Society, London ©2001 2001 mRNA translation mTOR protein synthesis translation factor Abbreviations used: eIF, eukaryotic initiation factor; 4E-BP1, eIF4E binding protein 1...
Biochem J (2001) 357 (3): 819–826.
Published: 25 July 2001
... matilde.salinas@hrc.es ). 23 2 2001 11 4 2001 11 5 2001 The Biochemical Society, London ©2001 2001 cerebral ischaemia initiation factors ribosomal protein S6 kinase protein phosphorylation protein synthesis Abbreviations used: DTT, dithiothreitol; eIF, eukaryotic...
Biochem J (2001) 355 (2): 389–395.
Published: 06 April 2001
..., ecology and phylogenetic status of the species from which the cells were derived. We confined our study to the two most prominent ATP consumers of cells: protein synthesis and the Na + /K + -ATPase, measuring their activity directly by [ 3 H]leucine incorporation and Rb + -flux respectively. We found...
Biochem J (2001) 353 (3): 621–626.
Published: 25 January 2001
...+ /CaM-independent eEF-2K activity to a similar extent, providing a mechanistic link between elevated cAMP and the inhibition of protein synthesis [Diggle, Redpath, Heesom and Denton (1998) Biochem. J. 336 , 525–529]. Here we describe the expression of glutathione S-transferase (GST)-eEF-2K fusion...
Biochem J (2001) 353 (1): 101–108.
Published: 18 December 2000
...Cristina MUÑOZ-PINEDO; F. Javier OLIVER; Abelardo LÓPEZ-RIVAS Treatment of haematopoietic BA/F3 cells with the thymidylate synthase inhibitor 5-fluoro-2′-deoxyuridine (FUdR) activated apoptosis through a mechanism that required continuous protein synthesis and was inhibited by Bcl-2 over-expression...
Biochem J (2000) 350 (2): 361–368.
Published: 23 August 2000
... glycogen synthase kinase-3 (GSK-3). Leucine enhanced System A transport by ≈ 50%. We have shown previously that this stimulation is protein-synthesis-dependent and in the current study we show that it was blocked by both wortmannin and rapamycin. Our findings indicate that PI3K and the mammalian target of...
Biochem J (2000) 347 (2): 399–406.
Published: 10 April 2000
...Miranda KLEIJN; Christopher G. PROUD In PC12 phaeochromocytoma cells, protein synthesis is activated by epidermal and nerve growth factors (EGF and NGF). EGF and NGF also regulate a number of components of the translational machinery in these cells. Here we show that the ability of EGF and NGF to...
Biochem J (2000) 346 (2): 281–293.
Published: 22 February 2000
... stress protein kinase protein synthesis translation Biochem. J. (2000) 346, 281 293 (Printed in Great Britain) 281 Pancreatic eukaryotic initiation factor-2a kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to...
Biochem J (2000) 346 (1): 99–105.
Published: 08 February 2000
...@cbm.uam.es). 12 7 1999 25 10 1999 25 11 1999 The Biochemical Society, London © 2000 2000 DNA synthesis hydroxyurea post-transcriptional regulation protein synthesis Biochem. J. (2000) 346, 99 105 (Printed in Great Britain) 99 Histone synthesis in Leishmania infantum is...
Biochem J (1999) 344 (3): 803–812.
Published: 08 December 1999
... either directly or indirectly reduce protein synthesis. Therefore a kinetic study was conducted in human primary T lymphocytes examining increased synthesis of proteins stimulated by either ionomycin+phorbol myristate acetate (PMA) or PMA alone. Three patterns of protein expression were observed...
Biochem J (1999) 342 (3): 519–526.
Published: 05 September 1999
... resulted in the activation of protein synthesis, enhanced phosphorylation of eIF4E and increased binding of the adapter protein, eIF4G, and poly(A)-binding protein (PABP) to eIF4E to form the functional initiation factor complex, eIF4F/PABP. We now show that cellular stresses such as arsenite, anisomycin...