... (protein-tyrosine phosphatase)-mediated catalysis. In the E- P (phosphoenzyme) formation step, Asp 181 functions as a general acid, while in the E- P hydrolysis step it acts as a general base. Most of our understanding of the role of Asp 181 is derived from studies with the Yersinia PTP and the mammalian...

... STAT1 activation and tyrosine phosphorylation. The inhibitory effect of ethanol was not reversed by pretreatment with either sodium vanadate, a non-selective tyrosine phosphatase inhibitor, or with MG132, a specific proteasome inhibitor. This suggests that protein tyrosine phosphatases or the ubiquitin...