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Keywords: proteoglycan
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Articles
Glycoengineering: scratching the surface
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2021) 478 (4): 703–719.
Published: 18 February 2021
... ( [email protected] ) 2 11 2020 22 12 2020 19 1 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 glycobiologybiology glycocalyx glycoproteinsbiology glycosaminoglycansbiology glycosylationbiology proteoglycan...
Articles
Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2019) 476 (2): 225–243.
Published: 18 January 2019
... on behalf of the Biochemical Society 2019 exostosis extracellular matrix glycosaminoglycan heparan sulfate perlecan proteoglycan Heparan sulfate (HS) is an ancient glycosaminoglycan and a highly conserved molecule which has persisted throughout vertebrate and invertebrate evolution over...
Articles
Proteoglycans, ion channels and cell–matrix adhesion
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Journal:
Biochemical Journal
Biochem J (2017) 474 (12): 1965–1979.
Published: 25 May 2017
...Ioli Mitsou; Hinke A.B. Multhaupt; John R. Couchman Cell surface proteoglycans comprise a transmembrane or membrane-associated core protein to which one or more glycosaminoglycan chains are covalently attached. They are ubiquitous receptors on nearly all animal cell surfaces. In mammals, the cell...
Articles
Kyohei Higashi, Keita Takeda, Ann Mukuno, Yusuke Okamoto, Sayaka Masuko, Robert J. Linhardt, Toshihiko Toida
Journal:
Biochemical Journal
Biochem J (2016) 473 (22): 4145–4158.
Published: 10 November 2016
... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . chondroitin sulfate chondroitinase Glycobiology keratan sulfate proteoglycan Glycosaminoglycans (GAGs), a group of structurally related polysaccharides, are primarily found as the glycan...
Includes: Supplementary data
Articles
Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells
Available to PurchaseChristine Y. Chuang, Georg Degendorfer, Astrid Hammer, John M. Whitelock, Ernst Malle, Michael J. Davies
Journal:
Biochemical Journal
Biochem J (2014) 459 (2): 313–322.
Published: 28 March 2014
... proteoglycan Atherosclerosis is a multi-factorial disease characterized by the accumulation of lipids in the artery wall and chronic inflammation [ 1 ]. Lesions contain large numbers of activated monocytes and macrophages that are capable of generating reactive oxidants, and it has been demonstrated...
Includes: Supplementary data
Articles
Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes
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Journal:
Biochemical Journal
Biochem J (2013) 454 (1): 133–145.
Published: 26 July 2013
... hepatocyte growth factor (HGF) signalling proteoglycan Isolated hepatocytes were treated with William's E Medium containing both 20 mIU of HSase from F. heparinum (EC 4.2.2.8) and 20 mIU Hepase from F. heparinum (EC 4.2.2.7) (Seikagaku Biobusiness) or with William's E Medium containing 10 mIU...
Includes: Supplementary data
Articles
Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition
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Journal:
Biochemical Journal
Biochem J (2012) 443 (2): 361–368.
Published: 27 March 2012
..., we compared the proteoglycans of uterine fibroids and keloid scars with corresponding normal tissues. Our analysis indicates that uterine fibroids and keloid scars contain higher amounts of glycosaminoglycans relative to normal myometrium and normal adult skin respectively. Proteoglycan composition...
Articles
Chondroitin 4- O -sulfotransferase-2 regulates the number of chondroitin sulfate chains initiated by chondroitin N -acetylgalactosaminyltransferase-1
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Journal:
Biochemical Journal
Biochem J (2012) 441 (2): 697–705.
Published: 21 December 2011
... be addressed (email [email protected] ). 11 8 2011 19 9 2011 27 9 2011 27 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 chondroitin sulfate glycosaminoglycan glycosyltransferase proteoglycan sulfotransferase CSs (chondroitin...
Articles
Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in co-operation with chondroitin N-acetylgalactosaminyltransferase-2
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Journal:
Biochemical Journal
Biochem J (2011) 434 (2): 321–331.
Published: 11 February 2011
[email protected] ). 10 9 2010 29 11 2010 8 12 2010 8 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 chondroitin sulfate glycosaminoglycan glycosyltransferase proteoglycan sulfotransferase CS (chondroitin sulfate) is a class of GAG...
Includes: Supplementary data
Articles
Ephrin-B3 binds to a sulfated cell-surface receptor
Available to PurchaseHalvor L. Holen, Lillian Zernichow, Kristine E. Fjelland, Ida M. Evenroed, Kristian Prydz, Heidi Tveit, Hans-Christian Aasheim
Journal:
Biochemical Journal
Biochem J (2011) 433 (1): 215–223.
Published: 15 December 2010
... receptor which is a heparan sulfate proteoglycan. Site-directed mutagenesis analysis revealed that Arg 178 and Lys 179 are important for heparin binding of ephrin-B3 and also for ephrin-B3 binding to cells. These amino acids, when introduced in the non-heparin-binding ephrin-B1, conferred the heparin...
Articles
Domain structure elucidation of human decorin glycosaminoglycans
Available to PurchaseTatiana N. Laremore, Mellisa Ly, Zhenqing Zhang, Kemal Solakyildirim, Scott A. McCallum, Richard T. Owens, Robert J. Linhardt
Journal:
Biochemical Journal
Biochem J (2010) 431 (2): 199–205.
Published: 28 September 2010
...Tatiana N. Laremore; Mellisa Ly; Zhenqing Zhang; Kemal Solakyildirim; Scott A. McCallum; Richard T. Owens; Robert J. Linhardt The structure of the GAG (glycosaminoglycan) chain of recombinantly expressed decorin proteoglycan was examined using a combination of intact-chain analysis and domain...
Includes: Supplementary data
Articles
Biosynthesis of heparan sulfate in EXT1 -deficient cells
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Journal:
Biochemical Journal
Biochem J (2010) 428 (3): 463–471.
Published: 27 May 2010
... 2 (EXT2) exostosin-like 2 (EXTL2) glycosaminoglycan heparan sulfate (HS) proteoglycan HS (heparan sulfate) proteoglycans are ubiquitously found at the cell surface and in the extracellular matrix, affecting a variety of biological processes, including specific signalling pathways [ 1 – 4...
Includes: Supplementary data
Articles
SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2008) 414 (2): 231–236.
Published: 12 August 2008
... glycosyltransferase proteoglycan Sry-type high-mobility-group box 9 (SOX9) sulfotransferase The transcription factor SOX9 (Sry-type high-mobility-group box 9) is expressed in all chondrocytes and is essential for the expression of the proteoglycan aggrecan, which is secreted by chondrocytes to form...
Articles
The molecular structure of human tissue type XV presents a unique conformation among the collagens
Available to PurchaseJeanne C. Myers, Peter S. Amenta, Arnold S. Dion, Justin P. Sciancalepore, Chandrasekaran Nagaswami, John W. Weisel, Peter D. Yurchenco
Journal:
Biochemical Journal
Biochem J (2007) 404 (3): 535–544.
Published: 29 May 2007
... 2007 basement membrane chondroitin sulfate extracellular matrix heparan sulfate proteoglycan rotary shadowing type XV collagen Two main sources of human type XV are umbilical cord and placenta ( Figure 2 ; also see [ 18 – 20 ]). Initial purification attempts using placenta...
Articles
Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor
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Journal:
Biochemical Journal
Biochem J (2007) 403 (3): 545–552.
Published: 12 April 2007
... ]. chondroitin sulfate chondroitin polymerization glycosyltransferase glycosaminoglycan protein interaction proteoglycan CS (chondroitin sulfate) is a class of GAG (glycosaminoglycan) that is distributed on the surface of virtually all cells and in the extracellular matrix. CS is covalently linked...
Articles
Cell surface chondroitin sulfate glycosaminoglycan in melanoma: role in the activation of pro-MMP-2 (pro-gelatinase A)
Available to PurchaseJoji Iida, Krista L. Wilhelmson, Janet Ng, Peter Lee, Charlotte Morrison, Eric Tam, Christopher M. Overall, James B. McCarthy
Journal:
Biochemical Journal
Biochem J (2007) 403 (3): 553–563.
Published: 12 April 2007
...Joji Iida; Krista L. Wilhelmson; Janet Ng; Peter Lee; Charlotte Morrison; Eric Tam; Christopher M. Overall; James B. McCarthy We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP...
Articles
Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells
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Journal:
Biochemical Journal
Biochem J (2007) 403 (1): 49–57.
Published: 13 March 2007
...Tiago Braga; Mirjana Grujic; Agneta Lukinius; Lars Hellman; Magnus Åbrink; Gunnar Pejler SG (serglycin) PGs (proteoglycans) are strongly implicated in the assembly of MC (mast cell) granules. However, this notion has mainly been on the basis of studies of MCs of the connective tissue subtype...
Articles
In vivo contribution of amino acid sulfur to cartilage proteoglycan sulfation
Available to PurchaseFabio Pecora, Benedetta Gualeni, Antonella Forlino, Andrea Superti-Furga, Ruggero Tenni, Giuseppe Cetta, Antonio Rossi
Journal:
Biochemical Journal
Biochem J (2006) 398 (3): 509–514.
Published: 29 August 2006
... in vivo . To check whether cysteine derivatives play a role, sulfation of cartilage proteoglycans was measured after treatment for 1 week of newborn mutant and wild-type mice with hypodermic NAC ( N -acetyl- L -cysteine). The relative amount of sulfated disaccharides increased in mutant mice treated...
Articles
Novel human-derived cell-penetrating peptides for specific subcellular delivery of therapeutic biomolecules
Available to PurchaseCatherine de Coupade, Antonio Fittipaldi, Vanessa Chagnas, Matthieu Michel, Sophie Carlier, Ennio Tasciotti, Audrey Darmon, Denis Ravel, Jonathan Kearsey, Mauro Giacca, Françoise Cailler
Journal:
Biochemical Journal
Biochem J (2005) 390 (2): 407–418.
Published: 23 August 2005
... of the cell-penetrating peptides to extracellular heparan sulphate proteoglycans, except for one particular peptide (DPV1047) that partially originates from an anti-DNA antibody and is internalized in a caveolar independent manner. These new therapeutic tools are currently being developed for intracellular...
Articles
Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity
Available to PurchaseSandra MÜLLER, Manuela SCHÖTTLER, Sylvia SCHÖN, Christian PRANTE, Thomas BRINKMANN, Joachim KUHN, Christian GÖTTING, Knut KLEESIEK
Journal:
Biochemical Journal
Biochem J (2005) 386 (2): 227–236.
Published: 22 February 2005
...Sandra MÜLLER; Manuela SCHÖTTLER; Sylvia SCHÖN; Christian PRANTE; Thomas BRINKMANN; Joachim KUHN; Christian GÖTTING; Knut KLEESIEK XT-I (xylosyltransferase I) is the initial enzyme in the post-translational biosynthesis of glycosaminoglycan chains in proteoglycans. To gain insight...
Articles
The ADAMTS metalloproteinases
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Journal:
Biochemical Journal
Biochem J (2005) 386 (1): 15–27.
Published: 08 February 2005
... are extracellular, multidomain enzymes whose known functions include: (i) collagen processing as procollagen N-proteinase; (ii) cleavage of the matrix proteoglycans aggrecan, versican and brevican; (iii) inhibition of angiogenesis; and (iv) blood coagulation homoeostasis as the von Willebrand factor cleaving...
Articles
Interleukin-8 binds to syndecan-2 on human endothelial cells
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 377 (2): 533–538.
Published: 15 January 2004
...-regulated by this inflammatory stimulus. By immunoprecipitation using an anti-syndecan-2 antibody on TNF-α-stimulated HUVEC lysates, inflammation-induced interleukin-8 was found to be an interaction partner of this HS (heparan sulphate) proteoglycan, but not of any other syndecan on these cells...
Articles
Effects of [3H]glucosamine concentration on [3H]chondroitin sulphate formation by cultured chondrocytes
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Journal:
Biochemical Journal
Biochem J (2003) 376 (2): 511–515.
Published: 01 December 2003
... proteoglycan xyloside Abbreviations used: GlcN, glucosamine; GalN, galactosamine; ΔDi-0S, 2-acetamido-2-deoxy-3- O -(β- d -Glc-4-enepyranosyluronic acid)- d -galactose; ΔDi-4S, 2-acetamido-2-deoxy-3- O -(β- d -Glc-4-enepyranosyluronic acid)-4- O -sulpho- d -galactose; ΔDi-6S, 2-acetamido-2-deoxy-3- O...
Articles
Variations in aggrecan structure modulate its susceptibility to aggrecanases
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Journal:
Biochemical Journal
Biochem J (2003) 375 (1): 183–189.
Published: 01 October 2003
...Peter J. ROUGHLEY; James BARNETT; Fengrong ZUO; John S. MORT Proteoglycan aggregates and purified aggrecan from adult and fetal bovine cartilage and adult and neonatal human cartilage were subjected to in vitro degradation by recombinant aggrecanase-1 and aggrecanase-2. The ability...
Articles
Formation of active monomers from tetrameric human beta-tryptase
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Journal:
Biochemical Journal
Biochem J (2003) 369 (3): 603–610.
Published: 01 February 2003
...Ignacio FAJARDO; Gunnar PEJLER Tryptase is a serine protease that is stored at low pH in the mast cell secretory granules in complex with heparin proteoglycan. When mast cells are activated, e.g. during allergic responses, the tryptase/heparin complexes are released together with a variety of other...
Articles
The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism
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Journal:
Biochemical Journal
Biochem J (2002) 362 (2): 465–472.
Published: 22 February 2002
..., but abundant release of GAG occurred in the presence of retinoic acid, with evidence of aggrecanase action. Treatment of fetal epiphyseal cartilage with retinoic acid INTRODUCTION The large aggregating proteoglycan, aggrecan, is a major struc- tural component of articular cartilage, on which it confers...
Articles
Human glycosaminoglycan glucuronyltransferase I gene and a related processed pseudogene: genomic structure, chromosomal mapping and characterization
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Journal:
Biochemical Journal
Biochem J (2001) 358 (3): 539–546.
Published: 10 September 2001
... The Biochemical Society, London ©2001 2001 gene expression gene structure glycosaminoglycans proteoglycan Abbreviations used: DAPI, 4,6-diamidino-2-phenylindole; FISH, fluorescence in situ hybridization; GAG, glycosaminoglycan; GlcAT-I, glucuronyltransferase I (EC 2.4.1.135); GlcAT-P...
Articles
Epidermal transformation leads to increased perlecan synthesis with heparin-binding-growth-factor affinity
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Journal:
Biochemical Journal
Biochem J (2001) 355 (2): 517–527.
Published: 06 April 2001
...Pairath TAPANADECHOPONE; Sarka TUMOVA; Xinnong JIANG; John R. COUCHMAN Perlecan, a proteoglycan of basement membrane and extracellular matrices, has important roles in both normal biological and pathological processes. As a result of its ability to store and protect growth factors, perlecan may...
Articles
The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1
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Journal:
Biochemical Journal
Biochem J (2000) 351 (1): 161–166.
Published: 26 September 2000
..., such as preferred peptide sequences for enzyme binding or enhanced accessibility to the core protein at these sites. Key words: ADAMTS, cartilage, degradation, osteoarthritis, proteoglycan. region and which have lost the C-terminal G3 domain. However, whether these species are products of aggrecanase and}or other...
Articles
Catabolism of aggrecan, decorin and biglycan in tendon
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Journal:
Biochemical Journal
Biochem J (2000) 350 (1): 181–188.
Published: 09 August 2000
...Sarah G. REES; Carl R. FLANNERY; Chris B. LITTLE; Clare E. HUGHES; Bruce CATERSON; Colin M. DENT We have examined the catabolism of the proteoglycans aggrecan, decorin and biglycan in fresh tendon samples and in explant cultures of tissue from the tensional and compressed regions of young...
Articles
Interaction of the collagen-like tail of asymmetric acetylcholinesterase with heparin depends on triple-helical conformation, sequence and stability
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Journal:
Biochemical Journal
Biochem J (2000) 350 (1): 283–290.
Published: 09 August 2000
...Paola DEPREZ; Ellen DOSS-PEPE; Barbara BRODSKY; Nibaldo C. INESTROSA The collagen-like tail of asymmetric acetylcholinesterase (AChE) contains two heparin-binding domains (HBDs) that interact with heparan sulphate proteoglycans, determining the anchoring of the enzyme at the basal lamina and its...
Articles
Activation of extracellular signal-regulated protein kinase1,2 results in down-regulation of decorin expression in fibroblasts
Available to PurchasePauliina LAINE, Niina REUNANEN, Laura RAVANTI, Marco FOSCHI, Manoranjan SANTRA, V. Renato IOZZO, Veli-Matti KÄHÄRI
Journal:
Biochemical Journal
Biochem J (2000) 349 (1): 19–25.
Published: 26 June 2000
...Pauliina LAINE; Niina REUNANEN; Laura RAVANTI; Marco FOSCHI; Manoranjan SANTRA; V. Renato IOZZO; Veli-Matti KÄHÄRI Decorin is a small leucine-rich extracellular matrix proteoglycan, the expression of which is down-regulated in proliferating and malignantly transformed cells. In the present study we...
Articles
The heparin-binding site in tetranectin is located in the N-terminal region and binding does not involve the carbohydrate recognition domain
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Journal:
Biochemical Journal
Biochem J (2000) 347 (1): 83–87.
Published: 27 March 2000
... 2000 2000 C-type lectin proteoglycan refolding Biochem. J. (2000) 347, 83 87 (Printed in Great Britain) 83 The heparin-binding site in tetranectin is located in the N-terminal region and binding does not involve the carbohydrate recognition domain Rikke H. LORENTSEN, Jonas H. GRAVERSEN...
Articles
Isolation and characterization of proteoglycans from human follicular fluid
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Journal:
Biochemical Journal
Biochem J (1999) 340 (3): 613–620.
Published: 08 June 1999
...Gitte V. ERIKSEN; Ingemar CARLSTEDT; Matthias MÖRGELIN; Niels ULDBJERG; Anders MALMSTRÖM Two proteoglycans differing in size and composition were isolated from human follicular fluid. The larger one of high density had a molecular mass of 3.0×10 6 Da, as determined by laser light-scattering...
