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Keywords: proteostasis
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Articles

Single-molecule observations of human small heat shock proteins in complex with aggregation-prone client proteins

Open Access
Lauren Rice, Nicholas Marzano, Dezerae Cox, Bailey Skewes, Antoine M. van Oijen, Heath Ecroyd
Journal: Biochemical Journal
Biochem J (2025) 482 (09): 413–432.
https://doi.org/10.1042/BCJ20240473
Published: 25 April 2025
... is crucial to our understanding of how these molecular chaperones act to inhibit protein aggregation and maintain cellular proteostasis. Correspondence: Heath Ecroyd ( [email protected] ) 16 08 2024 01 04 2025 © 2025 The Author(s). 2025 This is an open access article published...
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Includes: Supplementary data
Articles

Systematic approaches to identify E3 ligase substrates

Open Access
Mary Iconomou, Darren N. Saunders
Journal: Biochemical Journal
Biochem J (2016) 473 (22): 4083–4101.
https://doi.org/10.1042/BCJ20160719
Published: 10 November 2016
...-ND) . cancer functional genomics neurodegeneration proteomics proteostasis ubiquitin Conjugation of the small protein modifier ubiquitin (Ub) is one of the most abundant post-translational modifications in cellular signalling. Ubiquitylation regulates a wide range of cellular...
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Articles

Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans

Available to Purchase
Hanrui Zhang, Ni Pan, Siqin Xiong, Shenglong Zou, Haifeng Li, Lingyun Xiao, Zhijian Cao, Alan Tunnacliffe, Zebo Huang
Journal: Biochemical Journal
Biochem J (2012) 441 (1): 417–424.
https://doi.org/10.1042/BJ20110621
Published: 14 December 2011
...Hanrui Zhang; Ni Pan; Siqin Xiong; Shenglong Zou; Haifeng Li; Lingyun Xiao; Zhijian Cao; Alan Tunnacliffe; Zebo Huang Late-onset neurodegenerative diseases are characterized by progressive accumulation of aggregation-prone proteins and global disruption of the proteostasis network, e.g. abnormal...
View articletitled, Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans
Open the PDF for Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans in another window
Includes: Supplementary data