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Keywords: pyroglutamate (pGlu)
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Articles

Inhibition of glutaminyl cyclase attenuates cell migration modulated by monocyte chemoattractant proteins

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Yi-Ling Chen, Kai-Fa Huang, Wen-Chih Kuo, Yan-Chung Lo, Yu-May Lee, Andrew H.-J. Wang
Journal: Biochemical Journal
Biochem J (2012) 442 (2): 403–412.
https://doi.org/10.1042/BJ20110535
Published: 13 February 2012
...) monocyte monocyte chemoattractant protein (MCP) pyroglutamate (pGlu) QC (glutaminyl cyclase, EC 2.3.2.5) has been reported to be responsible for the conversion of numerous N-terminal glutaminyl peptides into pyroglutamyl peptides [ 1 – 4 ]. The formation of pGlu (pyroglutamate) at the N-terminus...
View article titled, Inhibition of glutaminyl cyclase attenuates cell migration modulated by monocyte chemoattractant proteins
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Includes: Supplementary data
Articles

A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis

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Kai-Fa Huang, Yu-Ruei Wang, En-Cheng Chang, Tsung-Lin Chou, Andrew H.-J. Wang
Journal: Biochemical Journal
Biochem J (2008) 411 (1): 181–190.
https://doi.org/10.1042/BJ20071073
Published: 13 March 2008
... (glutaminyl-peptide cyclotransferase QC) pyroglutamate (pGlu) hydrogen-bond network proton transfer site-directed mutagenesis synchrotron X-ray crystallography QCs (glutaminyl cyclases; glutaminyl-peptide cyclotransferases, EC 2.3.2.5) catalyse the conversion of protein N-terminal glutamine...
View article titled, A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis
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Includes: Supplementary data