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Keywords: pyruvate
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Biochem J (2015) 466 (3): 443–454.
Published: 06 March 2015
...Kyle S. McCommis; Brian N. Finck Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial enzymes that metabolize pyruvate are physically separated from cytosolic...
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Biochem J (2011) 437 (3): 373–379.
Published: 13 July 2011
... may come as a result of combined reactions of PK (pyruvate kinase) and PPDK (pyruvate, phosphate dikinase). The PP i formed in the PPDK/PK cycle ignites glycolysis in conditions of low [ATP] by involving PP i -dependent reactions. This saves ATP and makes metabolism under stress conditions more energy...
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Biochem J (2004) 380 (2): 419–424.
Published: 01 June 2004
... of a novel feedback loop for adjusting hypoxia-regulated gene expression. We have recently shown that HIF-1α stability, HIF-1 nuclear translocation and HIF-mediated gene expression in human glioma cell lines can be stimulated by pyruvate independently of hypoxia. In the present study we show...
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Biochem J (2003) 374 (1): e1–e2.
Published: 15 August 2003
...Mary C. SUGDEN; Mark J. HOLNESS Pyruvate occupies a central role in energy homoeostasis, and dysregulation of its cellular disposition underlies many metabolic disturbances. Although the mitochondrial membrane pyruvate transporter has been characterized, its molecular identity has proved elusive...
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Biochem J (1999) 343 (2): 281–299.
Published: 08 October 1999
...Andrew P. HALESTRAP; Nigel T. PRICE Monocarboxylates such as lactate and pyruvate play a central role in cellular metabolism and metabolic communication between tissues. Essential to these roles is their rapid transport across the plasma membrane, which is catalysed by a recently identified family...