...Kyle S. McCommis; Brian N. Finck Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial enzymes that metabolize pyruvate are physically separated from cytosolic...

... may come as a result of combined reactions of PK (pyruvate kinase) and PPDK (pyruvate, phosphate dikinase). The PP i formed in the PPDK/PK cycle ignites glycolysis in conditions of low [ATP] by involving PP i -dependent reactions. This saves ATP and makes metabolism under stress conditions more energy...

...Muthusamy Thangaraju; Kristina N. Carswell; Puttur D. Prasad; Vadivel Ganapathy Human colon cancer cells and primary colon cancer silence the gene coding for LDH (lactate dehydrogenase)-B and up-regulate the gene coding for LDH-A, resulting in effective conversion of pyruvate into lactate...

... mitochondrial activity. A model is proposed using the known passive transport of pyruvate by UCP1. 24 3 2005 19 9 2005 23 9 2005 23 9 2005 Several mitochondrial UCPs (uncoupling proteins) have been described so far (for reviews, see [ 1 – 3 ]). First identified in 1976 [ 4 , 5 ], UCP1...

... cells analysed were in a dynamic state, and cell number, time of plating, culture medium, extracellular volume and time of harvest and assay were strictly controlled. Intra- and extra-cellular lactate and pyruvate levels were measured in homoplasmic wild-type and mutant cells, and correlated with rates...

... of a novel feedback loop for adjusting hypoxia-regulated gene expression. We have recently shown that HIF-1α stability, HIF-1 nuclear translocation and HIF-mediated gene expression in human glioma cell lines can be stimulated by pyruvate independently of hypoxia. In the present study we show...

...Mary C. SUGDEN; Mark J. HOLNESS Pyruvate occupies a central role in energy homoeostasis, and dysregulation of its cellular disposition underlies many metabolic disturbances. Although the mitochondrial membrane pyruvate transporter has been characterized, its molecular identity has proved elusive...

...Andrew P. HALESTRAP; Nigel T. PRICE Monocarboxylates such as lactate and pyruvate play a central role in cellular metabolism and metabolic communication between tissues. Essential to these roles is their rapid transport across the plasma membrane, which is catalysed by a recently identified family...