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Keywords: pyruvate
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Biochem J (2015) 466 (3): 443–454.
Published: 06 March 2015
...Kyle S. McCommis; Brian N. Finck Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial enzymes that metabolize pyruvate are physically separated from cytosolic...
Biochem J (2011) 437 (3): 373–379.
Published: 13 July 2011
... may come as a result of combined reactions of PK (pyruvate kinase) and PPDK (pyruvate, phosphate dikinase). The PP i formed in the PPDK/PK cycle ignites glycolysis in conditions of low [ATP] by involving PP i -dependent reactions. This saves ATP and makes metabolism under stress conditions more energy...
Biochem J (2004) 380 (2): 419–424.
Published: 01 June 2004
... of a novel feedback loop for adjusting hypoxia-regulated gene expression. We have recently shown that HIF-1α stability, HIF-1 nuclear translocation and HIF-mediated gene expression in human glioma cell lines can be stimulated by pyruvate independently of hypoxia. In the present study we show...
Biochem J (2003) 374 (1): e1–e2.
Published: 15 August 2003
...Mary C. SUGDEN; Mark J. HOLNESS Pyruvate occupies a central role in energy homoeostasis, and dysregulation of its cellular disposition underlies many metabolic disturbances. Although the mitochondrial membrane pyruvate transporter has been characterized, its molecular identity has proved elusive...
Biochem J (1999) 343 (2): 281–299.
Published: 08 October 1999
...Andrew P. HALESTRAP; Nigel T. PRICE Monocarboxylates such as lactate and pyruvate play a central role in cellular metabolism and metabolic communication between tissues. Essential to these roles is their rapid transport across the plasma membrane, which is catalysed by a recently identified family...